Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Tcf7

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes TCF7
- Mouse genes Tcf7
- Rat genes Tcf7
- Zfish genes tcf7
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tcf7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	TCF7	IDA		Human	PMID:9488439
Molecular Function	GO:0003677	DNA binding	Tcf7	IDA		Mouse	PMID:1827138
Molecular Function	GO:0003677	DNA binding	Tcf7	IDA		Mouse	PMID:12235125
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Tcf7	IDA		Mouse	PMID:12235125
Molecular Function	GO:0001217	DNA-binding transcription repressor activity	Tcf7	IMP		Mouse	MGI:MGI:3695974\|PMID:17218525
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Tcf7	IMP		Mouse	MGI:MGI:5428344\|PMID:22723415
Molecular Function	GO:0005515	protein binding	TCF7	IPI	UniProtKB:P35222	Human	PMID:16442529
Molecular Function	GO:0005515	protein binding	TCF7	IPI	UniProtKB:Q9UN79	Human	PMID:17218525
Molecular Function	GO:0005515	protein binding	TCF7	IPI	UniProtKB:P35222	Human	PMID:17510365
Molecular Function	GO:0005515	protein binding	TCF7	IPI	UniProtKB:Q15038	Human	PMID:19304756
Molecular Function	GO:0005515	protein binding	TCF7	IPI	UniProtKB:P35222	Human	PMID:19358846
Molecular Function	GO:0005515	protein binding	TCF7	IPI	UniProtKB:Q9UN79	Human	PMID:20028982
Molecular Function	GO:0005515	protein binding	TCF7	IPI	UniProtKB:P35222	Human	PMID:25678599
Molecular Function	GO:0005515	protein binding	TCF7	IPI	UniProtKB:Q13015	Human	PMID:26079538
Molecular Function	GO:0005515	protein binding	TCF7	IPI	UniProtKB:O42478	Human	PMID:9783587
Molecular Function	GO:0005515	protein binding	Tcf7	IPI	UniProtKB:Q04891	Mouse	MGI:MGI:3695974\|PMID:17218525
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Tcf7	IDA		Mouse	MGI:MGI:5428344\|PMID:22723415
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	TCF7	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	TCF7	IDA		Human	PMID:18579517
Molecular Function	GO:0000976	transcription cis-regulatory region binding	TCF7	IDA		Human	PMID:20128911
Cellular Component	GO:0000791	euchromatin	Tcf7	IDA		Mouse	MGI:MGI:5428344\|PMID:22723415
Cellular Component	GO:0016604	nuclear body	TCF7	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	TCF7	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	TCF7	IDA		Human	PMID:18579517
Cellular Component	GO:0005634	nucleus	Tcf7	IDA		Mouse	MGI:MGI:4834989\|PMID:18579517
Cellular Component	GO:0005634	nucleus	Tcf7	IDA		Mouse	PMID:1827138
Biological Process	GO:0046632	alpha-beta T cell differentiation	Tcf7	IGI	MGI:MGI:96770	Mouse	PMID:9462507
Biological Process	GO:0060070	canonical Wnt signaling pathway	Tcf7	IDA		Mouse	PMID:12235125
Biological Process	GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process	Tcf7	IDA		Mouse	PMID:12235125
Biological Process	GO:0071353	cellular response to interleukin-4	TCF7	IDA		Human	PMID:18579517
Biological Process	GO:0048557	embryonic digestive tract morphogenesis	Tcf7	IGI	MGI:MGI:1202879	Mouse	PMID:15057272
Biological Process	GO:0030538	embryonic genitalia morphogenesis	Tcf7	IGI	MGI:MGI:1202879	Mouse	PMID:15057272
Biological Process	GO:0048619	embryonic hindgut morphogenesis	Tcf7	IGI	MGI:MGI:1202879	Mouse	PMID:15057272
Biological Process	GO:0033333	fin development	tcf7	IMP	ZFIN:ZDB-GENO-100122-4	Zfish	PMID:18065431
Biological Process	GO:0042492	gamma-delta T cell differentiation	Tcf7	IMP		Mouse	MGI:MGI:6276541\|PMID:30413363
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Tcf7	IMP		Mouse	MGI:MGI:5428344\|PMID:22723415
Biological Process	GO:0021915	neural tube development	Tcf7	IGI	MGI:MGI:1202879	Mouse	PMID:15057272
Biological Process	GO:0033339	pectoral fin development	tcf7	IMP	ZFIN:ZDB-GENO-100122-4	Zfish	PMID:18065431
Biological Process	GO:0042127	regulation of cell population proliferation	Tcf7	IDA		Mouse	PMID:12235125
Biological Process	GO:0006355	regulation of DNA-templated transcription	Tcf7	IMP		Mouse	MGI:MGI:5486619\|PMID:23562159
Biological Process	GO:0045586	regulation of gamma-delta T cell differentiation	Tcf7	IMP		Mouse	MGI:MGI:5486619\|PMID:23562159
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Tcf7	IDA		Mouse	PMID:12235125
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	tcf7	IGI	ZFIN:ZDB-GENE-990714-26	Zfish	PMID:17215296
Biological Process	GO:0021513	spinal cord dorsal/ventral patterning	tcf7	IMP	ZFIN:ZDB-MRPHLNO-070605-7	Zfish	PMID:18062957
Biological Process	GO:0033153	T cell receptor V(D)J recombination	Tcf7	IGI	MGI:MGI:96770	Mouse	PMID:9462507

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.