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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Sting1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sting1
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:00615072',3'-cyclic GMP-AMP bindingSTING1IDAHumanPMID:23747010
Molecular FunctionGO:00615072',3'-cyclic GMP-AMP bindingSTING1IDAHumanPMID:26669264
Molecular FunctionGO:00615072',3'-cyclic GMP-AMP bindingSTING1IDAHumanPMID:30842659
Molecular FunctionGO:00615072',3'-cyclic GMP-AMP bindingSTING1IDAHumanPMID:30842662
Molecular FunctionGO:00615072',3'-cyclic GMP-AMP bindingSting1IDAMouseMGI:MGI:5700266|PMID:26300263
Molecular FunctionGO:00615072',3'-cyclic GMP-AMP bindingSting1IDAMouseMGI:MGI:5487473|PMID:23258412
Molecular FunctionGO:00615072',3'-cyclic GMP-AMP bindingSting1IDAMouseMGI:MGI:5787716|PMID:26669264
Molecular FunctionGO:00615072',3'-cyclic GMP-AMP bindingSting1IDARatPMID:26669264|RGD:11344949
Molecular FunctionGO:0035438cyclic-di-GMP bindingSTING1IDAHumanPMID:22705373
Molecular FunctionGO:0035438cyclic-di-GMP bindingSTING1IDAHumanPMID:29694889
Molecular FunctionGO:0035438cyclic-di-GMP bindingSting1IDAMouseMGI:MGI:5700266|PMID:26300263
Molecular FunctionGO:0035438cyclic-di-GMP bindingSting1IDAMouseMGI:MGI:5487515|PMID:21947006
Molecular FunctionGO:0042802identical protein bindingSTING1IPIUniProtKB:Q86WV6HumanPMID:19433799
Molecular FunctionGO:0042802identical protein bindingSTING1IPIUniProtKB:Q86WV6HumanPMID:22312431
Molecular FunctionGO:0042802identical protein bindingSTING1IPIUniProtKB:Q86WV6HumanPMID:22728658
Molecular FunctionGO:0042802identical protein bindingSTING1IPIUniProtKB:Q86WV6HumanPMID:22728659
Molecular FunctionGO:0042802identical protein bindingSTING1IPIUniProtKB:Q86WV6HumanPMID:22728660
Molecular FunctionGO:0042802identical protein bindingSTING1IPIUniProtKB:Q86WV6HumanPMID:23542348
Molecular FunctionGO:0042802identical protein bindingSTING1IPIUniProtKB:Q86WV6HumanPMID:30405246
Molecular FunctionGO:0042802identical protein bindingSTING1IPIUniProtKB:Q86WV6HumanPMID:30842659
Molecular FunctionGO:0140677molecular function activator activitySTING1IDAHumanPMID:30842659
Molecular FunctionGO:0140677molecular function activator activitySTING1IDAHumanPMID:30842662
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:O95786HumanPMID:18724357
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:O95786-1HumanPMID:18724357
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:P43308HumanPMID:18724357
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q7Z434-1HumanPMID:18724357
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q9UHD2HumanPMID:18724357
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q7Z434HumanPMID:18818105
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:P09913HumanPMID:19416887
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:P09914HumanPMID:19416887
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q7Z434-1HumanPMID:19416887
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q9UHD2HumanPMID:19416887
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q9UHD2HumanPMID:19433799
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q7Z434-1HumanPMID:20080758
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:O94826HumanPMID:20628368
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q16666HumanPMID:20890285
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:O15260HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:O94822HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:O95470HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:P39656HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:P46977HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:P51617HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q96A33HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q96N66HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q9UHD2HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:P42226HumanPMID:22000020
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q7Z434HumanPMID:22000020
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:P0C6X5:PRO_0000283876HumanPMID:22312431
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q7Z434HumanPMID:22312431
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:O43657HumanPMID:22908223
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q7Z434HumanPMID:22908223
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:P27958:PRO_0000037575HumanPMID:22911572
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q7Z434HumanPMID:22911572
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q7Z434HumanPMID:23542348
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q99IB8:PRO_0000045601HumanPMID:23542348
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q9UHD2HumanPMID:23542348
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q7RTR2HumanPMID:24560620
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:P0C6X7:PRO_0000037311HumanPMID:24622840
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q7Z434HumanPMID:24622840
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q9UHD2HumanPMID:24622840
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q8WTX9HumanPMID:25299331
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:P03255HumanPMID:26405230
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:O15260HumanPMID:29251827
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q9H8X9HumanPMID:29429998
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q16666-8HumanPMID:30104205
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:P53992HumanPMID:30842662
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:B2RUZ4HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:O95214HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q13190HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q96DZ9-2HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q96HR9-2HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q9BWQ6HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q9NV29HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q9NZ01HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingSTING1IPIUniProtKB:Q9Y342HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingSting1IPIUniProtKB:Q9WUN2MouseMGI:MGI:5568884|PMID:24560620
Molecular FunctionGO:0005515protein bindingSting1IPIUniProtKB:Q91VN6|UniProtKB:Q9WUN2MouseMGI:MGI:5508701|PMID:23142775
Molecular FunctionGO:0005515protein bindingSting1IPIUniProtKB:Q9WUN2MouseMGI:MGI:5295319|PMID:22000020
Molecular FunctionGO:0005515protein bindingSting1IPIPR:Q91VN6MousePMID:21892174
Molecular FunctionGO:0005515protein bindingsting1IPIZFIN:ZDB-GENE-030131-5735ZfishPMID:31018131
Molecular FunctionGO:0042803protein homodimerization activitySTING1IDAHumanPMID:19433799
Molecular FunctionGO:0042803protein homodimerization activitySTING1IDAHumanPMID:21074459
Molecular FunctionGO:0042803protein homodimerization activitySTING1IDAHumanPMID:22705373
Molecular FunctionGO:0019901protein kinase bindingSTING1IDAHumanPMID:18818105
Molecular FunctionGO:0019901protein kinase bindingSTING1IPIUniProtKB:Q9WUN2HumanPMID:21074459
Molecular FunctionGO:0043539protein serine/threonine kinase activator activitySTING1IDAHumanPMID:25636800
Molecular FunctionGO:0061629RNA polymerase II-specific DNA-binding transcription factor bindingSTING1IDAHumanPMID:18818105
Molecular FunctionGO:0035591signaling adaptor activitySTING1IDAHumanPMID:23747010
Molecular FunctionGO:0035591signaling adaptor activitySTING1IDAHumanPMID:25636800
Molecular FunctionGO:0031625ubiquitin protein ligase bindingSting1IPIUniProtKB:Q80VI1MouseMGI:MGI:4849871|PMID:21074459
Cellular ComponentGO:0005776autophagosomeSTING1IDAHumanPMID:29694889
Cellular ComponentGO:0005776autophagosomeSting1IDAMouseMGI:MGI:5925643|PMID:29056340
Cellular ComponentGO:0005737cytoplasmSting1IDAMouseMGI:MGI:5568884|PMID:24560620
Cellular ComponentGO:0005829cytosolSTING1IDAHumanGO_REF:0000052
Cellular ComponentGO:0005783endoplasmic reticulumSting1IDAMousePMID:19926846
Cellular ComponentGO:0005783endoplasmic reticulumSting1IDAMousePMID:21892174
Cellular ComponentGO:0005783endoplasmic reticulumsting1IDAZfishPMID:23091644
Cellular ComponentGO:0005789endoplasmic reticulum membraneSTING1IDAHumanPMID:19433799
Cellular ComponentGO:0005789endoplasmic reticulum membraneSTING1IDAHumanPMID:25254379
Cellular ComponentGO:0005789endoplasmic reticulum membraneSTING1IDAHumanPMID:29694889
Cellular ComponentGO:0005789endoplasmic reticulum membraneSTING1IDAHumanPMID:30119996
Cellular ComponentGO:0005789endoplasmic reticulum membraneSTING1IDAHumanPMID:30842659
Cellular ComponentGO:0005789endoplasmic reticulum membraneSTING1IDAHumanPMID:30842662
Cellular ComponentGO:0005789endoplasmic reticulum membraneSting1IDAMouseMGI:MGI:4365649|PMID:19776740
Cellular ComponentGO:0005789endoplasmic reticulum membraneSting1IDAMouseMGI:MGI:5881983|PMID:27324217
Cellular ComponentGO:0033116endoplasmic reticulum-Golgi intermediate compartment membraneSTING1IDAHumanPMID:32690950
Cellular ComponentGO:0033116endoplasmic reticulum-Golgi intermediate compartment membraneSTING1IDAHumanPMID:30842662
Cellular ComponentGO:0005768endosomeSTING1IDAHumanPMID:29694889
Cellular ComponentGO:0005794Golgi apparatusSting1IDAMouseMGI:MGI:6709519|PMID:28930687
Cellular ComponentGO:0005794Golgi apparatusSting1IDAMousePMID:19926846
Cellular ComponentGO:0000139Golgi membraneSTING1IDAHumanPMID:29973723
Cellular ComponentGO:0000139Golgi membraneSting1IDAMouseMGI:MGI:6195680|PMID:29973723
Cellular ComponentGO:0000139Golgi membraneSting1IDAMouseMGI:MGI:5881983|PMID:27324217
Cellular ComponentGO:0005741mitochondrial outer membraneSTING1IDAHumanPMID:18818105
Cellular ComponentGO:0005654nucleoplasmSTING1IDAHumanGO_REF:0000052
Cellular ComponentGO:0048471perinuclear region of cytoplasmSting1IDAMouseMGI:MGI:4365649|PMID:19776740
Cellular ComponentGO:0005777peroxisomeSting1IDAMousePMID:22745163
Cellular ComponentGO:1990231STING complexSTING1IPIHumanPMID:30405246
Cellular ComponentGO:1990231STING complexSting1IPIMouseMGI:MGI:6827194|PMID:23910378
Biological ProcessGO:0002218activation of innate immune responseSTING1IMPHumanPMID:18818105
Biological ProcessGO:0002218activation of innate immune responseSTING1IDAHumanPMID:23910378
Biological ProcessGO:0002218activation of innate immune responseSTING1IDAHumanPMID:25636800
Biological ProcessGO:0002218activation of innate immune responseSTING1IDAHumanPMID:30842659
Biological ProcessGO:0002218activation of innate immune responseSTING1IDAHumanPMID:30842662
Biological ProcessGO:0002218activation of innate immune responseSting1IDAMouseMGI:MGI:6827194|PMID:23910378
Biological ProcessGO:0002218activation of innate immune responseSting1IMPMouseMGI:MGI:5487515|PMID:21947006
Biological ProcessGO:0002218activation of innate immune responseSting1IMPMouseMGI:MGI:5487473|PMID:23258412
Biological ProcessGO:0140374antiviral innate immune responseSTING1IDAHumanPMID:21074459
Biological ProcessGO:0000045autophagosome assemblySTING1IDAHumanPMID:30568238
Biological ProcessGO:0000045autophagosome assemblySTING1IDAHumanPMID:30842662
Biological ProcessGO:0000045autophagosome assemblySting1IMPMouseMGI:MGI:6305034|PMID:30568238
Biological ProcessGO:0071360cellular response to exogenous dsRNASTING1IMPHumanPMID:18818105
Biological ProcessGO:0035458cellular response to interferon-betaSting1IMPMousePMID:21892174
Biological ProcessGO:0071407cellular response to organic cyclic compoundSTING1IDAHumanPMID:26669264
Biological ProcessGO:0071407cellular response to organic cyclic compoundSting1IDAMouseMGI:MGI:5787716|PMID:26669264
Biological ProcessGO:0071407cellular response to organic cyclic compoundSting1IDARatPMID:26669264|RGD:11344949
Biological ProcessGO:0002753cytosolic pattern recognition receptor signaling pathwaySTING1IDAHumanPMID:23910378
Biological ProcessGO:0002753cytosolic pattern recognition receptor signaling pathwaysting1IDAZfishPMID:23091644
Biological ProcessGO:0051607defense response to virusSTING1IDAHumanPMID:21074459
Biological ProcessGO:0051607defense response to virusSTING1IDAHumanPMID:25254379
Biological ProcessGO:0051607defense response to virusSting1IMPMouseMGI:MGI:4365649|PMID:19776740
Biological ProcessGO:0051607defense response to virusSting1IMPMousePMID:21892174
Biological ProcessGO:0045087innate immune responseSTING1IMPHumanPMID:19433799
Biological ProcessGO:0045087innate immune responseSTING1IDAHumanPMID:21074459
Biological ProcessGO:0045087innate immune responseSTING1IDAHumanPMID:23910378
Biological ProcessGO:0045087innate immune responseSTING1IDAHumanPMID:25254379
Biological ProcessGO:0045087innate immune responseSting1IMPMouseMGI:MGI:3849536|PMID:19433799
Biological ProcessGO:0045087innate immune responseSting1IMPMouseMGI:MGI:4365649|PMID:19776740
Biological ProcessGO:0045087innate immune responseSting1IDAMouseMGI:MGI:6827194|PMID:23910378
Biological ProcessGO:0045087innate immune responsesting1IMPZFIN:ZDB-MRPHLNO-171109-1ZfishPMID:29942316
Biological ProcessGO:0038061NIK/NF-kappaB signalingsting1IGIZfishPMID:31018131
Biological ProcessGO:0038061NIK/NF-kappaB signalingsting1IGIZFIN:ZDB-GENE-030131-1927ZfishPMID:29942316
Biological ProcessGO:0002221pattern recognition receptor signaling pathwaySTING1IDAHumanPMID:23910378
Biological ProcessGO:0002230positive regulation of defense response to virus by hostSTING1IMPHumanPMID:18818105
Biological ProcessGO:0002230positive regulation of defense response to virus by hoststing1IDAZfishPMID:23091644
Biological ProcessGO:0051091positive regulation of DNA-binding transcription factor activitySTING1IDAHumanPMID:18818105
Biological ProcessGO:0032728positive regulation of interferon-beta productionSTING1IMPHumanPMID:19433799
Biological ProcessGO:0032728positive regulation of interferon-beta productionSTING1IDAHumanPMID:21074459
Biological ProcessGO:0032728positive regulation of interferon-beta productionSTING1IDAHumanPMID:25254379
Biological ProcessGO:0032728positive regulation of interferon-beta productionSting1IMPMouseMGI:MGI:4365649|PMID:19776740
Biological ProcessGO:0032728positive regulation of interferon-beta productionSting1IMPMouseMGI:MGI:3849536|PMID:19433799
Biological ProcessGO:0016239positive regulation of macroautophagySTING1IDAHumanPMID:30568238
Biological ProcessGO:0016239positive regulation of macroautophagySTING1IDAHumanPMID:30842662
Biological ProcessGO:0016239positive regulation of macroautophagySting1IMPMouseMGI:MGI:6305034|PMID:30568238
Biological ProcessGO:0016239positive regulation of macroautophagysting1IDAZfishPMID:30842662|ZFIN:ZDB-PUB-200522-33
Biological ProcessGO:0032092positive regulation of protein bindingSTING1IDAHumanPMID:18818105
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISTING1IDAHumanPMID:18818105
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISting1IDAMousePMID:21892174
Biological ProcessGO:0032481positive regulation of type I interferon productionSTING1IDAHumanPMID:22394562
Biological ProcessGO:0032481positive regulation of type I interferon productionSTING1IDAHumanPMID:23747010
Biological ProcessGO:0032481positive regulation of type I interferon productionSTING1IDAHumanPMID:25636800
Biological ProcessGO:0032481positive regulation of type I interferon productionSTING1IDAHumanPMID:26669264
Biological ProcessGO:0032481positive regulation of type I interferon productionSTING1IDAHumanPMID:29694889
Biological ProcessGO:0032481positive regulation of type I interferon productionSTING1IDAHumanPMID:29973723
Biological ProcessGO:0032481positive regulation of type I interferon productionSTING1IDAHumanPMID:30842659
Biological ProcessGO:0032481positive regulation of type I interferon productionSting1IDAMouseMGI:MGI:5787716|PMID:26669264
Biological ProcessGO:0032481positive regulation of type I interferon productionSting1IDAMouseMGI:MGI:6195680|PMID:29973723
Biological ProcessGO:0032481positive regulation of type I interferon productionSting1IDAMouseMGI:MGI:5881983|PMID:27324217
Biological ProcessGO:0032481positive regulation of type I interferon productionSting1IDARatPMID:26669264|RGD:11344949
Biological ProcessGO:0060340positive regulation of type I interferon-mediated signaling pathwaySTING1IDAHumanPMID:23910378
Biological ProcessGO:0060340positive regulation of type I interferon-mediated signaling pathwaySting1IDAMouseMGI:MGI:6827194|PMID:23910378
Biological ProcessGO:0051259protein complex oligomerizationSTING1IDAHumanPMID:30842659
Biological ProcessGO:0010506regulation of autophagysting1IGIZFIN:ZDB-GENE-041010-147,ZFIN:ZDB-MRPHLNO-140826-4ZfishPMID:24922577
Biological ProcessGO:0031323regulation of cellular metabolic processSting1IGIMGI:MGI:1328317MousePMID:28069950
Biological ProcessGO:0010468regulation of gene expressionSting1IGIMGI:MGI:1929658MousePMID:23160154
Biological ProcessGO:0010468regulation of gene expressionSting1IGIMGI:MGI:1859179MousePMID:23160154
Biological ProcessGO:0010468regulation of gene expressionSting1IGIMGI:MGI:1328317MousePMID:23160154
Biological ProcessGO:0010468regulation of gene expressionSting1IGIMGI:MGI:1859212MousePMID:23160154
Biological ProcessGO:0050727regulation of inflammatory responseSting1IGIMGI:MGI:1328317MousePMID:28069950
Biological ProcessGO:0009615response to virussting1IMPZFIN:ZDB-MRPHLNO-171109-1ZfishPMID:25972544
Biological ProcessGO:0061709reticulophagySting1IDAMouseMGI:MGI:5925643|PMID:29056340
Biological ProcessGO:0032606type I interferon productionsting1IDAZfishPMID:23091644

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory