Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SYNGAP1
  • Mouse genes Syngap1
  • Rat genes Syngap1
  • Zfish genes syngap1a,syngap1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Syngap1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005096	GTPase activator activity	Syngap1	IDA		Mouse	PMID:15014045
Molecular Function	GO:0005096	GTPase activator activity	Syngap1	IDA		Rat	PMID:14970204|RGD:7241546
Molecular Function	GO:0005096	GTPase activator activity	Syngap1	IDA		Rat	PMID:16427633|RGD:7241543
Molecular Function	GO:0005096	GTPase activator activity	Syngap1	IDA		Rat	PMID:21382555|RGD:7241548
Molecular Function	GO:0005515	protein binding	SYNGAP1	IPI	UniProtKB:O43639	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYNGAP1	IPI	UniProtKB:O43711	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYNGAP1	IPI	UniProtKB:O75031	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYNGAP1	IPI	UniProtKB:O95231	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYNGAP1	IPI	UniProtKB:P14373	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYNGAP1	IPI	UniProtKB:P51687	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYNGAP1	IPI	UniProtKB:Q13064	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYNGAP1	IPI	UniProtKB:Q5JVL4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYNGAP1	IPI	UniProtKB:Q96HA8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYNGAP1	IPI	UniProtKB:Q96NT3-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYNGAP1	IPI	UniProtKB:Q96PN8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYNGAP1	IPI	UniProtKB:Q99932-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYNGAP1	IPI	UniProtKB:Q9UJV3-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Syngap1	IPI	UniProtKB:Q9D415	Mouse	MGI:MGI:6092779|PMID:28671696
Molecular Function	GO:0005515	protein binding	Syngap1	IPI	UniProtKB:P16056	Mouse	MGI:MGI:7258354|PMID:27086544
Molecular Function	GO:0005515	protein binding	Syngap1	IPI	PR:O70405	Mouse	PMID:15014045
Molecular Function	GO:0005515	protein binding	Syngap1	IPI	UniProtKB:P31016	Rat	PMID:16054660|RGD:8554049
Molecular Function	GO:0005515	protein binding	Syngap1	IPI	UniProtKB:Q8K430	Rat	PMID:16054660|RGD:8554049
Molecular Function	GO:0005515	protein binding	Syngap1	IPI	UniProtKB:Q9JJ40	Rat	PMID:16054660|RGD:8554049
Molecular Function	GO:0019901	protein kinase binding	Syngap1	IPI	RGD:2261	Rat	PMID:12951199|RGD:7241547
Molecular Function	GO:0019901	protein kinase binding	Syngap1	IPI	UniProtKB:Q9R012	Rat	PMID:21382555|RGD:7241548
Cellular Component	GO:0043198	dendritic shaft	Syngap1	IDA		Mouse	PMID:16452659
Cellular Component	GO:0098978	glutamatergic synapse	Syngap1	IDA		Mouse	PMID:27565345
Cellular Component	GO:0098978	glutamatergic synapse	Syngap1	IMP		Mouse	PMID:27565345
Cellular Component	GO:0098978	glutamatergic synapse	Syngap1	IPI		Mouse	PMID:27565345
Cellular Component	GO:0098978	glutamatergic synapse	Syngap1	IDA		Rat	PMID:21736925|RGD:7241542
Cellular Component	GO:0016020	membrane	Syngap1	IDA		Mouse	PMID:15014045
Cellular Component	GO:0014069	postsynaptic density	Syngap1	IDA		Mouse	PMID:17114649
Cellular Component	GO:0014069	postsynaptic density	Syngap1	IDA		Rat	PMID:14970204|RGD:7241546
Cellular Component	GO:0014069	postsynaptic density	Syngap1	IDA		Rat	PMID:21736925|RGD:7241542
Cellular Component	GO:0099092	postsynaptic density, intracellular component	Syngap1	IDA		Rat	PMID:21736925|RGD:7241542
Cellular Component	GO:0045202	synapse	Syngap1	IDA		Rat	PMID:9620694|RGD:634128
Biological Process	GO:0007409	axonogenesis	Syngap1	IDA		Mouse	PMID:15014045
Biological Process	GO:0048854	brain morphogenesis	syngap1b	IGI	ZFIN:ZDB-MRPHLNO-150925-4,ZFIN:ZDB-MRPHLNO-150928-10	Zfish	PMID:25882707
Biological Process	GO:0048854	brain morphogenesis	syngap1b	IMP	ZFIN:ZDB-MRPHLNO-150928-10	Zfish	PMID:25882707
Biological Process	GO:0016358	dendrite development	Syngap1	IMP	MGI:MGI:3511175	Mouse	PMID:15470153
Biological Process	GO:0098880	maintenance of postsynaptic specialization structure	Syngap1	IDA		Mouse	PMID:27565345
Biological Process	GO:0098880	maintenance of postsynaptic specialization structure	Syngap1	IPI		Mouse	PMID:27565345
Biological Process	GO:0098880	maintenance of postsynaptic specialization structure	Syngap1	IMP		Mouse	PMID:27565345
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Syngap1	IDA		Mouse	PMID:27565345
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Syngap1	IPI		Mouse	PMID:27565345
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Syngap1	IMP		Mouse	PMID:27565345
Biological Process	GO:0050771	negative regulation of axonogenesis	Syngap1	IDA		Mouse	PMID:15014045
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Syngap1	IMP	MGI:MGI:3511175	Mouse	PMID:15733080
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction	Syngap1	IDA		Rat	PMID:21382555|RGD:7241548
Biological Process	GO:0051402	neuron apoptotic process	Syngap1	IMP	MGI:MGI:3511175	Mouse	PMID:15733080
Biological Process	GO:0007389	pattern specification process	Syngap1	IMP	MGI:MGI:3580631	Mouse	PMID:16452659
Biological Process	GO:0007265	Ras protein signal transduction	Syngap1	IDA		Mouse	PMID:15014045
Biological Process	GO:0043113	receptor clustering	Syngap1	IMP	MGI:MGI:3576223	Mouse	PMID:12598599
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	Syngap1	IGI	MGI:MGI:1277959	Mouse	PMID:12427827
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	Syngap1	IMP	MGI:MGI:3580631	Mouse	PMID:12427827
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	Syngap1	IMP	MGI:MGI:3576223	Mouse	PMID:15781580
Biological Process	GO:0043408	regulation of MAPK cascade	Syngap1	IMP	MGI:MGI:3580631	Mouse	PMID:12427827
Biological Process	GO:0050803	regulation of synapse structure or activity	Syngap1	IMP	MGI:MGI:3511175	Mouse	PMID:15470153
Biological Process	GO:0048167	regulation of synaptic plasticity	Syngap1	IDA		Rat	PMID:21382555|RGD:7241548
Biological Process	GO:0036269	swimming behavior	syngap1b	IMP	ZFIN:ZDB-MRPHLNO-150928-10	Zfish	PMID:25882707
Biological Process	GO:0036269	swimming behavior	syngap1b	IGI	ZFIN:ZDB-MRPHLNO-150925-4,ZFIN:ZDB-MRPHLNO-150928-10	Zfish	PMID:25882707
Biological Process	GO:0008542	visual learning	Syngap1	IMP	MGI:MGI:3580631	Mouse	PMID:12427827

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern