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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Tbx2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tbx2
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0003677DNA bindingTbx2IDAMousePMID:15843407
Molecular FunctionGO:0003700DNA-binding transcription factor activityTbx2IDAMousePMID:15843407
Molecular FunctionGO:0140297DNA-binding transcription factor bindingTbx2IPIUniProtKB:P41778MouseMGI:MGI:6710296|PMID:33795231
Molecular FunctionGO:0001227DNA-binding transcription repressor activity, RNA polymerase II-specificTBX2IDAHumanPMID:11111039
Molecular FunctionGO:0042826histone deacetylase bindingTbx2IPIUniProtKB:O09106|UniProtKB:P70288MouseMGI:MGI:6710296|PMID:33795231
Molecular FunctionGO:0005515protein bindingTBX2IPIUniProtKB:P29590HumanPMID:22002537
Molecular FunctionGO:0005515protein bindingTBX2IPIUniProtKB:A8MQ03HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingTBX2IPIUniProtKB:O14770-4HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingTBX2IPIUniProtKB:O14787-2HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingTBX2IPIUniProtKB:P0C7T5HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingTBX2IPIUniProtKB:P25791-3HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingTBX2IPIUniProtKB:Q6DKK2HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingTBX2IPIUniProtKB:Q9NZN8HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingTBX2IPIUniProtKB:Q9UHD4HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingTbx2IPIUniProtKB:P23198|UniProtKB:P30681|UniProtKB:Q6PDQ2MouseMGI:MGI:6710296|PMID:33795231
Molecular FunctionGO:0005515protein bindingTbx2IPIPR:P42582MousePMID:12023302
Molecular FunctionGO:0005515protein bindingtbx2aIPIZFIN:ZDB-GENE-030805-5ZfishPMID:24130849
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingTBX2IDAHumanPMID:11111039
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingTBX2IDAHumanPMID:12000749
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingTBX2IDAHumanPMID:30599067
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingTbx2IMPMouseMGI:MGI:6814712|PMID:26971330
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingTbx2IMPMouseMGI:MGI:6814711|PMID:28910203
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingTbx2IMPMouseMGI:MGI:6810282|PMID:26486273
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingTbx2IDAMouseMGI:MGI:6828672|PMID:9710594
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingTbx2IDAMouseMGI:MGI:5300829|PMID:22186728
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingTbx2IDAMouseMGI:MGI:6710296|PMID:33795231
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingTbx2IDAMouseMGI:MGI:6810280|PMID:18025091
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingTbx2IDAMouseMGI:MGI:2176288|PMID:11867218
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingTbx2IDAMouseMGI:MGI:5805984|PMID:27720610
Molecular FunctionGO:0043565sequence-specific DNA bindingTBX2IDAHumanPMID:11111039
Molecular FunctionGO:1990837sequence-specific double-stranded DNA bindingTBX2IDAHumanPMID:28473536
Cellular ComponentGO:0005737cytoplasmTbx2IDAMouseMGI:MGI:6810280|PMID:18025091
Cellular ComponentGO:0005634nucleusTBX2IDAHumanPMID:15042700
Cellular ComponentGO:0005634nucleusTBX2IDAHumanPMID:22844464
Cellular ComponentGO:0005634nucleusTBX2IDAHumanPMID:29726930
Cellular ComponentGO:0005634nucleusTbx2IDAMouseMGI:MGI:6814712|PMID:26971330
Cellular ComponentGO:0005634nucleusTbx2IDAMouseMGI:MGI:6810280|PMID:18025091
Cellular ComponentGO:0005634nucleusTbx2IDAMouseMGI:MGI:6810282|PMID:26486273
Cellular ComponentGO:0005634nucleusTbx2IDAMouseMGI:MGI:6814711|PMID:28910203
Cellular ComponentGO:0005634nucleusTbx2IDAMousePMID:15042700
Cellular ComponentGO:0005667transcription regulator complexTbx2IPIPR:P42582MousePMID:18285513
Cellular ComponentGO:0005667transcription regulator complexTbx2IPIPR:Q03358MousePMID:18285513
Cellular ComponentGO:0005667transcription regulator complexTbx2IDAMousePMID:12023302
Cellular ComponentGO:0005667transcription regulator complexTbx2IPIUniProtKB:Q9ERF6MousePMID:18285513
Biological ProcessGO:0035909aorta morphogenesisTbx2IMPMouseMGI:MGI:3487212|PMID:15459098
Biological ProcessGO:0006915apoptotic processTbx2IMPMouseMGI:MGI:6710296|PMID:33795231
Biological ProcessGO:0036302atrioventricular canal developmentTbx2IGIUniProtKB:P70324MouseMGI:MGI:5311550|PMID:22130515
Biological ProcessGO:0036302atrioventricular canal developmentTbx2IMPMouseMGI:MGI:3487212|PMID:15459098
Biological ProcessGO:0036302atrioventricular canal developmenttbx2bIGIZFIN:ZDB-GENO-161014-2ZfishPMID:27343557
Biological ProcessGO:1905222atrioventricular canal morphogenesisTbx2IGIUniProtKB:P70324MouseMGI:MGI:5311550|PMID:22130515
Biological ProcessGO:0048318axial mesoderm developmenttbx2bIDAZfishPMID:10331981
Biological ProcessGO:0030509BMP signaling pathwaytbx2bIMPZFIN:ZDB-GENO-181113-12ZfishPMID:28599080
Biological ProcessGO:0007420brain developmenttbx2bIMPZFIN:ZDB-MRPHLNO-051003-3ZfishPMID:16033799
Biological ProcessGO:0060219camera-type eye photoreceptor cell differentiationtbx2bIGIZFIN:ZDB-GENE-980526-373ZfishPMID:24681822
Biological ProcessGO:0060219camera-type eye photoreceptor cell differentiationtbx2bIMPZFIN:ZDB-GENO-080920-2ZfishPMID:24681822
Biological ProcessGO:0003205cardiac chamber developmenttbx2bIGIZFIN:ZDB-MRPHLNO-110718-2ZfishPMID:21448936
Biological ProcessGO:0003205cardiac chamber developmenttbx2aIGIZFIN:ZDB-MRPHLNO-110718-2ZfishPMID:21448936
Biological ProcessGO:1905072cardiac jelly developmentTBX2IMPHumanPMID:22130515
Biological ProcessGO:0060379cardiac muscle cell myoblast differentiationTbx2IDAMouseMGI:MGI:3487212|PMID:15459098
Biological ProcessGO:0048738cardiac muscle tissue developmentTbx2IMPMGI:MGI:3505715MousePMID:15459098
Biological ProcessGO:0007155cell adhesiontbx2bIMPZFIN:ZDB-MRPHLNO-051003-3ZfishPMID:16033799
Biological ProcessGO:0042074cell migration involved in gastrulationtbx2bIMPZFIN:ZDB-MRPHLNO-051003-3ZfishPMID:16033799
Biological ProcessGO:0090398cellular senescenceTBX2IDAHumanPMID:11748239
Biological ProcessGO:0090398cellular senescenceTBX2IDAHumanPMID:22002537
Biological ProcessGO:0090398cellular senescenceTbx2IDAMousePMID:11748239
Biological ProcessGO:0090103cochlea morphogenesisTbx2IMPMouseMGI:MGI:6710296|PMID:33795231
Biological ProcessGO:0060560developmental growth involved in morphogenesisTbx2IMPMGI:MGI:4415614MousePMID:19769959
Biological ProcessGO:0006351DNA-templated transcriptionTbx2IDAMouseMGI:MGI:3578601|PMID:15843407
Biological ProcessGO:0048596embryonic camera-type eye morphogenesisTbx2IMPMouseMGI:MGI:3487212|PMID:15459098
Biological ProcessGO:0042733embryonic digit morphogenesisTbx2IMPMouseMGI:MGI:3487212|PMID:15459098
Biological ProcessGO:0035050embryonic heart tube developmenttbx2bIMPZFIN:ZDB-MRPHLNO-080714-2ZfishPMID:18347092
Biological ProcessGO:0035050embryonic heart tube developmenttbx2aIMPZFIN:ZDB-MRPHLNO-080229-3ZfishPMID:17460765
Biological ProcessGO:0003272endocardial cushion formationTBX2IMPHumanPMID:22130515
Biological ProcessGO:0003203endocardial cushion morphogenesisTbx2IMPMouseMGI:MGI:3487212|PMID:15459098
Biological ProcessGO:0048484enteric nervous system developmenttbx2bIGIZFIN:ZDB-CRISPR-230208-8,ZFIN:ZDB-CRISPR-230208-9ZfishPMID:34358225
Biological ProcessGO:0048484enteric nervous system developmenttbx2aIGIZFIN:ZDB-CRISPR-230208-8,ZFIN:ZDB-CRISPR-230208-9ZfishPMID:34358225
Biological ProcessGO:0021538epithalamus developmenttbx2bIMPZFIN:ZDB-MRPHLNO-051012-1ZfishPMID:18385257
Biological ProcessGO:0021538epithalamus developmenttbx2bIMPZFIN:ZDB-GENO-080814-12ZfishPMID:18385257
Biological ProcessGO:0021538epithalamus developmenttbx2bIMPZFIN:ZDB-GENO-081208-1ZfishPMID:18629869
Biological ProcessGO:0021538epithalamus developmenttbx2bIMPZFIN:ZDB-MRPHLNO-050928-1ZfishPMID:18385257
Biological ProcessGO:0060441epithelial tube branching involved in lung morphogenesisTbx2IGIUniProtKB:P70324MouseMGI:MGI:5805984|PMID:27720610
Biological ProcessGO:0008543fibroblast growth factor receptor signaling pathwayTbx2IMPMouseMGI:MGI:6710296|PMID:33795231
Biological ProcessGO:0001947heart loopingtbx2bIMPZFIN:ZDB-MRPHLNO-080714-2ZfishPMID:18347092
Biological ProcessGO:0003007heart morphogenesisTbx2IMPMGI:MGI:3505715MousePMID:15459098
Biological ProcessGO:0070365hepatocyte differentiationtbx2bIMPZFIN:ZDB-GENO-181113-12ZfishPMID:28599080
Biological ProcessGO:0072068late distal convoluted tubule developmenttbx2bIGIZFIN:ZDB-GENE-990726-27ZfishPMID:30475208
Biological ProcessGO:0072068late distal convoluted tubule developmenttbx2bIMPZFIN:ZDB-MRPHLNO-051012-1ZfishPMID:27840199
Biological ProcessGO:0072068late distal convoluted tubule developmenttbx2bIMPZFIN:ZDB-GENO-190905-10ZfishPMID:30475208
Biological ProcessGO:0072068late distal convoluted tubule developmenttbx2aIMPZFIN:ZDB-MRPHLNO-140123-2ZfishPMID:27840199
Biological ProcessGO:0060596mammary placode formationTbx2IGIMGI:MGI:98495MousePMID:16222716
Biological ProcessGO:0097325melanocyte proliferationTbx2IMPMouseMGI:MGI:6810282|PMID:26486273
Biological ProcessGO:0060916mesenchymal cell proliferation involved in lung developmentTbx2IMPMouseMGI:MGI:5805984|PMID:27720610
Biological ProcessGO:0007521muscle cell fate determinationTbx2IMPMGI:MGI:3505715MousePMID:15459098
Biological ProcessGO:1901211negative regulation of cardiac chamber formationTbx2IMPMouseMGI:MGI:3039059|PMID:15042700
Biological ProcessGO:2000773negative regulation of cellular senescenceTBX2IDAHumanPMID:11062467
Biological ProcessGO:2000773negative regulation of cellular senescenceTBX2IMPHumanPMID:12000749
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionTBX2IDAHumanPMID:10468588
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionTBX2IDAHumanPMID:11062467
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionTBX2IDAHumanPMID:11111039
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionTBX2IDAHumanPMID:29726930
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionTbx2IDAMousePMID:11748239
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionTbx2IDAMousePMID:15843407
Biological ProcessGO:1901208negative regulation of heart loopingTbx2IMPMouseMGI:MGI:3039059|PMID:15042700
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IITBX2IDAHumanPMID:11062467
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IITBX2IDAHumanPMID:11111039
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IITBX2IMPHumanPMID:12000749
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IITBX2IDAHumanPMID:30599067
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IITbx2IMPMouseMGI:MGI:6814711|PMID:28910203
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IITbx2IMPMouseMGI:MGI:6814712|PMID:26971330
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IITbx2IDAMouseMGI:MGI:6810280|PMID:18025091
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IITbx2IDAMouseMGI:MGI:6828672|PMID:9710594
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IITbx2IMPMouseMGI:MGI:5805984|PMID:27720610
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IITbx2IDAMouseMGI:MGI:2176288|PMID:11867218
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IITbx2IMPMouseMGI:MGI:6710296|PMID:33795231
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IITbx2IDAMousePMID:15042700
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IITbx2IGIMGI:MGI:97168MousePMID:18285513
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IITbx2IGIMGI:MGI:97169MousePMID:18285513
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IITbx2IDAMousePMID:12023302
Biological ProcessGO:0022008neurogenesisTbx2IMPMouseMGI:MGI:6710296|PMID:33795231
Biological ProcessGO:0048663neuron fate commitmenttbx2bIMPZFIN:ZDB-MRPHLNO-051003-3ZfishPMID:16033799
Biological ProcessGO:0007219Notch signaling pathwayTbx2IDAMousePMID:23117660
Biological ProcessGO:0030903notochord developmenttbx2bIMPZFIN:ZDB-MRPHLNO-051003-3ZfishPMID:16033799
Biological ProcessGO:0003151outflow tract morphogenesisTbx2IMPMouseMGI:MGI:3039059|PMID:15042700
Biological ProcessGO:0003151outflow tract morphogenesisTbx2IMPMouseMGI:MGI:3487212|PMID:15459098
Biological ProcessGO:0003151outflow tract morphogenesisTbx2IMPMouseMGI:MGI:5300829|PMID:22186728
Biological ProcessGO:0003148outflow tract septum morphogenesisTbx2IMPMouseMGI:MGI:3487212|PMID:15459098
Biological ProcessGO:0060037pharyngeal system developmenttbx2aIMPZFIN:ZDB-MRPHLNO-140123-2ZfishPMID:24130849
Biological ProcessGO:0060465pharynx developmentTbx2IMPMouseMGI:MGI:3487212|PMID:15459098
Biological ProcessGO:0042461photoreceptor cell developmenttbx2bIMPZFIN:ZDB-GENO-130130-6ZfishPMID:24465536
Biological ProcessGO:0043704photoreceptor cell fate specificationtbx2bIMPZFIN:ZDB-GENO-080920-2ZfishPMID:19179291
Biological ProcessGO:0043474pigment metabolic process involved in pigmentationTbx2IMPMouseMGI:MGI:6814712|PMID:26971330
Biological ProcessGO:0021982pineal gland developmenttbx2bIMPZFIN:ZDB-MRPHLNO-051012-1ZfishPMID:27317804
Biological ProcessGO:0021982pineal gland developmenttbx2bIGIZFIN:ZDB-GENO-161014-12,ZFIN:ZDB-MRPHLNO-051012-1ZfishPMID:27317804
Biological ProcessGO:0060045positive regulation of cardiac muscle cell proliferationTbx2IMPMouseMGI:MGI:3039059|PMID:15042700
Biological ProcessGO:1902808positive regulation of cell cycle G1/S phase transitionTbx2IMPMouseMGI:MGI:6810282|PMID:26486273
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IITbx2IMPMouseMGI:MGI:6810282|PMID:26486273
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IITbx2IDAMouseMGI:MGI:5300829|PMID:22186728
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IITbx2IMPMouseMGI:MGI:2176288|PMID:11867218
Biological ProcessGO:0035777pronephric distal tubule developmenttbx2bIMPZFIN:ZDB-MRPHLNO-190523-1,ZFIN:ZDB-MRPHLNO-190523-2ZfishPMID:30575756
Biological ProcessGO:0035777pronephric distal tubule developmenttbx2bIGIZFIN:ZDB-GENE-990726-27ZfishPMID:30575756
Biological ProcessGO:0035777pronephric distal tubule developmenttbx2bIGIZFIN:ZDB-GENE-050208-123ZfishPMID:30575756
Biological ProcessGO:0048793pronephros developmenttbx2bIMPZFIN:ZDB-MRPHLNO-051012-1ZfishPMID:27840199
Biological ProcessGO:0048793pronephros developmenttbx2aIMPZFIN:ZDB-MRPHLNO-140123-2ZfishPMID:27840199
Biological ProcessGO:0072019proximal convoluted tubule developmenttbx2bIMPZFIN:ZDB-MRPHLNO-051012-1ZfishPMID:27840199
Biological ProcessGO:0072019proximal convoluted tubule developmenttbx2aIMPZFIN:ZDB-MRPHLNO-140123-2ZfishPMID:27840199
Biological ProcessGO:0006355regulation of DNA-templated transcriptionTbx2IDAMouseMGI:MGI:3578601|PMID:15843407
Biological ProcessGO:0008016regulation of heart contractiontbx2bIMPZFIN:ZDB-MRPHLNO-080714-2ZfishPMID:18347092
Biological ProcessGO:0006357regulation of transcription by RNA polymerase IITbx2IDAMouseMGI:MGI:3487212|PMID:15459098
Biological ProcessGO:0032526response to retinoic acidTbx2IDAMouseMGI:MGI:5300829|PMID:22186728
Biological ProcessGO:0046549retinal cone cell developmenttbx2bIMPZFIN:ZDB-MRPHLNO-050928-1ZfishPMID:15755805
Biological ProcessGO:0046549retinal cone cell developmenttbx2bIMPZFIN:ZDB-MRPHLNO-051012-1ZfishPMID:15755805
Biological ProcessGO:0046551retinal cone cell fate commitmenttbx2bIMPZFIN:ZDB-GENO-160104-4ZfishPMID:26936243
Biological ProcessGO:0042671retinal cone cell fate determinationtbx2bIMPZFIN:ZDB-GENO-130130-6ZfishPMID:30592497
Biological ProcessGO:0046548retinal rod cell developmenttbx2bIMPZFIN:ZDB-MRPHLNO-051012-1ZfishPMID:15755805
Biological ProcessGO:0046548retinal rod cell developmenttbx2bIMPZFIN:ZDB-MRPHLNO-050928-1ZfishPMID:15755805
Biological ProcessGO:0060021roof of mouth developmentTbx2IGIMGI:MGI:98495MousePMID:19769959
Biological ProcessGO:0060021roof of mouth developmentTbx2IMPMGI:MGI:4415614MousePMID:19769959
Biological ProcessGO:0051145smooth muscle cell differentiationTbx2IGIMGI:98495MousePMID:30478225
Biological ProcessGO:0072105ureteric peristalsisTbx2IGIMGI:98495MousePMID:30478225

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory