Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SUZ12
  • Mouse genes Suz12
  • Rat genes Suz12
  • Zfish genes suz12a,suz12b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Suz12

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Suz12	IDA		Mouse	PMID:16687444
Molecular Function	GO:0003682	chromatin binding	Suz12	IDA		Mouse	PMID:25547114
Molecular Function	GO:0031490	chromatin DNA binding	Suz12	IDA		Mouse	PMID:18483221
Molecular Function	GO:0008047	enzyme activator activity	SUZ12	IMP		Human	PMID:28229514
Molecular Function	GO:0042054	histone methyltransferase activity	SUZ12	IMP		Human	PMID:15385962
Molecular Function	GO:0106222	lncRNA binding	Suz12	IPI	MGI:MGI:2442953	Mouse	PMID:28041882
Molecular Function	GO:0035064	methylated histone binding	SUZ12	IDA		Human	PMID:21029866
Molecular Function	GO:1990841	promoter-specific chromatin binding	Suz12	IDA		Mouse	PMID:22770845
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:Q15156	Human	PMID:17560333
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:Q15910	Human	PMID:19734898
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:O75530	Human	PMID:20075857
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:Q15910	Human	PMID:20075857
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:Q92833-1	Human	PMID:20075857
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:O75530	Human	PMID:20543829
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:Q15910	Human	PMID:20543829
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:O75530	Human	PMID:21078963
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:Q9Y232	Human	PMID:22009739
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:O75530	Human	PMID:22439931
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:Q15910	Human	PMID:22439931
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:O15379	Human	PMID:23079660
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:Q15910	Human	PMID:23079660
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:Q5T6S3	Human	PMID:23104054
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:Q15910	Human	PMID:23238014
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:Q15910	Human	PMID:23684459
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:Q15910	Human	PMID:24183680
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:O75530	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:Q15910	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:O75530	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:Q15910	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:O75530	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:Q15910	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:Q15910	Human	PMID:27728805
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:Q15910	Human	PMID:28229514
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:O43189	Human	PMID:29628311
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:Q15910,UniProtKB:Q86X51	Human	PMID:29909548
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:Q5T9G4	Human	PMID:30026490
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:Q15910,UniProtKB:Q86X51	Human	PMID:30923826
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:Q15910	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:O75530	Human	PMID:35016035
Molecular Function	GO:0005515	protein binding	SUZ12	IPI	UniProtKB:Q15910	Human	PMID:35016035
Molecular Function	GO:0005515	protein binding	Suz12	IPI	UniProtKB:Q61188|UniProtKB:Q62315	Mouse	MGI:MGI:4436818|PMID:20064376
Molecular Function	GO:0005515	protein binding	Suz12	IPI	UniProtKB:Q7TNS8	Mouse	MGI:MGI:5507920|PMID:23180766
Molecular Function	GO:0005515	protein binding	Suz12	IPI	UniProtKB:Q62315	Mouse	MGI:MGI:4441020|PMID:20075857
Molecular Function	GO:0005515	protein binding	Suz12	IPI	UniProtKB:Q62315	Mouse	MGI:MGI:5286758|PMID:21811233
Molecular Function	GO:0005515	protein binding	Suz12	IPI	UniProtKB:Q6AXH7	Mouse	MGI:MGI:5499263|PMID:23624931
Molecular Function	GO:0005515	protein binding	Suz12	IPI	UniProtKB:Q61188	Mouse	MGI:MGI:5499261|PMID:23624935
Molecular Function	GO:0005515	protein binding	Suz12	IPI	UniProtKB:Q61188	Mouse	MGI:MGI:5553039|PMID:24074865
Molecular Function	GO:0005515	protein binding	Suz12	IPI	UniProtKB:Q3UXZ9	Mouse	MGI:MGI:4431292|PMID:20064375
Molecular Function	GO:0005515	protein binding	Suz12	IPI	UniProtKB:Q3UXZ9|UniProtKB:Q62315	Mouse	MGI:MGI:4431292|PMID:20064375
Molecular Function	GO:0005515	protein binding	Suz12	IPI	UniProtKB:P01108	Mouse	MGI:MGI:5887185|PMID:26523946
Molecular Function	GO:0005515	protein binding	Suz12	IPI	UniProtKB:Q61188|UniProtKB:Q62315	Mouse	MGI:MGI:4431292|PMID:20064375
Molecular Function	GO:0005515	protein binding	Suz12	IPI	RGD:1303205	Rat	PMID:23879974|RGD:9586746
Molecular Function	GO:0003723	RNA binding	Suz12	IPI	MGI:MGI:4439832	Mouse	PMID:26423156
Molecular Function	GO:0003723	RNA binding	Suz12	IPI	MGI:MGI:5434104	Mouse	PMID:23352431
Molecular Function	GO:0003723	RNA binding	Suz12	IPI	MGI:MGI:3623820	Mouse	PMID:22911650
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Suz12	IDA		Mouse	PMID:24268575
Molecular Function	GO:0043565	sequence-specific DNA binding	Suz12	IDA		Mouse	PMID:20956546
Molecular Function	GO:0001222	transcription corepressor binding	SUZ12	IPI	UniProtKB:Q96JN0	Human	PMID:29628311
Cellular Component	GO:0005677	chromatin silencing complex	Suz12	IDA		Mouse	PMID:26658965
Cellular Component	GO:0035098	ESC/E(Z) complex	SUZ12	IMP		Human	PMID:15385962
Cellular Component	GO:0035098	ESC/E(Z) complex	SUZ12	IDA		Human	PMID:20075857
Cellular Component	GO:0035098	ESC/E(Z) complex	SUZ12	IDA		Human	PMID:23104054
Cellular Component	GO:0035098	ESC/E(Z) complex	SUZ12	IDA		Human	PMID:23273982
Cellular Component	GO:0035098	ESC/E(Z) complex	Suz12	IDA		Mouse	MGI:MGI:5487475|PMID:23160351
Cellular Component	GO:0035098	ESC/E(Z) complex	Suz12	IDA		Mouse	MGI:MGI:4431292|PMID:20064375
Cellular Component	GO:0035098	ESC/E(Z) complex	Suz12	IDA		Mouse	MGI:MGI:5318799|PMID:22438827
Cellular Component	GO:0035098	ESC/E(Z) complex	Suz12	IDA		Mouse	MGI:MGI:4436818|PMID:20064376
Cellular Component	GO:0035098	ESC/E(Z) complex	Suz12	IDA		Mouse	MGI:MGI:4429983|PMID:20144788
Cellular Component	GO:0035098	ESC/E(Z) complex	Suz12	IDA		Mouse	PMID:31451685
Cellular Component	GO:0016604	nuclear body	SUZ12	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	SUZ12	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	SUZ12	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	SUZ12	HDA		Human	PMID:21630459
Cellular Component	GO:0005634	nucleus	Suz12	IDA		Mouse	PMID:19796622
Cellular Component	GO:0005634	nucleus	Suz12	IDA		Mouse	PMID:18483221
Cellular Component	GO:0032993	protein-DNA complex	Suz12	IDA		Mouse	PMID:18483221
Cellular Component	GO:1990904	ribonucleoprotein complex	Suz12	IPI	MGI:MGI:2442953	Mouse	PMID:28041882
Cellular Component	GO:0001739	sex chromatin	Suz12	IDA		Mouse	PMID:15525528
Biological Process	GO:0008283	cell population proliferation	Suz12	IMP	MGI:MGI:3530650	Mouse	PMID:15385962
Biological Process	GO:0006325	chromatin organization	Suz12	IMP		Mouse	PMID:16359901
Biological Process	GO:0009048	dosage compensation by inactivation of X chromosome	Suz12	IMP		Mouse	PMID:27892467
Biological Process	GO:0140718	facultative heterochromatin formation	Suz12	IDA		Mouse	MGI:MGI:4431292|PMID:20064375
Biological Process	GO:0140718	facultative heterochromatin formation	Suz12	IDA		Mouse	MGI:MGI:4436818|PMID:20064376
Biological Process	GO:0010467	gene expression	Suz12	IGI		Mouse	PMID:28041882
Biological Process	GO:0098532	histone H3-K27 trimethylation	Suz12	IMP		Rat	PMID:23192652|RGD:9586745
Biological Process	GO:0045596	negative regulation of cell differentiation	SUZ12	IMP		Human	PMID:19847889
Biological Process	GO:0032682	negative regulation of chemokine production	Suz12	IMP		Rat	PMID:23192652|RGD:9586745
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Suz12	IMP		Rat	PMID:23192652|RGD:9586745
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Suz12	IMP		Mouse	PMID:16687444
Biological Process	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	Suz12	IMP		Rat	PMID:23192652|RGD:9586745
Biological Process	GO:0048709	oligodendrocyte differentiation	Suz12	IMP		Mouse	PMID:28041882
Biological Process	GO:0008284	positive regulation of cell population proliferation	Suz12	IMP	MGI:MGI:3530650	Mouse	PMID:15385962
Biological Process	GO:0032526	response to retinoic acid	Suz12	IEP		Rat	PMID:20515739|RGD:9491842
Biological Process	GO:0021510	spinal cord development	Suz12	IEP		Rat	PMID:20515739|RGD:9491842

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern