Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TGFA
  • Mouse genes Tgfa
  • Rat genes Tgfa
  • Zfish genes tgfa
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tgfa

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005154	epidermal growth factor receptor binding	TGFA	IDA		Human	PMID:11278323
Molecular Function	GO:0005154	epidermal growth factor receptor binding	Tgfa	IDA		Rat	PMID:3299049|RGD:2317496
Molecular Function	GO:0008083	growth factor activity	TGFA	IDA		Human	PMID:11278323
Molecular Function	GO:0140313	molecular sequestering activity	tgfa	IMP	ZFIN:ZDB-GENO-210125-10	Zfish	PMID:31763451
Molecular Function	GO:0005515	protein binding	TGFA	IPI	UniProtKB:P00533	Human	PMID:12297049
Molecular Function	GO:0005515	protein binding	TGFA	IPI	UniProtKB:Q969F2	Human	PMID:15064403
Molecular Function	GO:0005515	protein binding	TGFA	IPI	UniProtKB:Q9EQJ9	Human	PMID:15652357
Molecular Function	GO:0005515	protein binding	TGFA	IPI	UniProtKB:Q969F2	Human	PMID:18757723
Molecular Function	GO:0005515	protein binding	TGFA	IPI	UniProtKB:P00533	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	TGFA	IPI	UniProtKB:O43765	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TGFA	IPI	UniProtKB:P00533	Human	PMID:28988771
Molecular Function	GO:0005515	protein binding	TGFA	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	Tgfa	IPI	PR:P28653	Mouse	PMID:15572151
Molecular Function	GO:0005515	protein binding	Tgfa	IPI	UniProtKB:Q9H190	Rat	PMID:11102519|RGD:13506269
Molecular Function	GO:0048018	receptor ligand activity	TGFA	IDA		Human	PMID:8702723
Molecular Function	GO:0048018	receptor ligand activity	Tgfa	IDA		Mouse	PMID:7752576
Molecular Function	GO:0048018	receptor ligand activity	Tgfa	IDA		Mouse	PMID:17881575
Cellular Component	GO:0016323	basolateral plasma membrane	TGFA	IDA		Human	PMID:17553928
Cellular Component	GO:0009986	cell surface	TGFA	IDA		Human	PMID:12743035
Cellular Component	GO:0031410	cytoplasmic vesicle	TGFA	IDA		Human	PMID:15064403
Cellular Component	GO:0005615	extracellular space	TGFA	IDA		Human	PMID:8702723
Cellular Component	GO:0005615	extracellular space	TGFA	IDA		Human	PMID:12743035
Cellular Component	GO:0005615	extracellular space	Tgfa	IDA		Mouse	PMID:7752576
Cellular Component	GO:0005615	extracellular space	Tgfa	IPI	UniProtKB:P00533	Mouse	PMID:6315706
Cellular Component	GO:0005615	extracellular space	Tgfa	IDA		Mouse	PMID:7678348
Cellular Component	GO:0005615	extracellular space	Tgfa	IDA		Rat	PMID:11487584|RGD:730227
Cellular Component	GO:0005634	nucleus	Tgfa	IDA		Rat	PMID:14656002|RGD:1578551
Cellular Component	GO:0048471	perinuclear region of cytoplasm	TGFA	IDA		Human	PMID:15064403
Cellular Component	GO:0005886	plasma membrane	Tgfa	IDA		Rat	PMID:3299049|RGD:2317496
Biological Process	GO:0001525	angiogenesis	Tgfa	IDA		Mouse	PMID:14998491
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Tgfa	IDA		Mouse	PMID:7752576
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Tgfa	IDA		Mouse	PMID:17881575
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	TGFA	IDA		Human	PMID:8702723
Biological Process	GO:0072574	hepatocyte proliferation	Tgfa	IDA		Mouse	MGI:MGI:3778721|PMID:10635333
Biological Process	GO:0072574	hepatocyte proliferation	Tgfa	IDA		Rat	PMID:10635333|RGD:10047310
Biological Process	GO:0060749	mammary gland alveolus development	Tgfa	IGI	MGI:MGI:95290	Mouse	PMID:10331984
Biological Process	GO:0060749	mammary gland alveolus development	Tgfa	IGI	MGI:MGI:88068	Mouse	PMID:10331984
Biological Process	GO:0043066	negative regulation of apoptotic process	Tgfa	IDA		Rat	PMID:11487584|RGD:730227
Biological Process	GO:0008284	positive regulation of cell population proliferation	Tgfa	IDA		Mouse	PMID:8702723
Biological Process	GO:0008284	positive regulation of cell population proliferation	Tgfa	IMP		Rat	PMID:12021046|RGD:730141
Biological Process	GO:0008284	positive regulation of cell population proliferation	Tgfa	IMP		Rat	PMID:19346670|RGD:2317475
Biological Process	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	TGFA	IDA		Human	PMID:11278323
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	TGFA	IDA		Human	PMID:11278323
Biological Process	GO:0043406	positive regulation of MAP kinase activity	TGFA	IDA		Human	PMID:11278323
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	TGFA	IDA		Human	PMID:11278323
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Tgfa	IDA		Mouse	PMID:8702723
Biological Process	GO:0045187	regulation of circadian sleep/wake cycle, sleep	tgfa	IMP	ZFIN:ZDB-GENO-210125-10	Zfish	PMID:31763451
Biological Process	GO:0009410	response to xenobiotic stimulus	Tgfa	IEP		Rat	PMID:16704299|RGD:2317491
Biological Process	GO:0042060	wound healing	Tgfa	IEP		Rat	PMID:16966143|RGD:2317488

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern