Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TBX6
  • Mouse genes Tbx6
  • Rat genes Tbx6
  • Zfish genes tbx16l,tbx6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tbx6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:O94842	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:Q6P1W5	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:Q93062-3	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:Q96LI6	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:O94842	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:Q6P1W5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:Q93062	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:Q96LI6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:O15496	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:O43186	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:O60806	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:O94842	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:P78424	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:P86480	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:Q08117-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:Q15038	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:Q16633	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:Q3LI66	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:Q5BKX5-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:Q5SWW7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:Q5TA45	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:Q70EL1-9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:Q86WV8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:Q8IUC1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:Q8N6F8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:Q93062-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:Q96A09	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:Q96G42	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:Q96LI6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:Q96SF7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:Q9NUJ3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:Q9Y5V3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:P13473-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:P31930	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TBX6	IPI	UniProtKB:Q9UMX0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	tbx6	IPI	ZFIN:ZDB-GENE-060113-1	Zfish	PMID:25259583
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Tbx6	IDA		Mouse	PMID:15986483
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Tbx6	IPI	UniProtKB:Q02591|UniProtKB:Q9WUI0	Mouse	MGI:MGI:5448510|PMID:22164283
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	TBX6	IDA		Human	PMID:28473536
Cellular Component	GO:0000785	chromatin	Tbx6	IDA		Mouse	MGI:MGI:5448510|PMID:22164283
Cellular Component	GO:0000785	chromatin	tbx6	IDA		Zfish	PMID:25725067
Cellular Component	GO:0005634	nucleus	Tbx6	IDA		Mouse	PMID:15986483
Biological Process	GO:0009952	anterior/posterior pattern specification	tbx6	IMP	ZFIN:ZDB-GENO-070123-6	Zfish	PMID:9007237
Biological Process	GO:0048514	blood vessel morphogenesis	tbx6	IMP	ZFIN:ZDB-GENO-130820-154	Zfish	PMID:16607654
Biological Process	GO:0048514	blood vessel morphogenesis	tbx6	IMP	ZFIN:ZDB-GENO-130820-7	Zfish	PMID:16607654
Biological Process	GO:0001707	mesoderm formation	Tbx6	IMP	MGI:MGI:2447721	Mouse	PMID:9490412
Biological Process	GO:0001707	mesoderm formation	Tbx6	IMP	MGI:MGI:3578143	Mouse	PMID:15755804
Biological Process	GO:0007501	mesodermal cell fate specification	Tbx6	IMP	MGI:MGI:2447721	Mouse	PMID:9490412
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	Tbx6	IDA		Mouse	MGI:MGI:5448510|PMID:22164283
Biological Process	GO:0014043	negative regulation of neuron maturation	Tbx6	IGI	MGI:MGI:97321	Mouse	PMID:23015435
Biological Process	GO:0014043	negative regulation of neuron maturation	Tbx6	IGI	MGI:MGI:1934030	Mouse	PMID:23015435
Biological Process	GO:0014043	negative regulation of neuron maturation	Tbx6	IGI	MGI:MGI:2152453	Mouse	PMID:23015435
Biological Process	GO:0010977	negative regulation of neuron projection development	Tbx6	IGI	MGI:MGI:97321	Mouse	PMID:23015435
Biological Process	GO:0010977	negative regulation of neuron projection development	Tbx6	IGI	MGI:MGI:1934030	Mouse	PMID:23015435
Biological Process	GO:0010977	negative regulation of neuron projection development	Tbx6	IGI	MGI:MGI:2152453	Mouse	PMID:23015435
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Tbx6	IDA		Mouse	MGI:MGI:5448510|PMID:22164283
Biological Process	GO:0048341	paraxial mesoderm formation	tbx16l	IGI	ZFIN:ZDB-GENO-171117-18	Zfish	PMID:28691257
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tbx6	IDA		Mouse	PMID:21750544
Biological Process	GO:0048641	regulation of skeletal muscle tissue development	tbx6	IGI	ZFIN:ZDB-GENO-160517-1	Zfish	PMID:25725067
Biological Process	GO:0048641	regulation of skeletal muscle tissue development	tbx6	IGI	ZFIN:ZDB-GENO-160517-2	Zfish	PMID:25725067
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	Tbx6	IDA		Mouse	PMID:18462699
Biological Process	GO:0021523	somatic motor neuron differentiation	tbx6	IMP	ZFIN:ZDB-GENO-070123-6	Zfish	PMID:9007237
Biological Process	GO:0061053	somite development	tbx6	IGI	ZFIN:ZDB-GENE-001207-7	Zfish	PMID:13678588
Biological Process	GO:0061053	somite development	tbx6	IMP	ZFIN:ZDB-GENO-080605-2	Zfish	PMID:23213474
Biological Process	GO:0061053	somite development	tbx6	IMP	ZFIN:ZDB-GENO-110113-6	Zfish	PMID:13678588
Biological Process	GO:0061053	somite development	tbx6	IMP	ZFIN:ZDB-GENO-080605-2	Zfish	PMID:13678588
Biological Process	GO:0061053	somite development	tbx6	IMP	ZFIN:ZDB-GENO-110113-6	Zfish	PMID:23213474
Biological Process	GO:0061053	somite development	tbx16l	IGI	ZFIN:ZDB-GENO-171117-18	Zfish	PMID:28691257
Biological Process	GO:0032525	somite rostral/caudal axis specification	Tbx6	IDA		Mouse	PMID:20346937
Biological Process	GO:0001756	somitogenesis	tbx6	IMP	ZFIN:ZDB-GENO-200903-5	Zfish	PMID:31444219
Biological Process	GO:0001756	somitogenesis	tbx6	IMP	ZFIN:ZDB-GENO-110113-6	Zfish	PMID:31444219
Biological Process	GO:0001756	somitogenesis	tbx6	IMP	ZFIN:ZDB-GENO-130820-7	Zfish	PMID:16607654
Biological Process	GO:0001756	somitogenesis	tbx6	IMP	ZFIN:ZDB-GENO-200219-3	Zfish	PMID:29624170
Biological Process	GO:0001756	somitogenesis	tbx6	IGI	ZFIN:ZDB-GENO-200219-5	Zfish	PMID:29624170
Biological Process	GO:0001756	somitogenesis	tbx6	IMP	ZFIN:ZDB-GENO-050209-19	Zfish	PMID:17849437
Biological Process	GO:0001756	somitogenesis	tbx6	IMP	ZFIN:ZDB-GENO-130820-154	Zfish	PMID:16607654
Biological Process	GO:0001756	somitogenesis	tbx6	IMP	ZFIN:ZDB-GENO-980202-1566	Zfish	PMID:9706695
Biological Process	GO:0001756	somitogenesis	tbx6	IMP	ZFIN:ZDB-GENO-070123-6	Zfish	PMID:15921674
Biological Process	GO:0001756	somitogenesis	tbx6	IMP	ZFIN:ZDB-GENO-080605-2	Zfish	PMID:22566537
Biological Process	GO:0001756	somitogenesis	tbx6	IMP	ZFIN:ZDB-GENO-070123-6	Zfish	PMID:9007237
Biological Process	GO:0001756	somitogenesis	tbx6	IMP	ZFIN:ZDB-MRPHLNO-081107-1	Zfish	PMID:22566537
Biological Process	GO:0001756	somitogenesis	tbx6	IMP	ZFIN:ZDB-GENO-980202-1566	Zfish	PMID:9007237

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern