Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SYTL2
  • Mouse genes Sytl2
  • Rat genes Sytl2
  • Zfish genes sytl2a,sytl2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sytl2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042043	neurexin family protein binding	Sytl2	IDA		Mouse	MGI:MGI:1932155|PMID:11243866
Molecular Function	GO:0019902	phosphatase binding	SYTL2	IDA		Human	PMID:19389623
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	SYTL2	IMP		Human	PMID:17182843
Molecular Function	GO:0001786	phosphatidylserine binding	SYTL2	IMP		Human	PMID:17182843
Molecular Function	GO:0005515	protein binding	SYTL2	IPI	UniProtKB:P62136	Human	PMID:15231748
Molecular Function	GO:0005515	protein binding	SYTL2	IPI	UniProtKB:P51159	Human	PMID:18812475
Molecular Function	GO:0005515	protein binding	SYTL2	IPI	UniProtKB:Q9ERI2	Human	PMID:18940603
Molecular Function	GO:0005515	protein binding	SYTL2	IPI	UniProtKB:P62136	Human	PMID:19389623
Molecular Function	GO:0005515	protein binding	Sytl2	IPI	UniProtKB:Q99P58	Mouse	MGI:MGI:3693417|PMID:16716193
Molecular Function	GO:0005515	protein binding	Sytl2	IPI	UniProtKB:Q684P5	Mouse	MGI:MGI:5576844|PMID:24284068
Molecular Function	GO:0005515	protein binding	Sytl2	IPI	UniProtKB:Q9ERI2	Mouse	MGI:MGI:3852304|PMID:18266782
Molecular Function	GO:0005515	protein binding	Sytl2	IPI	PR:Q9ERI2	Mouse	PMID:12590134
Cellular Component	GO:0005737	cytoplasm	SYTL2	IDA		Human	PMID:18812475
Cellular Component	GO:0070382	exocytic vesicle	SYTL2	IDA		Human	PMID:18812475
Cellular Component	GO:0019897	extrinsic component of plasma membrane	Sytl2	IDA		Mouse	MGI:MGI:1932155|PMID:11243866
Cellular Component	GO:0042470	melanosome	Sytl2	IDA		Mouse	MGI:MGI:2176311|PMID:11773082
Cellular Component	GO:0016020	membrane	Sytl2	IDA		Mouse	PMID:11243866
Cellular Component	GO:0005886	plasma membrane	SYTL2	IDA		Human	PMID:17182843
Cellular Component	GO:0005886	plasma membrane	Sytl2	IDA		Mouse	MGI:MGI:3852304|PMID:18266782
Cellular Component	GO:0005886	plasma membrane	Sytl2	IDA		Mouse	MGI:MGI:3852305|PMID:17182843
Cellular Component	GO:0005886	plasma membrane	Sytl2	IDA		Mouse	PMID:24284068
Biological Process	GO:0072554	blood vessel lumenization	sytl2b	IMP	ZFIN:ZDB-CRISPR-220324-1	Zfish	PMID:33853352
Biological Process	GO:0072554	blood vessel lumenization	sytl2b	IGI	ZFIN:ZDB-GENE-130723-2	Zfish	PMID:33853352
Biological Process	GO:0072554	blood vessel lumenization	sytl2b	IMP	ZFIN:ZDB-CRISPR-220324-2	Zfish	PMID:33853352
Biological Process	GO:0072554	blood vessel lumenization	sytl2a	IMP	ZFIN:ZDB-CRISPR-220324-1	Zfish	PMID:33853352
Biological Process	GO:0072554	blood vessel lumenization	sytl2a	IGI	ZFIN:ZDB-GENE-121214-363	Zfish	PMID:33853352
Biological Process	GO:0072554	blood vessel lumenization	sytl2a	IMP	ZFIN:ZDB-CRISPR-220324-2	Zfish	PMID:33853352
Biological Process	GO:0006887	exocytosis	SYTL2	IDA		Human	PMID:18812475
Biological Process	GO:0006887	exocytosis	Sytl2	IDA		Mouse	MGI:MGI:3852304|PMID:18266782
Biological Process	GO:0070257	positive regulation of mucus secretion	Sytl2	IMP		Mouse	MGI:MGI:3693417|PMID:16716193
Biological Process	GO:0072659	protein localization to plasma membrane	Sytl2	IDA		Mouse	PMID:24284068
Biological Process	GO:0006904	vesicle docking involved in exocytosis	SYTL2	IDA		Human	PMID:18812475

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern