Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TAP2
  • Mouse genes Tap2
  • Rat genes Tap2
  • Zfish genes tap2a,tap2c,tap2t
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tap2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015433	ABC-type peptide antigen transporter activity	TAP2	IMP		Human	PMID:1538751
Molecular Function	GO:0015433	ABC-type peptide antigen transporter activity	TAP2	IDA		Human	PMID:25377891
Molecular Function	GO:0015433	ABC-type peptide antigen transporter activity	TAP2	IMP		Human	PMID:25656091
Molecular Function	GO:0043531	ADP binding	Tap2	IDA		Rat	PMID:15611256|RGD:2312376
Molecular Function	GO:0005524	ATP binding	TAP2	IMP		Human	PMID:15793001
Molecular Function	GO:0005524	ATP binding	TAP2	IDA		Human	PMID:7673167
Molecular Function	GO:0005524	ATP binding	Tap2	IDA		Rat	PMID:12047747|RGD:5147838
Molecular Function	GO:0005524	ATP binding	Tap2	IMP		Rat	PMID:14622282|RGD:1300480
Molecular Function	GO:0042802	identical protein binding	Tap2	IPI	RGD:3818	Rat	PMID:16624807|RGD:2312375
Molecular Function	GO:0042288	MHC class I protein binding	Tap2	IDA		Rat	PMID:10508608|RGD:1601415
Molecular Function	GO:0042288	MHC class I protein binding	Tap2	IDA		Rat	PMID:12047747|RGD:5147838
Molecular Function	GO:0023029	MHC class Ib protein binding	TAP2	IPI	UniProtKB:P30511	Human	PMID:10605026
Molecular Function	GO:0000166	nucleotide binding	Tap2	IDA		Rat	PMID:14622282|RGD:1300480
Molecular Function	GO:0042605	peptide antigen binding	TAP2	IDA		Human	PMID:7500034
Molecular Function	GO:0042605	peptide antigen binding	Tap2	IDA		Rat	PMID:10508608|RGD:1601415
Molecular Function	GO:1904680	peptide transmembrane transporter activity	TAP2	IGI	UniProtKB:Q03518	Human	PMID:7673167
Molecular Function	GO:0005515	protein binding	TAP2	IPI	UniProtKB:O15533	Human	PMID:12213826
Molecular Function	GO:0005515	protein binding	TAP2	IPI	UniProtKB:Q03518-2	Human	PMID:12213826
Molecular Function	GO:0005515	protein binding	TAP2	IPI	UniProtKB:Q77CE4	Human	PMID:15793001
Molecular Function	GO:0005515	protein binding	TAP2	IPI	UniProtKB:Q03518	Human	PMID:16828748
Molecular Function	GO:0005515	protein binding	TAP2	IPI	UniProtKB:Q03518	Human	PMID:17055437
Molecular Function	GO:0005515	protein binding	TAP2	IPI	UniProtKB:Q03518	Human	PMID:18802093
Molecular Function	GO:0005515	protein binding	TAP2	IPI	UniProtKB:Q77CE4	Human	PMID:18802093
Molecular Function	GO:0005515	protein binding	TAP2	IPI	UniProtKB:O15533	Human	PMID:19201886
Molecular Function	GO:0005515	protein binding	TAP2	IPI	UniProtKB:P0C739	Human	PMID:19201886
Molecular Function	GO:0005515	protein binding	TAP2	IPI	UniProtKB:Q03518	Human	PMID:19201886
Molecular Function	GO:0005515	protein binding	TAP2	IPI	UniProtKB:Q03518	Human	PMID:19297616
Molecular Function	GO:0005515	protein binding	TAP2	IPI	UniProtKB:Q03518	Human	PMID:26789246
Molecular Function	GO:0005515	protein binding	TAP2	IPI	UniProtKB:Q03518	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	TAP2	IPI	UniProtKB:P13747	Human	PMID:9427624
Molecular Function	GO:0005515	protein binding	Tap2	IPI	PR:P14427	Mouse	PMID:14735325
Molecular Function	GO:0005515	protein binding	Tap2	IPI	UniProtKB:P36370,UniProtKB:Q77CE4	Rat	PMID:18802093|RGD:10448954
Molecular Function	GO:0005515	protein binding	Tap2	IPI	UniProtKB:Q77CE4	Rat	PMID:18802093|RGD:10448954
Molecular Function	GO:0005515	protein binding	Tap2	IPI	UniProtKB:Q99JC6	Rat	PMID:18802093|RGD:10448954
Molecular Function	GO:0042803	protein homodimerization activity	Tap2	IPI	UniProtKB:P36372	Rat	PMID:12047747|RGD:5147838
Molecular Function	GO:0044877	protein-containing complex binding	Tap2	IDA		Rat	PMID:11595746|RGD:2312377
Molecular Function	GO:0044877	protein-containing complex binding	Tap2	IDA		Rat	PMID:12047747|RGD:5147838
Molecular Function	GO:0046978	TAP1 binding	TAP2	IPI	UniProtKB:Q03518	Human	PMID:1538751
Molecular Function	GO:0046978	TAP1 binding	TAP2	IPI	UniProtKB:Q03518	Human	PMID:15518576
Molecular Function	GO:0046978	TAP1 binding	Tap2	IPI	UniProtKB:Q03518	Mouse	MGI:MGI:5009195|PMID:11133832
Molecular Function	GO:0046978	TAP1 binding	Tap2	IPI	RGD:3817	Rat	PMID:12047747|RGD:5147838
Molecular Function	GO:0046978	TAP1 binding	Tap2	IPI	UniProtKB:P36370	Rat	PMID:12047747|RGD:5147838
Molecular Function	GO:0046979	TAP2 binding	Tap2	IPI	UniProtKB:P36372	Rat	PMID:12047747|RGD:5147838
Molecular Function	GO:0046980	tapasin binding	Tap2	IDA		Rat	PMID:12047747|RGD:5147838
Molecular Function	GO:0046980	tapasin binding	Tap2	IPI	UniProtKB:O15533	Rat	PMID:12047747|RGD:5147838
Cellular Component	GO:0005783	endoplasmic reticulum	TAP2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005789	endoplasmic reticulum membrane	TAP2	IDA		Human	PMID:22638925
Cellular Component	GO:0005789	endoplasmic reticulum membrane	TAP2	IDA		Human	PMID:7673167
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Tap2	IDA		Rat	PMID:16624807|RGD:2312375
Cellular Component	GO:0016020	membrane	TAP2	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	TAP2	IDA		Human	PMID:8955196
Cellular Component	GO:0042824	MHC class I peptide loading complex	TAP2	IDA		Human	PMID:17947644
Cellular Component	GO:0042824	MHC class I peptide loading complex	Tap2	IDA		Rat	PMID:10508608|RGD:1601415
Cellular Component	GO:0042824	MHC class I peptide loading complex	Tap2	IDA		Rat	PMID:17947644|RGD:13792542
Cellular Component	GO:0016607	nuclear speck	TAP2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0042825	TAP complex	TAP2	IDA		Human	PMID:15518576
Cellular Component	GO:0042825	TAP complex	TAP2	IDA		Human	PMID:17947644
Cellular Component	GO:0042825	TAP complex	Tap2	IDA		Rat	PMID:11595746|RGD:2312377
Cellular Component	GO:0042825	TAP complex	Tap2	IDA		Rat	PMID:17947644|RGD:13792542
Biological Process	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I	TAP2	IMP		Human	PMID:1538751
Biological Process	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I	TAP2	IDA		Human	PMID:8496691
Biological Process	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I	Tap2	IDA		Rat	PMID:1758495|RGD:1299069
Biological Process	GO:0002485	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent	Tap2	IDA		Mouse	PMID:1538753
Biological Process	GO:0002489	antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent	TAP2	IMP		Human	PMID:1538751
Biological Process	GO:0002489	antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent	Tap2	IDA		Mouse	PMID:1538753
Biological Process	GO:0002481	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent	Tap2	IMP		Mouse	PMID:16299293
Biological Process	GO:0046967	cytosol to endoplasmic reticulum transport	TAP2	IMP		Human	PMID:7538543
Biological Process	GO:0046968	peptide antigen transport	TAP2	IMP		Human	PMID:1538751
Biological Process	GO:0046968	peptide antigen transport	TAP2	IDA		Human	PMID:8496691
Biological Process	GO:0015833	peptide transport	Tap2	IMP		Rat	PMID:15611256|RGD:2312376
Biological Process	GO:0002591	positive regulation of antigen processing and presentation of peptide antigen via MHC class I	Tap2	IMP		Rat	PMID:1758495|RGD:1299069
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	Tap2	IMP		Mouse	PMID:16299293
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	Tap2	IDA		Mouse	PMID:1538753
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	Tap2	IDA		Rat	PMID:1758495|RGD:1299069
Biological Process	GO:0042270	protection from natural killer cell mediated cytotoxicity	Tap2	IMP		Rat	PMID:8120379|RGD:2312378
Biological Process	GO:0065003	protein-containing complex assembly	Tap2	IDA		Rat	PMID:12047747|RGD:5147838
Biological Process	GO:0046686	response to cadmium ion	tap2a	IEP		Zfish	PMID:16799861
Biological Process	GO:0051597	response to methylmercury	tap2c	IDA		Zfish	PMID:15984772
Biological Process	GO:0002237	response to molecule of bacterial origin	Tap2	IMP		Mouse	PMID:16299293
Biological Process	GO:0001913	T cell mediated cytotoxicity	Tap2	IDA		Mouse	PMID:1538753
Biological Process	GO:0001913	T cell mediated cytotoxicity	Tap2	IMP		Mouse	PMID:16299293

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern