Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TCF7L1
  • Mouse genes Tcf7l1
  • Rat genes Tcf7l1
  • Zfish genes tcf7l1a,tcf7l1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tcf7l1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	Tcf7l1	IPI	PR:Q02248	Mouse	PMID:18202148
Molecular Function	GO:0008013	beta-catenin binding	Tcf7l1	IPI	PR:Q02248	Mouse	PMID:9488439
Molecular Function	GO:0003682	chromatin binding	Tcf7l1	IDA		Mouse	PMID:18467660
Molecular Function	GO:0003682	chromatin binding	Tcf7l1	IDA		Mouse	PMID:18202148
Molecular Function	GO:0003677	DNA binding	Tcf7l1	IDA		Mouse	PMID:16894029
Molecular Function	GO:0003677	DNA binding	tcf7l1a	IDA		Zfish	PMID:19176587
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Tcf7l1	IDA		Mouse	PMID:16894029
Molecular Function	GO:0005515	protein binding	TCF7L1	IPI	UniProtKB:Q15038	Human	PMID:19304756
Molecular Function	GO:0005515	protein binding	Tcf7l1	IPI	PR:P19785	Mouse	PMID:18202148
Molecular Function	GO:0005515	protein binding	Tcf7l1	IPI	PR:P27782	Mouse	PMID:18202148
Molecular Function	GO:0005515	protein binding	Tcf7l1	IPI	PR:Q02248	Mouse	PMID:18202148
Molecular Function	GO:0005515	protein binding	tcf7l1a	IPI	UniProtKB:Q66K89	Zfish	PMID:21666599|ZFIN:ZDB-PUB-110628-8
Molecular Function	GO:0005515	protein binding	tcf7l1a	IPI	ZFIN:ZDB-GENE-990415-86	Zfish	PMID:25371059
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	TCF7L1	IDA		Human	PMID:28473536
Cellular Component	GO:0005829	cytosol	TCF7L1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	TCF7L1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Tcf7l1	IDA		Mouse	PMID:19718027
Cellular Component	GO:0005634	nucleus	Tcf7l1	IDA		Mouse	PMID:18202148
Cellular Component	GO:0005634	nucleus	Tcf7l1	IDA		Mouse	PMID:10498690
Cellular Component	GO:0005634	nucleus	tcf7l1a	IDA		Zfish	PMID:11057671
Biological Process	GO:0008595	anterior/posterior axis specification, embryo	Tcf7l1	IMP	MGI:MGI:3044616	Mouse	PMID:14668413
Biological Process	GO:0048319	axial mesoderm morphogenesis	Tcf7l1	IMP	MGI:MGI:3044616	Mouse	PMID:14668413
Biological Process	GO:0035284	brain segmentation	tcf7l1b	IMP	ZFIN:ZDB-MRPHLNO-050308-11	Zfish	PMID:15659486
Biological Process	GO:0010456	cell proliferation in dorsal spinal cord	tcf7l1a	IGI	ZFIN:ZDB-MRPHLNO-070604-3,ZFIN:ZDB-MRPHLNO-080717-2	Zfish	PMID:18062957
Biological Process	GO:0010456	cell proliferation in dorsal spinal cord	tcf7l1b	IGI	ZFIN:ZDB-MRPHLNO-070604-3,ZFIN:ZDB-MRPHLNO-080717-2	Zfish	PMID:18062957
Biological Process	GO:0006351	DNA-templated transcription	Tcf7l1	IDA		Mouse	MGI:MGI:3689688|PMID:16894029
Biological Process	GO:0060900	embryonic camera-type eye formation	tcf7l1a	IMP	ZFIN:ZDB-GENO-080909-1	Zfish	PMID:30777146
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	tcf7l1a	IGI	ZFIN:ZDB-GENE-990415-128,ZFIN:ZDB-GENO-080909-1	Zfish	PMID:18694563
Biological Process	GO:0009880	embryonic pattern specification	tcf7l1b	IMP		Zfish	PMID:15366005
Biological Process	GO:0060847	endothelial cell fate specification	tcf7l1a	IMP	ZFIN:ZDB-MRPHLNO-060705-5	Zfish	PMID:23707897
Biological Process	GO:0060847	endothelial cell fate specification	tcf7l1a	IGI	ZFIN:ZDB-MRPHLNO-050308-11,ZFIN:ZDB-MRPHLNO-060705-5	Zfish	PMID:23707897
Biological Process	GO:0060847	endothelial cell fate specification	tcf7l1b	IMP	ZFIN:ZDB-MRPHLNO-050308-11	Zfish	PMID:23707897
Biological Process	GO:0060847	endothelial cell fate specification	tcf7l1b	IGI	ZFIN:ZDB-MRPHLNO-050308-11,ZFIN:ZDB-MRPHLNO-060705-5	Zfish	PMID:23707897
Biological Process	GO:0030900	forebrain development	tcf7l1a	IGI	ZFIN:ZDB-GENO-080909-1,ZFIN:ZDB-MRPHLNO-111104-1	Zfish	PMID:22007134
Biological Process	GO:0048699	generation of neurons	tcf7l1a	IGI	ZFIN:ZDB-MRPHLNO-070604-3,ZFIN:ZDB-MRPHLNO-080717-2	Zfish	PMID:19176587
Biological Process	GO:0048699	generation of neurons	tcf7l1b	IGI	ZFIN:ZDB-MRPHLNO-070604-3,ZFIN:ZDB-MRPHLNO-080717-2	Zfish	PMID:19176587
Biological Process	GO:0060323	head morphogenesis	tcf7l1a	IMP	ZFIN:ZDB-GENO-001107-1	Zfish	PMID:11057671
Biological Process	GO:0007507	heart development	tcf7l1a	IGI	ZFIN:ZDB-MRPHLNO-050308-11,ZFIN:ZDB-MRPHLNO-060705-5	Zfish	PMID:23707897
Biological Process	GO:0007507	heart development	tcf7l1a	IMP	ZFIN:ZDB-MRPHLNO-060705-5	Zfish	PMID:23707897
Biological Process	GO:0007507	heart development	tcf7l1b	IMP	ZFIN:ZDB-MRPHLNO-050308-11	Zfish	PMID:23707897
Biological Process	GO:0007507	heart development	tcf7l1b	IGI	ZFIN:ZDB-MRPHLNO-050308-11,ZFIN:ZDB-MRPHLNO-060705-5	Zfish	PMID:23707897
Biological Process	GO:0030902	hindbrain development	tcf7l1b	IMP	ZFIN:ZDB-MRPHLNO-050308-11	Zfish	PMID:15659486
Biological Process	GO:0030901	midbrain development	tcf7l1a	IMP	ZFIN:ZDB-MRPHLNO-070604-3	Zfish	PMID:17215296
Biological Process	GO:0030901	midbrain development	tcf7l1b	IMP		Zfish	PMID:17215296
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	tcf7l1a	IGI	ZFIN:ZDB-MRPHLNO-120403-3,ZFIN:ZDB-MRPHLNO-060705-5	Zfish	PMID:32702011
Biological Process	GO:0060829	negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation	tcf7l1a	IGI	ZFIN:ZDB-GENE-030827-4	Zfish	PMID:22100263
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Tcf7l1	IDA		Mouse	PMID:16894029
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	tcf7l1a	IMP	ZFIN:ZDB-GENO-001107-1	Zfish	PMID:11057671
Biological Process	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification	tcf7l1a	IGI	ZFIN:ZDB-GENE-030827-4	Zfish	PMID:22100263
Biological Process	GO:0008284	positive regulation of cell population proliferation	tcf7l1a	IGI	ZFIN:ZDB-MRPHLNO-070604-3,ZFIN:ZDB-MRPHLNO-080717-2	Zfish	PMID:19176587
Biological Process	GO:0008284	positive regulation of cell population proliferation	tcf7l1b	IGI	ZFIN:ZDB-MRPHLNO-070604-3,ZFIN:ZDB-MRPHLNO-080717-2	Zfish	PMID:19176587
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tcf7l1	IDA		Mouse	PMID:15907834
Biological Process	GO:0006355	regulation of DNA-templated transcription	Tcf7l1	IDA		Mouse	MGI:MGI:3689688|PMID:16894029
Biological Process	GO:1904672	regulation of somatic stem cell population maintenance	Tcf7l1	IMP		Mouse	PMID:18467660
Biological Process	GO:2000036	regulation of stem cell population maintenance	Tcf7l1	IMP		Mouse	PMID:18347094
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	tcf7l1b	IGI	ZFIN:ZDB-GENE-980605-30	Zfish	PMID:17215296
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	tcf7l1a	IGI	ZFIN:ZDB-GENE-991110-10	Zfish	PMID:17215296
Biological Process	GO:0021903	rostrocaudal neural tube patterning	tcf7l1a	IMP	ZFIN:ZDB-MRPHLNO-070604-3	Zfish	PMID:17215296
Biological Process	GO:0021903	rostrocaudal neural tube patterning	tcf7l1b	IMP		Zfish	PMID:17215296
Biological Process	GO:0043588	skin development	Tcf7l1	IGI	MGI:MGI:1202879	Mouse	PMID:19718027
Biological Process	GO:0035019	somatic stem cell population maintenance	Tcf7l1	IGI	MGI:MGI:1202879	Mouse	PMID:19718027
Biological Process	GO:0048863	stem cell differentiation	Tcf7l1	IMP	MGI:MGI:3044616	Mouse	PMID:16894029
Biological Process	GO:0006366	transcription by RNA polymerase II	Tcf7l1	IDA		Mouse	PMID:15907834

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern