Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TDG
  • Mouse genes Tdg
  • Rat genes Tdg
  • Zfish genes tdg.1,tdg.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tdg

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	TDG	IDA		Human	PMID:11889051
Molecular Function	GO:0031404	chloride ion binding	TDG	IDA		Human	PMID:15959518
Molecular Function	GO:0003677	DNA binding	Tdg	IDA		Mouse	MGI:MGI:5287540|PMID:21817016
Molecular Function	GO:0019104	DNA N-glycosylase activity	TDG	IDA		Human	PMID:21862836
Molecular Function	GO:0019104	DNA N-glycosylase activity	TDG	IDA		Human	PMID:22327402
Molecular Function	GO:0019104	DNA N-glycosylase activity	Tdg	IDA		Mouse	MGI:MGI:5287540|PMID:21817016
Molecular Function	GO:0019104	DNA N-glycosylase activity	Tdg	IDA		Mouse	MGI:MGI:5141157|PMID:21722948
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Tdg	IPI	RGD:3866	Rat	PMID:11438542|RGD:634482
Molecular Function	GO:0003690	double-stranded DNA binding	TDG	IDA		Human	PMID:11889051
Molecular Function	GO:0003690	double-stranded DNA binding	TDG	IDA		Human	PMID:18512959
Molecular Function	GO:0003690	double-stranded DNA binding	TDG	IDA		Human	PMID:22327402
Molecular Function	GO:0043739	G/U mismatch-specific uracil-DNA glycosylase activity	TDG	IMP		Human	PMID:18512959
Molecular Function	GO:0000287	magnesium ion binding	TDG	IDA		Human	PMID:15959518
Molecular Function	GO:0030983	mismatched DNA binding	TDG	IDA		Human	PMID:11889051
Molecular Function	GO:0030983	mismatched DNA binding	TDG	IDA		Human	PMID:15959518
Molecular Function	GO:0030983	mismatched DNA binding	TDG	IDA		Human	PMID:16626738
Molecular Function	GO:0030983	mismatched DNA binding	TDG	IDA		Human	PMID:18512959
Molecular Function	GO:0030983	mismatched DNA binding	TDG	IDA		Human	PMID:22573813
Molecular Function	GO:0003676	nucleic acid binding	TDG	EXP		Human	PMID:18512959
Molecular Function	GO:0005515	protein binding	TDG	IPI	UniProtKB:P63165	Human	PMID:15959518
Molecular Function	GO:0005515	protein binding	TDG	IPI	UniProtKB:Q15788	Human	PMID:16282588
Molecular Function	GO:0005515	protein binding	TDG	IPI	UniProtKB:Q15788-2	Human	PMID:16282588
Molecular Function	GO:0005515	protein binding	TDG	IPI	UniProtKB:P61956	Human	PMID:16626738
Molecular Function	GO:0005515	protein binding	TDG	IPI	UniProtKB:P63165	Human	PMID:16763556
Molecular Function	GO:0005515	protein binding	TDG	IPI	UniProtKB:O88846	Human	PMID:20696907
Molecular Function	GO:0005515	protein binding	TDG	IPI	UniProtKB:P24522	Human	PMID:21722948
Molecular Function	GO:0005515	protein binding	TDG	IPI	UniProtKB:Q9GZX7	Human	PMID:21722948
Molecular Function	GO:0005515	protein binding	TDG	IPI	UniProtKB:D3DTS7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TDG	IPI	UniProtKB:O60333-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TDG	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TDG	IPI	UniProtKB:P02766	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TDG	IPI	UniProtKB:P04792	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TDG	IPI	UniProtKB:P07196	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TDG	IPI	UniProtKB:P28799	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TDG	IPI	UniProtKB:P37840	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TDG	IPI	UniProtKB:P60891	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TDG	IPI	UniProtKB:Q92870-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TDG	IPI	UniProtKB:Q9Y3C5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Tdg	IPI	UniProtKB:Q15788	Mouse	MGI:MGI:3610710|PMID:16282588
Molecular Function	GO:0005515	protein binding	Tdg	IPI	UniProtKB:B9EJ16	Mouse	PMID:18945672
Molecular Function	GO:0019904	protein domain specific binding	Tdg	IPI	RGD:3866	Rat	PMID:11438542|RGD:634482
Molecular Function	GO:0042803	protein homodimerization activity	TDG	IDA		Human	PMID:22327402
Molecular Function	GO:0005080	protein kinase C binding	Tdg	IPI	PR:P20444	Mouse	PMID:19966277
Molecular Function	GO:0043621	protein self-association	TDG	IDA		Human	PMID:18512959
Molecular Function	GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity	TDG	IDA		Human	PMID:11889051
Molecular Function	GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity	TDG	IMP		Human	PMID:18512959
Molecular Function	GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity	TDG	IDA		Human	PMID:22573813
Molecular Function	GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity	TDG	IDA		Human	PMID:8662714
Molecular Function	GO:0031402	sodium ion binding	TDG	IDA		Human	PMID:15959518
Molecular Function	GO:0032183	SUMO binding	TDG	IPI	UniProtKB:P63165	Human	PMID:15959518
Molecular Function	GO:0032183	SUMO binding	Tdg	IPI	UniProtKB:P63165	Mouse	PMID:15569683
Molecular Function	GO:0003712	transcription coregulator activity	Tdg	IGI	MGI:MGI:2384495	Mouse	PMID:18945672
Molecular Function	GO:0003712	transcription coregulator activity	Tdg	IGI	MGI:MGI:2137495	Mouse	PMID:18945672
Molecular Function	GO:0003712	transcription coregulator activity	Tdg	IGI	MGI:MGI:3050795	Mouse	PMID:18945672
Molecular Function	GO:0004844	uracil DNA N-glycosylase activity	TDG	IDA		Human	PMID:11889051
Cellular Component	GO:0005654	nucleoplasm	TDG	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	TDG	IDA		Human	PMID:11889051
Cellular Component	GO:0005634	nucleus	TDG	IDA		Human	PMID:8662714
Cellular Component	GO:0005634	nucleus	Tdg	IDA		Mouse	PMID:19966277
Cellular Component	GO:0005634	nucleus	Tdg	IDA		Mouse	PMID:15569683
Cellular Component	GO:0005634	nucleus	Tdg	IDA		Rat	PMID:9473709|RGD:1580607
Cellular Component	GO:0005886	plasma membrane	TDG	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016605	PML body	Tdg	IDA		Mouse	PMID:15569683
Biological Process	GO:0006284	base-excision repair	TDG	IDA		Human	PMID:21862836
Biological Process	GO:0006284	base-excision repair	TDG	IDA		Human	PMID:22327402
Biological Process	GO:0006284	base-excision repair	Tdg	IDA		Mouse	MGI:MGI:5287540|PMID:21817016
Biological Process	GO:0006285	base-excision repair, AP site formation	TDG	IDA		Human	PMID:11889051
Biological Process	GO:0006285	base-excision repair, AP site formation	TDG	IMP		Human	PMID:18512959
Biological Process	GO:0080111	DNA demethylation	Tdg	IMP		Mouse	MGI:MGI:5487523|PMID:21278727
Biological Process	GO:0080111	DNA demethylation	Tdg	IDA		Mouse	MGI:MGI:5287540|PMID:21817016
Biological Process	GO:0080111	DNA demethylation	Tdg	IMP		Mouse	MGI:MGI:5141157|PMID:21722948
Biological Process	GO:0040029	epigenetic regulation of gene expression	Tdg	IMP		Mouse	MGI:MGI:5141157|PMID:21722948
Biological Process	GO:0040029	epigenetic regulation of gene expression	Tdg	IMP		Mouse	MGI:MGI:5487523|PMID:21278727
Biological Process	GO:0006298	mismatch repair	TDG	IDA		Human	PMID:22573813
Biological Process	GO:0035562	negative regulation of chromatin binding	Tdg	IDA		Mouse	PMID:18945672
Biological Process	GO:0032091	negative regulation of protein binding	Tdg	IDA		Mouse	PMID:18945672
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Tdg	IGI	MGI:MGI:3050795	Mouse	PMID:18945672
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Tdg	IGI	MGI:MGI:2137495	Mouse	PMID:18945672
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Tdg	IMP		Mouse	PMID:18945672
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Tdg	IGI	MGI:MGI:2384495	Mouse	PMID:18945672
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Tdg	IDA		Rat	PMID:11438542|RGD:634482
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Tdg	IMP		Rat	PMID:18945672|RGD:2317183
Biological Process	GO:1902544	regulation of DNA N-glycosylase activity	TDG	IMP		Human	PMID:18512959
Biological Process	GO:0045995	regulation of embryonic development	Tdg	IMP		Mouse	MGI:MGI:5487523|PMID:21278727
Biological Process	GO:0045995	regulation of embryonic development	Tdg	IMP		Mouse	MGI:MGI:5141157|PMID:21722948

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern