Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SYT4
  • Mouse genes Syt4
  • Rat genes Syt4
  • Zfish genes syt4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Syt4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	Syt4	IDA		Mouse	PMID:15197251
Molecular Function	GO:0005544	calcium-dependent phospholipid binding	Syt4	IDA		Mouse	MGI:MGI:5795832|PMID:8626542
Molecular Function	GO:0030276	clathrin binding	Syt4	IDA		Rat	PMID:7791877|RGD:61762
Molecular Function	GO:0001786	phosphatidylserine binding	Syt4	IDA		Rat	PMID:18508778|RGD:7241021
Molecular Function	GO:0005515	protein binding	SYT4	IPI	UniProtKB:O43765	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	SYT4	IPI	UniProtKB:O43765	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SYT4	IPI	UniProtKB:Q14596	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SYT4	IPI	UniProtKB:O43765	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYT4	IPI	UniProtKB:Q14596-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYT4	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYT4	IPI	UniProtKB:Q9UI09	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Syt4	IPI	UniProtKB:P21707	Rat	PMID:18046461|RGD:8554794
Molecular Function	GO:0005515	protein binding	Syt4	IPI	UniProtKB:P49185	Rat	PMID:18046461|RGD:8554794
Molecular Function	GO:0005515	protein binding	Syt4	IPI	UniProtKB:P49187	Rat	PMID:18046461|RGD:8554794
Molecular Function	GO:0005515	protein binding	Syt4	IPI	UniProtKB:F1M4A4	Rat	PMID:29166604|RGD:15023486
Molecular Function	GO:0005515	protein binding	Syt4	IPI	UniProtKB:F1LTE0	Rat	PMID:30021165|RGD:14995321
Molecular Function	GO:0005515	protein binding	Syt4	IPI	UniProtKB:P21707	Rat	PMID:9830048|RGD:8553400
Molecular Function	GO:0046982	protein heterodimerization activity	Syt4	IPI	UniProtKB:P21707	Rat	PMID:10397765|RGD:11535116
Molecular Function	GO:0042803	protein homodimerization activity	Syt4	IDA		Rat	PMID:10397765|RGD:11535116
Molecular Function	GO:0000149	SNARE binding	Syt4	IDA		Rat	PMID:18508778|RGD:7241021
Molecular Function	GO:0000149	SNARE binding	Syt4	IPI	UniProtKB:P32851,UniProtKB:P60881	Rat	PMID:20688915|RGD:11535104
Molecular Function	GO:0019905	syntaxin binding	Syt4	IPI	UniProtKB:P50279	Rat	PMID:10397765|RGD:11535116
Molecular Function	GO:0019905	syntaxin binding	Syt4	IPI	UniProtKB:Q08850	Rat	PMID:10397765|RGD:11535116
Molecular Function	GO:0019905	syntaxin binding	Syt4	IPI	UniProtKB:Q63635	Rat	PMID:16618809|RGD:11535113
Molecular Function	GO:0017075	syntaxin-1 binding	Syt4	IPI	UniProtKB:P32851	Rat	PMID:10397765|RGD:11535116
Molecular Function	GO:0030348	syntaxin-3 binding	Syt4	IPI	UniProtKB:Q08849	Rat	PMID:10397765|RGD:11535116
Cellular Component	GO:0097449	astrocyte projection	Syt4	IDA		Mouse	MGI:MGI:3047044|PMID:15197251
Cellular Component	GO:0097449	astrocyte projection	Syt4	IDA		Rat	PMID:15197251|RGD:11535103
Cellular Component	GO:0030424	axon	Syt4	IDA		Mouse	MGI:MGI:5795827|PMID:12135783
Cellular Component	GO:0030424	axon	Syt4	IDA		Mouse	MGI:MGI:4457852|PMID:19448629
Cellular Component	GO:0030424	axon	Syt4	IMP		Rat	PMID:29166604|RGD:15023486
Cellular Component	GO:0030425	dendrite	Syt4	IDA		Mouse	MGI:MGI:5795827|PMID:12135783
Cellular Component	GO:0030425	dendrite	Syt4	IDA		Mouse	MGI:MGI:4457852|PMID:19448629
Cellular Component	GO:0030425	dendrite	Syt4	IDA		Mouse	MGI:MGI:5795818|PMID:21576241
Cellular Component	GO:0031045	dense core granule	Syt4	IDA		Mouse	MGI:MGI:3836866|PMID:19136969
Cellular Component	GO:0031045	dense core granule	Syt4	IDA		Mouse	MGI:MGI:3795609|PMID:18468511
Cellular Component	GO:0031045	dense core granule	Syt4	IDA		Rat	PMID:10217258|RGD:11535095
Cellular Component	GO:0031045	dense core granule	Syt4	IDA		Rat	PMID:21551071|RGD:7205660
Cellular Component	GO:0070382	exocytic vesicle	Syt4	IDA		Rat	PMID:10217258|RGD:11535095
Cellular Component	GO:0098978	glutamatergic synapse	Syt4	IDA		Mouse	PMID:19448629
Cellular Component	GO:0098978	glutamatergic synapse	Syt4	EXP		Mouse	PMID:19448629
Cellular Component	GO:0098978	glutamatergic synapse	Syt4	IMP		Mouse	PMID:19448629
Cellular Component	GO:0005794	Golgi apparatus	Syt4	IDA		Mouse	MGI:MGI:4457852|PMID:19448629
Cellular Component	GO:0005794	Golgi apparatus	Syt4	IDA		Mouse	MGI:MGI:5795827|PMID:12135783
Cellular Component	GO:0005794	Golgi apparatus	Syt4	IDA		Rat	PMID:10646502|RGD:11535094
Cellular Component	GO:0005794	Golgi apparatus	Syt4	IDA		Rat	PMID:16618809|RGD:11535113
Cellular Component	GO:0005794	Golgi apparatus	Syt4	IDA		Rat	PMID:26750488|RGD:11535089
Cellular Component	GO:1990742	microvesicle	Syt4	IDA		Mouse	MGI:MGI:3836866|PMID:19136969
Cellular Component	GO:0043005	neuron projection	Syt4	IDA		Mouse	PMID:15197251
Cellular Component	GO:0043005	neuron projection	Syt4	IDA		Rat	PMID:10646502|RGD:11535094
Cellular Component	GO:0044306	neuron projection terminus	Syt4	IDA		Rat	PMID:10397765|RGD:11535116
Cellular Component	GO:0043025	neuronal cell body	Syt4	IDA		Mouse	MGI:MGI:5795818|PMID:21576241
Cellular Component	GO:0043025	neuronal cell body	Syt4	IDA		Rat	PMID:15197251|RGD:11535103
Cellular Component	GO:0098992	neuronal dense core vesicle	Syt4	IDA		Rat	PMID:29166604|RGD:15023486
Cellular Component	GO:0099012	neuronal dense core vesicle membrane	Syt4	IDA		Mouse	PMID:19136969
Cellular Component	GO:0099012	neuronal dense core vesicle membrane	Syt4	IPI		Mouse	PMID:19136969
Cellular Component	GO:0099012	neuronal dense core vesicle membrane	Syt4	IEP		Mouse	PMID:19136969
Cellular Component	GO:0099012	neuronal dense core vesicle membrane	Syt4	IDA		Mouse	PMID:19448629
Cellular Component	GO:0099012	neuronal dense core vesicle membrane	Syt4	IDA		Rat	PMID:30021165|RGD:14995321
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Syt4	IDA		Mouse	PMID:15197251
Cellular Component	GO:0005886	plasma membrane	Syt4	IDA		Mouse	MGI:MGI:5795827|PMID:12135783
Cellular Component	GO:0098793	presynapse	Syt4	IMP		Mouse	MGI:MGI:4457852|PMID:19448629
Cellular Component	GO:0030667	secretory granule membrane	Syt4	IDA		Rat	PMID:16618809|RGD:11535113
Cellular Component	GO:0036477	somatodendritic compartment	Syt4	IDA		Mouse	MGI:MGI:5795827|PMID:12135783
Cellular Component	GO:0008021	synaptic vesicle	Syt4	IDA		Rat	PMID:10217258|RGD:11535095
Cellular Component	GO:0031982	vesicle	Syt4	IDA		Mouse	MGI:MGI:4457852|PMID:19448629
Cellular Component	GO:0031982	vesicle	Syt4	IDA		Mouse	MGI:MGI:5795827|PMID:12135783
Biological Process	GO:0007420	brain development	Syt4	IEP		Rat	PMID:8872307|RGD:730127
Biological Process	GO:0099519	dense core granule cytoskeletal transport	Syt4	IMP		Mouse	MGI:MGI:6104122|PMID:29166604
Biological Process	GO:0099519	dense core granule cytoskeletal transport	Syt4	IMP		Rat	PMID:29166604|RGD:15023486
Biological Process	GO:0007613	memory	Syt4	IMP		Mouse	MGI:MGI:5796263|PMID:15390175
Biological Process	GO:0045955	negative regulation of calcium ion-dependent exocytosis	Syt4	IDA		Rat	PMID:21551071|RGD:7205660
Biological Process	GO:0033604	negative regulation of catecholamine secretion	SYT4	IGI	UniProtKB:P21707	Human	PMID:20735850
Biological Process	GO:0033604	negative regulation of catecholamine secretion	Syt4	IGI	UniProtKB:P21707	Rat	PMID:20735850|RGD:11535092
Biological Process	GO:1905414	negative regulation of dense core granule exocytosis	Syt4	IMP		Rat	PMID:20303854|RGD:11541109
Biological Process	GO:0046929	negative regulation of neurotransmitter secretion	Syt4	IDA		Rat	PMID:10397765|RGD:11535116
Biological Process	GO:0050709	negative regulation of protein secretion	Syt4	IMP		Mouse	MGI:MGI:4457852|PMID:19448629
Biological Process	GO:1905433	negative regulation of retrograde trans-synaptic signaling by neuropeptide	Syt4	IMP		Mouse	MGI:MGI:4457852|PMID:19448629
Biological Process	GO:0048174	negative regulation of short-term neuronal synaptic plasticity	Syt4	IMP		Mouse	MGI:MGI:5796263|PMID:15390175
Biological Process	GO:2000301	negative regulation of synaptic vesicle exocytosis	Syt4	IMP		Mouse	MGI:MGI:4457852|PMID:19448629
Biological Process	GO:0031339	negative regulation of vesicle fusion	Syt4	IDA		Rat	PMID:18508778|RGD:7241021
Biological Process	GO:0031339	negative regulation of vesicle fusion	Syt4	IDA		Rat	PMID:20688915|RGD:11535104
Biological Process	GO:0007269	neurotransmitter secretion	Syt4	IDA		Mouse	PMID:15197251
Biological Process	GO:1903861	positive regulation of dendrite extension	SYT4	IDA		Human	PMID:23999003
Biological Process	GO:1905415	positive regulation of dense core granule exocytosis	Syt4	IMP		Mouse	MGI:MGI:3795609|PMID:18468511
Biological Process	GO:0014049	positive regulation of glutamate secretion	Syt4	IMP		Mouse	MGI:MGI:3047044|PMID:15197251
Biological Process	GO:0017158	regulation of calcium ion-dependent exocytosis	Syt4	IMP		Mouse	MGI:MGI:4421257|PMID:20010821
Biological Process	GO:0017158	regulation of calcium ion-dependent exocytosis	Syt4	IMP		Mouse	MGI:MGI:3836866|PMID:19136969
Biological Process	GO:0014059	regulation of dopamine secretion	Syt4	IMP		Mouse	MGI:MGI:5795818|PMID:21576241
Biological Process	GO:0030100	regulation of endocytosis	Syt4	IMP		Mouse	MGI:MGI:3836866|PMID:19136969
Biological Process	GO:0030100	regulation of endocytosis	Syt4	IMP		Rat	PMID:20303854|RGD:11541109
Biological Process	GO:0150044	regulation of postsynaptic dense core vesicle exocytosis	Syt4	IMP		Mouse	PMID:19448629
Biological Process	GO:0150044	regulation of postsynaptic dense core vesicle exocytosis	Syt4	EXP		Mouse	PMID:19448629
Biological Process	GO:0150044	regulation of postsynaptic dense core vesicle exocytosis	Syt4	IDA		Mouse	PMID:19448629
Biological Process	GO:0150035	regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission	Syt4	IMP		Mouse	PMID:19448629
Biological Process	GO:0150035	regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission	Syt4	EXP		Mouse	PMID:19448629
Biological Process	GO:0150035	regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission	Syt4	IDA		Mouse	PMID:19448629
Biological Process	GO:0031338	regulation of vesicle fusion	Syt4	IMP		Mouse	MGI:MGI:3836866|PMID:19136969
Biological Process	GO:0031338	regulation of vesicle fusion	Syt4	IMP		Rat	PMID:20303854|RGD:11541109
Biological Process	GO:0061792	secretory granule maturation	Syt4	IMP		Rat	PMID:16618809|RGD:11535113
Biological Process	GO:0061782	vesicle fusion with vesicle	Syt4	IMP		Rat	PMID:16618809|RGD:11535113

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern