Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Stim1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes STIM1
- Mouse genes Stim1
- Rat genes Stim1
- Zfish genes stim1a,stim1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Stim1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005246	calcium channel regulator activity	STIM1	IDA		Human	PMID:25326555
Molecular Function	GO:0005246	calcium channel regulator activity	STIM1	IDA		Human	PMID:26322679
Molecular Function	GO:0005246	calcium channel regulator activity	STIM1	IGI	UniProtKB:Q96D31	Human	PMID:31009446
Molecular Function	GO:0005246	calcium channel regulator activity	Stim1	IMP	MGI:MGI:5008476	Mouse	PMID:31664108
Molecular Function	GO:0005246	calcium channel regulator activity	Stim1	IDA		Mouse	PMID:18452988
Molecular Function	GO:0005246	calcium channel regulator activity	Stim1	IMP		Rat	PMID:21541286\|RGD:7175076
Molecular Function	GO:0005509	calcium ion binding	STIM1	IDA		Human	PMID:16005298
Molecular Function	GO:0099103	channel activator activity	Stim1	IMP	MGI:MGI:5008476	Mouse	PMID:31664108
Molecular Function	GO:0099103	channel activator activity	Stim1	IDA		Mouse	PMID:18452988
Molecular Function	GO:0042802	identical protein binding	STIM1	IPI	UniProtKB:Q13586	Human	PMID:17517596
Molecular Function	GO:0042802	identical protein binding	STIM1	IPI	UniProtKB:Q13586	Human	PMID:19249086
Molecular Function	GO:0042802	identical protein binding	STIM1	IPI	UniProtKB:Q13586	Human	PMID:20418871
Molecular Function	GO:0042802	identical protein binding	STIM1	IPI	UniProtKB:Q13586	Human	PMID:21427704
Molecular Function	GO:0042802	identical protein binding	STIM1	IPI	UniProtKB:Q13586	Human	PMID:22451904
Molecular Function	GO:0042802	identical protein binding	STIM1	IPI	UniProtKB:Q13586	Human	PMID:24996186
Molecular Function	GO:0042802	identical protein binding	Stim1	IPI	UniProtKB:P70302	Mouse	MGI:MGI:5918299\|PMID:20037597
Molecular Function	GO:0099107	ion channel regulator activity involved in G protein-coupled receptor signaling pathway	Stim1	IMP	MGI:MGI:5008476	Mouse	PMID:31664108
Molecular Function	GO:0099107	ion channel regulator activity involved in G protein-coupled receptor signaling pathway	Stim1	IDA		Mouse	PMID:18452988
Molecular Function	GO:0051010	microtubule plus-end binding	STIM1	IDA		Human	PMID:19632184
Molecular Function	GO:0002020	protease binding	STIM1	IPI	UniProtKB:Q9CUS9	Human	PMID:25384971
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q9P246	Human	PMID:11463338
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q96D31	Human	PMID:17905723
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:P62157	Human	PMID:18484746
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q96D31	Human	PMID:19249086
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q15691	Human	PMID:19632184
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q96D31	Human	PMID:19706554
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:P48995	Human	PMID:19897728
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q96D31	Human	PMID:20418871
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q9BSW2	Human	PMID:20418871
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:P48995	Human	PMID:21408196
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q96D31	Human	PMID:21427704
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q96D31	Human	PMID:21876174
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:P30101	Human	PMID:21941299
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q96D31	Human	PMID:22451904
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q96BY9	Human	PMID:22464749
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q96D31	Human	PMID:22464749
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:P40146	Human	PMID:22494970
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q96D31	Human	PMID:22494970
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q12797-8	Human	PMID:22586105
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q96D31	Human	PMID:24954132
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q96D31	Human	PMID:24996186
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q969S6	Human	PMID:25996873
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q86TL2	Human	PMID:26322679
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:P31415	Human	PMID:27185316
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q96D31	Human	PMID:27185316
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q96D31	Human	PMID:28219928
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q9P246	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:P01112	Human	PMID:30194290
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q8N7U6	Human	PMID:30481768
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q8N7U6,UniProtKB:Q96D31	Human	PMID:30481768
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q96BY9	Human	PMID:30481768
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q96D31	Human	PMID:30481768
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:P15260	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:P30825	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q9UI14	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q9Y5U4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:P01112	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:P22607	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:P23284	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:P61981	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:P62937-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q14957	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q15047-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q5SUL5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q8TAP4-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q92993	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q96CV9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q9UMX0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:Q9Y649	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	STIM1	IPI	UniProtKB:P22607	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	Stim1	IPI	UniProtKB:P83093	Mouse	MGI:MGI:2148335\|PMID:11463338
Molecular Function	GO:0005515	protein binding	Stim1	IPI	UniProtKB:Q9CZ16	Mouse	MGI:MGI:5706679\|PMID:26644563
Molecular Function	GO:0005515	protein binding	Stim1	IPI	PR:Q8BWG9	Mouse	PMID:17343823
Molecular Function	GO:0005515	protein binding	Stim1	IPI	PR:O88452	Mouse	PMID:21746875
Molecular Function	GO:0015279	store-operated calcium channel activity	Stim1	IMP		Rat	PMID:21389210\|RGD:7175077
Cellular Component	GO:0032541	cortical endoplasmic reticulum	STIM1	IDA		Human	PMID:22586105
Cellular Component	GO:0005783	endoplasmic reticulum	STIM1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	STIM1	IDA		Human	PMID:27185316
Cellular Component	GO:0005783	endoplasmic reticulum	Stim1	IDA		Mouse	PMID:23840669
Cellular Component	GO:0005783	endoplasmic reticulum	Stim1	IDA		Mouse	PMID:31637311
Cellular Component	GO:0005783	endoplasmic reticulum	Stim1	IDA		Rat	PMID:21389210\|RGD:7175077
Cellular Component	GO:0005789	endoplasmic reticulum membrane	STIM1	IDA		Human	PMID:16208375
Cellular Component	GO:0005789	endoplasmic reticulum membrane	STIM1	IDA		Human	PMID:22586105
Cellular Component	GO:0030426	growth cone	Stim1	IDA		Rat	PMID:22712562\|RGD:7241221
Cellular Component	GO:0005886	plasma membrane	STIM1	IDA		Human	PMID:16208375
Cellular Component	GO:0005886	plasma membrane	STIM1	IDA		Human	PMID:19171672
Cellular Component	GO:0005886	plasma membrane	STIM1	IDA		Human	PMID:27185316
Cellular Component	GO:0005886	plasma membrane	STIM1	IDA		Human	PMID:28219928
Cellular Component	GO:0005886	plasma membrane	Stim1	IDA		Mouse	PMID:18452988
Cellular Component	GO:0005886	plasma membrane	Stim1	IDA		Rat	PMID:21541286\|RGD:7175076
Cellular Component	GO:0044853	plasma membrane raft	STIM1	IDA		Human	PMID:19171672
Cellular Component	GO:0032991	protein-containing complex	Stim1	IPI	PR:Q8BWG9	Mouse	PMID:20418871
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	STIM1	IDA		Human	PMID:25326555
Biological Process	GO:0032237	activation of store-operated calcium channel activity	STIM1	IDA		Human	PMID:16005298
Biological Process	GO:0032237	activation of store-operated calcium channel activity	STIM1	IDA		Human	PMID:26322679
Biological Process	GO:0032237	activation of store-operated calcium channel activity	STIM1	IDA		Human	PMID:28219928
Biological Process	GO:0032237	activation of store-operated calcium channel activity	Stim1	IMP		Rat	PMID:21541286\|RGD:7175076
Biological Process	GO:0048846	axon extension involved in axon guidance	stim1a	IMP	ZFIN:ZDB-MRPHLNO-200206-2	Zfish	PMID:31023836
Biological Process	GO:0048846	axon extension involved in axon guidance	stim1a	IMP	ZFIN:ZDB-MRPHLNO-200206-1	Zfish	PMID:31023836
Biological Process	GO:0005513	detection of calcium ion	STIM1	IDA		Human	PMID:16005298
Biological Process	GO:0070166	enamel mineralization	STIM1	IMP		Human	PMID:24621671
Biological Process	GO:0051649	establishment of localization in cell	Stim1	IMP		Mouse	PMID:17647013
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	Stim1	IMP		Mouse	PMID:31664108
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	Stim1	IMP		Mouse	PMID:30131394
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	Stim1	IMP	MGI:MGI:5008476	Mouse	PMID:31664108
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	Stim1	IDA		Mouse	PMID:18452988
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	Stim1	IMP		Mouse	PMID:31664108
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	Stim1	IMP		Mouse	PMID:30131394
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	Stim1	IMP	MGI:MGI:5008476	Mouse	PMID:31664108
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	Stim1	IDA		Mouse	PMID:18452988
Biological Process	GO:0006812	monoatomic cation transport	Stim1	IMP		Mouse	PMID:17647013
Biological Process	GO:0014902	myotube differentiation	Stim1	IMP		Mouse	PMID:23206701
Biological Process	GO:0007207	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	Stim1	IDA		Mouse	PMID:18452988
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Stim1	IMP		Mouse	PMID:31664108
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Stim1	IMP	MGI:MGI:5008476	Mouse	PMID:31664108
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Stim1	IMP		Mouse	PMID:30131394
Biological Process	GO:0045762	positive regulation of adenylate cyclase activity	STIM1	IDA		Human	PMID:19171672
Biological Process	GO:0045766	positive regulation of angiogenesis	STIM1	IMP		Human	PMID:26694763
Biological Process	GO:0032024	positive regulation of insulin secretion	Stim1	IMP	MGI:MGI:5008476	Mouse	PMID:31664108
Biological Process	GO:0032024	positive regulation of insulin secretion	Stim1	IMP		Mouse	PMID:31664108
Biological Process	GO:0032024	positive regulation of insulin secretion	Stim1	IMP		Mouse	PMID:30131394
Biological Process	GO:0032024	positive regulation of insulin secretion	Stim1	IDA		Mouse	PMID:18452988
Biological Process	GO:0051924	regulation of calcium ion transport	STIM1	IDA		Human	PMID:16005298
Biological Process	GO:2001256	regulation of store-operated calcium entry	STIM1	IMP		Human	PMID:23332920
Biological Process	GO:2001256	regulation of store-operated calcium entry	Stim1	IMP		Rat	PMID:22712562\|RGD:7241221
Biological Process	GO:0002115	store-operated calcium entry	STIM1	IDA		Human	PMID:28219928
Biological Process	GO:0002115	store-operated calcium entry	Stim1	IMP		Mouse	PMID:31637311
Biological Process	GO:0002115	store-operated calcium entry	Stim1	IGI	MGI:MGI:1925542	Mouse	PMID:17343823
Biological Process	GO:0002115	store-operated calcium entry	Stim1	IMP		Rat	PMID:21389210\|RGD:7175077
Biological Process	GO:0002115	store-operated calcium entry	Stim1	IDA		Rat	PMID:27237974\|RGD:41404721

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.