Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Syk

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SYK
- Mouse genes Syk
- Rat genes Syk
- Zfish genes syk
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Syk

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Syk	IDA		Mouse	PMID:8798454
Molecular Function	GO:0005178	integrin binding	SYK	IPI	UniProtKB:P05107	Human	PMID:12885943
Molecular Function	GO:0016170	interleukin-15 receptor binding	SYK	IPI	UniProtKB:Q13261	Human	PMID:15123770
Molecular Function	GO:0016301	kinase activity	SYK	IDA		Human	PMID:9490415
Molecular Function	GO:0140677	molecular function activator activity	Syk	IDA		Mouse	PMID:9199344
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	SYK	IDA		Human	PMID:11606584
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	SYK	IGI	UniProtKB:P16885	Human	PMID:14656219
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	SYK	IDA		Human	PMID:8163536
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	Syk	IDA		Mouse	PMID:8626447
Molecular Function	GO:0019902	phosphatase binding	Syk	IPI	UniProtKB:P29351	Mouse	MGI:MGI:5478702\|PMID:22496641
Molecular Function	GO:0019902	phosphatase binding	Syk	IPI	UniprotKB:Q8BGG7	Mouse	PMID:27609517
Molecular Function	GO:0043274	phospholipase binding	SYK	IPI	UniProtKB:P16885	Human	PMID:14656219
Molecular Function	GO:0043274	phospholipase binding	SYK	IPI	UniProtKB:P16885	Human	PMID:32514138
Molecular Function	GO:0001784	phosphotyrosine residue binding	SYK	IMP		Human	PMID:12051764
Molecular Function	GO:0001784	phosphotyrosine residue binding	SYK	IPI	UniProtKB:Q96P31	Human	PMID:12051764
Molecular Function	GO:0001784	phosphotyrosine residue binding	SYK	IPI	UniProtKB:Q6GX35	Human	PMID:20624904
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P05106	Human	PMID:11940607
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P06239	Human	PMID:15536084
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P00533	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P04626	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P21860	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P22681	Human	PMID:18273061
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:Q96P31	Human	PMID:19843936
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P40763	Human	PMID:20133729
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:Q8TF42	Human	PMID:20585042
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P21333	Human	PMID:20713593
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P54274	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P40763	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:Q9UHP3	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:Q63HR2	Human	PMID:22019427
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P11049	Human	PMID:22624718
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P14317	Human	PMID:23001182
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:Q8N6F7	Human	PMID:23299888
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P36888	Human	PMID:24525236
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P08581	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:Q13480	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P40763	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:Q9NP31	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:Q9UHP3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:Q9ULZ3	Human	PMID:25605870
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:Q96IP4	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P36888	Human	PMID:28086240
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P40763	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P40763	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:Q9UHP3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:Q9UHP3	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P07766	Human	PMID:7761456
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P20273	Human	PMID:8627166
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P20273	Human	PMID:8647200
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P19174	Human	PMID:8657103
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P06239	Human	PMID:8798676
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P30273	Human	PMID:8810294
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P30273	Human	PMID:9280292
Molecular Function	GO:0005515	protein binding	SYK	IPI	UniProtKB:P07766	Human	PMID:9698567
Molecular Function	GO:0005515	protein binding	Syk	IPI	UniProtKB:P42227	Mouse	MGI:MGI:5915342\|PMID:20133729
Molecular Function	GO:0005515	protein binding	Syk	IPI	UniProtKB:O54885\|UniProtKB:P20491	Mouse	MGI:MGI:3693026\|PMID:17086186
Molecular Function	GO:0005515	protein binding	Syk	IPI	UniProtKB:Q64693	Mouse	MGI:MGI:3690194\|PMID:16713566
Molecular Function	GO:0005515	protein binding	Syk	IPI	UniProtKB:Q9Z1S8	Mouse	MGI:MGI:3768863\|PMID:16456001
Molecular Function	GO:0005515	protein binding	Syk	IPI	UniProtKB:Q9D2Z1	Mouse	MGI:MGI:5695712\|PMID:26195794
Molecular Function	GO:0005515	protein binding	Syk	IPI	UniProtKB:Q9D3G9	Mouse	MGI:MGI:3827034\|PMID:19124738
Molecular Function	GO:0005515	protein binding	Syk	IPI	UniProtKB:P31809	Mouse	MGI:MGI:5478702\|PMID:22496641
Molecular Function	GO:0005515	protein binding	Syk	IPI	UniProtKB:P25911	Mouse	MGI:MGI:5478702\|PMID:22496641
Molecular Function	GO:0005515	protein binding	Syk	IPI	UniProtKB:P20491	Mouse	MGI:MGI:3831068\|PMID:19098920
Molecular Function	GO:0005515	protein binding	Syk	IPI	UniProtKB:Q6QLQ4	Mouse	MGI:MGI:3576850\|PMID:15845454
Molecular Function	GO:0005515	protein binding	Syk	IPI	UniProtKB:P08487	Mouse	MGI:MGI:5508257\|PMID:16410013
Molecular Function	GO:0005515	protein binding	Syk	IPI	PR:Q9JID9	Mouse	PMID:10872802
Molecular Function	GO:0005515	protein binding	Syk	IPI	PR:P11911	Mouse	PMID:8626447
Molecular Function	GO:0005515	protein binding	Syk	IPI	UniProtKB:P58195	Rat	PMID:18579528\|RGD:2303650
Molecular Function	GO:0019904	protein domain specific binding	Syk	IDA		Rat	PMID:16861349\|RGD:2299903
Molecular Function	GO:0004672	protein kinase activity	SYK	IDA		Human	PMID:18818202
Molecular Function	GO:0004672	protein kinase activity	Syk	IDA		Rat	PMID:16861349\|RGD:2299903
Molecular Function	GO:0019901	protein kinase binding	Syk	IPI	UniProtKB:P14234	Mouse	MGI:MGI:3640451\|PMID:11672534
Molecular Function	GO:0004674	protein serine/threonine kinase activity	SYK	IDA		Human	PMID:23071339
Molecular Function	GO:0004713	protein tyrosine kinase activity	SYK	EXP		Human	PMID:10648173
Molecular Function	GO:0004713	protein tyrosine kinase activity	SYK	EXP		Human	PMID:17993265
Molecular Function	GO:0004713	protein tyrosine kinase activity	SYK	EXP		Human	PMID:18818202
Molecular Function	GO:0004713	protein tyrosine kinase activity	SYK	EXP		Human	PMID:22041900
Molecular Function	GO:0004713	protein tyrosine kinase activity	SYK	IMP		Human	PMID:33782605
Molecular Function	GO:0004713	protein tyrosine kinase activity	SYK	EXP		Human	PMID:8629002
Molecular Function	GO:0004713	protein tyrosine kinase activity	SYK	EXP		Human	PMID:8657103
Molecular Function	GO:0004713	protein tyrosine kinase activity	Syk	IMP		Mouse	MGI:MGI:3768863\|PMID:16456001
Molecular Function	GO:0004713	protein tyrosine kinase activity	Syk	EXP		Mouse	MGI:MGI:6216164\|PMID:8629002
Molecular Function	GO:0004713	protein tyrosine kinase activity	Syk	IMP		Mouse	MGI:MGI:6705760\|PMID:33782605
Molecular Function	GO:0004713	protein tyrosine kinase activity	Syk	IDA		Mouse	PMID:9199344
Molecular Function	GO:0004713	protein tyrosine kinase activity	Syk	IDA		Mouse	PMID:27609517
Molecular Function	GO:0004713	protein tyrosine kinase activity	Syk	IDA		Mouse	PMID:7744830
Molecular Function	GO:0004713	protein tyrosine kinase activity	Syk	IDA		Mouse	PMID:8798454
Molecular Function	GO:0004713	protein tyrosine kinase activity	Syk	IDA		Mouse	PMID:9099676
Molecular Function	GO:0004713	protein tyrosine kinase activity	Syk	IDA		Mouse	PMID:7499277
Molecular Function	GO:0004713	protein tyrosine kinase activity	Syk	IDA		Mouse	PMID:10872802
Molecular Function	GO:0004713	protein tyrosine kinase activity	Syk	EXP		Rat	PMID:10931839\|RGD:11059586
Molecular Function	GO:0097110	scaffold protein binding	SYK	IPI	UniProtKB:Q8WV28	Human	PMID:11606584
Molecular Function	GO:0042169	SH2 domain binding	Syk	IDA		Mouse	PMID:27609517
Molecular Function	GO:0005102	signaling receptor binding	SYK	IPI	UniProtKB:Q9HCN6	Human	PMID:31145836
Molecular Function	GO:0035325	Toll-like receptor binding	Syk	IPI	UniProtKB:Q9QUK6	Mouse	MGI:MGI:5478702\|PMID:22496641
Molecular Function	GO:0031625	ubiquitin protein ligase binding	Syk	IPI	RGD:1561386	Rat	PMID:8920860\|RGD:11576303
Cellular Component	GO:0019815	B cell receptor complex	Syk	IDA		Mouse	PMID:8626447
Cellular Component	GO:0005737	cytoplasm	SYK	IDA		Human	PMID:23071339
Cellular Component	GO:0032009	early phagosome	Syk	IDA		Mouse	MGI:MGI:3576850\|PMID:15845454
Cellular Component	GO:0005634	nucleus	SYK	IDA		Human	PMID:23071339
Cellular Component	GO:0032991	protein-containing complex	SYK	IDA		Human	PMID:23071339
Cellular Component	GO:0032991	protein-containing complex	Syk	IDA		Mouse	PMID:22451653
Cellular Component	GO:0042101	T cell receptor complex	SYK	IDA		Human	PMID:8176201
Biological Process	GO:0030183	B cell differentiation	Syk	IMP	MGI:MGI:1857421	Mouse	PMID:7477353
Biological Process	GO:0030183	B cell differentiation	Syk	IMP	MGI:MGI:2384078	Mouse	PMID:7477352
Biological Process	GO:0050853	B cell receptor signaling pathway	SYK	IMP		Human	PMID:15509800
Biological Process	GO:0050853	B cell receptor signaling pathway	Syk	IDA		Mouse	PMID:9199344
Biological Process	GO:0050853	B cell receptor signaling pathway	Syk	IDA		Mouse	PMID:7499277
Biological Process	GO:0050853	B cell receptor signaling pathway	Syk	IDA		Mouse	PMID:8626447
Biological Process	GO:0043366	beta selection	Syk	IGI	MGI:MGI:99613	Mouse	PMID:9275205
Biological Process	GO:0048514	blood vessel morphogenesis	Syk	IMP		Mouse	MGI:MGI:3653293\|PMID:12522250
Biological Process	GO:0019722	calcium-mediated signaling	Syk	IMP	MGI:MGI:2384078	Mouse	PMID:9000133
Biological Process	GO:0001775	cell activation	Syk	IMP		Mouse	MGI:MGI:3844414\|PMID:19136564
Biological Process	GO:0007166	cell surface receptor signaling pathway	Syk	IDA		Mouse	PMID:9099676
Biological Process	GO:0007166	cell surface receptor signaling pathway	Syk	IMP	MGI:MGI:2384078	Mouse	PMID:9000133
Biological Process	GO:1990858	cellular response to lectin	Syk	IMP		Mouse	MGI:MGI:3844414\|PMID:19136564
Biological Process	GO:0071396	cellular response to lipid	SYK	IMP		Human	PMID:32514138
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus	Syk	IDA		Mouse	MGI:MGI:5700288\|PMID:23395392
Biological Process	GO:0071226	cellular response to molecule of fungal origin	Syk	IMP		Mouse	MGI:MGI:3576850\|PMID:15845454
Biological Process	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	Syk	IMP		Mouse	PMID:27609517
Biological Process	GO:0042742	defense response to bacterium	Syk	IMP		Mouse	MGI:MGI:4414596\|PMID:19797524
Biological Process	GO:0007167	enzyme-linked receptor protein signaling pathway	Syk	IDA		Mouse	PMID:7744830
Biological Process	GO:0051649	establishment of localization in cell	Syk	IMP	MGI:MGI:2384078	Mouse	PMID:9000133
Biological Process	GO:0042492	gamma-delta T cell differentiation	Syk	IMP	MGI:MGI:1857421	Mouse	PMID:8790395
Biological Process	GO:0042492	gamma-delta T cell differentiation	Syk	IMP	MGI:MGI:2384078	Mouse	PMID:7477352
Biological Process	GO:0032604	granulocyte macrophage colony-stimulating factor production	Syk	IMP	MGI:MGI:2384078	Mouse	PMID:9000133
Biological Process	GO:0045087	innate immune response	Syk	IMP		Mouse	MGI:MGI:3576850\|PMID:15845454
Biological Process	GO:0007229	integrin-mediated signaling pathway	Syk	IMP		Mouse	MGI:MGI:5306324\|PMID:11940607
Biological Process	GO:0007229	integrin-mediated signaling pathway	Syk	IMP		Mouse	MGI:MGI:3693026\|PMID:17086186
Biological Process	GO:0032632	interleukin-3 production	Syk	IMP	MGI:MGI:2384078	Mouse	PMID:9000133
Biological Process	GO:0038156	interleukin-3-mediated signaling pathway	Syk	IMP		Mouse	MGI:MGI:3831068\|PMID:19098920
Biological Process	GO:0035556	intracellular signal transduction	SYK	IDA		Human	PMID:11606584
Biological Process	GO:0035556	intracellular signal transduction	SYK	IGI	UniProtKB:P16885	Human	PMID:14656219
Biological Process	GO:0035556	intracellular signal transduction	SYK	IDA		Human	PMID:15509800
Biological Process	GO:0035556	intracellular signal transduction	SYK	IMP		Human	PMID:32514138
Biological Process	GO:0035556	intracellular signal transduction	Syk	IMP		Mouse	MGI:MGI:3844414\|PMID:19136564
Biological Process	GO:0035556	intracellular signal transduction	Syk	IMP	MGI:MGI:2384078	Mouse	PMID:9000133
Biological Process	GO:0035556	intracellular signal transduction	Syk	IDA		Mouse	PMID:8626447
Biological Process	GO:0002366	leukocyte activation involved in immune response	Syk	IMP		Mouse	MGI:MGI:3576850\|PMID:15845454
Biological Process	GO:0007159	leukocyte cell-cell adhesion	SYK	IDA		Human	PMID:12885943
Biological Process	GO:0019370	leukotriene biosynthetic process	Syk	IMP	MGI:MGI:2384078	Mouse	PMID:9000133
Biological Process	GO:0001945	lymph vessel development	Syk	IMP		Mouse	MGI:MGI:3653293\|PMID:12522250
Biological Process	GO:0001946	lymphangiogenesis	syk	IGI	ZFIN:ZDB-GENE-040702-3,ZFIN:ZDB-GENE-050522-257	Zfish	PMID:20096681
Biological Process	GO:0001946	lymphangiogenesis	syk	IMP	ZFIN:ZDB-MRPHLNO-100407-1	Zfish	PMID:20096681
Biological Process	GO:0002281	macrophage activation involved in immune response	Syk	IMP		Mouse	MGI:MGI:3693026\|PMID:17086186
Biological Process	GO:0032762	mast cell cytokine production	Syk	IMP	MGI:MGI:2384078	Mouse	PMID:9000133
Biological Process	GO:0043303	mast cell degranulation	Syk	IMP	MGI:MGI:2384078	Mouse	PMID:9000133
Biological Process	GO:0002283	neutrophil activation involved in immune response	Syk	IMP		Mouse	MGI:MGI:3693026\|PMID:17086186
Biological Process	GO:0030593	neutrophil chemotaxis	SYK	IDA		Human	PMID:12885943
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Syk	IDA		Mouse	PMID:23071339
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	SYK	IDA		Human	PMID:11606584
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	SYK	IMP		Human	PMID:11606584
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	SYK	IGI	UniProtKB:P16885	Human	PMID:14656219
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	SYK	IMP		Human	PMID:15509800
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Syk	IMP		Mouse	MGI:MGI:3768863\|PMID:16456001
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Syk	IDA		Mouse	PMID:8798454
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Syk	IDA		Mouse	PMID:10872802
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Syk	IDA		Mouse	PMID:7499277
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Syk	IDA		Mouse	PMID:9099676
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Syk	IMP	MGI:MGI:2384078	Mouse	PMID:9000133
Biological Process	GO:0046638	positive regulation of alpha-beta T cell differentiation	Syk	IGI	MGI:MGI:99613	Mouse	PMID:9275205
Biological Process	GO:0046641	positive regulation of alpha-beta T cell proliferation	Syk	IGI	MGI:MGI:99613	Mouse	PMID:9275205
Biological Process	GO:0045579	positive regulation of B cell differentiation	SYK	IMP		Human	PMID:18369315
Biological Process	GO:0045579	positive regulation of B cell differentiation	Syk	IMP	MGI:MGI:1857421	Mouse	PMID:7477353
Biological Process	GO:0045579	positive regulation of B cell differentiation	Syk	IMP	MGI:MGI:2384078	Mouse	PMID:7477352
Biological Process	GO:0045780	positive regulation of bone resorption	Syk	IMP		Mouse	MGI:MGI:3703840\|PMID:17353363
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	Syk	IMP	MGI:MGI:2384078	Mouse	PMID:9000133
Biological Process	GO:0033630	positive regulation of cell adhesion mediated by integrin	Syk	IMP		Mouse	MGI:MGI:5306324\|PMID:11940607
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	syk	IGI	ZFIN:ZDB-GENE-040702-3,ZFIN:ZDB-GENE-050522-257	Zfish	PMID:20096681
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	syk	IMP	ZFIN:ZDB-MRPHLNO-100407-2	Zfish	PMID:20096681
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	syk	IMP	ZFIN:ZDB-MRPHLNO-100407-1	Zfish	PMID:20096681
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Syk	IMP		Mouse	MGI:MGI:6112333\|PMID:29235464
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	SYK	IMP		Human	PMID:22267217
Biological Process	GO:0001819	positive regulation of cytokine production	Syk	IGI	MGI:MGI:2157947	Mouse	PMID:19770268
Biological Process	GO:0045588	positive regulation of gamma-delta T cell differentiation	Syk	IMP	MGI:MGI:2384078	Mouse	PMID:7477352
Biological Process	GO:0045588	positive regulation of gamma-delta T cell differentiation	Syk	IMP	MGI:MGI:1857421	Mouse	PMID:8790395
Biological Process	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	Syk	IMP	MGI:MGI:2384078	Mouse	PMID:9000133
Biological Process	GO:0032733	positive regulation of interleukin-10 production	SYK	IMP		Human	PMID:19358895
Biological Process	GO:0032735	positive regulation of interleukin-12 production	SYK	IMP		Human	PMID:19358895
Biological Process	GO:0032752	positive regulation of interleukin-3 production	Syk	IMP	MGI:MGI:2384078	Mouse	PMID:9000133
Biological Process	GO:0032753	positive regulation of interleukin-4 production	Syk	IMP		Mouse	MGI:MGI:3831068\|PMID:19098920
Biological Process	GO:0032755	positive regulation of interleukin-6 production	SYK	IMP		Human	PMID:19358895
Biological Process	GO:0032757	positive regulation of interleukin-8 production	SYK	IMP		Human	PMID:25251945
Biological Process	GO:0043507	positive regulation of JUN kinase activity	Syk	IMP	MGI:MGI:2384078	Mouse	PMID:9000133
Biological Process	GO:0051712	positive regulation of killing of cells of another organism	SYK	IMP		Human	PMID:19358895
Biological Process	GO:0043410	positive regulation of MAPK cascade	Syk	IMP	MGI:MGI:2384078	Mouse	PMID:9000133
Biological Process	GO:0043410	positive regulation of MAPK cascade	Syk	IDA		Mouse	PMID:8626447
Biological Process	GO:0032765	positive regulation of mast cell cytokine production	Syk	IMP	MGI:MGI:2384078	Mouse	PMID:9000133
Biological Process	GO:0043306	positive regulation of mast cell degranulation	Syk	IMP	MGI:MGI:2384078	Mouse	PMID:9000133
Biological Process	GO:0043306	positive regulation of mast cell degranulation	Syk	IMP		Rat	PMID:16861349\|RGD:2299903
Biological Process	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	SYK	IMP		Human	PMID:25251945
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Syk	IMP	MGI:MGI:2384078	Mouse	PMID:9000133
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	SYK	IMP		Human	PMID:22267217
Biological Process	GO:0002092	positive regulation of receptor internalization	Syk	IMP		Mouse	MGI:MGI:5300392\|PMID:22078883
Biological Process	GO:0002092	positive regulation of receptor internalization	Syk	IMP		Mouse	MGI:MGI:5619729\|PMID:23962979
Biological Process	GO:0032930	positive regulation of superoxide anion generation	SYK	IMP		Human	PMID:19358895
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	SYK	IMP		Human	PMID:19358895
Biological Process	GO:0032481	positive regulation of type I interferon production	Syk	IMP		Mouse	MGI:MGI:5300392\|PMID:22078883
Biological Process	GO:0046777	protein autophosphorylation	Syk	IDA		Mouse	PMID:8626447
Biological Process	GO:0046777	protein autophosphorylation	Syk	IDA		Mouse	PMID:8798454
Biological Process	GO:0046777	protein autophosphorylation	Syk	IDA		Mouse	PMID:9099676
Biological Process	GO:0046777	protein autophosphorylation	Syk	IDA		Rat	PMID:16861349\|RGD:2299903
Biological Process	GO:0006606	protein import into nucleus	SYK	IMP		Human	PMID:23071339
Biological Process	GO:0006468	protein phosphorylation	SYK	IDA		Human	PMID:17681949
Biological Process	GO:0031623	receptor internalization	Syk	IDA		Mouse	MGI:MGI:5700288\|PMID:23395392
Biological Process	GO:0090237	regulation of arachidonic acid secretion	Syk	IMP		Mouse	MGI:MGI:87668\|PMID:9171347
Biological Process	GO:0051090	regulation of DNA-binding transcription factor activity	SYK	IMP		Human	PMID:23071339
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	Syk	IMP		Mouse	MGI:MGI:4414596\|PMID:19797524
Biological Process	GO:0050776	regulation of immune response	Syk	IDA		Rat	PMID:12417718\|RGD:730070
Biological Process	GO:0043313	regulation of neutrophil degranulation	Syk	IMP		Mouse	MGI:MGI:4414596\|PMID:19797524
Biological Process	GO:0050764	regulation of phagocytosis	Syk	IMP		Mouse	MGI:MGI:4414596\|PMID:19797524
Biological Process	GO:0010543	regulation of platelet activation	Syk	IMP		Mouse	MGI:MGI:87668\|PMID:9171347
Biological Process	GO:0090330	regulation of platelet aggregation	Syk	IMP		Mouse	MGI:MGI:87668\|PMID:9171347
Biological Process	GO:0032928	regulation of superoxide anion generation	Syk	IMP		Mouse	MGI:MGI:4414596\|PMID:19797524
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	SYK	IMP		Human	PMID:19151749
Biological Process	GO:0001820	serotonin secretion	Syk	IMP	MGI:MGI:2384078	Mouse	PMID:9000133
Biological Process	GO:0002554	serotonin secretion by platelet	Syk	IMP		Mouse	MGI:MGI:87668\|PMID:9171347
Biological Process	GO:0002223	stimulatory C-type lectin receptor signaling pathway	Syk	IMP		Mouse	MGI:MGI:3844414\|PMID:19136564

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/05/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.