Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TBC1D21
  • Mouse genes Tbc1d21
  • Rat genes Tbc1d21
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tbc1d21

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	Tbc1d21	IDA		Mouse	PMID:21128978
Molecular Function	GO:0005096	GTPase activator activity	TBC1D21	IDA		Human	PMID:28067790
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:P61026	Human	PMID:28067790
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:O43903-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:O76014	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:O76015	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:P14136	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:P19012	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:P29083	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:P62072	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:P80188	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:Q04864-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:Q15019-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:Q16342	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:Q6A162	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:Q6NSM0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:Q6P1K2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:Q6P1K2-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:Q8N443	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:Q92764	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:Q96CN4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:Q96M91	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:Q96QF0-7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:Q99081-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:Q9NZ72	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:Q9ULI4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:Q9UNH6-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBC1D21	IPI	UniProtKB:Q9UPU9-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Tbc1d21	IPI	UniProtKB:Q9DCC8	Mouse	MGI:MGI:6490732|PMID:32976492
Molecular Function	GO:0005515	protein binding	Tbc1d21	IPI	UniProtKB:Q80X86	Mouse	MGI:MGI:6507113|PMID:33536340
Molecular Function	GO:0005515	protein binding	Tbc1d21	IPI	UniProtKB:P62835	Mouse	MGI:MGI:6827196|PMID:30360518
Cellular Component	GO:0001669	acrosomal vesicle	Tbc1d21	IDA		Mouse	PMID:21128978
Cellular Component	GO:0070062	extracellular exosome	TBC1D21	HDA		Human	PMID:19056867
Cellular Component	GO:0097225	sperm midpiece	Tbc1d21	IDA		Mouse	MGI:MGI:6827196|PMID:30360518
Cellular Component	GO:0097225	sperm midpiece	Tbc1d21	IDA		Mouse	MGI:MGI:6490732|PMID:32976492
Biological Process	GO:0030317	flagellated sperm motility	Tbc1d21	IMP		Mouse	MGI:MGI:6490732|PMID:32976492
Biological Process	GO:0007288	sperm axoneme assembly	Tbc1d21	IMP		Mouse	MGI:MGI:6490732|PMID:32976492
Biological Process	GO:0120317	sperm mitochondrial sheath assembly	Tbc1d21	IMP		Mouse	MGI:MGI:6507113|PMID:33536340
Biological Process	GO:0007283	spermatogenesis	Tbc1d21	IMP		Mouse	MGI:MGI:6490732|PMID:32976492

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern