Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TBX18
  • Mouse genes Tbx18
  • Rat genes Tbx18
  • Zfish genes tbx18
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tbx18

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Tbx18	IDA		Mouse	MGI:MGI:3722519|PMID:17584735
Molecular Function	GO:0005515	protein binding	TBX18	IPI	UniProtKB:Q04726	Human	PMID:26235987
Molecular Function	GO:0005515	protein binding	TBX18	IPI	UniProtKB:Q15475	Human	PMID:26235987
Molecular Function	GO:0005515	protein binding	TBX18	IPI	UniProtKB:Q13077	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX18	IPI	UniProtKB:Q58EX7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX18	IPI	UniProtKB:Q7LC44	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX18	IPI	UniProtKB:Q8IUC2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Tbx18	IPI	PR:Q62231	Mouse	PMID:20110314
Molecular Function	GO:0005515	protein binding	Tbx18	IPI	PR:O70306	Mouse	PMID:17584735
Molecular Function	GO:0042803	protein homodimerization activity	Tbx18	IPI	UniProtKB:Q9EPZ6	Mouse	MGI:MGI:3722519|PMID:17584735
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Tbx18	IDA		Mouse	MGI:MGI:3722519|PMID:17584735
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Tbx18	IPI	UniProtKB:P42582|UniProtKB:Q08369	Mouse	MGI:MGI:3722519|PMID:17584735
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	TBX18	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Tbx18	IDA		Mouse	MGI:MGI:3722519|PMID:17584735
Cellular Component	GO:0005654	nucleoplasm	TBX18	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	TBX18	IDA		Human	PMID:26235987
Cellular Component	GO:0005634	nucleus	Tbx18	IDA		Mouse	MGI:MGI:3722519|PMID:17584735
Cellular Component	GO:0090571	RNA polymerase II transcription repressor complex	Tbx18	IDA		Mouse	MGI:MGI:3722519|PMID:17584735
Biological Process	GO:0048646	anatomical structure formation involved in morphogenesis	Tbx18	IMP	MGI:MGI:3714982	Mouse	PMID:19096026
Biological Process	GO:0009948	anterior/posterior axis specification	Tbx18	IMP	MGI:MGI:3044914	Mouse	PMID:15155583
Biological Process	GO:0030154	cell differentiation	Tbx18	IMP	MGI:MGI:3044915	Mouse	PMID:18353863
Biological Process	GO:0090103	cochlea morphogenesis	Tbx18	IMP	MGI:MGI:3044915	Mouse	PMID:18353863
Biological Process	GO:0050673	epithelial cell proliferation	Tbx18	IMP	MGI:MGI:3044914	Mouse	PMID:16511601
Biological Process	GO:0010463	mesenchymal cell proliferation	Tbx18	IMP	MGI:MGI:3044914	Mouse	PMID:16511601
Biological Process	GO:0072198	mesenchymal cell proliferation involved in ureter development	Tbx18	IGI	MGI:MGI:102780	Mouse	PMID:20110314
Biological Process	GO:0016331	morphogenesis of embryonic epithelium	Tbx18	IMP	MGI:MGI:3044914	Mouse	PMID:16511601
Biological Process	GO:0051450	myoblast proliferation	Tbx18	IGI	MGI:MGI:102780	Mouse	PMID:20110314
Biological Process	GO:0060829	negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation	Tbx18	IDA		Mouse	MGI:MGI:3722519|PMID:17584735
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Tbx18	IDA		Mouse	MGI:MGI:3722519|PMID:17584735
Biological Process	GO:0022409	positive regulation of cell-cell adhesion	Tbx18	IMP	MGI:MGI:3044915	Mouse	PMID:18353863
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Tbx18	IMP	MGI:MGI:3044914	Mouse	PMID:16511601
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	Tbx18	IMP	MGI:MGI:3044914	Mouse	PMID:16511601
Biological Process	GO:2000729	positive regulation of mesenchymal cell proliferation involved in ureter development	Tbx18	IGI	MGI:MGI:102780	Mouse	PMID:20110314
Biological Process	GO:2000288	positive regulation of myoblast proliferation	Tbx18	IGI	MGI:MGI:102780	Mouse	PMID:20110314
Biological Process	GO:2000648	positive regulation of stem cell proliferation	Tbx18	IMP	MGI:MGI:3044914	Mouse	PMID:16511601
Biological Process	GO:0098907	regulation of SA node cell action potential	TBX18	IMP		Human	PMID:23242162
Biological Process	GO:0007605	sensory perception of sound	Tbx18	IMP	MGI:MGI:3044915	Mouse	PMID:18353863
Biological Process	GO:0060931	sinoatrial node cell development	TBX18	IMP		Human	PMID:23242162
Biological Process	GO:0060930	sinoatrial node cell fate commitment	TBX18	IMP		Human	PMID:23242162
Biological Process	GO:0003163	sinoatrial node development	Tbx18	IMP	MGI:MGI:3714982	Mouse	PMID:19096026
Biological Process	GO:0051145	smooth muscle cell differentiation	Tbx18	IMP	MGI:MGI:3044914	Mouse	PMID:16511601
Biological Process	GO:0001756	somitogenesis	Tbx18	IMP	MGI:MGI:3044914	Mouse	PMID:15155583
Biological Process	GO:0048863	stem cell differentiation	Tbx18	IMP	MGI:MGI:3044915	Mouse	PMID:18353863
Biological Process	GO:0072089	stem cell proliferation	Tbx18	IMP	MGI:MGI:3044914	Mouse	PMID:16511601
Biological Process	GO:0072189	ureter development	TBX18	IMP		Human	PMID:26235987
Biological Process	GO:0072189	ureter development	Tbx18	IGI	MGI:MGI:98371	Mouse	PMID:20881014

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern