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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Tbx1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tbx1
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0001228DNA-binding transcription activator activity, RNA polymerase II-specificTbx1IDAMouseMGI:MGI:3621085|PMID:16556915
Molecular FunctionGO:0005515protein bindingTBX1IPIUniProtKB:P57055HumanPMID:30241482
Molecular FunctionGO:0005515protein bindingTbx1IPIUniProtKB:P28359MouseMGI:MGI:5559282|PMID:22842189
Molecular FunctionGO:0005515protein bindingTbx1IPIUniProtKB:Q924S9MouseMGI:MGI:4879036|PMID:21177346
Molecular FunctionGO:0005515protein bindingTbx1IPIUniProtKB:Q61466MouseMGI:MGI:5318804|PMID:22438823
Molecular FunctionGO:0005515protein bindingTbx1IPIPR:Q91X20MousePMID:20463296
Molecular FunctionGO:0005515protein bindingTbx1IPIPR:P97474MousePMID:20816801
Molecular FunctionGO:0005515protein bindingtbx1IPIZFIN:ZDB-GENE-990917-4ZfishPMID:24130849
Molecular FunctionGO:0042803protein homodimerization activityTBX1IDAHumanPMID:11111039
Molecular FunctionGO:0001162RNA polymerase II intronic transcription regulatory region sequence-specific DNA bindingTbx1IDAMouseMGI:MGI:3621085|PMID:16556915
Molecular FunctionGO:0043565sequence-specific DNA bindingTBX1IDAHumanPMID:11111039
Molecular FunctionGO:1990837sequence-specific double-stranded DNA bindingTBX1IDAHumanPMID:28473536
Cellular ComponentGO:0005737cytoplasmTbx1IDARatRGD:1598407
Cellular ComponentGO:0005634nucleusTBX1IDAHumanPMID:15703190
Cellular ComponentGO:0005634nucleusTbx1IDAMousePMID:17164259
Cellular ComponentGO:0005634nucleusTbx1IDAMousePMID:18816853
Biological ProcessGO:0036305ameloblast differentiationTbx1IMPMGI:MGI:2179136MousePMID:20816801
Biological ProcessGO:0036305ameloblast differentiationTbx1IMPMGI:MGI:2179136MousePMID:19233155
Biological ProcessGO:0001525angiogenesisTbx1IMPMGI:MGI:2179136MousePMID:11971873
Biological ProcessGO:0009952anterior/posterior pattern specificationTbx1IGIMGI:MGI:104686MousePMID:16399080
Biological ProcessGO:0009952anterior/posterior pattern specificationTbx1IMPMGI:MGI:2179191MousePMID:15084464
Biological ProcessGO:0035909aorta morphogenesisTbx1IGIMGI:MGI:109344MousePMID:21364285
Biological ProcessGO:0035909aorta morphogenesisTbx1IGIMGI:MGI:102780MousePMID:21364285
Biological ProcessGO:0035909aorta morphogenesisTbx1IMPMGI:MGI:3664784MousePMID:17916582
Biological ProcessGO:0035909aorta morphogenesisTbx1IGIMGI:MGI:99604MousePMID:21364285
Biological ProcessGO:0048844artery morphogenesisTbx1IGIMGI:MGI:99655MousePMID:24821700
Biological ProcessGO:0048844artery morphogenesisTbx1IGIMGI:MGI:2444748MousePMID:19855134
Biological ProcessGO:0048844artery morphogenesisTbx1IGIMGI:MGI:95668MousePMID:19700621
Biological ProcessGO:0048844artery morphogenesisTbx1IMPMGI:MGI:2179190MousePMID:11242110
Biological ProcessGO:0001568blood vessel developmentTbx1IGIMGI:MGI:104686MousePMID:16399080
Biological ProcessGO:0001568blood vessel developmentTbx1IMPMousePMID:16284121
Biological ProcessGO:0001568blood vessel developmentTbx1IMPMGI:MGI:2179136MousePMID:11242049
Biological ProcessGO:0048514blood vessel morphogenesisTbx1IMPMGI:MGI:2179191MousePMID:11239417
Biological ProcessGO:0001974blood vessel remodelingTbx1IGIMGI:MGI:99604MousePMID:17000704
Biological ProcessGO:0001974blood vessel remodelingTbx1IGIMGI:MGI:1099809MousePMID:17000704
Biological ProcessGO:0055007cardiac muscle cell differentiationtbx1IMPZFIN:ZDB-GENO-980202-1096ZfishPMID:23533583
Biological ProcessGO:0060536cartilage morphogenesistbx1IMPZFIN:ZDB-GENO-980202-1518ZfishPMID:9007254
Biological ProcessGO:0060536cartilage morphogenesistbx1IMPZFIN:ZDB-GENO-980202-1096ZfishPMID:9007254
Biological ProcessGO:0008283cell population proliferationTbx1IMPMGI:MGI:3046793MousePMID:16141220
Biological ProcessGO:0044344cellular response to fibroblast growth factor stimulusTbx1IMPMouseMGI:MGI:5285152|PMID:20807544
Biological ProcessGO:0071300cellular response to retinoic acidTbx1IEPMouseMGI:MGI:3809313|PMID:18816858
Biological ProcessGO:0090103cochlea morphogenesisTbx1IGIUniProtKB:P62515MouseMGI:MGI:5284768|PMID:18231833
Biological ProcessGO:0090103cochlea morphogenesisTbx1IMPMGI:MGI:2179136MousePMID:17825816
Biological ProcessGO:0060982coronary artery morphogenesisTbx1IMPMGI:MGI:2179190MousePMID:18583714
Biological ProcessGO:1904888cranial skeletal system developmentTbx1IGIMGI:MGI:1313268MousePMID:19247433
Biological ProcessGO:0007368determination of left/right symmetryTbx1IMPMGI:MGI:2179191MousePMID:16556915
Biological ProcessGO:0043583ear developmenttbx1IMPZfishPMID:10985854
Biological ProcessGO:0042471ear morphogenesisTbx1IMPMGI:MGI:2179191MousePMID:15190012
Biological ProcessGO:0042471ear morphogenesistbx1IMPZFIN:ZDB-GENO-980202-1518ZfishPMID:9007244
Biological ProcessGO:0042471ear morphogenesistbx1IMPZFIN:ZDB-GENO-980202-1096ZfishPMID:9007244
Biological ProcessGO:0048701embryonic cranial skeleton morphogenesisTbx1IMPMGI:MGI:2179191MousePMID:15190012
Biological ProcessGO:0003143embryonic heart tube morphogenesistbx1IMPZFIN:ZDB-MRPHLNO-100715-1ZfishPMID:20529560
Biological ProcessGO:0048703embryonic viscerocranium morphogenesisTBX1IMPHumanPMID:14585638
Biological ProcessGO:0070166enamel mineralizationTbx1IMPMGI:MGI:2179136MousePMID:19233155
Biological ProcessGO:0050673epithelial cell proliferationTbx1IMPMGI:MGI:2179136MousePMID:19233155
Biological ProcessGO:0050673epithelial cell proliferationTbx1IMPMGI:MGI:3046793MousePMID:17074316
Biological ProcessGO:0050673epithelial cell proliferationTbx1IMPMGI:MGI:2179136MousePMID:20816801
Biological ProcessGO:0060325face morphogenesisTbx1IMPMGI:MGI:2179191MousePMID:20501333
Biological ProcessGO:0060022hard palate developmentTbx1IMPMousePMID:30121012
Biological ProcessGO:0007507heart developmentTBX1IMPHumanPMID:14585638
Biological ProcessGO:0007507heart developmentTbx1IMPMouseMGI:MGI:4879036|PMID:21177346
Biological ProcessGO:0007507heart developmentTbx1IMPMGI:MGI:2179136MousePMID:11971873
Biological ProcessGO:0007507heart developmentTbx1IMPMGI:MGI:2179190MousePMID:11242110
Biological ProcessGO:0007507heart developmentTbx1IMPMGI:MGI:2179191MousePMID:16556915
Biological ProcessGO:0007507heart developmentTbx1IMPMGI:MGI:2179191MousePMID:11239417
Biological ProcessGO:0007507heart developmentTbx1IGIMGI:MGI:109340MousePMID:16556915
Biological ProcessGO:0007507heart developmentTbx1IGIMGI:MGI:104686MousePMID:16399080
Biological ProcessGO:0001947heart loopingtbx1IMPZFIN:ZDB-GENO-980202-1096ZfishPMID:23533583
Biological ProcessGO:0001947heart loopingtbx1IGIZFIN:ZDB-GENO-130508-3ZfishPMID:23533583
Biological ProcessGO:0001947heart loopingtbx1IGIZFIN:ZDB-GENE-980526-249,ZFIN:ZDB-GENO-980202-1096ZfishPMID:23533583
Biological ProcessGO:0003007heart morphogenesisTbx1IMPMGI:MGI:3046792MousePMID:15175244
Biological ProcessGO:0003007heart morphogenesisTbx1IMPMGI:MGI:3046795MousePMID:16696966
Biological ProcessGO:0003007heart morphogenesisTbx1IMPMGI:MGI:2179191MousePMID:15190012
Biological ProcessGO:0003007heart morphogenesisTbx1IMPMGI:MGI:2179136MousePMID:16914493
Biological ProcessGO:0042472inner ear morphogenesisTbx1IMPMGI:MGI:3046196,MGI:MGI:3619149MousePMID:16600992
Biological ProcessGO:0042472inner ear morphogenesisTbx1IMPMGI:MGI:2179136MousePMID:12913075
Biological ProcessGO:0042472inner ear morphogenesisTbx1IMPMGI:MGI:2179190MousePMID:15652707
Biological ProcessGO:0042472inner ear morphogenesisTbx1IMPMGI:MGI:2179191MousePMID:15084464
Biological ProcessGO:0001945lymph vessel developmentTbx1IMPMGI:MGI:2450311,MGI:MGI:3046793MousePMID:20439995
Biological ProcessGO:0097152mesenchymal cell apoptotic processTbx1IMPMouseMGI:MGI:5284768|PMID:18231833
Biological ProcessGO:0010463mesenchymal cell proliferationTbx1IDAMousePMID:16914493
Biological ProcessGO:0007498mesoderm developmentTbx1IMPMGI:MGI:2179190MousePMID:11242110
Biological ProcessGO:0042474middle ear morphogenesisTbx1IMPMGI:MGI:2179191MousePMID:20501333
Biological ProcessGO:0042474middle ear morphogenesisTbx1IMPMGI:MGI:2179190MousePMID:15652707
Biological ProcessGO:0042474middle ear morphogenesisTbx1IMPMGI:MGI:1932522,MGI:MGI:3619149MousePMID:16600992
Biological ProcessGO:0042693muscle cell fate commitmentTbx1IMPMGI:MGI:2179190MousePMID:18816853
Biological ProcessGO:0007517muscle organ developmentTbx1IMPMGI:MGI:2179190MousePMID:15385444
Biological ProcessGO:0048644muscle organ morphogenesisTbx1IGIMGI:MGI:97252MousePMID:19531352
Biological ProcessGO:0060415muscle tissue morphogenesisTbx1IMPMGI:MGI:2179190MousePMID:19531352
Biological ProcessGO:0045596negative regulation of cell differentiationTbx1IMPMGI:MGI:2179136MousePMID:19745164
Biological ProcessGO:2001054negative regulation of mesenchymal cell apoptotic processTbx1IGIUniProtKB:P62515MouseMGI:MGI:5284768|PMID:18231833
Biological ProcessGO:0010656negative regulation of muscle cell apoptotic processTbx1IMPRatPMID:31982878|RGD:155882591
Biological ProcessGO:0046426negative regulation of receptor signaling pathway via JAK-STATTbx1IMPRatPMID:31982878|RGD:155882591
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IITbx1IMPMouseMGI:MGI:4453944|PMID:20122914
Biological ProcessGO:0014032neural crest cell developmenttbx1IMPZFIN:ZDB-MRPHLNO-100715-2ZfishPMID:24286429
Biological ProcessGO:0001755neural crest cell migrationTbx1IMPMGI:MGI:2179190MousePMID:15652707
Biological ProcessGO:0001755neural crest cell migrationTbx1IMPMGI:MGI:2179191MousePMID:20501333
Biological ProcessGO:0001755neural crest cell migrationtbx1IMPZfishPMID:10985854
Biological ProcessGO:0048665neuron fate specificationTbx1IGIMGI:MGI:1351209MousePMID:15064766
Biological ProcessGO:0048665neuron fate specificationTbx1IMPMGI:MGI:2179191MousePMID:15084464
Biological ProcessGO:0042475odontogenesis of dentin-containing toothTbx1IMPMGI:MGI:2179136MousePMID:19233155
Biological ProcessGO:0042475odontogenesis of dentin-containing toothTbx1IMPMGI:MGI:2179136MousePMID:20816801
Biological ProcessGO:0071600otic vesicle morphogenesisTbx1IMPMGI:MGI:3046793MousePMID:17074316
Biological ProcessGO:0042473outer ear morphogenesisTbx1IMPMGI:MGI:1932522,MGI:MGI:3619149MousePMID:16600992
Biological ProcessGO:0003151outflow tract morphogenesisTbx1IGIMGI:MGI:109344MousePMID:21364285
Biological ProcessGO:0003151outflow tract morphogenesisTbx1IMPMGI:MGI:2179190MousePMID:18583714
Biological ProcessGO:0003151outflow tract morphogenesisTbx1IMPMGI:MGI:3664784MousePMID:17916582
Biological ProcessGO:0003151outflow tract morphogenesisTbx1IGIMGI:MGI:99604MousePMID:21364285
Biological ProcessGO:0003151outflow tract morphogenesisTbx1IGIMGI:MGI:102780MousePMID:21364285
Biological ProcessGO:0003148outflow tract septum morphogenesisTbx1IMPMouseMGI:MGI:5285152|PMID:20807544
Biological ProcessGO:0060017parathyroid gland developmentTBX1IMPHumanPMID:14585638
Biological ProcessGO:0007389pattern specification processTbx1IGIMGI:MGI:104686MousePMID:16399080
Biological ProcessGO:0007389pattern specification processTbx1IMPMGI:MGI:2179190MousePMID:15385444
Biological ProcessGO:0007389pattern specification processTbx1IMPMGI:MGI:2179190MousePMID:15652707
Biological ProcessGO:0043282pharyngeal muscle developmenttbx1IMPZFIN:ZDB-MRPHLNO-100510-2ZfishPMID:19409884
Biological ProcessGO:0060037pharyngeal system developmentTBX1IMPHumanPMID:14585638
Biological ProcessGO:0060037pharyngeal system developmentTbx1IMPMouseMGI:MGI:4879036|PMID:21177346
Biological ProcessGO:0060037pharyngeal system developmentTbx1IMPMGI:MGI:3046793MousePMID:16141220
Biological ProcessGO:0060037pharyngeal system developmentTbx1IGIMGI:MGI:99604MousePMID:21364285
Biological ProcessGO:0060037pharyngeal system developmentTbx1IGIMGI:MGI:109344MousePMID:21364285
Biological ProcessGO:0060037pharyngeal system developmentTbx1IGIMGI:MGI:102780MousePMID:21364285
Biological ProcessGO:0060037pharyngeal system developmenttbx1IMPZFIN:ZDB-GENO-980202-1518ZfishPMID:30067987
Biological ProcessGO:0060037pharyngeal system developmenttbx1IGIZFIN:ZDB-GENE-990415-72ZfishPMID:25142463
Biological ProcessGO:0060037pharyngeal system developmenttbx1IMPZFIN:ZDB-GENO-980202-1518ZfishPMID:25142463
Biological ProcessGO:0060037pharyngeal system developmenttbx1IMPZfishPMID:10985854
Biological ProcessGO:0060037pharyngeal system developmenttbx1IMPZFIN:ZDB-MRPHLNO-100715-1ZfishPMID:20529560
Biological ProcessGO:0060037pharyngeal system developmenttbx1IMPZFIN:ZDB-GENO-980202-1518ZfishPMID:12952905
Biological ProcessGO:0060037pharyngeal system developmenttbx1IGIZFIN:ZDB-GENE-980526-249ZfishPMID:25142463
Biological ProcessGO:0060045positive regulation of cardiac muscle cell proliferationTbx1IMPRatPMID:31982878|RGD:155882591
Biological ProcessGO:1902808positive regulation of cell cycle G1/S phase transitionTbx1IMPRatPMID:31982878|RGD:155882591
Biological ProcessGO:0008284positive regulation of cell population proliferationTbx1IMPMGI:MGI:3046793MousePMID:16141220
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionTbx1IDAMousePMID:15175244
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionTbx1IDAMousePMID:16684884
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionTbx1IDAMousePMID:15843409
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionTbx1IDAMousePMID:15703190
Biological ProcessGO:0050679positive regulation of epithelial cell proliferationTbx1IMPMouseMGI:MGI:5284768|PMID:18231833
Biological ProcessGO:0050679positive regulation of epithelial cell proliferationTbx1IMPMGI:MGI:2179136MousePMID:19233155
Biological ProcessGO:0050679positive regulation of epithelial cell proliferationTbx1IMPMGI:MGI:2179136MousePMID:20816801
Biological ProcessGO:0050679positive regulation of epithelial cell proliferationTbx1IMPMGI:MGI:3046793MousePMID:17074316
Biological ProcessGO:0050679positive regulation of epithelial cell proliferationTbx1IMPMGI:MGI:2179136MousePMID:17825816
Biological ProcessGO:0010628positive regulation of gene expressionTbx1IMPRatPMID:31982878|RGD:155882591
Biological ProcessGO:0043410positive regulation of MAPK cascadeTbx1IMPMouseMGI:MGI:5285152|PMID:20807544
Biological ProcessGO:0002053positive regulation of mesenchymal cell proliferationTbx1IMPMouseMGI:MGI:5284768|PMID:18231833
Biological ProcessGO:0001934positive regulation of protein phosphorylationTbx1IMPMouseMGI:MGI:5285152|PMID:20807544
Biological ProcessGO:0072513positive regulation of secondary heart field cardioblast proliferationTbx1IDAMousePMID:19745164
Biological ProcessGO:0072513positive regulation of secondary heart field cardioblast proliferationtbx1IMPZFIN:ZDB-GENO-980202-1518ZfishPMID:23335360
Biological ProcessGO:2001037positive regulation of tongue muscle cell differentiationTbx1IMPMouseMGI:MGI:3809313|PMID:18816858
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IITbx1IDAMouseMGI:MGI:3621085|PMID:16556915
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IITbx1IDAMouseMGI:MGI:4879036|PMID:21177346
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IITbx1IMPMouseMGI:MGI:4453944|PMID:20122914
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IITbx1IGIMGI:MGI:1344416MousePMID:20463296
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IITbx1IGIMGI:MGI:97350MousePMID:16556915
Biological ProcessGO:2000027regulation of animal organ morphogenesisTbx1IMPMGI:MGI:2179191MousePMID:17164259
Biological ProcessGO:2000027regulation of animal organ morphogenesisTbx1IMPMGI:MGI:2179136MousePMID:19389367
Biological ProcessGO:2000027regulation of animal organ morphogenesisTbx1IGIMGI:MGI:99604MousePMID:19389367
Biological ProcessGO:0010468regulation of gene expressionTbx1IMPRatRGD:1598407
Biological ProcessGO:0006357regulation of transcription by RNA polymerase IITbx1IGIMGI:MGI:109340MousePMID:20816801
Biological ProcessGO:0048384retinoic acid receptor signaling pathwayTbx1IMPMouseMGI:MGI:3809313|PMID:18816858
Biological ProcessGO:0048752semicircular canal morphogenesisTbx1IGIMGI:MGI:2444748MousePMID:19855134
Biological ProcessGO:0048752semicircular canal morphogenesistbx1IMPZFIN:ZDB-GENO-980202-1096ZfishPMID:12952905
Biological ProcessGO:0007605sensory perception of soundTbx1IMPMGI:MGI:2179191MousePMID:15190012
Biological ProcessGO:0007605sensory perception of soundTbx1IMPMGI:MGI:1932522,MGI:MGI:3619149MousePMID:16600992
Biological ProcessGO:0035176social behaviorTbx1IMPMGI:MGI:2179136MousePMID:16684884
Biological ProcessGO:0060023soft palate developmentTBX1IMPHumanPMID:14585638
Biological ProcessGO:0048538thymus developmentTBX1IMPHumanPMID:14585638
Biological ProcessGO:0048538thymus developmentTbx1IMPMGI:MGI:3664784MousePMID:17916582
Biological ProcessGO:0030878thyroid gland developmentTbx1IMPMGI:MGI:2179191MousePMID:17164259
Biological ProcessGO:0030878thyroid gland developmentTbx1IGIMGI:MGI:99604MousePMID:19389367
Biological ProcessGO:0030878thyroid gland developmentTbx1IMPMGI:MGI:2179136MousePMID:19389367
Biological ProcessGO:0030878thyroid gland developmentTbx1IMPMGI:MGI:2179191MousePMID:15190012
Biological ProcessGO:0043587tongue morphogenesisTbx1IMPMouseMGI:MGI:3809313|PMID:18816858
Biological ProcessGO:0021644vagus nerve morphogenesisTbx1IMPMGI:MGI:2179136MousePMID:20939858

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory