Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TET2
  • Mouse genes Tet2
  • Rat genes Tet2
  • Zfish genes tet2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tet2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008198	ferrous iron binding	TET2	IDA		Human	PMID:24315485
Molecular Function	GO:0070579	methylcytosine dioxygenase activity	TET2	IMP		Human	PMID:21057493
Molecular Function	GO:0070579	methylcytosine dioxygenase activity	TET2	IMP		Human	PMID:23222540
Molecular Function	GO:0070579	methylcytosine dioxygenase activity	TET2	IDA		Human	PMID:24315485
Molecular Function	GO:0070579	methylcytosine dioxygenase activity	TET2	IMP		Human	PMID:32518946
Molecular Function	GO:0070579	methylcytosine dioxygenase activity	Tet2	IDA		Mouse	MGI:MGI:5287540|PMID:21817016
Molecular Function	GO:0070579	methylcytosine dioxygenase activity	Tet2	IDA		Mouse	MGI:MGI:3844762|PMID:19372391
Molecular Function	GO:0070579	methylcytosine dioxygenase activity	Tet2	IMP		Mouse	MGI:MGI:4888067|PMID:21057493
Molecular Function	GO:0070579	methylcytosine dioxygenase activity	Tet2	IDA		Mouse	MGI:MGI:5287327|PMID:21778364
Molecular Function	GO:0070579	methylcytosine dioxygenase activity	Tet2	IDA		Mouse	PMID:20639862
Molecular Function	GO:0070579	methylcytosine dioxygenase activity	tet2	IMP	ZFIN:ZDB-GENO-180802-6	Zfish	PMID:28926578
Molecular Function	GO:0070579	methylcytosine dioxygenase activity	tet2	IGI	ZFIN:ZDB-GENE-060526-109	Zfish	PMID:28926578
Molecular Function	GO:0035516	oxidative DNA demethylase activity	tet2	IMP	ZFIN:ZDB-MRPHLNO-140402-10	Zfish	PMID:24396069
Molecular Function	GO:0005515	protein binding	TET2	IPI	UniProtKB:O15294	Human	PMID:23222540
Molecular Function	GO:0005515	protein binding	TET2	IPI	UniProtKB:O15294	Human	PMID:23353889
Molecular Function	GO:0005515	protein binding	TET2	IPI	UniProtKB:P51610	Human	PMID:23353889
Molecular Function	GO:0005515	protein binding	TET2	IPI	UniProtKB:P19544	Human	PMID:25601757
Molecular Function	GO:0005515	protein binding	TET2	IPI	UniProtKB:P29590	Human	PMID:29735542
Molecular Function	GO:0005515	protein binding	TET2	IPI	UniProtKB:P06396	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TET2	IPI	UniProtKB:P22607	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TET2	IPI	UniProtKB:Q86XN7	Human	PMID:34667079
Molecular Function	GO:0005515	protein binding	Tet2	IPI	UniProtKB:P22561	Mouse	MGI:MGI:5630032|PMID:25601757
Molecular Function	GO:0005515	protein binding	Tet2	IPI	UniProtKB:Q8CGY8	Mouse	MGI:MGI:6716957|PMID:23222540
Molecular Function	GO:0008270	zinc ion binding	TET2	IDA		Human	PMID:24315485
Biological Process	GO:0006211	5-methylcytosine catabolic process	TET2	IDA		Human	PMID:24315485
Biological Process	GO:0019857	5-methylcytosine metabolic process	Tet2	IMP	MGI:MGI:5301343	Mouse	PMID:21803851
Biological Process	GO:0000904	cell morphogenesis involved in differentiation	tet2	IMP	ZFIN:ZDB-GENO-180802-6	Zfish	PMID:28926578
Biological Process	GO:0000904	cell morphogenesis involved in differentiation	tet2	IGI	ZFIN:ZDB-GENE-090312-98	Zfish	PMID:28926578
Biological Process	GO:0000904	cell morphogenesis involved in differentiation	tet2	IGI	ZFIN:ZDB-GENE-060526-109	Zfish	PMID:28926578
Biological Process	GO:0019858	cytosine metabolic process	Tet2	IMP	MGI:MGI:5301343	Mouse	PMID:21803851
Biological Process	GO:0080111	DNA demethylation	TET2	IDA		Human	PMID:24315485
Biological Process	GO:0080111	DNA demethylation	Tet2	IDA		Mouse	PMID:20639862
Biological Process	GO:0098508	endothelial to hematopoietic transition	tet2	IGI	ZFIN:ZDB-GENE-060526-109	Zfish	PMID:26257178
Biological Process	GO:0030218	erythrocyte differentiation	tet2	IMP	ZFIN:ZDB-GENO-220817-1	Zfish	PMID:34588613
Biological Process	GO:0030218	erythrocyte differentiation	tet2	IGI	ZFIN:ZDB-GENE-980526-268,ZFIN:ZDB-MRPHLNO-140402-10	Zfish	PMID:24396069
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	tet2	IMP	ZFIN:ZDB-GENO-220817-1	Zfish	PMID:34588613
Biological Process	GO:0061484	hematopoietic stem cell homeostasis	Tet2	IMP	MGI:MGI:5301344	Mouse	PMID:21803851
Biological Process	GO:0061484	hematopoietic stem cell homeostasis	Tet2	IMP	MGI:MGI:5301343	Mouse	PMID:21803851
Biological Process	GO:0071425	hematopoietic stem cell proliferation	tet2	IMP	ZFIN:ZDB-GENO-220817-1	Zfish	PMID:34588613
Biological Process	GO:0020027	hemoglobin metabolic process	Tet2	IMP	MGI:MGI:5301343	Mouse	PMID:21803851
Biological Process	GO:0030097	hemopoiesis	Tet2	IMP	MGI:MGI:5141120	Mouse	PMID:21723200
Biological Process	GO:0030097	hemopoiesis	Tet2	IMP		Mouse	PMID:21723201
Biological Process	GO:0030097	hemopoiesis	Tet2	IMP	MGI:MGI:5285412	Mouse	PMID:21873190
Biological Process	GO:0030097	hemopoiesis	tet2	IGI	ZFIN:ZDB-GENE-060526-109	Zfish	PMID:26257178
Biological Process	GO:0048872	homeostasis of number of cells	Tet2	IMP	MGI:MGI:5301343	Mouse	PMID:21803851
Biological Process	GO:0001822	kidney development	Tet2	IMP	MGI:MGI:3813933	Mouse	PMID:18288583
Biological Process	GO:0002521	leukocyte differentiation	TET2	IMP		Human	PMID:32518946
Biological Process	GO:0072576	liver morphogenesis	Tet2	IMP	MGI:MGI:5301343	Mouse	PMID:21803851
Biological Process	GO:0030099	myeloid cell differentiation	TET2	IMP		Human	PMID:21057493
Biological Process	GO:0030099	myeloid cell differentiation	Tet2	IMP		Mouse	MGI:MGI:4888067|PMID:21057493
Biological Process	GO:0030099	myeloid cell differentiation	tet2	IMP	ZFIN:ZDB-GENO-220817-1	Zfish	PMID:34588613
Biological Process	GO:0002318	myeloid progenitor cell differentiation	Tet2	IMP	MGI:MGI:5301343	Mouse	PMID:21803851
Biological Process	GO:0007219	Notch signaling pathway	tet2	IMP	ZFIN:ZDB-GENO-180802-6	Zfish	PMID:28926578
Biological Process	GO:0007219	Notch signaling pathway	tet2	IGI	ZFIN:ZDB-GENE-060526-109	Zfish	PMID:28926578
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	TET2	IMP		Human	PMID:23222540
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	TET2	IMP		Human	PMID:23353889
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tet2	IMP		Mouse	MGI:MGI:5473922|PMID:23353889
Biological Process	GO:0009791	post-embryonic development	Tet2	IMP	MGI:MGI:3813933	Mouse	PMID:18288583
Biological Process	GO:0060319	primitive erythrocyte differentiation	tet2	IMP	ZFIN:ZDB-MRPHLNO-140402-10	Zfish	PMID:24396069
Biological Process	GO:0006493	protein O-linked glycosylation	TET2	IDA		Human	PMID:23222540
Biological Process	GO:0006493	protein O-linked glycosylation	TET2	IMP		Human	PMID:23353889
Biological Process	GO:0006493	protein O-linked glycosylation	Tet2	IMP		Mouse	MGI:MGI:5473922|PMID:23353889
Biological Process	GO:0010468	regulation of gene expression	tet2	IGI	ZFIN:ZDB-GENE-060526-109	Zfish	PMID:28926578
Biological Process	GO:0010468	regulation of gene expression	tet2	IMP	ZFIN:ZDB-GENO-180802-6	Zfish	PMID:28926578
Biological Process	GO:0014070	response to organic cyclic compound	Tet2	IEP		Rat	PMID:25154389|RGD:9586748
Biological Process	GO:0048536	spleen development	Tet2	IMP	MGI:MGI:5301343	Mouse	PMID:21803851
Biological Process	GO:0016055	Wnt signaling pathway	tet2	IMP	ZFIN:ZDB-GENO-180802-6	Zfish	PMID:28926578
Biological Process	GO:0016055	Wnt signaling pathway	tet2	IGI	ZFIN:ZDB-GENE-090312-98	Zfish	PMID:28926578

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern