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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Tcf7l2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tcf7l2
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0070016armadillo repeat domain bindingTCF7L2IPIUniProtKB:Q02248HumanPMID:12408825
Molecular FunctionGO:0008013beta-catenin bindingTCF7L2IPIUniProtKB:Q02248HumanPMID:12408825
Molecular FunctionGO:0008013beta-catenin bindingTCF7L2IPIUniProtKB:P35222HumanPMID:19443654
Molecular FunctionGO:0008013beta-catenin bindingTCF7L2IDAHumanPMID:9065401
Molecular FunctionGO:0008013beta-catenin bindingTcf7l2IDAMousePMID:19503085
Molecular FunctionGO:0008013beta-catenin bindingTcf7l2IPIPR:Q02248MousePMID:9488439
Molecular FunctionGO:0008013beta-catenin bindingTcf7l2IPIPR:Q02248MousePMID:12874278
Molecular FunctionGO:0008013beta-catenin bindingTcf7l2IDAMousePMID:9784592
Molecular FunctionGO:0003682chromatin bindingTcf7l2IGIMGI:MGI:88276MousePMID:23824574
Molecular FunctionGO:0003682chromatin bindingTcf7l2IDAMousePMID:17727834
Molecular FunctionGO:0001228DNA-binding transcription activator activity, RNA polymerase II-specificTcf7l2IDAMouseMGI:MGI:5009785|PMID:20044351
Molecular FunctionGO:0003700DNA-binding transcription factor activityTCF7L2IDAHumanPMID:9727977
Molecular FunctionGO:0045295gamma-catenin bindingTCF7L2IPIUniProtKB:P14923HumanPMID:14661054
Molecular FunctionGO:0060090molecular adaptor activityTCF7L2EXPHumanPMID:11237626
Molecular FunctionGO:0060090molecular adaptor activityTCF7L2EXPHumanPMID:11713476
Molecular FunctionGO:0016922nuclear receptor bindingTCF7L2IPIUniProtKB:P10275HumanPMID:12799378
Molecular FunctionGO:0003676nucleic acid bindingTCF7L2EXPHumanPMID:11237626
Molecular FunctionGO:1990841promoter-specific chromatin bindingTcf7l2IDARatPMID:21901280|RGD:152995490
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:P35222HumanPMID:11713475
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:P35222HumanPMID:11713476
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:P35222HumanPMID:16442529
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:P35222HumanPMID:16569639
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:Q9UER7HumanPMID:16569639
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:P35222HumanPMID:16724116
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:Q14526HumanPMID:16724116
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:P12956HumanPMID:17283121
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:P35222HumanPMID:17283121
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:Q15834HumanPMID:17873903
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:O60907HumanPMID:18193033
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:P35222HumanPMID:18772112
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:Q13761HumanPMID:18772112
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:P35222HumanPMID:19202075
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:Q15038HumanPMID:19304756
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:P35222HumanPMID:19816403
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:Q9UKE5HumanPMID:19816403
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:P35222HumanPMID:20126258
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:P35222HumanPMID:22014570
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:P35222HumanPMID:22056988
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:P98170HumanPMID:22304967
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:Q04726HumanPMID:22304967
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:Q9Y657HumanPMID:24589551
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:P35222HumanPMID:28829046
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:P12956HumanPMID:30833792
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:P35222HumanPMID:30833792
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:Q93009HumanPMID:30833792
Molecular FunctionGO:0005515protein bindingTCF7L2IPIUniProtKB:Q93009HumanPMID:35044719
Molecular FunctionGO:0005515protein bindingTcf7l2IPIUniProtKB:Q9R1Y5MouseMGI:MGI:3701023|PMID:16724116
Molecular FunctionGO:0005515protein bindingTcf7l2IPIUniProtKB:P39428MouseMGI:MGI:3688344|PMID:15102471
Molecular FunctionGO:0005515protein bindingTcf7l2IPIUniProtKB:Q62232MouseMGI:MGI:5442222|PMID:22902740
Molecular FunctionGO:0005515protein bindingTcf7l2IPIPR:O09106MousePMID:19503085
Molecular FunctionGO:0005515protein bindingTcf7l2IPIPR:P70288MousePMID:19503085
Molecular FunctionGO:0005515protein bindingTcf7l2IPIPR:Q02248MousePMID:20044351
Molecular FunctionGO:0019901protein kinase bindingTCF7L2IPIUniProtKB:Q9UBE8HumanPMID:16714285
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingTCF7L2IDAHumanPMID:19443654
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingTcf7l2IDAMouseMGI:MGI:5009785|PMID:20044351
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingTcf7l2IDAMousePMID:23028378
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingTcf7l2IDAMousePMID:23260145
Molecular FunctionGO:0061629RNA polymerase II-specific DNA-binding transcription factor bindingTCF7L2IPIUniProtKB:P05412HumanPMID:16007074
Molecular FunctionGO:0061629RNA polymerase II-specific DNA-binding transcription factor bindingTCF7L2IPIUniProtKB:P35638HumanPMID:16434966
Molecular FunctionGO:0061629RNA polymerase II-specific DNA-binding transcription factor bindingTCF7L2IPIUniProtKB:Q9H6I2HumanPMID:17875931
Molecular FunctionGO:0061629RNA polymerase II-specific DNA-binding transcription factor bindingTCF7L2IPIUniProtKB:Q9UI95HumanPMID:19443654
Molecular FunctionGO:0043565sequence-specific DNA bindingTCF7L2IDAHumanPMID:14661054
Molecular FunctionGO:0043565sequence-specific DNA bindingTCF7L2IMPHumanPMID:16532032
Molecular FunctionGO:0043565sequence-specific DNA bindingTcf7l2IDAMouseMGI:MGI:1196720|PMID:9488439
Molecular FunctionGO:0000976transcription cis-regulatory region bindingTCF7L2IDAHumanPMID:20128911
Molecular FunctionGO:0000976transcription cis-regulatory region bindingTcf7l2IDAMousePMID:20044351
Cellular ComponentGO:0070369beta-catenin-TCF7L2 complexTCF7L2IDAHumanPMID:9065401
Cellular ComponentGO:0070369beta-catenin-TCF7L2 complexTCF7L2IDAHumanPMID:9065402
Cellular ComponentGO:0071664catenin-TCF7L2 complexTcf7l2IDAMouseMGI:MGI:1196720|PMID:9488439
Cellular ComponentGO:0000785chromatinTCF7L2IDAHumanPMID:19443654
Cellular ComponentGO:0005829cytosolTcf7l2IDAMouseMGI:MGI:3799610|PMID:15578569
Cellular ComponentGO:0005654nucleoplasmTCF7L2IDAHumanPMID:19168596
Cellular ComponentGO:0005634nucleusTCF7L2IDAHumanPMID:16532032
Cellular ComponentGO:0005634nucleusTCF7L2IDAHumanPMID:19304756
Cellular ComponentGO:0005634nucleusTCF7L2IDAHumanPMID:19386626
Cellular ComponentGO:0005634nucleusTCF7L2IDAHumanPMID:9065401
Cellular ComponentGO:0005634nucleusTcf7l2IDAMouseMGI:MGI:3799610|PMID:15578569
Cellular ComponentGO:0005634nucleusTcf7l2IDAMousePMID:23028378
Cellular ComponentGO:0005634nucleusTcf7l2IDAMousePMID:19718027
Cellular ComponentGO:0005634nucleusTcf7l2IDAMousePMID:23260145
Cellular ComponentGO:0005634nucleusTcf7l2IDAMousePMID:20044351
Cellular ComponentGO:0005634nucleusTcf7l2IDAMousePMID:9697701
Cellular ComponentGO:0005634nucleustcf7l2IDAZfishPMID:27793772
Cellular ComponentGO:0032993protein-DNA complexTCF7L2IDAHumanPMID:14661054
Cellular ComponentGO:0005667transcription regulator complexTcf7l2IDAMousePMID:12861022
Biological ProcessGO:0001568blood vessel developmentTCF7L2IMPHumanPMID:15578569
Biological ProcessGO:0030509BMP signaling pathwayTcf7l2IMPMGI:MGI:1926344MousePMID:17919533
Biological ProcessGO:0030282bone mineralizationTcf7l2IGIMGI:MGI:101948MousePMID:19213727
Biological ProcessGO:0060070canonical Wnt signaling pathwayTcf7l2IGIMGI:MGI:96770MousePMID:17699607
Biological ProcessGO:0060070canonical Wnt signaling pathwayTcf7l2IDAMousePMID:9488439
Biological ProcessGO:0060070canonical Wnt signaling pathwayTcf7l2IMPMousePMID:10937998
Biological ProcessGO:0060070canonical Wnt signaling pathwaytcf7l2IMPZFIN:ZDB-MRPHLNO-101207-4ZfishPMID:21103407
Biological ProcessGO:0044334canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transitionTCF7L2IMPHumanPMID:17072303
Biological ProcessGO:0009267cellular response to starvationTcf7l2IMPMGI:MGI:5430317MousePMID:23260145
Biological ProcessGO:0035462determination of left/right asymmetry in diencephalontcf7l2IMPZFIN:ZDB-GENO-150127-1ZfishPMID:25201686
Biological ProcessGO:0035462determination of left/right asymmetry in diencephalontcf7l2IMPZFIN:ZDB-GENO-071217-3ZfishPMID:25201686
Biological ProcessGO:0035462determination of left/right asymmetry in diencephalontcf7l2IMPZFIN:ZDB-GENO-150127-2ZfishPMID:25201686
Biological ProcessGO:0055123digestive system developmenttcf7l2IGIZFIN:ZDB-GENE-031112-7ZfishPMID:19374549
Biological ProcessGO:0048557embryonic digestive tract morphogenesisTcf7l2IGIMGI:MGI:98507MousePMID:15057272
Biological ProcessGO:0030538embryonic genitalia morphogenesisTcf7l2IGIMGI:MGI:98507MousePMID:15057272
Biological ProcessGO:0048619embryonic hindgut morphogenesisTcf7l2IGIMGI:MGI:98507MousePMID:15057272
Biological ProcessGO:0050673epithelial cell proliferationTcf7l2IMPMGI:MGI:1926344MousePMID:19251639
Biological ProcessGO:0031017exocrine pancreas developmenttcf7l2IMPZFIN:ZDB-GENO-071217-3ZfishPMID:28851992
Biological ProcessGO:0031017exocrine pancreas developmenttcf7l2IMPZFIN:ZDB-GENO-180621-3ZfishPMID:28851992
Biological ProcessGO:0060325face morphogenesisTcf7l2IGIMGI:MGI:96770MousePMID:17699607
Biological ProcessGO:0045444fat cell differentiationTCF7L2IDAHumanPMID:10937998
Biological ProcessGO:0008543fibroblast growth factor receptor signaling pathwayTcf7l2IMPMGI:MGI:1926344MousePMID:17919533
Biological ProcessGO:0042593glucose homeostasisTCF7L2IDAHumanPMID:15525634
Biological ProcessGO:0042593glucose homeostasisTcf7l2IMPMGI:MGI:4431951MousePMID:23028378
Biological ProcessGO:0006006glucose metabolic processTcf7l2IMPMGI:MGI:1926344MousePMID:23260145
Biological ProcessGO:0005977glycogen metabolic processTcf7l2IMPMGI:MGI:1926344MousePMID:23260145
Biological ProcessGO:0021986habenula developmenttcf7l2IMPZFIN:ZDB-GENO-150127-1ZfishPMID:25201686
Biological ProcessGO:0021986habenula developmenttcf7l2IMPZFIN:ZDB-GENO-071217-3ZfishPMID:25201686
Biological ProcessGO:0021986habenula developmenttcf7l2IMPZFIN:ZDB-GENO-150127-2ZfishPMID:25201686
Biological ProcessGO:0001701in utero embryonic developmentTcf7l2IMPMGI:MGI:4431951MousePMID:27996060
Biological ProcessGO:1901142insulin metabolic processTcf7l2IMPMGI:MGI:1926344MousePMID:23260145
Biological ProcessGO:0060729intestinal epithelial structure maintenancetcf7l2IMPZFIN:ZDB-MRPHLNO-101207-4ZfishPMID:21103407
Biological ProcessGO:0001678intracellular glucose homeostasisTcf7l2IMPMGI:MGI:4431951MousePMID:23028378
Biological ProcessGO:0043570maintenance of DNA repeat elementsTCF7L2IMPHumanPMID:18755497
Biological ProcessGO:0035264multicellular organism growthTcf7l2IMPMGI:MGI:1926344MousePMID:23260145
Biological ProcessGO:0048625myoblast fate commitmentTCF7L2IDAHumanPMID:10937998
Biological ProcessGO:0048625myoblast fate commitmentTcf7l2IMPMousePMID:10937998
Biological ProcessGO:0030514negative regulation of BMP signaling pathwayTcf7l2IMPMGI:MGI:1926344MousePMID:17919533
Biological ProcessGO:0090090negative regulation of canonical Wnt signaling pathwayTCF7L2IMPHumanPMID:16532032
Biological ProcessGO:0043433negative regulation of DNA-binding transcription factor activityTCF7L2IDAHumanPMID:12799378
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionTCF7L2IDAHumanPMID:12799378
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionTCF7L2IDAHumanPMID:15525634
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionTCF7L2IMPHumanPMID:16532032
Biological ProcessGO:2001237negative regulation of extrinsic apoptotic signaling pathwayTcf7l2IMPRatPMID:21965303|RGD:14974246
Biological ProcessGO:0045599negative regulation of fat cell differentiationTcf7l2IMPMousePMID:10937998
Biological ProcessGO:0040037negative regulation of fibroblast growth factor receptor signaling pathwayTcf7l2IMPMGI:MGI:1926344MousePMID:17919533
Biological ProcessGO:0045721negative regulation of gluconeogenesisTcf7l2IMPRatPMID:21901280|RGD:152995490
Biological ProcessGO:0046621negative regulation of organ growthTcf7l2IMPMGI:MGI:1926344MousePMID:17919533
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IITCF7L2IDAHumanPMID:12799378
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IITcf7l2IMPMGI:MGI:1926344MousePMID:23260145
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IITcf7l2IMPRatPMID:21901280|RGD:152995490
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IITcf7l2IMPRatPMID:21965303|RGD:14974246
Biological ProcessGO:2000675negative regulation of type B pancreatic cell apoptotic processTcf7l2IMPRatPMID:21965303|RGD:14974246
Biological ProcessGO:0021915neural tube developmentTcf7l2IGIMGI:MGI:98507MousePMID:15057272
Biological ProcessGO:0042475odontogenesis of dentin-containing toothTcf7l2IGIMGI:MGI:96770MousePMID:17699607
Biological ProcessGO:0014003oligodendrocyte developmentTcf7l2IMPMGI:MGI:1926344MousePMID:19741146
Biological ProcessGO:0035265organ growthTcf7l2IMPMGI:MGI:1926344MousePMID:17919533
Biological ProcessGO:0021983pituitary gland developmentTcf7l2IMPMGI:MGI:1926344MousePMID:17919533
Biological ProcessGO:0043065positive regulation of apoptotic processTcf7l2IMPMGI:MGI:1926344MousePMID:17919533
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionTcf7l2IMPMouseMGI:MGI:4412432|PMID:19168596
Biological ProcessGO:0050679positive regulation of epithelial cell proliferationTCF7L2IMPHumanPMID:12408868
Biological ProcessGO:0050679positive regulation of epithelial cell proliferationTcf7l2IMPMGI:MGI:1926344MousePMID:19251639
Biological ProcessGO:0045722positive regulation of gluconeogenesisTcf7l2IMPMGI:MGI:5430317MousePMID:23260145
Biological ProcessGO:0010909positive regulation of heparan sulfate proteoglycan biosynthetic processTCF7L2IMPHumanPMID:15853773
Biological ProcessGO:0032024positive regulation of insulin secretionTCF7L2IMPHumanPMID:19386626
Biological ProcessGO:0032024positive regulation of insulin secretionTcf7l2IMPMouseMGI:MGI:4412432|PMID:19168596
Biological ProcessGO:0046889positive regulation of lipid biosynthetic processTcf7l2IMPMGI:MGI:1926344MousePMID:23260145
Biological ProcessGO:0032092positive regulation of protein bindingTCF7L2IDAHumanPMID:12799378
Biological ProcessGO:0051897positive regulation of protein kinase B signalingTCF7L2IMPHumanPMID:19386626
Biological ProcessGO:1900182positive regulation of protein localization to nucleusTCF7L2IMPHumanPMID:19386626
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IITCF7L2IDAHumanPMID:19168596
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IITCF7L2IDAHumanPMID:9065401
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IITcf7l2IDAMouseMGI:MGI:4947862|PMID:21335239
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IITcf7l2IDAMousePMID:20044351
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IITcf7l2IGIMGI:MGI:88276MousePMID:15778706
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IITcf7l2IDAMousePMID:23260145
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IITcf7l2IMPMGI:MGI:1926344MousePMID:23260145
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IITcf7l2IMPRatPMID:21965303|RGD:14974246
Biological ProcessGO:0010867positive regulation of triglyceride biosynthetic processTcf7l2IMPMGI:MGI:1926344MousePMID:23260145
Biological ProcessGO:0009791post-embryonic developmentTcf7l2IMPMGI:MGI:1926344MousePMID:23260145
Biological ProcessGO:0006355regulation of DNA-templated transcriptionTcf7l2IDAMousePMID:12861022
Biological ProcessGO:0006111regulation of gluconeogenesisTcf7l2IMPMGI:MGI:4431951MousePMID:23028378
Biological ProcessGO:0032350regulation of hormone metabolic processTCF7L2IDAHumanPMID:15525634
Biological ProcessGO:0061178regulation of insulin secretion involved in cellular response to glucose stimulusTcf7l2IMPMousePMID:19168596
Biological ProcessGO:0031641regulation of myelinationTcf7l2IMPMousePMID:19503085
Biological ProcessGO:0048713regulation of oligodendrocyte differentiationTcf7l2IMPMousePMID:19503085
Biological ProcessGO:0048641regulation of skeletal muscle tissue developmentTcf7l2IMPMGI:MGI:4881345MousePMID:21177349
Biological ProcessGO:0048660regulation of smooth muscle cell proliferationTCF7L2IMPHumanPMID:17122440
Biological ProcessGO:0006357regulation of transcription by RNA polymerase IITCF7L2IDAHumanPMID:9727977
Biological ProcessGO:0006357regulation of transcription by RNA polymerase IITcf7l2IMPMouseMGI:MGI:4412432|PMID:19168596
Biological ProcessGO:0009749response to glucoseTcf7l2IMPMouseMGI:MGI:4412432|PMID:19168596
Biological ProcessGO:0010226response to lithium iontcf7l2IMPZFIN:ZDB-MRPHLNO-061208-5ZfishPMID:27793772
Biological ProcessGO:0032252secretory granule localizationTcf7l2IMPMousePMID:19168596
Biological ProcessGO:0043588skin developmentTcf7l2IGIMGI:MGI:1202876MousePMID:19718027
Biological ProcessGO:0035019somatic stem cell population maintenanceTcf7l2IMPMGI:MGI:1926344MousePMID:10027409
Biological ProcessGO:0035019somatic stem cell population maintenanceTcf7l2IMPMGI:MGI:1926344MousePMID:9697701
Biological ProcessGO:0035019somatic stem cell population maintenanceTcf7l2IMPMGI:MGI:1926344MousePMID:19251639
Biological ProcessGO:0035019somatic stem cell population maintenanceTcf7l2IGIMGI:MGI:1202876MousePMID:19718027

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory