Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TCIRG1
  • Mouse genes Tcirg1
  • Rat genes Tcirg1
  • Zfish genes tcirg1a,tcirg1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tcirg1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	TCIRG1	IPI	UniProtKB:O43711	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TCIRG1	IPI	UniProtKB:Q7Z3K3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Tcirg1	IPI	PR:Q9ERI2|PR:P51150	Mouse	PMID:29712939
Cellular Component	GO:0016324	apical plasma membrane	TCIRG1	IDA		Human	PMID:15800125
Cellular Component	GO:0005770	late endosome	Tcirg1	IDA		Mouse	PMID:19549681
Cellular Component	GO:0005770	late endosome	Tcirg1	IDA		Mouse	PMID:12672822
Cellular Component	GO:0005765	lysosomal membrane	TCIRG1	HDA		Human	PMID:17897319
Cellular Component	GO:0005764	lysosome	Tcirg1	IDA		Mouse	PMID:19549681
Cellular Component	GO:0005764	lysosome	Tcirg1	IDA		Mouse	PMID:12672822
Cellular Component	GO:0005739	mitochondrion	Tcirg1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005634	nucleus	Tcirg1	IDA		Mouse	PMID:22245629
Cellular Component	GO:0045335	phagocytic vesicle	Tcirg1	IDA		Mouse	PMID:19549681
Cellular Component	GO:0030670	phagocytic vesicle membrane	Tcirg1	IDA		Mouse	PMID:19549681
Cellular Component	GO:0005886	plasma membrane	Tcirg1	IDA		Mouse	PMID:10722719
Cellular Component	GO:0005886	plasma membrane	Tcirg1	IDA		Mouse	PMID:12672822
Cellular Component	GO:0030667	secretory granule membrane	Tcirg1	IDA		Mouse	PMID:17046993
Biological Process	GO:0006915	apoptotic process	Tcirg1	IMP		Mouse	PMID:23908015
Biological Process	GO:0006915	apoptotic process	Tcirg1	IMP	MGI:MGI:5496553	Mouse	PMID:21305608
Biological Process	GO:0000045	autophagosome assembly	Tcirg1	IMP		Mouse	PMID:23908015
Biological Process	GO:0006914	autophagy	Tcirg1	IMP		Mouse	PMID:23908015
Biological Process	GO:0030183	B cell differentiation	Tcirg1	IMP	MGI:MGI:1856973	Mouse	PMID:15284856
Biological Process	GO:0030183	B cell differentiation	Tcirg1	IMP	MGI:MGI:1856973	Mouse	PMID:16797412
Biological Process	GO:0030183	B cell differentiation	Tcirg1	IMP	MGI:MGI:3054898	Mouse	PMID:15294947
Biological Process	GO:0045453	bone resorption	Tcirg1	IMP		Mouse	PMID:23908015
Biological Process	GO:0045453	bone resorption	Tcirg1	IMP		Mouse	PMID:23166162
Biological Process	GO:0045453	bone resorption	Tcirg1	IMP	MGI:MGI:5496553	Mouse	PMID:21305608
Biological Process	GO:0045453	bone resorption	Tcirg1	IMP	MGI:MGI:1856973	Mouse	PMID:22087326
Biological Process	GO:0045453	bone resorption	Tcirg1	IMP	MGI:MGI:1856973	Mouse	PMID:18768394
Biological Process	GO:0071345	cellular response to cytokine stimulus	Tcirg1	IMP	MGI:MGI:3054898	Mouse	PMID:15294947
Biological Process	GO:0097188	dentin mineralization	Tcirg1	IMP	MGI:MGI:1856973	Mouse	PMID:23174213
Biological Process	GO:0070166	enamel mineralization	Tcirg1	IMP	MGI:MGI:1856973	Mouse	PMID:23174213
Biological Process	GO:0030010	establishment of cell polarity	Tcirg1	IMP		Mouse	PMID:23908015
Biological Process	GO:0051650	establishment of vesicle localization	Tcirg1	IMP		Mouse	PMID:29712939
Biological Process	GO:0010467	gene expression	Tcirg1	IMP		Mouse	PMID:23908015
Biological Process	GO:0061484	hematopoietic stem cell homeostasis	Tcirg1	IMP	MGI:MGI:1856973	Mouse	PMID:22351931
Biological Process	GO:0048872	homeostasis of number of cells	Tcirg1	IMP	MGI:MGI:1856973	Mouse	PMID:22087326
Biological Process	GO:0048872	homeostasis of number of cells	Tcirg1	IMP	MGI:MGI:1856973	Mouse	PMID:22351931
Biological Process	GO:0016064	immunoglobulin mediated immune response	Tcirg1	IMP		Mouse	PMID:16542376
Biological Process	GO:0002377	immunoglobulin production	Tcirg1	IMP	MGI:MGI:3054898	Mouse	PMID:15294947
Biological Process	GO:0006954	inflammatory response	Tcirg1	IMP		Mouse	PMID:23166162
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Tcirg1	IMP	MGI:MGI:1856973	Mouse	PMID:19448635
Biological Process	GO:0051452	intracellular pH reduction	Tcirg1	IMP		Mouse	PMID:23908015
Biological Process	GO:0016236	macroautophagy	Tcirg1	IMP	MGI:MGI:1856973	Mouse	PMID:23704209
Biological Process	GO:0035709	memory T cell activation	Tcirg1	IMP		Mouse	PMID:16542376
Biological Process	GO:0030099	myeloid cell differentiation	Tcirg1	IMP	MGI:MGI:1856973	Mouse	PMID:15284856
Biological Process	GO:0042476	odontogenesis	Tcirg1	IMP	MGI:MGI:1856973	Mouse	PMID:22245629
Biological Process	GO:0021554	optic nerve development	Tcirg1	IMP	MGI:MGI:3852642	Mouse	PMID:20711468
Biological Process	GO:0001503	ossification	Tcirg1	IMP	MGI:MGI:1856973	Mouse	PMID:22087326
Biological Process	GO:0030316	osteoclast differentiation	Tcirg1	IMP		Mouse	PMID:23908015
Biological Process	GO:0030316	osteoclast differentiation	Tcirg1	IMP	MGI:MGI:1856973	Mouse	PMID:18768394
Biological Process	GO:0030316	osteoclast differentiation	Tcirg1	IMP	MGI:MGI:5496553	Mouse	PMID:21305608
Biological Process	GO:0030316	osteoclast differentiation	Tcirg1	IMP	MGI:MGI:1856973	Mouse	PMID:22245629
Biological Process	GO:0030316	osteoclast differentiation	Tcirg1	IMP		Mouse	PMID:23166162
Biological Process	GO:0002158	osteoclast proliferation	Tcirg1	IMP	MGI:MGI:1856973	Mouse	PMID:22087326
Biological Process	GO:0045851	pH reduction	Tcirg1	IMP		Mouse	PMID:23297412
Biological Process	GO:0045851	pH reduction	Tcirg1	IMP	MGI:MGI:1856973	Mouse	PMID:19448635
Biological Process	GO:0090383	phagosome acidification	Tcirg1	IMP	MGI:MGI:3852642	Mouse	PMID:19549681
Biological Process	GO:0007039	protein catabolic process in the vacuole	Tcirg1	IMP	MGI:MGI:1856973	Mouse	PMID:23704209
Biological Process	GO:0033365	protein localization to organelle	Tcirg1	IMP		Mouse	PMID:29712939
Biological Process	GO:0010468	regulation of gene expression	Tcirg1	IMP	MGI:MGI:3054898	Mouse	PMID:15294947
Biological Process	GO:0010468	regulation of gene expression	Tcirg1	IMP		Mouse	PMID:23297412
Biological Process	GO:0010468	regulation of gene expression	Tcirg1	IMP	MGI:MGI:5496553	Mouse	PMID:21305608
Biological Process	GO:0050796	regulation of insulin secretion	Tcirg1	IMP	MGI:MGI:1856973	Mouse	PMID:17046993
Biological Process	GO:0045667	regulation of osteoblast differentiation	Tcirg1	IMP	MGI:MGI:1856973	Mouse	PMID:22351931
Biological Process	GO:0010155	regulation of proton transport	Tcirg1	IMP	MGI:MGI:5496553	Mouse	PMID:21305608
Biological Process	GO:0010272	response to silver ion	Tcirg1	IMP	MGI:MGI:3054898	Mouse	PMID:15294947
Biological Process	GO:0060041	retina development in camera-type eye	Tcirg1	IMP	MGI:MGI:3852642	Mouse	PMID:20711468
Biological Process	GO:0031529	ruffle organization	Tcirg1	IMP		Mouse	PMID:23908015
Biological Process	GO:0030217	T cell differentiation	Tcirg1	IMP	MGI:MGI:3054898	Mouse	PMID:15294947
Biological Process	GO:0043029	T cell homeostasis	Tcirg1	IMP		Mouse	PMID:23166162
Biological Process	GO:0035711	T-helper 1 cell activation	Tcirg1	IMP	MGI:MGI:1856973	Mouse	PMID:15284856
Biological Process	GO:0044691	tooth eruption	Tcirg1	IMP	MGI:MGI:1856973	Mouse	PMID:22245629
Biological Process	GO:0032609	type II interferon production	Tcirg1	IMP	MGI:MGI:1856973	Mouse	PMID:15284856

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern