Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TERT
  • Mouse genes Tert
  • Rat genes Tert
  • Zfish genes tert
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tert

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	TERT	IDA		Human	PMID:21937513
Molecular Function	GO:0042802	identical protein binding	TERT	IPI	UniProtKB:O14746	Human	PMID:23474713
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:Q96BK5	Human	PMID:11701125
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:P12956	Human	PMID:12377759
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:P13010	Human	PMID:12377759
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:Q86US8	Human	PMID:12699629
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:Q9UPR3	Human	PMID:12699629
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:Q96EZ8-2	Human	PMID:15044100
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:Q96BK5	Human	PMID:15381700
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:O14773-1	Human	PMID:17237767
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:Q96AP0	Human	PMID:17237767
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:Q86US8	Human	PMID:17940095
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:Q9H0A0	Human	PMID:18082603
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:Q9Y265	Human	PMID:18358808
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:Q9BUR4	Human	PMID:19179534
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:Q9NVN8	Human	PMID:19487455
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:P29590-5	Human	PMID:19567472
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:P35222	Human	PMID:19571879
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:P51532	Human	PMID:19571879
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:P03126	Human	PMID:19843693
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:Q96BK5	Human	PMID:21119197
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:Q92900	Human	PMID:21829167
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:Q9H2U1	Human	PMID:21846770
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:Q86US8	Human	PMID:22011238
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:O15381	Human	PMID:22226966
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:P51532	Human	PMID:24550003
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:Q9BVP2	Human	PMID:24550003
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:Q96AP0	Human	PMID:25172512
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:Q9BQ15	Human	PMID:25589350
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:P06748	Human	PMID:28255170
Molecular Function	GO:0005515	protein binding	TERT	IPI	UniProtKB:Q96BK5	Human	PMID:28255170
Molecular Function	GO:0005515	protein binding	Tert	IPI	UniProtKB:Q3TKT4	Mouse	MGI:MGI:3850567|PMID:19571879
Molecular Function	GO:0005515	protein binding	Tert	IPI	PR:P17809	Mouse	PMID:24970747
Molecular Function	GO:0005515	protein binding	Tert	IPI	PR:P14142	Mouse	PMID:24970747
Molecular Function	GO:0005515	protein binding	Tert	IPI	PR:Q8BFW9	Mouse	PMID:24970747
Molecular Function	GO:0005515	protein binding	Tert	IPI	PR:Q80SX8-1	Mouse	PMID:17130244
Molecular Function	GO:0005515	protein binding	Tert	IPI	UniProtKB:A7VJC2	Rat	PMID:23184978|RGD:11567256
Molecular Function	GO:0042803	protein homodimerization activity	TERT	IDA		Human	PMID:11432839
Molecular Function	GO:0042803	protein homodimerization activity	TERT	IPI	UniProtKB:O14746	Human	PMID:23474713
Molecular Function	GO:0051087	protein-folding chaperone binding	TERT	IPI	UniProtKB:G1TGF1	Human	PMID:10197982
Molecular Function	GO:0051087	protein-folding chaperone binding	TERT	IPI	UniProtKB:P07900	Human	PMID:10197982
Molecular Function	GO:0051087	protein-folding chaperone binding	TERT	IPI	UniProtKB:P08238	Human	PMID:10197982
Molecular Function	GO:0051087	protein-folding chaperone binding	TERT	IPI	UniProtKB:Q15185	Human	PMID:10197982
Molecular Function	GO:0051087	protein-folding chaperone binding	TERT	IPI	UniProtKB:Q9R0Q7	Human	PMID:10197982
Molecular Function	GO:0051087	protein-folding chaperone binding	TERT	IPI	UniProtKB:P07900	Human	PMID:19751963
Molecular Function	GO:0051087	protein-folding chaperone binding	TERT	IPI	UniProtKB:P08238	Human	PMID:19751963
Molecular Function	GO:0051087	protein-folding chaperone binding	TERT	IPI	UniProtKB:Q15185	Human	PMID:19751963
Molecular Function	GO:0003723	RNA binding	TERT	IPI	RNAcentral:URS00004416C5_9606	Human	PMID:16507993
Molecular Function	GO:0003723	RNA binding	TERT	IPI	RNAcentral:URS00004416C5_9606	Human	PMID:17940095
Molecular Function	GO:0003723	RNA binding	TERT	IPI	RNAcentral:URS00004416C5_9606	Human	PMID:18082603
Molecular Function	GO:0003723	RNA binding	TERT	IPI	RNAcentral:URS00004416C5_9606	Human	PMID:19701182
Molecular Function	GO:0003723	RNA binding	TERT	IPI	RNAcentral:URS00004416C5_9606	Human	PMID:20351177
Molecular Function	GO:0003723	RNA binding	Tert	IPI	RNAcentral:URS00004416C5_9606	Mouse	MGI:MGI:5700305|PMID:16507993
Molecular Function	GO:0003968	RNA-dependent RNA polymerase activity	TERT	IDA		Human	PMID:19701182
Molecular Function	GO:0003964	RNA-directed DNA polymerase activity	TERT	IDA		Human	PMID:21937513
Molecular Function	GO:0003720	telomerase activity	TERT	IDA		Human	PMID:12135483
Molecular Function	GO:0003720	telomerase activity	TERT	IDA		Human	PMID:16043710
Molecular Function	GO:0003720	telomerase activity	TERT	IDA		Human	PMID:16507993
Molecular Function	GO:0003720	telomerase activity	TERT	IDA		Human	PMID:17940095
Molecular Function	GO:0003720	telomerase activity	TERT	IDA		Human	PMID:18082603
Molecular Function	GO:0003720	telomerase activity	TERT	IDA		Human	PMID:21531765
Molecular Function	GO:0003720	telomerase activity	TERT	IDA		Human	PMID:29695869
Molecular Function	GO:0003720	telomerase activity	TERT	IDA		Human	PMID:9398860
Molecular Function	GO:0003720	telomerase activity	TERT	IDA		Human	PMID:9443919
Molecular Function	GO:0003720	telomerase activity	Tert	IDA		Mouse	PMID:14701760
Molecular Function	GO:0003720	telomerase activity	tert	IMP	ZFIN:ZDB-FISH-150901-14193	Zfish	PMID:32117990
Molecular Function	GO:0003720	telomerase activity	tert	IMP	ZFIN:ZDB-MRPHLNO-090505-1	Zfish	PMID:18846223
Molecular Function	GO:0003720	telomerase activity	tert	IMP	ZFIN:ZDB-GENO-130225-1	Zfish	PMID:23349637
Molecular Function	GO:0003720	telomerase activity	tert	IMP	ZFIN:ZDB-MRPHLNO-090505-2	Zfish	PMID:18846223
Molecular Function	GO:0070034	telomerase RNA binding	TERT	IDA		Human	PMID:11432839
Molecular Function	GO:0070034	telomerase RNA binding	TERT	IPI	RNAcentral:URS00004A7003_9606	Human	PMID:16507993
Molecular Function	GO:0070034	telomerase RNA binding	TERT	IPI	RNAcentral:URS00004A7003_9606	Human	PMID:17940095
Molecular Function	GO:0070034	telomerase RNA binding	TERT	IPI	RNAcentral:URS00004A7003_9606	Human	PMID:18082603
Molecular Function	GO:0070034	telomerase RNA binding	TERT	IPI	RNAcentral:URS00004A7003_9606	Human	PMID:19701182
Molecular Function	GO:0070034	telomerase RNA binding	TERT	IPI	RNAcentral:URS00004A7003_9606	Human	PMID:20351177
Molecular Function	GO:0070034	telomerase RNA binding	Tert	IPI	RNAcentral:URS00004A7003_9606	Mouse	MGI:MGI:5700305|PMID:16507993
Molecular Function	GO:0003721	telomerase RNA reverse transcriptase activity	TERT	IMP		Human	PMID:11313459
Molecular Function	GO:0003721	telomerase RNA reverse transcriptase activity	TERT	IDA		Human	PMID:15632080
Molecular Function	GO:0003721	telomerase RNA reverse transcriptase activity	TERT	IDA		Human	PMID:17940095
Molecular Function	GO:0003721	telomerase RNA reverse transcriptase activity	TERT	IDA		Human	PMID:19701182
Molecular Function	GO:0003721	telomerase RNA reverse transcriptase activity	TERT	IDA		Human	PMID:9398860
Molecular Function	GO:0098680	template-free RNA nucleotidyltransferase	TERT	IDA		Human	PMID:19701182
Molecular Function	GO:0001223	transcription coactivator binding	TERT	IPI	UniProtKB:P51532	Human	PMID:19571879
Molecular Function	GO:0001223	transcription coactivator binding	Tert	IPI	UniProtKB:Q3TKT4	Mouse	MGI:MGI:3850567|PMID:19571879
Molecular Function	GO:0000049	tRNA binding	TERT	IDA		Human	PMID:21937513
Cellular Component	GO:0000781	chromosome, telomeric region	TERT	IDA		Human	PMID:25589350
Cellular Component	GO:0005737	cytoplasm	Tert	IDA		Mouse	PMID:24970747
Cellular Component	GO:0005737	cytoplasm	Tert	IDA		Rat	PMID:11485973|RGD:2291978
Cellular Component	GO:0005829	cytosol	TERT	IDA		Human	GO_REF:0000052
Cellular Component	GO:0042645	mitochondrial nucleoid	TERT	IDA		Human	PMID:21937513
Cellular Component	GO:0005739	mitochondrion	Tert	IDA		Mouse	MGI:MGI:5607222|PMID:21937513
Cellular Component	GO:0005739	mitochondrion	Tert	IDA		Rat	PMID:21937513|RGD:10047279
Cellular Component	GO:0016607	nuclear speck	TERT	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	TERT	IDA		Human	PMID:22226966
Cellular Component	GO:0005654	nucleoplasm	TERT	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	TERT	IDA		Human	PMID:19567472
Cellular Component	GO:0005634	nucleus	TERT	IDA		Human	PMID:21829167
Cellular Component	GO:0005634	nucleus	TERT	IDA		Human	PMID:24415760
Cellular Component	GO:0005634	nucleus	Tert	IDA		Rat	PMID:11485973|RGD:2291978
Cellular Component	GO:0005634	nucleus	tert	IDA		Zfish	PMID:18157659
Cellular Component	GO:0005886	plasma membrane	Tert	IDA		Mouse	PMID:24970747
Cellular Component	GO:0016605	PML body	TERT	IDA		Human	PMID:19567472
Cellular Component	GO:0031379	RNA-directed RNA polymerase complex	TERT	IPI	RNAcentral:URS000075C8FA_9606	Human	PMID:19701182
Cellular Component	GO:0000333	telomerase catalytic core complex	TERT	IMP		Human	PMID:11313459
Cellular Component	GO:0000333	telomerase catalytic core complex	TERT	IDA		Human	PMID:16507993
Cellular Component	GO:0000333	telomerase catalytic core complex	TERT	IDA		Human	PMID:17940095
Cellular Component	GO:0000333	telomerase catalytic core complex	TERT	IDA		Human	PMID:18082603
Cellular Component	GO:0000333	telomerase catalytic core complex	TERT	IPI	RNAcentral:URS00004A7003_9606	Human	PMID:19701182
Cellular Component	GO:0000333	telomerase catalytic core complex	TERT	IDA		Human	PMID:9398860
Cellular Component	GO:0000333	telomerase catalytic core complex	TERT	IDA		Human	PMID:9443919
Cellular Component	GO:0000333	telomerase catalytic core complex	Tert	IMP		Mouse	MGI:MGI:3588604|PMID:16037417
Cellular Component	GO:0005697	telomerase holoenzyme complex	TERT	IDA		Human	PMID:12135483
Cellular Component	GO:0005697	telomerase holoenzyme complex	TERT	IDA		Human	PMID:18082603
Cellular Component	GO:0005697	telomerase holoenzyme complex	TERT	IPI	RNAcentral:URS00004A7003_9606	Human	PMID:19701182
Cellular Component	GO:0005697	telomerase holoenzyme complex	TERT	IDA		Human	PMID:29695869
Cellular Component	GO:1990572	TERT-RMRP complex	TERT	IPI		Human	PMID:19701182
Cellular Component	GO:1990572	TERT-RMRP complex	TERT	IDA		Human	PMID:19701182
Biological Process	GO:0071456	cellular response to hypoxia	TERT	IMP		Human	PMID:11313459
Biological Process	GO:0071456	cellular response to hypoxia	Tert	IEP		Rat	PMID:24376652|RGD:11038675
Biological Process	GO:0071897	DNA biosynthetic process	TERT	IDA		Human	PMID:19701182
Biological Process	GO:0071897	DNA biosynthetic process	TERT	IDA		Human	PMID:9398860
Biological Process	GO:0022616	DNA strand elongation	TERT	IDA		Human	PMID:16043710
Biological Process	GO:0043249	erythrocyte maturation	tert	IMP	ZFIN:ZDB-MRPHLNO-090505-1	Zfish	PMID:18846223
Biological Process	GO:0043249	erythrocyte maturation	tert	IMP	ZFIN:ZDB-MRPHLNO-090505-2	Zfish	PMID:18846223
Biological Process	GO:0070200	establishment of protein localization to telomere	TERT	IDA		Human	PMID:25589350
Biological Process	GO:0030097	hemopoiesis	tert	IMP	ZFIN:ZDB-GENO-130225-1	Zfish	PMID:23349637
Biological Process	GO:0060729	intestinal epithelial structure maintenance	tert	IMP	ZFIN:ZDB-GENO-130225-1	Zfish	PMID:23349637
Biological Process	GO:0060729	intestinal epithelial structure maintenance	tert	IGI	ZFIN:ZDB-GENO-130308-4	Zfish	PMID:23349637
Biological Process	GO:0007005	mitochondrion organization	TERT	IDA		Human	PMID:21937513
Biological Process	GO:0043066	negative regulation of apoptotic process	Tert	IMP		Rat	PMID:20138964|RGD:11038674
Biological Process	GO:2000773	negative regulation of cellular senescence	TERT	IMP		Human	PMID:11313459
Biological Process	GO:2000773	negative regulation of cellular senescence	TERT	IDA		Human	PMID:11927518
Biological Process	GO:2000773	negative regulation of cellular senescence	tert	IMP	ZFIN:ZDB-GENO-130225-1	Zfish	PMID:26789415
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	Tert	IDA		Rat	PMID:23013219|RGD:11038770
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	TERT	IMP		Human	PMID:10449030
Biological Process	GO:0010629	negative regulation of gene expression	TERT	IDA		Human	PMID:11927518
Biological Process	GO:0060253	negative regulation of glial cell proliferation	Tert	IDA		Rat	PMID:21940960|RGD:11038672
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Tert	IMP		Rat	PMID:23968592|RGD:11038670
Biological Process	GO:0045766	positive regulation of angiogenesis	Tert	IDA		Rat	PMID:23013219|RGD:11038770
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	Tert	IMP		Rat	PMID:24376652|RGD:11038675
Biological Process	GO:0046326	positive regulation of glucose import	Tert	IMP		Mouse	PMID:24970747
Biological Process	GO:0042635	positive regulation of hair cycle	Tert	IMP		Mouse	MGI:MGI:3589051|PMID:16107853
Biological Process	GO:0042635	positive regulation of hair cycle	Tert	IMP		Mouse	MGI:MGI:3588604|PMID:16037417
Biological Process	GO:1902895	positive regulation of miRNA transcription	TERT	IMP		Human	PMID:25569094
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	TERT	IDA		Human	PMID:11927518
Biological Process	GO:0032092	positive regulation of protein binding	TERT	IDA		Human	PMID:24415760
Biological Process	GO:1904751	positive regulation of protein localization to nucleolus	TERT	IDA		Human	PMID:24415760
Biological Process	GO:2000648	positive regulation of stem cell proliferation	Tert	IMP		Mouse	MGI:MGI:3588604|PMID:16037417
Biological Process	GO:2000648	positive regulation of stem cell proliferation	Tert	IMP		Mouse	MGI:MGI:3589051|PMID:16107853
Biological Process	GO:1903620	positive regulation of transdifferentiation	Tert	IMP		Rat	PMID:24376652|RGD:11038675
Biological Process	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	Tert	IMP		Rat	PMID:24376652|RGD:11038675
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	Tert	IMP		Rat	PMID:24376652|RGD:11038675
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	TERT	IGI	UniProtKB:O70372	Human	PMID:19571879
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	Tert	IGI	UniProtKB:O88566	Mouse	MGI:MGI:3850567|PMID:19571879
Biological Process	GO:0031647	regulation of protein stability	TERT	IDA		Human	PMID:24415760
Biological Process	GO:0031647	regulation of protein stability	TERT	IDA		Human	PMID:26194824
Biological Process	GO:0031647	regulation of protein stability	TERT	IMP		Human	PMID:26194824
Biological Process	GO:0090399	replicative senescence	TERT	IMP		Human	PMID:9454332
Biological Process	GO:0046686	response to cadmium ion	Tert	IEP		Rat	PMID:21181359|RGD:11038678
Biological Process	GO:0006278	RNA-templated DNA biosynthetic process	TERT	IDA		Human	PMID:9398860
Biological Process	GO:0001172	RNA-templated transcription	TERT	IDA		Human	PMID:19701182
Biological Process	GO:0030422	siRNA processing	TERT	IDA		Human	PMID:19701182
Biological Process	GO:0140745	siRNA transcription	TERT	IDA		Human	PMID:19701182
Biological Process	GO:0007283	spermatogenesis	tert	IGI	ZFIN:ZDB-GENO-130308-4	Zfish	PMID:23349637
Biological Process	GO:0007283	spermatogenesis	tert	IMP	ZFIN:ZDB-GENO-130225-1	Zfish	PMID:23349637
Biological Process	GO:0007004	telomere maintenance via telomerase	TERT	IDA		Human	PMID:16043710
Biological Process	GO:0007004	telomere maintenance via telomerase	TERT	IDA		Human	PMID:17940095
Biological Process	GO:0007004	telomere maintenance via telomerase	TERT	IDA		Human	PMID:19701182
Biological Process	GO:0007004	telomere maintenance via telomerase	TERT	IDA		Human	PMID:21531765
Biological Process	GO:0007004	telomere maintenance via telomerase	TERT	IDA		Human	PMID:29695869
Biological Process	GO:0007004	telomere maintenance via telomerase	TERT	IDA		Human	PMID:9443919
Biological Process	GO:0007004	telomere maintenance via telomerase	TERT	IMP		Human	PMID:9454332
Biological Process	GO:0007004	telomere maintenance via telomerase	tert	IMP	ZFIN:ZDB-GENO-131125-2	Zfish	PMID:23744274

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern