Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TCF21
  • Mouse genes Tcf21
  • Rat genes Tcf21
  • Zfish genes tcf21
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tcf21

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043425	bHLH transcription factor binding	TCF21	IPI	UniProtKB:P15923	Human	PMID:12493738
Molecular Function	GO:0043425	bHLH transcription factor binding	Tcf21	IPI	UniProtKB:P15806	Mouse	MGI:MGI:1203942|PMID:9545521
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Tcf21	IDA		Mouse	MGI:MGI:1203941|PMID:9545526
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	TCF21	IDA		Human	PMID:12493738
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Tcf21	IDA		Mouse	MGI:MGI:1934523|PMID:11287187
Molecular Function	GO:0070888	E-box binding	Tcf21	IDA		Mouse	MGI:MGI:3588448|PMID:15919722
Molecular Function	GO:0070888	E-box binding	Tcf21	IPI	UniProtKB:O35437	Mouse	MGI:MGI:1203942|PMID:9545521
Molecular Function	GO:0042826	histone deacetylase binding	Tcf21	IPI	UniProtKB:Q13547	Mouse	MGI:MGI:3588448|PMID:15919722
Molecular Function	GO:0050681	nuclear androgen receptor binding	Tcf21	IPI	UniProtKB:P19091	Mouse	MGI:MGI:3588448|PMID:15919722
Molecular Function	GO:0005515	protein binding	TCF21	IPI	UniProtKB:O00560	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TCF21	IPI	UniProtKB:P15172	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TCF21	IPI	UniProtKB:Q99081-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TCF21	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Tcf21	IPI	PR:P15806	Mouse	PMID:11591653
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	TCF21	IDA		Human	PMID:28473536
Cellular Component	GO:0005654	nucleoplasm	TCF21	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	TCF21	IDA		Human	PMID:12493738
Cellular Component	GO:0005634	nucleus	tcf21	IDA		Zfish	PMID:20627128|ZFIN:ZDB-PUB-100719-53
Cellular Component	GO:0005667	transcription regulator complex	Tcf21	IDA		Mouse	MGI:MGI:1203942|PMID:9545521
Biological Process	GO:0009887	animal organ morphogenesis	Tcf21	IMP	MGI:MGI:2148205	Mouse	PMID:10944221
Biological Process	GO:0060840	artery development	tcf21	IGI	ZFIN:ZDB-GENE-980526-321	Zfish	PMID:26255850
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	Tcf21	IMP		Mouse	PMID:9507058
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	Tcf21	IMP	MGI:MGI:2148207	Mouse	PMID:10572052
Biological Process	GO:0014707	branchiomeric skeletal muscle development	Tcf21	IGI	UniProtKB:O88940	Mouse	MGI:MGI:3653784|PMID:12493912
Biological Process	GO:0014707	branchiomeric skeletal muscle development	tcf21	IMP	ZFIN:ZDB-GENO-160708-28	Zfish	PMID:26255850
Biological Process	GO:0060435	bronchiole development	Tcf21	IMP	MGI:MGI:2148207	Mouse	PMID:10572052
Biological Process	GO:0060539	diaphragm development	Tcf21	IGI	UniProtKB:O88940	Mouse	MGI:MGI:3653784|PMID:12493912
Biological Process	GO:0048557	embryonic digestive tract morphogenesis	Tcf21	IMP		Rat	PMID:11804032|RGD:727206
Biological Process	GO:0030855	epithelial cell differentiation	Tcf21	IMP	MGI:MGI:2148207	Mouse	PMID:10572052
Biological Process	GO:0048732	gland development	Tcf21	IMP		Rat	PMID:11804032|RGD:727206
Biological Process	GO:0032835	glomerulus development	Tcf21	IMP	MGI:MGI:2148207	Mouse	PMID:10572052
Biological Process	GO:0001822	kidney development	Tcf21	IMP	MGI:MGI:2148207	Mouse	PMID:10572052
Biological Process	GO:0048286	lung alveolus development	Tcf21	IMP	MGI:MGI:2148207	Mouse	PMID:10572052
Biological Process	GO:0060425	lung morphogenesis	Tcf21	IMP	MGI:MGI:2148207	Mouse	PMID:10572052
Biological Process	GO:0060426	lung vasculature development	Tcf21	IMP	MGI:MGI:2148207	Mouse	PMID:10572052
Biological Process	GO:0072277	metanephric glomerular capillary formation	Tcf21	IMP		Mouse	MGI:MGI:2651771|PMID:12619136
Biological Process	GO:0072162	metanephric mesenchymal cell differentiation	Tcf21	IMP		Mouse	MGI:MGI:2651771|PMID:12619136
Biological Process	GO:0001763	morphogenesis of a branching structure	Tcf21	IMP	MGI:MGI:2148207	Mouse	PMID:10572052
Biological Process	GO:0060766	negative regulation of androgen receptor signaling pathway	Tcf21	IDA		Mouse	MGI:MGI:3588448|PMID:15919722
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	TCF21	IDA		Human	PMID:12493738
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Tcf21	IDA		Mouse	MGI:MGI:3588448|PMID:15919722
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Tcf21	IDA		Mouse	MGI:MGI:1934523|PMID:11287187
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tcf21	IDA		Mouse	MGI:MGI:1203941|PMID:9545526
Biological Process	GO:0048608	reproductive structure development	Tcf21	IMP	MGI:MGI:2148207	Mouse	PMID:10572052
Biological Process	GO:0060541	respiratory system development	Tcf21	IMP	MGI:MGI:2148207	Mouse	PMID:10572052
Biological Process	GO:0060021	roof of mouth development	Tcf21	IGI	UniProtKB:O88940	Mouse	MGI:MGI:3653784|PMID:12493912
Biological Process	GO:0060008	Sertoli cell differentiation	Tcf21	IDA		Rat	PMID:21637323|RGD:8553815
Biological Process	GO:0007530	sex determination	Tcf21	IMP	MGI:MGI:2148207	Mouse	PMID:10572052
Biological Process	GO:0007548	sex differentiation	Tcf21	IMP	MGI:MGI:2148207	Mouse	PMID:15289436
Biological Process	GO:0007519	skeletal muscle tissue development	tcf21	IGI	ZFIN:ZDB-MRPHLNO-111214-4	Zfish	PMID:21347725
Biological Process	GO:0007519	skeletal muscle tissue development	tcf21	IMP	ZFIN:ZDB-MRPHLNO-111214-1	Zfish	PMID:21347725
Biological Process	GO:0048536	spleen development	Tcf21	IMP		Mouse	MGI:MGI:1888654|PMID:10944221
Biological Process	GO:0001657	ureteric bud development	Tcf21	IMP	MGI:MGI:2148207	Mouse	PMID:10572052
Biological Process	GO:0001944	vasculature development	Tcf21	IMP	MGI:MGI:2148207	Mouse	PMID:10572052

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern