Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TFAP2C
  • Mouse genes Tfap2c
  • Rat genes Tfap2c
  • Zfish genes tfap2c
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tfap2c

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	TFAP2C	IDA		Human	PMID:12072434
Molecular Function	GO:0003677	DNA binding	Tfap2c	IDA		Mouse	PMID:9765260
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	TFAP2C	IDA		Human	PMID:11278550
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Tfap2c	IDA		Mouse	PMID:15475956
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Tfap2c	IMP		Mouse	PMID:9765260
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Tfap2c	IDA		Mouse	PMID:8349681
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	TFAP2C	IDA		Human	PMID:11278550
Molecular Function	GO:0005515	protein binding	TFAP2C	IPI	UniProtKB:Q99967	Human	PMID:11694877
Molecular Function	GO:0005515	protein binding	TFAP2C	IPI	UniProtKB:P63279	Human	PMID:12072434
Molecular Function	GO:0005515	protein binding	TFAP2C	IPI	UniProtKB:Q99967	Human	PMID:12586840
Molecular Function	GO:0005515	protein binding	TFAP2C	IPI	UniProtKB:Q99967-1	Human	PMID:12586840
Molecular Function	GO:0005515	protein binding	TFAP2C	IPI	UniProtKB:Q719H9	Human	PMID:19115315
Molecular Function	GO:0005515	protein binding	TFAP2C	IPI	UniProtKB:Q13330	Human	PMID:24413532
Molecular Function	GO:0005515	protein binding	TFAP2C	IPI	UniProtKB:P63279	Human	PMID:24835590
Molecular Function	GO:0005515	protein binding	Tfap2c	IPI	UniProtKB:Q6PGA9	Mouse	PMID:11694877
Molecular Function	GO:0005515	protein binding	Tfap2c	IPI	PR:Q6VUP9	Mouse	PMID:14572467
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	TFAP2C	IDA		Human	PMID:24413532
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Tfap2c	IDA		Mouse	PMID:10068641
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Tfap2c	IDA		Mouse	PMID:20176728
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	TFAP2C	IDA		Human	PMID:28473536
Cellular Component	GO:0005739	mitochondrion	TFAP2C	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	TFAP2C	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	TFAP2C	IDA		Human	PMID:24413532
Cellular Component	GO:0005634	nucleus	Tfap2c	IDA		Mouse	PMID:18824566
Cellular Component	GO:0005634	nucleus	Tfap2c	IDA		Mouse	PMID:9765260
Biological Process	GO:0021987	cerebral cortex development	Tfap2c	IMP	MGI:MGI:2176695	Mouse	PMID:19749747
Biological Process	GO:0060598	dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis	Tfap2c	IMP	MGI:MGI:3040993	Mouse	PMID:20131354
Biological Process	GO:0071696	ectodermal placode development	tfap2c	IGI	ZFIN:ZDB-MRPHLNO-080220-1,ZFIN:ZDB-MRPHLNO-080226-1	Zfish	PMID:23078916
Biological Process	GO:0060788	ectodermal placode formation	tfap2c	IGI	ZFIN:ZDB-MRPHLNO-061106-7,ZFIN:ZDB-MRPHLNO-080220-1,ZFIN:ZDB-MRPHLNO-080226-1,ZFIN:ZDB-MRPHLNO-101026-8	Zfish	PMID:20885782
Biological Process	GO:0040029	epigenetic regulation of gene expression	TFAP2C	IMP		Human	PMID:24413532
Biological Process	GO:0030855	epithelial cell differentiation	Tfap2c	IMP	MGI:MGI:3040993	Mouse	PMID:11940672
Biological Process	GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation	Tfap2c	IMP	MGI:MGI:3040993	Mouse	PMID:20131354
Biological Process	GO:0021877	forebrain neuron fate commitment	Tfap2c	IMP	MGI:MGI:2176695	Mouse	PMID:19749747
Biological Process	GO:0030718	germ-line stem cell population maintenance	Tfap2c	IMP	MGI:MGI:2176695	Mouse	PMID:19776388
Biological Process	GO:0001942	hair follicle development	Tfap2c	IGI	MGI:MGI:104671	Mouse	PMID:18824566
Biological Process	GO:0003334	keratinocyte development	Tfap2c	IGI	MGI:MGI:104671	Mouse	PMID:18824566
Biological Process	GO:0008584	male gonad development	TFAP2C	IEP		Human	PMID:17848411
Biological Process	GO:0014032	neural crest cell development	tfap2c	IGI	ZFIN:ZDB-GENO-980202-957,ZFIN:ZDB-MRPHLNO-080220-1	Zfish	PMID:22241841
Biological Process	GO:0014032	neural crest cell development	tfap2c	IGI	ZFIN:ZDB-MRPHLNO-080220-1,ZFIN:ZDB-MRPHLNO-080226-1	Zfish	PMID:22241841
Biological Process	GO:0014032	neural crest cell development	tfap2c	IGI	ZFIN:ZDB-GENO-980202-957,ZFIN:ZDB-MRPHLNO-080220-1	Zfish	PMID:17258188
Biological Process	GO:0014032	neural crest cell development	tfap2c	IGI	ZFIN:ZDB-MRPHLNO-060927-3,ZFIN:ZDB-MRPHLNO-080213-3	Zfish	PMID:17724731
Biological Process	GO:0014036	neural crest cell fate specification	tfap2c	IGI	ZFIN:ZDB-MRPHLNO-080220-1,ZFIN:ZDB-MRPHLNO-080226-1	Zfish	PMID:20885782
Biological Process	GO:0071698	olfactory placode development	tfap2c	IGI	ZFIN:ZDB-MRPHLNO-080220-1,ZFIN:ZDB-MRPHLNO-080226-1	Zfish	PMID:23078916
Biological Process	GO:0043049	otic placode formation	tfap2c	IGI	ZFIN:ZDB-MRPHLNO-080220-1,ZFIN:ZDB-MRPHLNO-080226-1	Zfish	PMID:23078916
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	TFAP2C	IDA		Human	PMID:22735262
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tfap2c	IDA		Mouse	PMID:11694877
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tfap2c	IDA		Mouse	PMID:19749747
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tfap2c	IDA		Mouse	PMID:8349681
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tfap2c	IDA		Mouse	PMID:10068641
Biological Process	GO:0006355	regulation of DNA-templated transcription	Tfap2c	IMP		Mouse	PMID:9765260
Biological Process	GO:0045682	regulation of epidermis development	Tfap2c	IMP	MGI:MGI:2182570	Mouse	PMID:18353300
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Tfap2c	IDA		Mouse	PMID:15475956
Biological Process	GO:0048733	sebaceous gland development	Tfap2c	IGI	MGI:MGI:104671	Mouse	PMID:18824566
Biological Process	GO:0043588	skin development	Tfap2c	IGI	MGI:MGI:104671	Mouse	PMID:18824566
Biological Process	GO:0035019	somatic stem cell population maintenance	Tfap2c	IMP	MGI:MGI:3040993	Mouse	PMID:20404091
Biological Process	GO:0048863	stem cell differentiation	Tfap2c	IMP	MGI:MGI:3040993	Mouse	PMID:20404091
Biological Process	GO:0019827	stem cell population maintenance	Tfap2c	IMP		Mouse	PMID:20176728
Biological Process	GO:0019827	stem cell population maintenance	Tfap2c	IDA		Mouse	PMID:20176728
Biological Process	GO:0006366	transcription by RNA polymerase II	Tfap2c	IDA		Mouse	PMID:11694877
Biological Process	GO:0001829	trophectodermal cell differentiation	Tfap2c	IMP	MGI:MGI:3040993	Mouse	PMID:20404091

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern