Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TEK
  • Mouse genes Tek
  • Rat genes Tek
  • Zfish genes tek
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tek

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019838	growth factor binding	Tek	IPI	RGD:628896	Rat	PMID:15714275|RGD:1578337
Molecular Function	GO:0042802	identical protein binding	TEK	IPI	UniProtKB:Q02763	Human	PMID:19424712
Molecular Function	GO:0005515	protein binding	TEK	IPI	UniProtKB:O15123-1	Human	PMID:15893672
Molecular Function	GO:0005515	protein binding	TEK	IPI	UniProtKB:Q06124	Human	PMID:15985432
Molecular Function	GO:0005515	protein binding	TEK	IPI	UniProtKB:O15123-1	Human	PMID:16732286
Molecular Function	GO:0005515	protein binding	TEK	IPI	UniProtKB:P08575	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	TEK	IPI	UniProtKB:P23467	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	TEK	IPI	UniProtKB:Q05209	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	TEK	IPI	UniProtKB:Q12913	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	TEK	IPI	UniProtKB:Q15262	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	TEK	IPI	UniProtKB:Q16827	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	TEK	IPI	UniProtKB:P23467	Human	PMID:19451274
Molecular Function	GO:0005515	protein binding	TEK	IPI	UniProtKB:O15123	Human	PMID:19922791
Molecular Function	GO:0005515	protein binding	TEK	IPI	UniProtKB:Q15389	Human	PMID:19922791
Molecular Function	GO:0005515	protein binding	TEK	IPI	UniProtKB:O15123	Human	PMID:20708158
Molecular Function	GO:0005515	protein binding	TEK	IPI	UniProtKB:Q15389	Human	PMID:20708158
Molecular Function	GO:0005515	protein binding	TEK	IPI	UniProtKB:Q16678	Human	PMID:28620713
Molecular Function	GO:0005515	protein binding	TEK	IPI	UniProtKB:Q15389	Human	PMID:29106382
Molecular Function	GO:0005515	protein binding	TEK	IPI	UniProtKB:Q15389	Human	PMID:8980223
Molecular Function	GO:0005515	protein binding	Tek	IPI	UniProtKB:B2RU80	Mouse	MGI:MGI:4412467|PMID:10557082
Molecular Function	GO:0005515	protein binding	Tek	IPI	UniProtKB:Q03160|UniProtKB:Q60631	Mouse	MGI:MGI:5508745|PMID:10521483
Molecular Function	GO:0005515	protein binding	Tek	IPI	PR:O35608	Mouse	PMID:9204896
Molecular Function	GO:0005515	protein binding	Tek	IPI	PR:Q99JG7	Mouse	PMID:20060382
Molecular Function	GO:0004713	protein tyrosine kinase activity	TEK	IDA		Human	PMID:11513602
Molecular Function	GO:0004713	protein tyrosine kinase activity	Tek	IDA		Mouse	MGI:MGI:68132|PMID:7958865
Molecular Function	GO:0038023	signaling receptor activity	Tek	IPI	PR:O08538	Mouse	PMID:8980223
Cellular Component	GO:0005884	actin filament	TEK	IDA		Human	PMID:18425119
Cellular Component	GO:0016324	apical plasma membrane	TEK	IDA		Human	PMID:19424712
Cellular Component	GO:0009925	basal plasma membrane	TEK	IDA		Human	PMID:18425120
Cellular Component	GO:0016323	basolateral plasma membrane	TEK	IDA		Human	PMID:19424712
Cellular Component	GO:0009986	cell surface	TEK	IDA		Human	PMID:19689429
Cellular Component	GO:0005911	cell-cell junction	TEK	IDA		Human	PMID:18425120
Cellular Component	GO:0034451	centriolar satellite	TEK	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045121	membrane raft	TEK	IDA		Human	PMID:19615361
Cellular Component	GO:0005902	microvillus	TEK	IDA		Human	PMID:19424712
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Tek	IDA		Mouse	PMID:20060382
Cellular Component	GO:0005886	plasma membrane	TEK	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	TEK	IDA		Human	PMID:19689429
Cellular Component	GO:0001725	stress fiber	TEK	IDA		Human	PMID:18425119
Biological Process	GO:0001525	angiogenesis	Tek	IMP		Mouse	MGI:MGI:74274|PMID:7596437
Biological Process	GO:0001525	angiogenesis	Tek	IMP	MGI:MGI:2159357	Mouse	PMID:9846489
Biological Process	GO:0001525	angiogenesis	tek	IGI	ZFIN:ZDB-MRPHLNO-050513-12,ZFIN:ZDB-MRPHLNO-151026-1	Zfish	PMID:25001479
Biological Process	GO:0001525	angiogenesis	tek	IMP	ZFIN:ZDB-MRPHLNO-151026-1	Zfish	PMID:25001479
Biological Process	GO:0098609	cell-cell adhesion	Tek	IMP	MGI:MGI:2159358	Mouse	PMID:9683559
Biological Process	GO:0007160	cell-matrix adhesion	Tek	IMP	MGI:MGI:2159358	Mouse	PMID:9683559
Biological Process	GO:0001958	endochondral ossification	Tek	IEP		Rat	PMID:11735002|RGD:1601509
Biological Process	GO:0001935	endothelial cell proliferation	Tek	IMP		Mouse	MGI:MGI:68132|PMID:7958865
Biological Process	GO:0072012	glomerulus vasculature development	Tek	IMP		Rat	PMID:20056745|RGD:8554659
Biological Process	GO:0007507	heart development	Tek	IMP		Mouse	MGI:MGI:68132|PMID:7958865
Biological Process	GO:0007507	heart development	tek	IGI	ZFIN:ZDB-GENO-110210-1,ZFIN:ZDB-MRPHLNO-110113-3	Zfish	PMID:21045210
Biological Process	GO:0060347	heart trabecula formation	Tek	IMP		Mouse	MGI:MGI:68132|PMID:7958865
Biological Process	GO:0030097	hemopoiesis	Tek	IMP	MGI:MGI:2159357	Mouse	PMID:9846489
Biological Process	GO:0030097	hemopoiesis	Tek	IMP		Mouse	PMID:15260986
Biological Process	GO:0016525	negative regulation of angiogenesis	TEK	IMP		Human	PMID:18425120
Biological Process	GO:0043066	negative regulation of apoptotic process	Tek	IGI	MGI:MGI:108448	Mouse	PMID:19409199
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	Tek	IMP		Mouse	MGI:MGI:3691072|PMID:11375937
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	TEK	IDA		Human	PMID:11513602
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Tek	IDA		Mouse	MGI:MGI:68132|PMID:7958865
Biological Process	GO:2000251	positive regulation of actin cytoskeleton reorganization	TEK	IMP		Human	PMID:12816861
Biological Process	GO:0045766	positive regulation of angiogenesis	TEK	IDA		Human	PMID:15284220
Biological Process	GO:0045766	positive regulation of angiogenesis	TEK	IMP		Human	PMID:18425120
Biological Process	GO:0045766	positive regulation of angiogenesis	Tek	IMP		Rat	PMID:9329972|RGD:1601511
Biological Process	GO:0045785	positive regulation of cell adhesion	Tek	IMP		Mouse	PMID:15260986
Biological Process	GO:0002720	positive regulation of cytokine production involved in immune response	Tek	IDA		Mouse	PMID:20060382
Biological Process	GO:0010595	positive regulation of endothelial cell migration	TEK	IMP		Human	PMID:12816861
Biological Process	GO:0010595	positive regulation of endothelial cell migration	TEK	IDA		Human	PMID:15284220
Biological Process	GO:0010595	positive regulation of endothelial cell migration	TEK	IMP		Human	PMID:18425120
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	TEK	IMP		Human	PMID:18425120
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	TEK	IDA		Human	PMID:19615361
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	TEK	IMP		Human	PMID:18425120
Biological Process	GO:1902533	positive regulation of intracellular signal transduction	TEK	IMP		Human	PMID:19223473
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	Tek	IGI	MGI:MGI:108448	Mouse	PMID:19409199
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	TEK	IMP		Human	PMID:12816861
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	TEK	IMP		Human	PMID:18425120
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	TEK	IMP		Human	PMID:12816861
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	TEK	IMP		Human	PMID:18425120
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	TEK	IMP		Human	PMID:19223473
Biological Process	GO:0042307	positive regulation of protein import into nucleus	Tek	IDA		Mouse	PMID:20060382
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	TEK	IMP		Human	PMID:18425120
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	TEK	IDA		Human	PMID:19615361
Biological Process	GO:0001934	positive regulation of protein phosphorylation	TEK	IDA		Human	PMID:15284220
Biological Process	GO:0001934	positive regulation of protein phosphorylation	TEK	IMP		Human	PMID:15985432
Biological Process	GO:0001934	positive regulation of protein phosphorylation	TEK	IMP		Human	PMID:18425120
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Tek	IDA		Mouse	PMID:20060382
Biological Process	GO:0046777	protein autophosphorylation	TEK	IDA		Human	PMID:11513602
Biological Process	GO:0045765	regulation of angiogenesis	Tek	IMP	MGI:MGI:2159358	Mouse	PMID:9683559
Biological Process	GO:0030334	regulation of cell migration	Tek	IMP	MGI:MGI:2159358	Mouse	PMID:9683559
Biological Process	GO:0030334	regulation of cell migration	Tek	IDA		Mouse	PMID:20060382
Biological Process	GO:0032878	regulation of establishment or maintenance of cell polarity	TEK	IMP		Human	PMID:18425119
Biological Process	GO:1901222	regulation of NIK/NF-kappaB signaling	Tek	IGI	MGI:MGI:108448	Mouse	PMID:20060382
Biological Process	GO:0051591	response to cAMP	Tek	IEP		Rat	PMID:11397875|RGD:1601510
Biological Process	GO:0043627	response to estrogen	Tek	IDA		Rat	PMID:11856554|RGD:631873
Biological Process	GO:0001666	response to hypoxia	Tek	IDA		Rat	PMID:11504684|RGD:628494
Biological Process	GO:0010033	response to organic substance	Tek	IEP		Rat	PMID:16762501|RGD:1601492
Biological Process	GO:0043434	response to peptide hormone	Tek	IEP		Rat	PMID:15945074|RGD:1601495
Biological Process	GO:0032526	response to retinoic acid	Tek	IDA		Mouse	MGI:MGI:3799604|PMID:18439490
Biological Process	GO:0002040	sprouting angiogenesis	TEK	IMP		Human	PMID:14665640
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	TEK	IMP		Human	PMID:18425119
Biological Process	GO:0048014	Tie signaling pathway	TEK	IDA		Human	PMID:15284220
Biological Process	GO:0048014	Tie signaling pathway	TEK	IDA		Human	PMID:19223473
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	TEK	IDA		Human	PMID:15284220
Biological Process	GO:0001570	vasculogenesis	Tek	IMP		Mouse	MGI:MGI:68132|PMID:7958865

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern