Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes STK11
  • Mouse genes Stk11
  • Rat genes Stk11
  • Zfish genes stk11
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Stk11

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	STK11	IDA		Human	PMID:12805220
Molecular Function	GO:0030275	LRR domain binding	Stk11	IPI	UniProtKB:Q8N1F8	Mouse	MGI:MGI:4412462|PMID:11741830
Molecular Function	GO:0000287	magnesium ion binding	STK11	IDA		Human	PMID:12805220
Molecular Function	GO:0002039	p53 binding	STK11	IDA		Human	PMID:11430832
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q8NFZ5	Human	PMID:12595760
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q8NFZ5	Human	PMID:12753905
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q7RTN6	Human	PMID:12805220
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:P07900	Human	PMID:14676191
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q13451	Human	PMID:14676191
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q16543	Human	PMID:14676191
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q7RTN6	Human	PMID:14676191
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q96L34	Human	PMID:14676191
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q9C0K7	Human	PMID:14676191
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q9Y376	Human	PMID:14676191
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q9NNW5	Human	PMID:17216128
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:P54646	Human	PMID:19274086
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q7RTN6-1	Human	PMID:19513107
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q9Y376	Human	PMID:19513107
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q7RTN6	Human	PMID:19892943
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q9Y376	Human	PMID:19892943
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q13451	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q16543	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q7RTN6	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q9C0K7	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q9Y376	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:P63104	Human	PMID:22575644
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:O95835	Human	PMID:24362629
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:P26927	Human	PMID:24362629
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:P07900	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q13451	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q16543	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:P54646	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q7RTN6	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q9Y376	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:P38936	Human	PMID:25329316
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q13451	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q7RTN6	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q9BT78	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q9Y376	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q7RTN6-1	Human	PMID:26479318
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q9Y376	Human	PMID:26479318
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:P08238	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q13451	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q7RTN6	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q9Y376	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:P07900	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:P08238	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q13451	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q16543	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q7RTN6	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q9BT78	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q9C0K7	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q9Y376	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q13451	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q16543	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q7RTN6	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q9BT78	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q9C0K7	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	STK11	IPI	UniProtKB:Q9Y376	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	Stk11	IPI	UniProtKB:P39689	Mouse	MGI:MGI:5613877|PMID:25329316
Molecular Function	GO:0005515	protein binding	Stk11	IPI	UniProtKB:P54646	Mouse	MGI:MGI:6355494|PMID:19274086
Molecular Function	GO:0005515	protein binding	Stk11	IPI	UniProtKB:Q9CSB4	Mouse	MGI:MGI:5620591|PMID:24859006
Molecular Function	GO:0005515	protein binding	Stk11	IPI	UniProtKB:Q5RJI5|UniProtKB:Q69Z98	Mouse	MGI:MGI:4462353|PMID:17482548
Molecular Function	GO:0030295	protein kinase activator activity	STK11	IDA		Human	PMID:19892943
Molecular Function	GO:0030295	protein kinase activator activity	Stk11	IDA		Mouse	MGI:MGI:4462353|PMID:17482548
Molecular Function	GO:0030295	protein kinase activator activity	Stk11	IMP		Mouse	MGI:MGI:3611510|PMID:16308421
Molecular Function	GO:0004674	protein serine/threonine kinase activity	STK11	IDA		Human	PMID:11430832
Molecular Function	GO:0004674	protein serine/threonine kinase activity	STK11	IDA		Human	PMID:12805220
Molecular Function	GO:0004674	protein serine/threonine kinase activity	STK11	IDA		Human	PMID:19892943
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Stk11	IMP		Mouse	MGI:MGI:3611510|PMID:16308421
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Stk11	IDA		Mouse	MGI:MGI:5142374|PMID:11853558
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Stk11	IDA		Mouse	MGI:MGI:4462353|PMID:17482548
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Stk11	IMP		Rat	PMID:14511394|RGD:1600691
Molecular Function	GO:0044877	protein-containing complex binding	Stk11	IDA		Rat	PMID:14511394|RGD:1600691
Molecular Function	GO:0044877	protein-containing complex binding	Stk11	IPI	RGD:1306390|RGD:727905	Rat	PMID:14511394|RGD:1600691
Cellular Component	GO:0005737	cytoplasm	STK11	IDA		Human	PMID:11430832
Cellular Component	GO:0005737	cytoplasm	STK11	IDA		Human	PMID:12805220
Cellular Component	GO:0005737	cytoplasm	STK11	IDA		Human	PMID:14517248
Cellular Component	GO:0005737	cytoplasm	STK11	IDA		Human	PMID:17216128
Cellular Component	GO:0005737	cytoplasm	STK11	IDA		Human	PMID:18854309
Cellular Component	GO:0005737	cytoplasm	Stk11	IDA		Mouse	MGI:MGI:1342126|PMID:10400995
Cellular Component	GO:0005737	cytoplasm	Stk11	IDA		Mouse	MGI:MGI:4412462|PMID:11741830
Cellular Component	GO:0005737	cytoplasm	Stk11	IDA		Mouse	PMID:24367100
Cellular Component	GO:0005737	cytoplasm	Stk11	IDA		Mouse	PMID:20142099
Cellular Component	GO:0005829	cytosol	STK11	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Stk11	IDA		Mouse	MGI:MGI:5142382|PMID:11297520
Cellular Component	GO:0070062	extracellular exosome	STK11	HDA		Human	PMID:19056867
Cellular Component	GO:0140535	intracellular protein-containing complex	STK11	IDA		Human	PMID:12805220
Cellular Component	GO:0016020	membrane	Stk11	IDA		Mouse	MGI:MGI:5142382|PMID:11297520
Cellular Component	GO:0005739	mitochondrion	STK11	IDA		Human	PMID:11430832
Cellular Component	GO:0005654	nucleoplasm	STK11	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	STK11	IDA		Human	PMID:12805220
Cellular Component	GO:0005634	nucleus	STK11	IDA		Human	PMID:18854309
Cellular Component	GO:0005634	nucleus	Stk11	IDA		Mouse	MGI:MGI:1342126|PMID:10400995
Cellular Component	GO:0005634	nucleus	Stk11	IDA		Mouse	MGI:MGI:4462353|PMID:17482548
Cellular Component	GO:0005634	nucleus	Stk11	IDA		Mouse	MGI:MGI:5142382|PMID:11297520
Cellular Component	GO:0005634	nucleus	Stk11	IDA		Mouse	MGI:MGI:5284815|PMID:12234250
Cellular Component	GO:0005634	nucleus	Stk11	IDA		Mouse	MGI:MGI:5142374|PMID:11853558
Cellular Component	GO:0005634	nucleus	Stk11	IDA		Mouse	MGI:MGI:4412462|PMID:11741830
Cellular Component	GO:0005634	nucleus	Stk11	IDA		Rat	PMID:17098823|RGD:1601391
Cellular Component	GO:0032991	protein-containing complex	Stk11	IDA		Rat	PMID:14511394|RGD:1600691
Cellular Component	GO:1902554	serine/threonine protein kinase complex	STK11	IPI		Human	PMID:19892943
Cellular Component	GO:0030018	Z disc	Stk11	IDA		Rat	PMID:26971467|RGD:14398836
Biological Process	GO:0032147	activation of protein kinase activity	STK11	IMP		Human	PMID:15731909
Biological Process	GO:0032147	activation of protein kinase activity	STK11	IDA		Human	PMID:19892943
Biological Process	GO:0043276	anoikis	STK11	IMP		Human	PMID:19622832
Biological Process	GO:0007409	axonogenesis	Stk11	IMP		Mouse	MGI:MGI:4462353|PMID:17482548
Biological Process	GO:0007409	axonogenesis	Stk11	IGI	MGI:MGI:1891699	Mouse	PMID:21111240
Biological Process	GO:0007409	axonogenesis	Stk11	IMP		Rat	PMID:12114407|RGD:2291948
Biological Process	GO:0071493	cellular response to UV-B	STK11	IDA		Human	PMID:25329316
Biological Process	GO:0071493	cellular response to UV-B	Stk11	IDA		Mouse	MGI:MGI:5613877|PMID:25329316
Biological Process	GO:0097484	dendrite extension	Stk11	IMP	MGI:MGI:2387402	Mouse	PMID:24367100
Biological Process	GO:0048565	digestive tract development	stk11	IMP	ZFIN:ZDB-MRPHLNO-101117-7	Zfish	PMID:20925120
Biological Process	GO:0006974	DNA damage response	STK11	IMP		Human	PMID:25329316
Biological Process	GO:0006974	DNA damage response	Stk11	IMP		Mouse	MGI:MGI:5613877|PMID:25329316
Biological Process	GO:0097009	energy homeostasis	stk11	IMP	ZFIN:ZDB-GENO-110630-26	Zfish	PMID:21368212
Biological Process	GO:0097009	energy homeostasis	stk11	IMP	ZFIN:ZDB-GENO-110630-25	Zfish	PMID:21368212
Biological Process	GO:0060767	epithelial cell proliferation involved in prostate gland development	Stk11	IMP	MGI:MGI:3579498	Mouse	PMID:18381428
Biological Process	GO:0030010	establishment of cell polarity	STK11	IMP		Human	PMID:24643070
Biological Process	GO:0030010	establishment of cell polarity	Stk11	IMP		Mouse	MGI:MGI:5604606|PMID:24643070
Biological Process	GO:0030010	establishment of cell polarity	Stk11	IMP		Mouse	MGI:MGI:4462353|PMID:17482548
Biological Process	GO:0030010	establishment of cell polarity	Stk11	IMP		Rat	PMID:24643070|RGD:30309925
Biological Process	GO:0070314	G1 to G0 transition	STK11	IPI	UniProtKB:Q7RTN6	Human	PMID:12805220
Biological Process	GO:0070314	G1 to G0 transition	STK11	IDA		Human	PMID:17216128
Biological Process	GO:0042593	glucose homeostasis	Stk11	IMP		Mouse	MGI:MGI:3611510|PMID:16308421
Biological Process	GO:0042593	glucose homeostasis	stk11	IMP	ZFIN:ZDB-GENO-161214-1	Zfish	PMID:27264935
Biological Process	GO:0051645	Golgi localization	Stk11	IMP	MGI:MGI:2387402	Mouse	PMID:24367100
Biological Process	GO:0051645	Golgi localization	Stk11	IMP		Mouse	PMID:21111240
Biological Process	GO:0060575	intestinal epithelial cell differentiation	stk11	IMP	ZFIN:ZDB-MRPHLNO-101115-6	Zfish	PMID:20925120
Biological Process	GO:0060575	intestinal epithelial cell differentiation	stk11	IMP	ZFIN:ZDB-MRPHLNO-101117-7	Zfish	PMID:20925120
Biological Process	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	STK11	IDA		Human	PMID:11430832
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	STK11	IMP		Human	PMID:15731909
Biological Process	GO:0030308	negative regulation of cell growth	Stk11	IDA		Mouse	MGI:MGI:5142382|PMID:11297520
Biological Process	GO:0008285	negative regulation of cell population proliferation	STK11	IMP		Human	PMID:17216128
Biological Process	GO:0008285	negative regulation of cell population proliferation	STK11	IMP		Human	PMID:25329316
Biological Process	GO:0008285	negative regulation of cell population proliferation	Stk11	IMP		Mouse	MGI:MGI:5613877|PMID:25329316
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	Stk11	IMP		Mouse	MGI:MGI:5897938|PMID:27461402
Biological Process	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	Stk11	IMP	MGI:MGI:3579498	Mouse	PMID:18381428
Biological Process	GO:1904262	negative regulation of TORC1 signaling	STK11	IMP		Human	PMID:23878245
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	STK11	IDA		Human	PMID:12805220
Biological Process	GO:0010508	positive regulation of autophagy	STK11	IMP		Human	PMID:23878245
Biological Process	GO:0050772	positive regulation of axonogenesis	Stk11	IGI	MGI:MGI:1891699	Mouse	PMID:21111240
Biological Process	GO:0045722	positive regulation of gluconeogenesis	Stk11	IMP		Rat	PMID:17083919|RGD:2291956
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	Stk11	IMP		Mouse	PMID:24768298
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	STK11	IMP		Human	PMID:18311138
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	Stk11	IMP		Mouse	MGI:MGI:3788958|PMID:18311138
Biological Process	GO:1901610	positive regulation of vesicle transport along microtubule	STK11	IMP		Human	PMID:24643070
Biological Process	GO:1901610	positive regulation of vesicle transport along microtubule	Stk11	IMP		Mouse	MGI:MGI:5604606|PMID:24643070
Biological Process	GO:1901610	positive regulation of vesicle transport along microtubule	Stk11	IMP		Rat	PMID:24643070|RGD:30309925
Biological Process	GO:0045059	positive thymic T cell selection	Stk11	IMP	MGI:MGI:2387402,MGI:MGI:3054844	Mouse	PMID:21487392
Biological Process	GO:0045059	positive thymic T cell selection	Stk11	IMP	MGI:MGI:2386448,MGI:MGI:2387402	Mouse	PMID:21487392
Biological Process	GO:0046777	protein autophosphorylation	STK11	IDA		Human	PMID:11430832
Biological Process	GO:0046777	protein autophosphorylation	Stk11	IDA		Mouse	MGI:MGI:5142374|PMID:11853558
Biological Process	GO:0006470	protein dephosphorylation	STK11	IMP		Human	PMID:15731909
Biological Process	GO:0034504	protein localization to nucleus	Stk11	IMP		Mouse	PMID:24768298
Biological Process	GO:0006468	protein phosphorylation	STK11	IDA		Human	PMID:12805220
Biological Process	GO:0006468	protein phosphorylation	STK11	IDA		Human	PMID:25329316
Biological Process	GO:0006468	protein phosphorylation	Stk11	IDA		Mouse	MGI:MGI:5613877|PMID:25329316
Biological Process	GO:0006468	protein phosphorylation	Stk11	IMP		Mouse	PMID:24768298
Biological Process	GO:0010506	regulation of autophagy	stk11	IGI	ZFIN:ZDB-GENO-110630-26,ZFIN:ZDB-MRPHLNO-140826-3	Zfish	PMID:28779098
Biological Process	GO:0010506	regulation of autophagy	stk11	IMP	ZFIN:ZDB-GENO-110630-26	Zfish	PMID:28779098
Biological Process	GO:0001558	regulation of cell growth	Stk11	IDA		Mouse	MGI:MGI:5142374|PMID:11853558
Biological Process	GO:0048814	regulation of dendrite morphogenesis	Stk11	IMP	MGI:MGI:2387402	Mouse	PMID:24367100
Biological Process	GO:0051896	regulation of protein kinase B signaling	Stk11	IMP	MGI:MGI:3579498	Mouse	PMID:18381428
Biological Process	GO:0030111	regulation of Wnt signaling pathway	Stk11	IMP	MGI:MGI:3579498	Mouse	PMID:18381428
Biological Process	GO:0014823	response to activity	Stk11	IEP		Rat	PMID:15292028|RGD:14398835
Biological Process	GO:0033762	response to glucagon	Stk11	IEP		Rat	PMID:15494402|RGD:1601392
Biological Process	GO:0010212	response to ionizing radiation	Stk11	IDA		Mouse	MGI:MGI:5284815|PMID:12234250
Biological Process	GO:0033993	response to lipid	Stk11	IDA		Rat	PMID:16644805|RGD:2291957
Biological Process	GO:0043434	response to peptide hormone	Stk11	IEP		Rat	PMID:15494402|RGD:1601392
Biological Process	GO:0097066	response to thyroid hormone	Stk11	IEP		Rat	PMID:18669938|RGD:10059691
Biological Process	GO:0007286	spermatid development	Stk11	IMP		Mouse	MGI:MGI:3829517|PMID:18774945
Biological Process	GO:0050852	T cell receptor signaling pathway	Stk11	IMP	MGI:MGI:2387402,MGI:MGI:3054844	Mouse	PMID:21487392
Biological Process	GO:0050852	T cell receptor signaling pathway	Stk11	IGI	MGI:MGI:96756	Mouse	PMID:21487392
Biological Process	GO:0001894	tissue homeostasis	Stk11	IMP	MGI:MGI:3579498	Mouse	PMID:18381428
Biological Process	GO:0001944	vasculature development	Stk11	IMP		Mouse	MGI:MGI:2148431|PMID:11509733

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern