Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SUFU
  • Mouse genes Sufu
  • Rat genes Sufu
  • Zfish genes sufu
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sufu

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	Sufu	IDA		Mouse	PMID:11477086
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:P10071	Human	PMID:10564661
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q9NRP7	Human	PMID:10806483
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q7Z412	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q8NEA6	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q96D15	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q96H86	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q9NWS9-2	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:P08151	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q7Z353	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q8NEA6	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q9BV97	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:P08151	Human	PMID:22439934
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q9UF56	Human	PMID:24035498
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:P08151	Human	PMID:24217340
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q0VGT2	Human	PMID:24217340
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:P08151	Human	PMID:24311597
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:P10071	Human	PMID:24311597
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:P08151	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q9NRP7	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q9BV97	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:P08151	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q9UF56	Human	PMID:27234298
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q13515	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q96H86	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q9BV97	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:P08151	Human	PMID:28965847
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:P10071	Human	PMID:28965847
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q9BV97	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:O00746	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:O43186	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:O95678	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:P08151	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:P51114-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q08117-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q0D2J5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q13515	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q15915	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q53ET0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q7Z353	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q7Z3Y8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q86VQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q8N4C7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q8NC26	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q8TBC5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q96D15	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q96GZ6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q96H86	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q96JM7-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q9NRI5-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q9NWS9-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q9P2A4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q9UJ55	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q9Y250	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q9Y3S2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q86V38	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:Q92876	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:P10070	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:P10070	Human	PMID:35140242
Molecular Function	GO:0005515	protein binding	SUFU	IPI	UniProtKB:P10071	Human	PMID:35140242
Molecular Function	GO:0005515	protein binding	Sufu	IPI	UniProtKB:O55128|UniProtKB:P16110	Mouse	MGI:MGI:5009176|PMID:14611647
Molecular Function	GO:0005515	protein binding	Sufu	IPI	UniProtKB:Q2M1P5	Mouse	MGI:MGI:4359116|PMID:19592253
Molecular Function	GO:0005515	protein binding	Sufu	IPI	UniProtKB:Q61602	Mouse	MGI:MGI:4440990|PMID:20360384
Molecular Function	GO:0005515	protein binding	Sufu	IPI	UniProtKB:O88907|UniProtKB:P50636	Mouse	MGI:MGI:5009176|PMID:14611647
Molecular Function	GO:0005515	protein binding	Sufu	IPI	UniProtKB:Q9WV60	Mouse	MGI:MGI:3695869|PMID:17182001
Molecular Function	GO:0005515	protein binding	Sufu	IPI	UniProtKB:Q8VDL9	Mouse	MGI:MGI:5292436|PMID:21816948
Molecular Function	GO:0005515	protein binding	Sufu	IPI	UniProtKB:P19538	Mouse	PMID:11252182
Molecular Function	GO:0005515	protein binding	Sufu	IPI	UniProtKB:P23647	Mouse	PMID:11252182
Molecular Function	GO:0005515	protein binding	Sufu	IPI	PR:Q0VGT2	Mouse	PMID:19286674
Molecular Function	GO:0005515	protein binding	sufu	IPI	UniProtKB:Q800Z9	Zfish	PMID:15647323
Molecular Function	GO:0019901	protein kinase binding	SUFU	IPI	UniProtKB:Q6PHR2	Human	PMID:20643644
Molecular Function	GO:0008270	zinc ion binding	sufu	IDA		Zfish	PMID:28894158
Cellular Component	GO:0005929	cilium	Sufu	IDA		Mouse	MGI:MGI:4888042|PMID:21209331
Cellular Component	GO:0005929	cilium	Sufu	IDA		Mouse	PMID:19684112
Cellular Component	GO:0005929	cilium	Sufu	IDA		Mouse	PMID:16254602
Cellular Component	GO:0005737	cytoplasm	SUFU	IDA		Human	PMID:10564661
Cellular Component	GO:0005737	cytoplasm	SUFU	IDA		Human	PMID:10806483
Cellular Component	GO:0005737	cytoplasm	SUFU	IMP		Human	PMID:28965847
Cellular Component	GO:0005737	cytoplasm	Sufu	IDA		Mouse	MGI:MGI:4440990|PMID:20360384
Cellular Component	GO:1990788	GLI-SUFU complex	SUFU	IPI		Human	PMID:24311597
Cellular Component	GO:0035301	Hedgehog signaling complex	sufu	IDA		Zfish	PMID:15647323
Cellular Component	GO:0005654	nucleoplasm	SUFU	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	SUFU	IDA		Human	PMID:10806483
Cellular Component	GO:0005634	nucleus	SUFU	IMP		Human	PMID:28965847
Cellular Component	GO:0005634	nucleus	Sufu	IDA		Mouse	PMID:16254602
Biological Process	GO:0035904	aorta development	Sufu	IMP		Mouse	PMID:25807483
Biological Process	GO:0060976	coronary vasculature development	Sufu	IMP		Mouse	PMID:25807483
Biological Process	GO:0042994	cytoplasmic sequestering of transcription factor	Sufu	IGI	MGI:MGI:95728	Mouse	PMID:16316410
Biological Process	GO:0042994	cytoplasmic sequestering of transcription factor	Sufu	IGI	MGI:MGI:95727	Mouse	PMID:16316410
Biological Process	GO:0007368	determination of left/right symmetry	Sufu	IMP	MGI:MGI:3512046	Mouse	PMID:16155214
Biological Process	GO:0033333	fin development	sufu	IMP		Zfish	PMID:9007245
Biological Process	GO:0001947	heart looping	Sufu	IMP	MGI:MGI:3512046	Mouse	PMID:16155214
Biological Process	GO:0030097	hemopoiesis	sufu	IMP	ZFIN:ZDB-MRPHLNO-110607-2	Zfish	PMID:21571218
Biological Process	GO:0002088	lens development in camera-type eye	sufu	IMP	ZFIN:ZDB-GENO-980202-883	Zfish	PMID:17397257
Biological Process	GO:1990787	negative regulation of hh target transcription factor activity	SUFU	IDA		Human	PMID:24311597
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	SUFU	IMP		Human	PMID:27234298
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	SUFU	IMP		Human	PMID:28965847
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	Sufu	IMP		Mouse	MGI:MGI:5789064|PMID:27234298
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	Sufu	IMP	MGI:MGI:3619046	Mouse	PMID:16459298
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	Sufu	IMP		Mouse	PMID:18488998
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	sufu	IMP	ZFIN:ZDB-GENO-980202-883	Zfish	PMID:16121254
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	sufu	IGI	ZFIN:ZDB-GENE-050307-1	Zfish	PMID:15647323
Biological Process	GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning	Sufu	IMP	MGI:MGI:4840420	Mouse	PMID:19684112
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	SUFU	IDA		Human	PMID:10564661
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Sufu	IDA		Mouse	PMID:16459298
Biological Process	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	Sufu	IGI	MGI:MGI:1343085	Mouse	PMID:19684112
Biological Process	GO:0001843	neural tube closure	Sufu	IMP	MGI:MGI:3512046	Mouse	PMID:16155214
Biological Process	GO:2001040	positive regulation of cellular response to drug	Sufu	IEP		Rat	PMID:30790292|RGD:150573813
Biological Process	GO:0043588	skin development	Sufu	IMP	MGI:MGI:3619046	Mouse	PMID:16459298
Biological Process	GO:0007224	smoothened signaling pathway	Sufu	IMP	MGI:MGI:4461193	Mouse	PMID:29487109
Biological Process	GO:0007224	smoothened signaling pathway	Sufu	IMP	MGI:MGI:3619046	Mouse	PMID:16459298
Biological Process	GO:0007224	smoothened signaling pathway	sufu	IGI	ZFIN:ZDB-MRPHLNO-060828-2,ZFIN:ZDB-MRPHLNO-130308-1	Zfish	PMID:23166330
Biological Process	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning	Sufu	IMP	MGI:MGI:4840420	Mouse	PMID:19684112
Biological Process	GO:0021776	smoothened signaling pathway involved in spinal cord motor neuron cell fate specification	Sufu	IMP	MGI:MGI:4840420	Mouse	PMID:19684112
Biological Process	GO:0021775	smoothened signaling pathway involved in ventral spinal cord interneuron specification	Sufu	IMP	MGI:MGI:4840420	Mouse	PMID:19684112
Biological Process	GO:0007286	spermatid development	Sufu	IEP		Rat	PMID:21893610|RGD:150573809
Biological Process	GO:0021513	spinal cord dorsal/ventral patterning	Sufu	IMP	MGI:MGI:3619046	Mouse	PMID:16459298
Biological Process	GO:0003281	ventricular septum development	Sufu	IMP		Mouse	PMID:25807483

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern