Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TESC
  • Mouse genes Tesc
  • Rat genes Tesc
  • Zfish genes tesca,tescb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tesc

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	TESC	IDA		Human	PMID:11696366
Molecular Function	GO:0005509	calcium ion binding	TESC	IDA		Human	PMID:21553168
Molecular Function	GO:0005509	calcium ion binding	Tesc	IDA		Mouse	MGI:MGI:3688373|PMID:14661968
Molecular Function	GO:0000287	magnesium ion binding	Tesc	IDA		Mouse	MGI:MGI:3688373|PMID:14661968
Molecular Function	GO:0019212	phosphatase inhibitor activity	Tesc	IDA		Mouse	MGI:MGI:3688373|PMID:14661968
Molecular Function	GO:0005515	protein binding	TESC	IPI	UniProtKB:P19634	Human	PMID:11696366
Molecular Function	GO:0005515	protein binding	TESC	IPI	UniProtKB:P19634	Human	PMID:12809501
Molecular Function	GO:0005515	protein binding	TESC	IPI	UniProtKB:Q9NP66	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	TESC	IPI	UniProtKB:P26431	Human	PMID:18321853
Molecular Function	GO:0005515	protein binding	TESC	IPI	UniProtKB:Q9Y2W2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TESC	IPI	UniProtKB:P19634	Human	PMID:30287853
Molecular Function	GO:0005515	protein binding	TESC	IPI	UniProtKB:P19634	Human	PMID:31912575
Molecular Function	GO:0042803	protein homodimerization activity	Tesc	IDA		Mouse	MGI:MGI:3688373|PMID:14661968
Cellular Component	GO:0005737	cytoplasm	TESC	IDA		Human	PMID:18321853
Cellular Component	GO:0005737	cytoplasm	TESC	IDA		Human	PMID:19345287
Cellular Component	GO:0005737	cytoplasm	TESC	IDA		Human	PMID:21553168
Cellular Component	GO:0005737	cytoplasm	Tesc	IDA		Mouse	MGI:MGI:3847165|PMID:19345287
Cellular Component	GO:0005737	cytoplasm	Tesc	IDA		Mouse	MGI:MGI:3688373|PMID:14661968
Cellular Component	GO:0005829	cytosol	TESC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030027	lamellipodium	TESC	IDA		Human	PMID:11696366
Cellular Component	GO:0030027	lamellipodium	Tesc	IDA		Mouse	MGI:MGI:3688373|PMID:14661968
Cellular Component	GO:0005654	nucleoplasm	TESC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	TESC	IDA		Human	PMID:17717601
Cellular Component	GO:0005634	nucleus	TESC	IDA		Human	PMID:18321853
Cellular Component	GO:0005634	nucleus	TESC	IDA		Human	PMID:19345287
Cellular Component	GO:0005634	nucleus	Tesc	IDA		Mouse	MGI:MGI:3688373|PMID:14661968
Cellular Component	GO:0005886	plasma membrane	TESC	IDA		Human	PMID:18321853
Cellular Component	GO:0005886	plasma membrane	TESC	IDA		Human	PMID:21553168
Cellular Component	GO:0001726	ruffle	Tesc	IDA		Mouse	MGI:MGI:3688373|PMID:14661968
Biological Process	GO:0071300	cellular response to retinoic acid	TESC	IDA		Human	PMID:20060826
Biological Process	GO:0008584	male gonad development	Tesc	IEP		Mouse	MGI:MGI:1930324|PMID:11145610
Biological Process	GO:0030219	megakaryocyte differentiation	Tesc	IEP		Mouse	MGI:MGI:4359362|PMID:17717601
Biological Process	GO:0008285	negative regulation of cell population proliferation	TESC	IMP		Human	PMID:17717601
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	TESC	IMP		Human	PMID:17717601
Biological Process	GO:0010628	positive regulation of gene expression	TESC	IMP		Human	PMID:17717601
Biological Process	GO:0030854	positive regulation of granulocyte differentiation	TESC	IDA		Human	PMID:20060826
Biological Process	GO:0045654	positive regulation of megakaryocyte differentiation	TESC	IMP		Human	PMID:17717601
Biological Process	GO:0032417	positive regulation of sodium:proton antiporter activity	TESC	IDA		Human	PMID:18321853
Biological Process	GO:0072659	protein localization to plasma membrane	TESC	IDA		Human	PMID:18321853
Biological Process	GO:0051604	protein maturation	TESC	IDA		Human	PMID:18321853
Biological Process	GO:0050821	protein stabilization	TESC	IDA		Human	PMID:18321853
Biological Process	GO:0033628	regulation of cell adhesion mediated by integrin	TESC	IMP		Human	PMID:17717601

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern