Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TDP1
  • Mouse genes Tdp1
  • Rat genes Tdp1
  • Zfish genes tdp1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tdp1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0017005	3'-tyrosyl-DNA phosphodiesterase activity	TDP1	IDA		Human	PMID:17118488
Molecular Function	GO:0017005	3'-tyrosyl-DNA phosphodiesterase activity	TDP1	IDA		Human	PMID:17576665
Molecular Function	GO:0017005	3'-tyrosyl-DNA phosphodiesterase activity	TDP1	IDA		Human	PMID:17948061
Molecular Function	GO:0017005	3'-tyrosyl-DNA phosphodiesterase activity	TDP1	IDA		Human	PMID:22822062
Molecular Function	GO:0003690	double-stranded DNA binding	TDP1	IDA		Human	PMID:15811850
Molecular Function	GO:0090580	phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands	tdp1	IMP	ZFIN:ZDB-GENO-220909-3	Zfish	PMID:33514542
Molecular Function	GO:0090580	phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands	tdp1	IMP	ZFIN:ZDB-GENO-220909-1	Zfish	PMID:33514542
Molecular Function	GO:0005515	protein binding	TDP1	IPI	UniProtKB:P49916	Human	PMID:15744309
Molecular Function	GO:0005515	protein binding	TDP1	IPI	UniProtKB:P18887	Human	PMID:19851285
Molecular Function	GO:0005515	protein binding	TDP1	IPI	UniProtKB:P18887	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	TDP1	IPI	UniProtKB:A4FUJ8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TDP1	IPI	UniProtKB:O75925	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TDP1	IPI	UniProtKB:P46379-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TDP1	IPI	UniProtKB:Q08AM6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TDP1	IPI	UniProtKB:Q15554-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TDP1	IPI	UniProtKB:Q6ZNA4-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TDP1	IPI	UniProtKB:Q8IUW3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TDP1	IPI	UniProtKB:Q8N488	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TDP1	IPI	UniProtKB:Q9BYZ2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TDP1	IPI	UniProtKB:Q9H816	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TDP1	IPI	UniProtKB:Q9NS23-4	Human	PMID:32814053
Molecular Function	GO:0003697	single-stranded DNA binding	TDP1	IDA		Human	PMID:15811850
Cellular Component	GO:0005737	cytoplasm	TDP1	IDA		Human	PMID:17948061
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	TDP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	TDP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Tdp1	IDA		Mouse	PMID:17948061
Cellular Component	GO:0005886	plasma membrane	TDP1	IDA		Human	GO_REF:0000052
Biological Process	GO:0008344	adult locomotory behavior	tdp1	IMP	ZFIN:ZDB-GENO-220909-3	Zfish	PMID:33514542
Biological Process	GO:0006281	DNA repair	TDP1	IDA		Human	PMID:17948061
Biological Process	GO:0006281	DNA repair	Tdp1	IMP		Mouse	PMID:21390131
Biological Process	GO:0006302	double-strand break repair	TDP1	IDA		Human	PMID:12023295
Biological Process	GO:0000012	single strand break repair	TDP1	IDA		Human	PMID:15811850
Biological Process	GO:0000012	single strand break repair	TDP1	IMP		Human	PMID:17600775
Biological Process	GO:0000012	single strand break repair	Tdp1	IMP	MGI:MGI:3818340	Mouse	PMID:17948061
Biological Process	GO:0000012	single strand break repair	Tdp1	IMP	MGI:MGI:3818340	Mouse	PMID:17914460

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern