Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TBX21
  • Mouse genes Tbx21
  • Rat genes Tbx21
  • Zfish genes tbx21
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tbx21

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Tbx21	IMP		Mouse	MGI:MGI:5543347|PMID:23616576
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Tbx21	IDA		Mouse	MGI:MGI:1354779|PMID:10761931
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	TBX21	IDA		Human	PMID:18504404
Molecular Function	GO:0005515	protein binding	TBX21	IPI	UniProtKB:P23771	Human	PMID:15662016
Molecular Function	GO:0005515	protein binding	TBX21	IPI	UniProtKB:P08047	Human	PMID:17075044
Molecular Function	GO:0005515	protein binding	TBX21	IPI	UniProtKB:P23771	Human	PMID:17075044
Molecular Function	GO:0005515	protein binding	TBX21	IPI	UniProtKB:Q09472	Human	PMID:17075044
Molecular Function	GO:0005515	protein binding	TBX21	IPI	UniProtKB:Q92793	Human	PMID:17075044
Molecular Function	GO:0005515	protein binding	TBX21	IPI	UniProtKB:Q14694	Human	PMID:24845384
Molecular Function	GO:0005515	protein binding	Tbx21	IPI	UniProtKB:P41183	Mouse	MGI:MGI:5428372|PMID:22406686
Molecular Function	GO:0005515	protein binding	Tbx21	IPI	UniProtKB:Q03347	Mouse	MGI:MGI:4868293|PMID:21151104
Molecular Function	GO:0005515	protein binding	Tbx21	IPI	UniProtKB:Q64131	Mouse	MGI:MGI:4868293|PMID:21151104
Molecular Function	GO:0005515	protein binding	Tbx21	IPI	UniProtKB:P00520|UniProtKB:P23772	Mouse	MGI:MGI:5142352|PMID:21690296
Molecular Function	GO:0005515	protein binding	Tbx21	IPI	UniProtKB:Q3TKT4|UniProtKB:Q5NCY0	Mouse	MGI:MGI:4866963|PMID:21095589
Molecular Function	GO:0005515	protein binding	Tbx21	IPI	UniProtKB:P23772|UniProtKB:Q03526	Mouse	MGI:MGI:5917559|PMID:15662016
Molecular Function	GO:0005515	protein binding	Tbx21	IPI	UniProtKB:P23772|UniProtKB:Q04207|UniProtKB:Q60591	Mouse	MGI:MGI:5543347|PMID:23616576
Molecular Function	GO:0043565	sequence-specific DNA binding	TBX21	IDA		Human	PMID:23332764
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	TBX21	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	TBX21	IDA		Human	PMID:19805038
Cellular Component	GO:0043025	neuronal cell body	Tbx21	IDA		Mouse	PMID:15677725
Cellular Component	GO:0005634	nucleus	Tbx21	IDA		Mouse	MGI:MGI:5142352|PMID:21690296
Cellular Component	GO:0005634	nucleus	Tbx21	IDA		Mouse	MGI:MGI:5543347|PMID:23616576
Cellular Component	GO:0005634	nucleus	Tbx21	IDA		Mouse	MGI:MGI:5917559|PMID:15662016
Cellular Component	GO:0005634	nucleus	Tbx21	IDA		Mouse	PMID:21752992
Biological Process	GO:0071310	cellular response to organic substance	Tbx21	IDA		Mouse	PMID:21737317
Biological Process	GO:0072676	lymphocyte migration	TBX21	IDA		Human	PMID:19805038
Biological Process	GO:0072676	lymphocyte migration	Tbx21	IMP		Mouse	MGI:MGI:4366125|PMID:19805038
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Tbx21	IMP		Mouse	MGI:MGI:5917559|PMID:15662016
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Tbx21	IMP		Mouse	MGI:MGI:5543347|PMID:23616576
Biological Process	GO:0032703	negative regulation of interleukin-2 production	Tbx21	IMP		Mouse	MGI:MGI:5543347|PMID:23616576
Biological Process	GO:2000320	negative regulation of T-helper 17 cell differentiation	Tbx21	IDA		Mouse	MGI:MGI:4868293|PMID:21151104
Biological Process	GO:2000329	negative regulation of T-helper 17 cell lineage commitment	Tbx21	IMP		Mouse	MGI:MGI:4868293|PMID:21151104
Biological Process	GO:2000552	negative regulation of T-helper 2 cell cytokine production	Tbx21	IMP		Mouse	MGI:MGI:5543347|PMID:23616576
Biological Process	GO:2000552	negative regulation of T-helper 2 cell cytokine production	Tbx21	IDA		Mouse	MGI:MGI:1354779|PMID:10761931
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	TBX21	IDA		Human	PMID:18504404
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	TBX21	IDA		Human	PMID:19805038
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Tbx21	IMP		Mouse	MGI:MGI:4366125|PMID:19805038
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Tbx21	IMP		Mouse	MGI:MGI:5543347|PMID:23616576
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Tbx21	IDA		Mouse	MGI:MGI:5142352|PMID:21690296
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Tbx21	IMP		Mouse	MGI:MGI:5917559|PMID:15662016
Biological Process	GO:0010628	positive regulation of gene expression	Tbx21	IGI	MGI:MGI:103062	Mouse	PMID:22851706
Biological Process	GO:0048304	positive regulation of isotype switching to IgG isotypes	Tbx21	IMP	MGI:MGI:2180194	Mouse	PMID:12882831
Biological Process	GO:2000556	positive regulation of T-helper 1 cell cytokine production	Tbx21	IDA		Mouse	MGI:MGI:1354779|PMID:10761931
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tbx21	IDA		Mouse	MGI:MGI:1354779|PMID:10761931
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Tbx21	IMP		Mouse	MGI:MGI:5543347|PMID:23616576
Biological Process	GO:0050776	regulation of immune response	Tbx21	IMP	MGI:MGI:2180194	Mouse	PMID:12882831
Biological Process	GO:0045580	regulation of T cell differentiation	Tbx21	IMP		Mouse	MGI:MGI:5142352|PMID:21690296
Biological Process	GO:0009615	response to virus	TBX21	IEP		Human	PMID:20583921
Biological Process	GO:0030217	T cell differentiation	Tbx21	IMP	MGI:MGI:2180194	Mouse	PMID:20399120
Biological Process	GO:0002296	T-helper 1 cell lineage commitment	Tbx21	IDA		Mouse	MGI:MGI:1354779|PMID:10761931

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern