Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TFE3
  • Mouse genes Tfe3
  • Rat genes Tfe3
  • Zfish genes tfe3a,tfe3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tfe3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Tfe3	IDA		Mouse	PMID:15994295
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Tfe3	IDA		Mouse	MGI:MGI:3662947|PMID:16936731
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Tfe3	IDA		Mouse	MGI:MGI:3662947|PMID:16936731
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Tfe3	IDA		Mouse	MGI:MGI:6393150|PMID:27913603
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	tfe3a	IDA		Zfish	PMID:11543618
Molecular Function	GO:0005515	protein binding	TFE3	IPI	UniProtKB:O15397	Human	PMID:26168401
Molecular Function	GO:0005515	protein binding	TFE3	IPI	UniProtKB:Q9UHA4	Human	PMID:32296183
Molecular Function	GO:0046982	protein heterodimerization activity	Tfe3	IPI	UniProtKB:Q9R210	Mouse	MGI:MGI:3662947|PMID:16936731
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Tfe3	IDA		Mouse	MGI:MGI:3662947|PMID:16936731
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	TFE3	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Tfe3	IDA		Mouse	MGI:MGI:3662947|PMID:16936731
Cellular Component	GO:0005737	cytoplasm	TFE3	IDA		Human	PMID:22692423
Cellular Component	GO:0005737	cytoplasm	Tfe3	IMP		Mouse	MGI:MGI:5487525|PMID:21209915
Cellular Component	GO:0005829	cytosol	TFE3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Tfe3	IDA		Mouse	MGI:MGI:6393150|PMID:27913603
Cellular Component	GO:0005654	nucleoplasm	TFE3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	TFE3	IMP		Human	PMID:21209915
Cellular Component	GO:0005634	nucleus	TFE3	IDA		Human	PMID:22692423
Cellular Component	GO:0005634	nucleus	Tfe3	IDA		Mouse	MGI:MGI:5487525|PMID:21209915
Cellular Component	GO:0005634	nucleus	Tfe3	IDA		Mouse	MGI:MGI:6393150|PMID:27913603
Biological Process	GO:0006351	DNA-templated transcription	tfe3a	IDA		Zfish	PMID:11543618
Biological Process	GO:0006959	humoral immune response	Tfe3	IMP		Mouse	MGI:MGI:3662947|PMID:16936731
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	Tfe3	IMP		Mouse	MGI:MGI:5525952|PMID:23885019
Biological Process	GO:0090336	positive regulation of brown fat cell differentiation	Tfe3	IMP		Mouse	MGI:MGI:6393150|PMID:27913603
Biological Process	GO:0045785	positive regulation of cell adhesion	TFE3	IMP		Human	PMID:21209915
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	TFE3	IMP		Human	PMID:29146937
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Tfe3	IDA		Mouse	MGI:MGI:6393150|PMID:27913603
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Tfe3	IMP		Mouse	MGI:MGI:6304577|PMID:29146937
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Tfe3	IDA		Mouse	PMID:15994295
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	TFE3	IMP		Human	PMID:21209915
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tfe3	IDA		Mouse	MGI:MGI:3662947|PMID:16936731
Biological Process	GO:0045670	regulation of osteoclast differentiation	Tfe3	IGI	MGI:MGI:104554	Mouse	PMID:11930005

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern