Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TFRC
  • Mouse genes Tfrc
  • Rat genes Tfrc
  • Zfish genes tfr1a,tfr1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tfrc

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003725	double-stranded RNA binding	TFRC	IDA		Human	PMID:21266579
Molecular Function	GO:0030544	Hsp70 protein binding	Tfrc	IPI	RGD:621725	Rat	PMID:11133993|RGD:2326097
Molecular Function	GO:0042802	identical protein binding	TFRC	IPI	UniProtKB:P02786	Human	PMID:20208545
Molecular Function	GO:0042802	identical protein binding	TFRC	IPI	UniProtKB:P02786	Human	PMID:23384347
Molecular Function	GO:0042802	identical protein binding	TFRC	IPI	UniProtKB:P02786	Human	PMID:29302006
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:Q30201	Human	PMID:10638746
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:P02787	Human	PMID:14691533
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:Q30201-1	Human	PMID:14691533
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:Q30201	Human	PMID:15965644
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:P02787	Human	PMID:16271884
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:Q9P0V3	Human	PMID:16325581
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:P02787	Human	PMID:16354665
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:P02787	Human	PMID:18353247
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:P02794	Human	PMID:20133674
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:Q30201-1	Human	PMID:20133674
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:P02787	Human	PMID:20404192
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:Q30201	Human	PMID:20618438
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:P02787	Human	PMID:21788477
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:Q9Y6K9	Human	PMID:23016877
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:P02768	Human	PMID:23384347
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:O43765	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:Q8CI59|UniProtKB:Q9QVP9	Human	PMID:26642240
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:A5K736	Human	PMID:29302006
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:P02787	Human	PMID:29302006
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:P02787	Human	PMID:29388418
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:A5K736	Human	PMID:29950717
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:O00258	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:O14880	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:O43765	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:O75459	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:P07307-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:P31937	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:P54219-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:Q14973	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:Q3SXY8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:Q5JX71	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:Q86WH2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:Q8NC24	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:Q8TAF8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:Q8TDT2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:Q96BA8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:Q96HA4-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:Q96KR6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:Q96TC7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:Q9GZY8-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:Q30201	Human	PMID:9465039
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:P02787	Human	PMID:9546397
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:Q30201	Human	PMID:9546397
Molecular Function	GO:0005515	protein binding	TFRC	IPI	UniProtKB:Q30201	Human	PMID:9990067
Molecular Function	GO:0005515	protein binding	Tfrc	IPI	UniProtKB:P70387	Mouse	MGI:MGI:3695785|PMID:16893896
Molecular Function	GO:0005515	protein binding	Tfrc	IPI	PR:Q9EQH3	Mouse	PMID:23416069
Molecular Function	GO:0005515	protein binding	Tfrc	IPI	PR:O70492	Mouse	PMID:23416069
Molecular Function	GO:0005515	protein binding	Tfrc	IPI	UniProtKB:O14863	Rat	PMID:26728129|RGD:12903241
Molecular Function	GO:0005515	protein binding	Tfrc	IPI	UniProtKB:Q9BRI3	Rat	PMID:26728129|RGD:12903241
Molecular Function	GO:0042803	protein homodimerization activity	TFRC	IPI	UniProtKB:P02786	Human	PMID:9546397
Molecular Function	GO:0019901	protein kinase binding	TFRC	IPI	UniProtKB:O14920	Human	PMID:23016877
Molecular Function	GO:0019901	protein kinase binding	TFRC	IPI	UniProtKB:O15111	Human	PMID:23016877
Molecular Function	GO:0044877	protein-containing complex binding	TFRC	IPI	ComplexPortal:CPX-3269	Human	PMID:23016877
Molecular Function	GO:0051087	protein-folding chaperone binding	Tfrc	IPI	RGD:621725	Rat	PMID:11133993|RGD:2326097
Molecular Function	GO:0003723	RNA binding	TFRC	HDA		Human	PMID:22658674
Molecular Function	GO:0004998	transferrin receptor activity	TFRC	IDA		Human	PMID:26642240
Molecular Function	GO:0004998	transferrin receptor activity	Tfrc	IDA		Rat	PMID:12707050|RGD:737675
Cellular Component	GO:0016323	basolateral plasma membrane	TFRC	IDA		Human	PMID:9990067
Cellular Component	GO:0072562	blood microparticle	TFRC	HDA		Human	PMID:22516433
Cellular Component	GO:0009986	cell surface	TFRC	IDA		Human	PMID:7556058
Cellular Component	GO:0009986	cell surface	Tfrc	IDA		Mouse	PMID:17716972
Cellular Component	GO:0009986	cell surface	Tfrc	IDA		Mouse	PMID:23416069
Cellular Component	GO:0009986	cell surface	Tfrc	IDA		Rat	PMID:15474526|RGD:151665813
Cellular Component	GO:0009986	cell surface	Tfrc	IDA		Rat	PMID:17373738|RGD:1601530
Cellular Component	GO:0009986	cell surface	Tfrc	IDA		Rat	PMID:18619525|RGD:2301072
Cellular Component	GO:0009986	cell surface	Tfrc	IDA		Rat	PMID:19029245|RGD:8553977
Cellular Component	GO:0005905	clathrin-coated pit	TFRC	IDA		Human	PMID:12857860
Cellular Component	GO:0005905	clathrin-coated pit	Tfrc	IDA		Mouse	PMID:18434600
Cellular Component	GO:0005737	cytoplasm	Tfrc	IDA		Rat	PMID:21437659|RGD:11062091
Cellular Component	GO:0031410	cytoplasmic vesicle	TFRC	IDA		Human	PMID:15229288
Cellular Component	GO:0005769	early endosome	Tfrc	IDA		Mouse	PMID:26432893
Cellular Component	GO:0005768	endosome	TFRC	IDA		Human	PMID:14612438
Cellular Component	GO:0005768	endosome	Tfrc	IDA		Mouse	PMID:11092755
Cellular Component	GO:0005768	endosome	Tfrc	IDA		Mouse	PMID:18321981
Cellular Component	GO:0005768	endosome	Tfrc	IDA		Mouse	PMID:16227996
Cellular Component	GO:0005768	endosome	Tfrc	IDA		Mouse	PMID:14668490
Cellular Component	GO:0005768	endosome	Tfrc	IDA		Mouse	PMID:23303939
Cellular Component	GO:0005768	endosome	Tfrc	IDA		Mouse	PMID:14562105
Cellular Component	GO:0005768	endosome	Tfrc	IDA		Mouse	PMID:14718562
Cellular Component	GO:0010008	endosome membrane	TFRC	IDA		Human	PMID:16380373
Cellular Component	GO:0009897	external side of plasma membrane	TFRC	IGI	UniProtKB:P61769,UniProtKB:Q30201	Human	PMID:18353247
Cellular Component	GO:0009897	external side of plasma membrane	Tfrc	IDA		Mouse	PMID:20711497
Cellular Component	GO:0009897	external side of plasma membrane	Tfrc	IDA		Mouse	PMID:20424607
Cellular Component	GO:0070062	extracellular exosome	TFRC	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	Tfrc	IDA		Mouse	PMID:19724054
Cellular Component	GO:0070062	extracellular exosome	Tfrc	IDA		Rat	PMID:11133993|RGD:2326097
Cellular Component	GO:0005576	extracellular region	TFRC	IDA		Human	PMID:1871153
Cellular Component	GO:0005615	extracellular space	TFRC	HDA		Human	PMID:22664934
Cellular Component	GO:0005615	extracellular space	Tfrc	IDA		Rat	PMID:21437659|RGD:11062091
Cellular Component	GO:1903561	extracellular vesicle	TFRC	HDA		Human	PMID:24769233
Cellular Component	GO:1990712	HFE-transferrin receptor complex	TFRC	IDA		Human	PMID:9465039
Cellular Component	GO:1990712	HFE-transferrin receptor complex	TFRC	IDA		Human	PMID:9546397
Cellular Component	GO:1990712	HFE-transferrin receptor complex	TFRC	IDA		Human	PMID:9990067
Cellular Component	GO:1990712	HFE-transferrin receptor complex	Tfrc	IDA		Mouse	MGI:MGI:3695785|PMID:16893896
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	TFRC	IDA		Human	PMID:26214738
Cellular Component	GO:0016020	membrane	Tfrc	IMP		Mouse	MGI:MGI:4420830|PMID:20080761
Cellular Component	GO:0016020	membrane	Tfrc	IDA		Rat	PMID:21437659|RGD:11062091
Cellular Component	GO:0005739	mitochondrion	Tfrc	IDA		Rat	PMID:17091493|RGD:2292034
Cellular Component	GO:0005634	nucleus	Tfrc	IDA		Rat	PMID:21437659|RGD:11062091
Cellular Component	GO:0048471	perinuclear region of cytoplasm	TFRC	IDA		Human	PMID:16380373
Cellular Component	GO:0048471	perinuclear region of cytoplasm	TFRC	IDA		Human	PMID:20202662
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Tfrc	IDA		Mouse	PMID:10444069
Cellular Component	GO:0005886	plasma membrane	TFRC	IGI	UniProtKB:P61769,UniProtKB:Q30201	Human	PMID:18353247
Cellular Component	GO:0005886	plasma membrane	TFRC	IDA		Human	PMID:23137377
Cellular Component	GO:0005886	plasma membrane	Tfrc	IDA		Mouse	PMID:21700773
Cellular Component	GO:0005886	plasma membrane	Tfrc	IDA		Mouse	PMID:16227996
Cellular Component	GO:0005886	plasma membrane	Tfrc	IDA		Mouse	PMID:14562105
Cellular Component	GO:0005886	plasma membrane	Tfrc	IDA		Mouse	PMID:23303939
Cellular Component	GO:0005886	plasma membrane	Tfrc	IDA		Mouse	PMID:10444069
Cellular Component	GO:0005886	plasma membrane	Tfrc	IDA		Rat	PMID:10747907|RGD:1358386
Cellular Component	GO:0005886	plasma membrane	Tfrc	IDA		Rat	PMID:17177850|RGD:2292033
Cellular Component	GO:0055037	recycling endosome	TFRC	IDA		Human	PMID:22456507
Cellular Component	GO:0055037	recycling endosome	TFRC	IDA		Human	PMID:24561039
Cellular Component	GO:0055037	recycling endosome	Tfrc	IDA		Mouse	PMID:23395379
Cellular Component	GO:0055037	recycling endosome	Tfrc	IDA		Mouse	PMID:26432893
Cellular Component	GO:0055038	recycling endosome membrane	Tfrc	IDA		Rat	PMID:10468577|RGD:4892345
Biological Process	GO:0006953	acute-phase response	Tfrc	IEP		Rat	PMID:17417667|RGD:1601529
Biological Process	GO:0006953	acute-phase response	Tfrc	IEP		Rat	PMID:21437659|RGD:11062091
Biological Process	GO:0007568	aging	Tfrc	IEP		Rat	PMID:18395385|RGD:2292027
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Tfrc	IEP		Mouse	PMID:20439489
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	TFRC	IDA		Human	PMID:16254249
Biological Process	GO:0035162	embryonic hemopoiesis	tfr1a	IMP	ZFIN:ZDB-GENO-980202-862	Zfish	PMID:9007251
Biological Process	GO:0030218	erythrocyte differentiation	tfr1a	IMP	ZFIN:ZDB-GENO-980202-862	Zfish	PMID:15563524
Biological Process	GO:0030218	erythrocyte differentiation	tfr1a	IMP	ZFIN:ZDB-GENO-041220-3	Zfish	PMID:15563524
Biological Process	GO:0042541	hemoglobin biosynthetic process	tfr1a	IMP	ZFIN:ZDB-MRPHLNO-041220-1	Zfish	PMID:15563524
Biological Process	GO:0042541	hemoglobin biosynthetic process	tfr1a	IMP	ZFIN:ZDB-MRPHLNO-041220-1	Zfish	PMID:19047682
Biological Process	GO:0042541	hemoglobin biosynthetic process	tfr1b	IMP	ZFIN:ZDB-GENO-041220-3	Zfish	PMID:15563524
Biological Process	GO:0006879	intracellular iron ion homeostasis	Tfrc	IMP	MGI:MGI:1859944	Mouse	PMID:10192390
Biological Process	GO:0006879	intracellular iron ion homeostasis	tfr1a	IMP	ZFIN:ZDB-GENO-041220-3	Zfish	PMID:15563524
Biological Process	GO:0006879	intracellular iron ion homeostasis	tfr1b	IMP	ZFIN:ZDB-GENO-041220-3	Zfish	PMID:15563524
Biological Process	GO:0035556	intracellular signal transduction	TFRC	IMP		Human	PMID:26214738
Biological Process	GO:0006826	iron ion transport	TFRC	IDA		Human	PMID:7556058
Biological Process	GO:0043066	negative regulation of apoptotic process	TFRC	IMP		Human	PMID:23016877
Biological Process	GO:0010637	negative regulation of mitochondrial fusion	TFRC	IMP		Human	PMID:26214738
Biological Process	GO:0030316	osteoclast differentiation	Tfrc	IMP		Mouse	MGI:MGI:3838421|PMID:19252502
Biological Process	GO:0030890	positive regulation of B cell proliferation	TFRC	IDA		Human	PMID:26642240
Biological Process	GO:0030890	positive regulation of B cell proliferation	Tfrc	IDA		Mouse	MGI:MGI:5775517|PMID:26642240
Biological Process	GO:0045780	positive regulation of bone resorption	Tfrc	IDA		Mouse	MGI:MGI:3838421|PMID:19252502
Biological Process	GO:0010628	positive regulation of gene expression	TFRC	IMP	UniProtKB:Q13489|UniProtKB:Q7KZF4	Human	PMID:23016877
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	TFRC	IMP		Human	PMID:23016877
Biological Process	GO:0045830	positive regulation of isotype switching	TFRC	IDA		Human	PMID:26642240
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	TFRC	IMP		Human	PMID:23016877
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	TFRC	IMP	UniProtKB:Q04206	Human	PMID:23016877
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	TFRC	IMP	UniProtKB:Q04206	Human	PMID:23016877
Biological Process	GO:0001934	positive regulation of protein phosphorylation	TFRC	IMP	ComplexPortal:CPX-3269	Human	PMID:23016877
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	TFRC	IMP	ComplexPortal:CPX-3269	Human	PMID:23016877
Biological Process	GO:0042102	positive regulation of T cell proliferation	TFRC	IDA		Human	PMID:26642240
Biological Process	GO:0042102	positive regulation of T cell proliferation	Tfrc	IDA		Mouse	MGI:MGI:5775517|PMID:26642240
Biological Process	GO:0031623	receptor internalization	TFRC	IDA		Human	PMID:26642240
Biological Process	GO:0046688	response to copper ion	Tfrc	IEP		Rat	PMID:17298691|RGD:2292032
Biological Process	GO:0001666	response to hypoxia	Tfrc	IEP		Rat	PMID:17091493|RGD:2292034
Biological Process	GO:0010035	response to inorganic substance	Tfrc	IEP		Rat	PMID:18340409|RGD:2292029
Biological Process	GO:0010039	response to iron ion	Tfrc	IEP		Rat	PMID:17060373|RGD:2292035
Biological Process	GO:0010039	response to iron ion	Tfrc	IEP		Rat	PMID:23635304|RGD:7244375
Biological Process	GO:0010042	response to manganese ion	Tfrc	IEP		Rat	PMID:17060373|RGD:2292035
Biological Process	GO:0007584	response to nutrient	Tfrc	IEP		Rat	PMID:18340409|RGD:2292029
Biological Process	GO:0010033	response to organic substance	Tfrc	IEP		Rat	PMID:17551831|RGD:2292031
Biological Process	GO:0032526	response to retinoic acid	Tfrc	IEP		Rat	PMID:18029484|RGD:2292030
Biological Process	GO:0033572	transferrin transport	TFRC	IDA		Human	PMID:26642240

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern