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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Tbk1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tbk1
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0042802identical protein bindingTbk1IPIUniProtKB:Q9WUN2MouseMGI:MGI:5919660|PMID:22728658
Molecular FunctionGO:0042802identical protein bindingTbk1IPIUniProtKB:Q9WUN2MouseMGI:MGI:5918457|PMID:23746807
Molecular FunctionGO:0016301kinase activityTBK1IDAHumanPMID:25526307
Molecular FunctionGO:0140677molecular function activator activityTBK1IDAHumanPMID:25636800
Molecular FunctionGO:0140677molecular function activator activityTBK1IDAHumanPMID:31662325
Molecular FunctionGO:0003676nucleic acid bindingTbk1IDAMousePMID:19158679
Molecular FunctionGO:0051219phosphoprotein bindingTBK1IPIUniProtKB:Q8IUC6HumanPMID:14530355
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:A7MCY6HumanPMID:14743216
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:P08238HumanPMID:14743216
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q12933HumanPMID:14743216
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q92844HumanPMID:14743216
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q9H6S1HumanPMID:14743216
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q9Y6K9HumanPMID:14743216
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:P27958:PRO_0000037573HumanPMID:15841462
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q14653HumanPMID:15841462
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q8IUC6HumanPMID:15841462
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:O95786HumanPMID:16281057
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q60803HumanPMID:16306936
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:A7MCY6HumanPMID:17568778
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q92844HumanPMID:17568778
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q14164HumanPMID:17599067
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q14653HumanPMID:17599067
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q92985HumanPMID:17599067
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q92844HumanPMID:18307994
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q96CV9HumanPMID:18307994
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q14653HumanPMID:18583960
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q62167HumanPMID:18583960
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q9NQC7HumanPMID:18636086
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q86WV6HumanPMID:18724357
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q05127HumanPMID:19153231
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q14653HumanPMID:19153231
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:P59596HumanPMID:19380580
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q86WV6HumanPMID:19416887
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q8IUC6HumanPMID:19416887
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:P12931HumanPMID:19419966
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q86WV6HumanPMID:19433799
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q9Y6K9HumanPMID:20098747
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q96CV9HumanPMID:20174559
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q12933HumanPMID:20562859
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:O94826,UniProtKB:P07900,UniProtKB:Q14653HumanPMID:20628368
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:O14879HumanPMID:21813773
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:A7MCY6HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:P40222HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q12933HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q13137HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q14164HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q14653HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q6DT37HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q7Z3C6HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q7Z434HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q86WV6HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q86YT6HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q8BHN1HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q8IUC6HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q92844HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q96AX9HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q96CV9HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q9H6S1HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q9NVV4HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q9UKV8HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:A7MCY6HumanPMID:21931555
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q92844HumanPMID:21931555
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q9H6S1HumanPMID:21931555
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q92844HumanPMID:21988832
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:P42226HumanPMID:22000020
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:P08238HumanPMID:22939624
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:K7Y1A2HumanPMID:23096996
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:P27958:PRO_0000037572HumanPMID:23096996
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q96CV9HumanPMID:23414517
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q86WV6HumanPMID:23542348
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q96KP1HumanPMID:24056301
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:I6W9F2HumanPMID:24335286
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:P59596HumanPMID:24509444
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q7RTR2HumanPMID:24560620
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q86WV6HumanPMID:24622840
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q7Z434HumanPMID:24643253
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:O41932HumanPMID:24696485
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:O14730HumanPMID:24807708
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q14653HumanPMID:24807708
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q8IUC6HumanPMID:25736436
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q14653HumanPMID:25803835
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q96CV9HumanPMID:25803835
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q96CV9HumanPMID:27086836
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q60803HumanPMID:27094905
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q8TEV9HumanPMID:27103069
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q12933HumanPMID:27135603
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q13114HumanPMID:27135603
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q9Y6W8HumanPMID:27135603
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q14166HumanPMID:28011935
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q7Z434HumanPMID:28011935
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:P40222HumanPMID:28514442
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q13137HumanPMID:28514442
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:O95801HumanPMID:29251827
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q14164HumanPMID:29251827
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q92844HumanPMID:29251827
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q9H6S1HumanPMID:29251827
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q5SW79HumanPMID:30354798
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q12933HumanPMID:30561431
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q92844HumanPMID:30561431
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q9Y6K9HumanPMID:30561431
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:P0DTD1:PRO_0000449630HumanPMID:32353859
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:A7MCY6HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:P40222HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q12933HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q13137HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q6DT37HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q92844HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q96CV9HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q9H6S1HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:P0DTD1:PRO_0000449630HumanPMID:32979938
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:P0DTD1:PRO_0000449630HumanPMID:33060197
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:P0DTC5HumanPMID:33372174
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q13114HumanPMID:33372174
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q7Z434HumanPMID:33372174
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:P0DTD1:PRO_0000449630HumanPMID:33707416
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:P0DTC5HumanPMID:34084167
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:P59596HumanPMID:34084167
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:Q13114HumanPMID:34084167
Molecular FunctionGO:0005515protein bindingTBK1IPIUniProtKB:P0DTD1:PRO_0000449630HumanPMID:34166398
Molecular FunctionGO:0005515protein bindingTbk1IPIUniProtKB:P70347MouseMGI:MGI:5918457|PMID:23746807
Molecular FunctionGO:0005515protein bindingTbk1IPIUniProtKB:Q86WV6MouseMGI:MGI:4849871|PMID:21074459
Molecular FunctionGO:0005515protein bindingTbk1IPIUniProtKB:Q3TBT3MouseMGI:MGI:5568884|PMID:24560620
Molecular FunctionGO:0005515protein bindingTbk1IPIUniProtKB:O41932MouseMGI:MGI:5810255|PMID:24696485
Molecular FunctionGO:0005515protein bindingTbk1IPIUniProtKB:P70347MouseMGI:MGI:1928254|PMID:10581243
Molecular FunctionGO:0005515protein bindingTbk1IPIUniProtKB:Q80UF7MouseMGI:MGI:5318897|PMID:22454496
Molecular FunctionGO:0005515protein bindingTbk1IPIUniProtKB:Q3TBT3MouseMGI:MGI:5295319|PMID:22000020
Molecular FunctionGO:0005515protein bindingTbk1IPIUniProtKB:Q80UF7MouseMGI:MGI:5002402|PMID:21441935
Molecular FunctionGO:0005515protein bindingTbk1IPIUniProtKB:Q3TBT3MouseMGI:MGI:5508701|PMID:23142775
Molecular FunctionGO:0005515protein bindingTbk1IPIUniProtKB:A2A9T0|UniProtKB:P70347MouseMGI:MGI:5508590|PMID:18583960
Molecular FunctionGO:0005515protein bindingtbk1IPIUniProtKB:Q1LUQ2ZfishPMID:17372010
Molecular FunctionGO:0019903protein phosphatase bindingTbk1IPIUniProtKB:P35235MouseMGI:MGI:3760575|PMID:17954568
Molecular FunctionGO:0004674protein serine/threonine kinase activityTBK1IDAHumanPMID:14703513
Molecular FunctionGO:0004674protein serine/threonine kinase activityTBK1IDAHumanPMID:22394562
Molecular FunctionGO:0004674protein serine/threonine kinase activityTBK1IDAHumanPMID:22921120
Molecular FunctionGO:0004674protein serine/threonine kinase activityTBK1IDAHumanPMID:25636800
Molecular FunctionGO:0004674protein serine/threonine kinase activityTBK1IDAHumanPMID:25803835
Molecular FunctionGO:0004674protein serine/threonine kinase activityTBK1IDAHumanPMID:27103069
Molecular FunctionGO:0004674protein serine/threonine kinase activityTBK1IDAHumanPMID:29441066
Molecular FunctionGO:0004674protein serine/threonine kinase activityTBK1EXPHumanPMID:30420664
Molecular FunctionGO:0004674protein serine/threonine kinase activityTBK1IDAHumanPMID:31662325
Molecular FunctionGO:0004674protein serine/threonine kinase activityTBK1IDAHumanPMID:31709703
Molecular FunctionGO:0004674protein serine/threonine kinase activityTbk1IDAMouseMGI:MGI:5645201|PMID:21617041
Cellular ComponentGO:0005737cytoplasmTBK1IDAHumanPMID:14703513
Cellular ComponentGO:0005737cytoplasmTBK1IDAHumanPMID:21813773
Cellular ComponentGO:0005737cytoplasmTBK1IDAHumanPMID:29251827
Cellular ComponentGO:0005829cytosolTBK1IDAHumanPMID:21813773
Cellular ComponentGO:0043231intracellular membrane-bounded organelleTBK1IDAHumanGO_REF:0000052
Cellular ComponentGO:0005654nucleoplasmTBK1IDAHumanGO_REF:0000052
Biological ProcessGO:0002218activation of innate immune responseTBK1IDAHumanPMID:25636800
Biological ProcessGO:0002218activation of innate immune responseTbk1IMPMGI:MGI:3046789MousePMID:15661922
Biological ProcessGO:0140374antiviral innate immune responseTBK1IDAHumanPMID:22394562
Biological ProcessGO:0002753cytosolic pattern recognition receptor signaling pathwayTBK1IDAHumanPMID:29441066
Biological ProcessGO:0050830defense response to Gram-positive bacteriumTbk1IMPMGI:MGI:3046789MousePMID:15661922
Biological ProcessGO:0044565dendritic cell proliferationTbk1IGIMGI:MGI:1351332MousePMID:23610142
Biological ProcessGO:0045087innate immune responseTBK1IDAHumanPMID:25636800
Biological ProcessGO:0032608interferon-beta productionTbk1IMPMGI:MGI:3046789MousePMID:15661922
Biological ProcessGO:0010629negative regulation of gene expressionTbk1IMPMouseMGI:MGI:4457239|PMID:18665841
Biological ProcessGO:0032480negative regulation of type I interferon productiontbk1IDAZfishPMID:33101307
Biological ProcessGO:0018105peptidyl-serine phosphorylationTBK1IDAHumanPMID:25636800
Biological ProcessGO:0018105peptidyl-serine phosphorylationTBK1IDAHumanPMID:25803835
Biological ProcessGO:0018105peptidyl-serine phosphorylationTBK1IDAHumanPMID:27103069
Biological ProcessGO:0018105peptidyl-serine phosphorylationTbk1IDAMouseMGI:MGI:5645201|PMID:21617041
Biological ProcessGO:0018107peptidyl-threonine phosphorylationTBK1IDAHumanPMID:25636800
Biological ProcessGO:0018107peptidyl-threonine phosphorylationTBK1IDAHumanPMID:27103069
Biological ProcessGO:0010508positive regulation of autophagyTBK1IDAHumanPMID:28871090
Biological ProcessGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingTBK1IEPHumanPMID:12761501
Biological ProcessGO:0032727positive regulation of interferon-alpha productionTBK1IDAHumanPMID:16127453
Biological ProcessGO:0032728positive regulation of interferon-beta productionTBK1IDAHumanPMID:16127453
Biological ProcessGO:0032728positive regulation of interferon-beta productionTbk1IMPMGI:MGI:3046789MousePMID:15661922
Biological ProcessGO:0016239positive regulation of macroautophagyTBK1IDAHumanPMID:27103069
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IITBK1IDAHumanPMID:16127453
Biological ProcessGO:0032481positive regulation of type I interferon productionTBK1IDAHumanPMID:14703513
Biological ProcessGO:0032481positive regulation of type I interferon productionTBK1IDAHumanPMID:25636800
Biological ProcessGO:0032481positive regulation of type I interferon productionTBK1IDAHumanPMID:29441066
Biological ProcessGO:0060340positive regulation of type I interferon-mediated signaling pathwayTbk1IMPMouseMGI:MGI:5792628|PMID:27129230
Biological ProcessGO:1904417positive regulation of xenophagyTbk1IMPMouseMGI:MGI:5645201|PMID:21617041
Biological ProcessGO:0006468protein phosphorylationTBK1IDAHumanPMID:27103069
Biological ProcessGO:0031323regulation of cellular metabolic processTbk1IGIMGI:MGI:1328317MousePMID:28069950
Biological ProcessGO:0010468regulation of gene expressionTbk1IGIMGI:MGI:1919762MousePMID:23160154
Biological ProcessGO:0010468regulation of gene expressionTbk1IGIMGI:MGI:1859212MousePMID:23160154
Biological ProcessGO:0010468regulation of gene expressionTbk1IGIMGI:MGI:1328317MousePMID:23160154
Biological ProcessGO:0010468regulation of gene expressionTbk1IGIMGI:MGI:1859179MousePMID:23160154
Biological ProcessGO:0032479regulation of type I interferon productionTBK1IDAHumanPMID:25636800

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory