Comparative GO Graph (mouse, human, rat)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Stk4

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes STK4
- Mouse genes Stk4
- Rat genes Stk4
- Zfish genes
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Stk4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	STK4	IDA		Human	PMID:8566796
Molecular Function	GO:0042802	identical protein binding	STK4	IPI	UniProtKB:Q13043	Human	PMID:20562859
Molecular Function	GO:0042802	identical protein binding	STK4	IPI	UniProtKB:Q13043	Human	PMID:23386615
Molecular Function	GO:0042802	identical protein binding	STK4	IPI	UniProtKB:Q13043	Human	PMID:8702870
Molecular Function	GO:0000287	magnesium ion binding	STK4	IDA		Human	PMID:8566796
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q9NS23-2	Human	PMID:14729613
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q8WWW0	Human	PMID:15109305
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q9NS23-2	Human	PMID:15109305
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q8WWW0-2	Human	PMID:16892067
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q9H4B6	Human	PMID:16930133
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:P31749	Human	PMID:17932490
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:P19429	Human	PMID:18986304
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:P50749	Human	PMID:19525978
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:O95166	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:P50749	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:P60520	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q13188	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q8WWW0	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q9GZQ8	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q9H0R8	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q9H2L5	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q9H4B6	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:P50749	Human	PMID:20920251
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q13188	Human	PMID:20920251
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q6ZTQ3	Human	PMID:20920251
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q86WH2	Human	PMID:20920251
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q8WWW0-3	Human	PMID:20920251
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q9H2L5	Human	PMID:20920251
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q9H4B6	Human	PMID:20920251
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q9NS23-2	Human	PMID:20920251
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q9NS23	Human	PMID:21199877
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q96EB6	Human	PMID:21212262
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:P10275	Human	PMID:21512132
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:P35700	Human	PMID:21516123
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q9H8S9	Human	PMID:21516123
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q91VJ4	Human	PMID:21730291
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q7L9L4	Human	PMID:22863277
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:P50749	Human	PMID:23386615
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q06830	Human	PMID:23386615
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q13188	Human	PMID:23386615
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q14BN4	Human	PMID:23386615
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q9H4B6	Human	PMID:23386615
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q9H8S9	Human	PMID:23386615
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:P50749	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q13188	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q86WH2	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q8WWW0	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q9H2L5	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q9H4B6	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:P50749	Human	PMID:24255178
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q13188	Human	PMID:24255178
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q14BN4	Human	PMID:24255178
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q7L9L4	Human	PMID:24255178
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q86WH2	Human	PMID:24255178
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q8WWW0	Human	PMID:24255178
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q9H4B6	Human	PMID:24255178
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q9H8S9	Human	PMID:24255178
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:P50749	Human	PMID:24366813
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q13188	Human	PMID:24366813
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q14BN4	Human	PMID:24366813
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q6ZTQ3	Human	PMID:24366813
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q86WH2	Human	PMID:24366813
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q8WWW0	Human	PMID:24366813
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q9H2L5	Human	PMID:24366813
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q9H4B6	Human	PMID:24366813
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:P50749	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q13188	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q8WWW0	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q9H4B6	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:P27448	Human	PMID:28087714
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q8TDM6	Human	PMID:28087714
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q14160	Human	PMID:28169360
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q9H8S9	Human	PMID:28373298
Molecular Function	GO:0005515	protein binding	STK4	IPI	UniProtKB:Q13188	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Stk4	IPI	UniProtKB:E9Q9R9	Mouse	MGI:MGI:5823491\|PMID:28087714
Molecular Function	GO:0005515	protein binding	Stk4	IPI	UniProtKB:Q5EBH1	Mouse	MGI:MGI:3662967\|PMID:16892067
Molecular Function	GO:0042803	protein homodimerization activity	STK4	IDA		Human	PMID:11805089
Molecular Function	GO:0004672	protein kinase activity	STK4	IGI	UniProtKB:P50749	Human	PMID:19962960
Molecular Function	GO:0004674	protein serine/threonine kinase activity	STK4	EXP		Human	PMID:11278283
Molecular Function	GO:0004674	protein serine/threonine kinase activity	STK4	IDA		Human	PMID:11805089
Molecular Function	GO:0004674	protein serine/threonine kinase activity	STK4	EXP		Human	PMID:15109305
Molecular Function	GO:0004674	protein serine/threonine kinase activity	STK4	EXP		Human	PMID:15688006
Molecular Function	GO:0004674	protein serine/threonine kinase activity	STK4	IDA		Human	PMID:16751106
Molecular Function	GO:0004674	protein serine/threonine kinase activity	STK4	EXP		Human	PMID:16930133
Molecular Function	GO:0004674	protein serine/threonine kinase activity	STK4	IDA		Human	PMID:18328708
Molecular Function	GO:0004674	protein serine/threonine kinase activity	STK4	IDA		Human	PMID:18986304
Molecular Function	GO:0004674	protein serine/threonine kinase activity	STK4	IDA		Human	PMID:19525978
Molecular Function	GO:0004674	protein serine/threonine kinase activity	STK4	IDA		Human	PMID:21212262
Molecular Function	GO:0004674	protein serine/threonine kinase activity	STK4	IDA		Human	PMID:21512132
Molecular Function	GO:0004674	protein serine/threonine kinase activity	STK4	IDA		Human	PMID:30865227
Molecular Function	GO:0004674	protein serine/threonine kinase activity	STK4	IDA		Human	PMID:8566796
Molecular Function	GO:0004674	protein serine/threonine kinase activity	STK4	EXP		Human	PMID:9545236
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	STK4	IPI	UniProtKB:O43524	Human	PMID:16751106
Cellular Component	GO:0005737	cytoplasm	STK4	IDA		Human	PMID:17932490
Cellular Component	GO:0005737	cytoplasm	STK4	IDA		Human	PMID:19525978
Cellular Component	GO:0005737	cytoplasm	STK4	IDA		Human	PMID:21512132
Cellular Component	GO:0005737	cytoplasm	Stk4	IDA		Mouse	PMID:11805089
Cellular Component	GO:0005737	cytoplasm	Stk4	IDA		Mouse	PMID:12384512
Cellular Component	GO:0005737	cytoplasm	Stk4	IDA		Mouse	PMID:18369314
Cellular Component	GO:0005829	cytosol	STK4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016604	nuclear body	STK4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	STK4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	STK4	IDA		Human	PMID:17932490
Cellular Component	GO:0005634	nucleus	STK4	IDA		Human	PMID:21512132
Cellular Component	GO:0005634	nucleus	Stk4	IDA		Mouse	PMID:18369314
Cellular Component	GO:0005634	nucleus	Stk4	IDA		Mouse	PMID:12384512
Cellular Component	GO:0032991	protein-containing complex	STK4	IDA		Human	PMID:19962960
Biological Process	GO:0006915	apoptotic process	STK4	IDA		Human	PMID:21212262
Biological Process	GO:0006915	apoptotic process	Stk4	IGI	MGI:MGI:1928487	Mouse	PMID:20080598
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	Stk4	IGI	MGI:MGI:1928487	Mouse	PMID:19786569
Biological Process	GO:0060070	canonical Wnt signaling pathway	Stk4	IGI	MGI:MGI:1928487	Mouse	PMID:20080598
Biological Process	GO:0060706	cell differentiation involved in embryonic placenta development	Stk4	IGI	MGI:MGI:1928487	Mouse	PMID:19786569
Biological Process	GO:0000902	cell morphogenesis	STK4	IDA		Human	PMID:11805089
Biological Process	GO:0008283	cell population proliferation	Stk4	IGI	MGI:MGI:1928487	Mouse	PMID:20080598
Biological Process	GO:0008283	cell population proliferation	Stk4	IGI	MGI:MGI:1928487	Mouse	PMID:19786569
Biological Process	GO:0007417	central nervous system development	Stk4	IGI	MGI:MGI:1928487	Mouse	PMID:19786569
Biological Process	GO:0003157	endocardium development	Stk4	IGI	MGI:MGI:1928487	Mouse	PMID:19786569
Biological Process	GO:0050673	epithelial cell proliferation	Stk4	IGI	MGI:MGI:1928487	Mouse	PMID:20080598
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	Stk4	IGI	MGI:MGI:104798	Mouse	PMID:20080598
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	Stk4	IGI	MGI:MGI:1928487	Mouse	PMID:20080598
Biological Process	GO:0097284	hepatocyte apoptotic process	Stk4	IGI	MGI:MGI:104798	Mouse	PMID:20080598
Biological Process	GO:0097284	hepatocyte apoptotic process	Stk4	IGI	MGI:MGI:1928487	Mouse	PMID:20080598
Biological Process	GO:0035329	hippo signaling	STK4	IDA		Human	PMID:20412773
Biological Process	GO:0035329	hippo signaling	Stk4	IMP		Mouse	MGI:MGI:4420842\|PMID:20080689
Biological Process	GO:0035329	hippo signaling	Stk4	IGI	MGI:MGI:103262	Mouse	PMID:18369314
Biological Process	GO:0035329	hippo signaling	Stk4	IGI	MGI:MGI:1929004	Mouse	PMID:18369314
Biological Process	GO:0035329	hippo signaling	Stk4	IGI	MGI:MGI:1354386	Mouse	PMID:18369314
Biological Process	GO:0035329	hippo signaling	Stk4	IGI	MGI:MGI:1333883	Mouse	PMID:18369314
Biological Process	GO:0035329	hippo signaling	Stk4	IGI	MGI:MGI:1927144	Mouse	PMID:18369314
Biological Process	GO:0035556	intracellular signal transduction	STK4	IDA		Human	PMID:8566796
Biological Process	GO:0030216	keratinocyte differentiation	Stk4	IGI	MGI:MGI:103262	Mouse	PMID:18369314
Biological Process	GO:0030216	keratinocyte differentiation	Stk4	IGI	MGI:MGI:1927144	Mouse	PMID:18369314
Biological Process	GO:0030216	keratinocyte differentiation	Stk4	IGI	MGI:MGI:1333883	Mouse	PMID:18369314
Biological Process	GO:0030216	keratinocyte differentiation	Stk4	IGI	MGI:MGI:1929004	Mouse	PMID:18369314
Biological Process	GO:0030216	keratinocyte differentiation	Stk4	IGI	MGI:MGI:1354386	Mouse	PMID:18369314
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	STK4	IMP		Human	PMID:20412773
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Stk4	IGI	MGI:MGI:1928487	Mouse	PMID:20080598
Biological Process	GO:0008285	negative regulation of cell population proliferation	Stk4	IGI	MGI:MGI:1928487	Mouse	PMID:20080598
Biological Process	GO:0008285	negative regulation of cell population proliferation	Stk4	IGI	MGI:MGI:1928487	Mouse	PMID:19786569
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Stk4	IGI	MGI:MGI:1928487	Mouse	PMID:20080598
Biological Process	GO:0046621	negative regulation of organ growth	Stk4	IGI	MGI:MGI:1928487	Mouse	PMID:20080598
Biological Process	GO:0001841	neural tube formation	Stk4	IGI	MGI:MGI:1928487	Mouse	PMID:19786569
Biological Process	GO:0035265	organ growth	Stk4	IGI	MGI:MGI:1928487	Mouse	PMID:20080598
Biological Process	GO:0018105	peptidyl-serine phosphorylation	STK4	IDA		Human	PMID:16751106
Biological Process	GO:0043065	positive regulation of apoptotic process	STK4	IDA		Human	PMID:15109305
Biological Process	GO:0043065	positive regulation of apoptotic process	Stk4	IGI	MGI:MGI:1928487	Mouse	PMID:20080598
Biological Process	GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	Stk4	IGI	MGI:MGI:104798	Mouse	PMID:20080598
Biological Process	GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	Stk4	IGI	MGI:MGI:1928487	Mouse	PMID:20080598
Biological Process	GO:0045600	positive regulation of fat cell differentiation	Stk4	IGI	MGI:MGI:1928487	Mouse	PMID:22292086
Biological Process	GO:1903945	positive regulation of hepatocyte apoptotic process	Stk4	IGI	MGI:MGI:1928487	Mouse	PMID:20080598
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	STK4	IDA		Human	PMID:19962960
Biological Process	GO:0032092	positive regulation of protein binding	STK4	IDA		Human	PMID:22292086
Biological Process	GO:0001934	positive regulation of protein phosphorylation	STK4	IDA		Human	PMID:19962960
Biological Process	GO:1904237	positive regulation of substrate-dependent cell migration, cell attachment to substrate	Stk4	IMP		Mouse	MGI:MGI:3821942\|PMID:19073936
Biological Process	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	Stk4	IMP		Rat	PMID:23485012\|RGD:13506273
Biological Process	GO:0060215	primitive hemopoiesis	Stk4	IGI	MGI:MGI:1928487	Mouse	PMID:19786569
Biological Process	GO:0046777	protein autophosphorylation	STK4	IDA		Human	PMID:11805089
Biological Process	GO:0006606	protein import into nucleus	STK4	IDA		Human	PMID:16751106
Biological Process	GO:0006606	protein import into nucleus	STK4	IGI	UniProtKB:Q13188	Human	PMID:16751106
Biological Process	GO:0006468	protein phosphorylation	STK4	IDA		Human	PMID:11805089
Biological Process	GO:0006468	protein phosphorylation	STK4	IDA		Human	PMID:8566796
Biological Process	GO:0050821	protein stabilization	STK4	IDA		Human	PMID:19962960
Biological Process	GO:0050821	protein stabilization	Stk4	IMP	MGI:MGI:4414818	Mouse	PMID:19962960
Biological Process	GO:0060800	regulation of cell differentiation involved in embryonic placenta development	Stk4	IGI	MGI:MGI:1928487	Mouse	PMID:24595170

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.