Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TFEB
  • Mouse genes Tfeb
  • Rat genes Tfeb
  • Zfish genes tfeb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tfeb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Tfeb	IDA		Mouse	PMID:15994295
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Tfeb	IDA		Mouse	MGI:MGI:3662947|PMID:16936731
Molecular Function	GO:0003700	DNA-binding transcription factor activity	TFEB	IDA		Human	PMID:19556463
Molecular Function	GO:0003700	DNA-binding transcription factor activity	TFEB	IDA		Human	PMID:21617040
Molecular Function	GO:0003700	DNA-binding transcription factor activity	TFEB	IDA		Human	PMID:22343943
Molecular Function	GO:0003700	DNA-binding transcription factor activity	TFEB	IDA		Human	PMID:22576015
Molecular Function	GO:0003700	DNA-binding transcription factor activity	TFEB	IDA		Human	PMID:22692423
Molecular Function	GO:0003700	DNA-binding transcription factor activity	TFEB	IDA		Human	PMID:25720963
Molecular Function	GO:0003700	DNA-binding transcription factor activity	TFEB	IDA		Human	PMID:32753672
Molecular Function	GO:0003700	DNA-binding transcription factor activity	TFEB	IDA		Human	PMID:35662396
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Tfeb	IDA		Mouse	MGI:MGI:3662947|PMID:16936731
Molecular Function	GO:0019899	enzyme binding	TFEB	IPI	UniProtKB:P42345	Human	PMID:22576015
Molecular Function	GO:0019899	enzyme binding	TFEB	IPI	UniProtKB:P42345	Human	PMID:22692423
Molecular Function	GO:0005515	protein binding	TFEB	IPI	UniProtKB:P42345	Human	PMID:22343943
Molecular Function	GO:0046982	protein heterodimerization activity	Tfeb	IPI	UniProtKB:Q64092	Mouse	MGI:MGI:3662947|PMID:16936731
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Tfeb	IDA		Mouse	MGI:MGI:3662947|PMID:16936731
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	TFEB	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	TFEB	IDA		Human	PMID:19556463
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Tfeb	IDA		Mouse	MGI:MGI:3662947|PMID:16936731
Cellular Component	GO:0005737	cytoplasm	TFEB	IDA		Human	PMID:19556463
Cellular Component	GO:0005737	cytoplasm	TFEB	IDA		Human	PMID:27278822
Cellular Component	GO:0005737	cytoplasm	Tfeb	IDA		Mouse	MGI:MGI:5881999|PMID:27278822
Cellular Component	GO:0005737	cytoplasm	Tfeb	IDA		Mouse	MGI:MGI:5787845|PMID:27184844
Cellular Component	GO:0005829	cytosol	TFEB	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	TFEB	IDA		Human	PMID:21617040
Cellular Component	GO:0005829	cytosol	TFEB	IDA		Human	PMID:22576015
Cellular Component	GO:0005829	cytosol	TFEB	IDA		Human	PMID:25720963
Cellular Component	GO:0005829	cytosol	TFEB	IDA		Human	PMID:32753672
Cellular Component	GO:0005829	cytosol	TFEB	IDA		Human	PMID:35662396
Cellular Component	GO:0005765	lysosomal membrane	TFEB	IDA		Human	PMID:22343943
Cellular Component	GO:0005765	lysosomal membrane	TFEB	IDA		Human	PMID:22692423
Cellular Component	GO:0005634	nucleus	TFEB	IDA		Human	PMID:25720963
Cellular Component	GO:0005634	nucleus	TFEB	IDA		Human	PMID:32753672
Cellular Component	GO:0005634	nucleus	TFEB	IDA		Human	PMID:35662396
Cellular Component	GO:0005634	nucleus	TFEB	IDA		Human	PMID:19556463
Cellular Component	GO:0005634	nucleus	TFEB	IDA		Human	PMID:21617040
Cellular Component	GO:0005634	nucleus	TFEB	IDA		Human	PMID:22343943
Cellular Component	GO:0005634	nucleus	TFEB	IDA		Human	PMID:22576015
Cellular Component	GO:0005634	nucleus	TFEB	IDA		Human	PMID:22692423
Cellular Component	GO:0005634	nucleus	TFEB	IDA		Human	PMID:27278822
Cellular Component	GO:0005634	nucleus	Tfeb	IDA		Mouse	MGI:MGI:5881999|PMID:27278822
Cellular Component	GO:0005634	nucleus	Tfeb	IDA		Mouse	MGI:MGI:5787845|PMID:27184844
Cellular Component	GO:0005667	transcription regulator complex	Tfeb	IDA		Mouse	PMID:15994295
Biological Process	GO:0140367	antibacterial innate immune response	TFEB	IDA		Human	PMID:32753672
Biological Process	GO:0140367	antibacterial innate immune response	TFEB	IDA		Human	PMID:35662396
Biological Process	GO:0034198	cellular response to amino acid starvation	TFEB	IDA		Human	PMID:22343943
Biological Process	GO:0034198	cellular response to amino acid starvation	TFEB	IDA		Human	PMID:22576015
Biological Process	GO:0034198	cellular response to amino acid starvation	TFEB	IDA		Human	PMID:22692423
Biological Process	GO:0009267	cellular response to starvation	TFEB	IDA		Human	PMID:21617040
Biological Process	GO:0009267	cellular response to starvation	TFEB	IDA		Human	PMID:22343943
Biological Process	GO:0009267	cellular response to starvation	TFEB	IDA		Human	PMID:22576015
Biological Process	GO:0009267	cellular response to starvation	TFEB	IDA		Human	PMID:22692423
Biological Process	GO:0022010	central nervous system myelination	tfeb	IGI	ZFIN:ZDB-GENO-190307-19	Zfish	PMID:30399334
Biological Process	GO:0050829	defense response to Gram-negative bacterium	Tfeb	IMP		Mouse	MGI:MGI:5787845|PMID:27184844
Biological Process	GO:0001892	embryonic placenta development	Tfeb	IMP		Mouse	MGI:MGI:1306865|PMID:9806910
Biological Process	GO:0006959	humoral immune response	Tfeb	IMP		Mouse	MGI:MGI:3662947|PMID:16936731
Biological Process	GO:0032418	lysosome localization	TFEB	IMP		Human	PMID:29146937
Biological Process	GO:0007040	lysosome organization	TFEB	IDA		Human	PMID:22692423
Biological Process	GO:0007040	lysosome organization	TFEB	IMP		Human	PMID:23434374
Biological Process	GO:0007040	lysosome organization	TFEB	IDA		Human	PMID:32753672
Biological Process	GO:0007040	lysosome organization	TFEB	IDA		Human	PMID:35662396
Biological Process	GO:0007040	lysosome organization	Tfeb	IMP		Mouse	PMID:31637311
Biological Process	GO:0010508	positive regulation of autophagy	TFEB	IDA		Human	PMID:21617040
Biological Process	GO:0010508	positive regulation of autophagy	TFEB	IDA		Human	PMID:22576015
Biological Process	GO:0010508	positive regulation of autophagy	TFEB	IMP		Human	PMID:23434374
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	TFEB	IDA		Human	PMID:21617040
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	TFEB	IDA		Human	PMID:22343943
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	TFEB	IDA		Human	PMID:22576015
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	TFEB	IDA		Human	PMID:22692423
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	TFEB	IDA		Human	PMID:27278822
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	TFEB	IDA		Human	PMID:29146937
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Tfeb	IDA		Mouse	MGI:MGI:6304577|PMID:29146937
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Tfeb	IDA		Mouse	PMID:15994295
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	TFEB	IDA		Human	PMID:19556463
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tfeb	IDA		Mouse	MGI:MGI:3662947|PMID:16936731

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern