Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes STIM2
  • Mouse genes Stim2
  • Rat genes Stim2
  • Zfish genes stim2a,stim2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Stim2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005246	calcium channel regulator activity	STIM2	IMP		Human	PMID:18160041
Molecular Function	GO:0005246	calcium channel regulator activity	Stim2	IMP		Rat	PMID:21541286|RGD:7175076
Molecular Function	GO:0005509	calcium ion binding	STIM2	IDA		Human	PMID:18166150
Molecular Function	GO:0005515	protein binding	STIM2	IPI	UniProtKB:Q13586	Human	PMID:11463338
Molecular Function	GO:0005515	protein binding	STIM2	IPI	UniProtKB:Q96D31	Human	PMID:17905723
Molecular Function	GO:0005515	protein binding	STIM2	IPI	UniProtKB:Q13586	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	Stim2	IPI	UniProtKB:P70302	Mouse	MGI:MGI:2148335|PMID:11463338
Molecular Function	GO:0005515	protein binding	Stim2	IPI	UniProtKB:Q5M848	Rat	PMID:23711249|RGD:10047297
Molecular Function	GO:0015279	store-operated calcium channel activity	STIM2	IDA		Human	PMID:16860747
Cellular Component	GO:0005783	endoplasmic reticulum	STIM2	IDA		Human	PMID:18160041
Cellular Component	GO:0005886	plasma membrane	STIM2	IDA		Human	PMID:18160041
Cellular Component	GO:0005886	plasma membrane	Stim2	IDA		Rat	PMID:21541286|RGD:7175076
Biological Process	GO:0032237	activation of store-operated calcium channel activity	STIM2	IDA		Human	PMID:17905723
Biological Process	GO:0032237	activation of store-operated calcium channel activity	STIM2	IMP		Human	PMID:18160041
Biological Process	GO:0032237	activation of store-operated calcium channel activity	Stim2	IMP		Rat	PMID:21541286|RGD:7175076
Biological Process	GO:0006874	intracellular calcium ion homeostasis	STIM2	IMP		Human	PMID:18160041
Biological Process	GO:0051928	positive regulation of calcium ion transport	STIM2	IDA		Human	PMID:17905723
Biological Process	GO:0051928	positive regulation of calcium ion transport	STIM2	IMP		Human	PMID:18160041

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern