Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TFAP4
  • Mouse genes Tfap4
  • Rat genes Tfap4
  • Zfish genes tfap4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tfap4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	TFAP4	IDA		Human	PMID:9931457
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	TFAP4	IDA		Human	PMID:2833704
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Tfap4	IDA		Mouse	PMID:15944155
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Tfap4	IMP		Mouse	PMID:15944155
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	TFAP4	IDA		Human	PMID:2833704
Molecular Function	GO:0070888	E-box binding	TFAP4	IDA		Human	PMID:11171123
Molecular Function	GO:0070888	E-box binding	TFAP4	IDA		Human	PMID:12663744
Molecular Function	GO:0070888	E-box binding	TFAP4	IDA		Human	PMID:18818310
Molecular Function	GO:0070888	E-box binding	TFAP4	IDA		Human	PMID:19505873
Molecular Function	GO:0070888	E-box binding	TFAP4	IDA		Human	PMID:7933101
Molecular Function	GO:0070888	E-box binding	Tfap4	IDA		Mouse	MGI:MGI:4456960|PMID:11171123
Molecular Function	GO:0042826	histone deacetylase binding	TFAP4	IPI	UniProtKB:Q13547	Human	PMID:16540471
Molecular Function	GO:0042826	histone deacetylase binding	TFAP4	IPI	UniProtKB:O15379	Human	PMID:16924111
Molecular Function	GO:0042826	histone deacetylase binding	Tfap4	IPI	UniProtKB:O15379	Mouse	MGI:MGI:3663964|PMID:16924111
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:P55040	Human	PMID:16924111
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:P04637	Human	PMID:19505873
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:P08047	Human	PMID:19505873
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:P09429	Human	PMID:19505873
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:P12004	Human	PMID:19505873
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:P27695	Human	PMID:19505873
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:P49711	Human	PMID:19505873
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:Q13363	Human	PMID:19505873
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:Q13469	Human	PMID:19505873
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:Q13547	Human	PMID:19505873
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:Q15853	Human	PMID:19505873
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:Q92769	Human	PMID:19505873
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:Q08379	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:Q13077	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:Q96B26	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:P17568	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:P26045	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:Q08379	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:Q0VD86	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:Q13077	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:Q2NL98	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:Q5VUG0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:Q8WW24	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:Q96B26	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:Q96EZ8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:Q96IF1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:Q9BUZ4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFAP4	IPI	UniProtKB:Q92876	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Tfap4	IPI	UniProtKB:Q03347	Mouse	MGI:MGI:5291878|PMID:21873191
Molecular Function	GO:0005515	protein binding	Tfap4	IPI	UniProtKB:O88513	Mouse	MGI:MGI:3663964|PMID:16924111
Molecular Function	GO:0042803	protein homodimerization activity	TFAP4	IPI	UniProtKB:Q01664	Human	PMID:2123466
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Tfap4	IDA		Mouse	PMID:15944155
Molecular Function	GO:0043565	sequence-specific DNA binding	TFAP4	IDA		Human	PMID:2123466
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	TFAP4	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	TFAP4	IDA		Human	PMID:14645924
Molecular Function	GO:0000976	transcription cis-regulatory region binding	TFAP4	IDA		Human	PMID:16540471
Molecular Function	GO:0000976	transcription cis-regulatory region binding	TFAP4	IDA		Human	PMID:2833704
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Tfap4	IDA		Mouse	MGI:MGI:3663964|PMID:16924111
Cellular Component	GO:0005739	mitochondrion	TFAP4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	TFAP4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	TFAP4	IDA		Human	PMID:11171123
Cellular Component	GO:0005634	nucleus	TFAP4	IDA		Human	PMID:12663744
Cellular Component	GO:0005634	nucleus	TFAP4	IDA		Human	PMID:19505873
Cellular Component	GO:0005634	nucleus	TFAP4	IDA		Human	PMID:7933101
Cellular Component	GO:0005634	nucleus	TFAP4	IDA		Human	PMID:9931457
Cellular Component	GO:0005634	nucleus	Tfap4	IDA		Mouse	MGI:MGI:4456960|PMID:11171123
Cellular Component	GO:0005634	nucleus	Tfap4	IDA		Mouse	MGI:MGI:3663964|PMID:16924111
Cellular Component	GO:0017053	transcription repressor complex	Tfap4	IMP		Mouse	MGI:MGI:3663964|PMID:16924111
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Tfap4	IDA		Mouse	MGI:MGI:4456943|PMID:15944155
Biological Process	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	TFAP4	IDA		Human	PMID:18818310
Biological Process	GO:0043922	negative regulation by host of viral transcription	TFAP4	IDA		Human	PMID:14645924
Biological Process	GO:0043922	negative regulation by host of viral transcription	TFAP4	IDA		Human	PMID:16540471
Biological Process	GO:0008285	negative regulation of cell population proliferation	TFAP4	IMP		Human	PMID:18818310
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	TFAP4	IDA		Human	PMID:18818310
Biological Process	GO:0043392	negative regulation of DNA binding	TFAP4	IDA		Human	PMID:16540471
Biological Process	GO:0043392	negative regulation of DNA binding	TFAP4	IDA		Human	PMID:7933101
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	TFAP4	IDA		Human	PMID:16924111
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	TFAP4	IMP		Human	PMID:18818310
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	TFAP4	IDA		Human	PMID:19505873
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	TFAP4	IDA		Human	PMID:9931457
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Tfap4	IDA		Mouse	MGI:MGI:3663964|PMID:16924111
Biological Process	GO:0010629	negative regulation of gene expression	Tfap4	IDA		Mouse	MGI:MGI:3663964|PMID:16924111
Biological Process	GO:0043923	positive regulation by host of viral transcription	TFAP4	IDA		Human	PMID:2833704
Biological Process	GO:0043065	positive regulation of apoptotic process	TFAP4	IDA		Human	PMID:18818310
Biological Process	GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	Tfap4	IMP		Mouse	PMID:15944155
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	TFAP4	IMP		Human	PMID:12663744
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tfap4	IMP		Mouse	PMID:15944155
Biological Process	GO:0065003	protein-containing complex assembly	TFAP4	IDA		Human	PMID:19505873
Biological Process	GO:0065003	protein-containing complex assembly	Tfap4	IDA		Mouse	MGI:MGI:3663964|PMID:16924111
Biological Process	GO:1901990	regulation of mitotic cell cycle phase transition	TFAP4	IDA		Human	PMID:18818310

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern