Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TANK
  • Mouse genes Tank
  • Rat genes Tank
  • Zfish genes tank
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tank

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	TANK	IMP		Human	PMID:25861989
Molecular Function	GO:0035800	deubiquitinase activator activity	TANK	IMP		Human	PMID:25861989
Molecular Function	GO:0060090	molecular adaptor activity	TANK	IDA		Human	PMID:21931631
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q13114	Human	PMID:12005438
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q12933	Human	PMID:14743216
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q13114	Human	PMID:14743216
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q9UHD2	Human	PMID:14743216
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:P42858	Human	PMID:17500595
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q14164	Human	PMID:17568778
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q9UHD2	Human	PMID:17568778
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q9UHD2	Human	PMID:18307994
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q12933	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:P61956	Human	PMID:21212807
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:P63165	Human	PMID:21212807
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q14164	Human	PMID:21212807
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q92574	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:P26651	Human	PMID:21784977
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:O96018	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q12933	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q13114	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q9UHD2	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:P17362	Human	PMID:21931555
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q14164	Human	PMID:21931555
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q9UHD2	Human	PMID:21931555
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:P53350	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q12933	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q9UHD2	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q9Y6K9	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:P03495	Human	PMID:24008843
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q05519	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q13625-3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q96MT8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q14164	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q14694|UniProtKB:Q5D1E8|UniProtKB:Q9Y4K3|UniProtKB:Q9Y6K9	Human	PMID:25861989
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q96MT8	Human	PMID:26638075
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q9UHD2	Human	PMID:29251827
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q12933	Human	PMID:30561431
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q13114	Human	PMID:30561431
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q9UHD2	Human	PMID:30561431
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q9Y6K9	Human	PMID:30561431
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q9UHD2	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	TANK	IPI	UniProtKB:Q13114	Human	PMID:34084167
Molecular Function	GO:0005515	protein binding	Tank	IPI	UniProtKB:Q9WUN2	Mouse	MGI:MGI:1928254|PMID:10581243
Molecular Function	GO:0005515	protein binding	Tank	IPI	UniProtKB:Q9WUN2	Mouse	MGI:MGI:5508590|PMID:18583960
Molecular Function	GO:0005515	protein binding	Tank	IPI	UniProtKB:Q9WUN2	Mouse	MGI:MGI:5918457|PMID:23746807
Molecular Function	GO:0005515	protein binding	Tank	IPI	UniProtKB:P39428|UniProtKB:P39429	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0031625	ubiquitin protein ligase binding	TANK	IPI	UniProtKB:O94972	Human	PMID:11279055
Cellular Component	GO:0005737	cytoplasm	TANK	IDA		Human	PMID:21931631
Cellular Component	GO:0005829	cytosol	TANK	IDA		Human	GO_REF:0000052
Cellular Component	GO:0032991	protein-containing complex	TANK	IDA		Human	PMID:25861989
Biological Process	GO:0071347	cellular response to interleukin-1	TANK	IMP		Human	PMID:25861989
Biological Process	GO:0071479	cellular response to ionizing radiation	TANK	IMP		Human	PMID:25861989
Biological Process	GO:0071356	cellular response to tumor necrosis factor	TANK	IMP		Human	PMID:25861989
Biological Process	GO:0006974	DNA damage response	TANK	IMP		Human	PMID:25861989
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Tank	IDA		Mouse	PMID:8710854
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	TANK	IMP		Human	PMID:25861989
Biological Process	GO:1903003	positive regulation of protein deubiquitination	TANK	IMP		Human	PMID:25861989
Biological Process	GO:0032481	positive regulation of type I interferon production	TANK	IDA		Human	PMID:21931631
Biological Process	GO:2000158	positive regulation of ubiquitin-specific protease activity	TANK	IMP		Human	PMID:25861989

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern