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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Tgfbr3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tgfbr3
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0048185activin bindingTgfbr3IDARatPMID:12385827|RGD:1579945
Molecular FunctionGO:0015026coreceptor activityTGFBR3IDAHumanPMID:10746731
Molecular FunctionGO:0017134fibroblast growth factor bindingTgfbr3IDARatPMID:1556106|RGD:1579950
Molecular FunctionGO:0005539glycosaminoglycan bindingTgfbr3IDAMouseMGI:MGI:2663364|PMID:12773577
Molecular FunctionGO:0008201heparin bindingTgfbr3IDARatPMID:8106553|RGD:1579949
Molecular FunctionGO:0030165PDZ domain bindingTgfbr3IPIUniProtKB:Q9Z0G0MouseMGI:MGI:3807767|PMID:11546783
Molecular FunctionGO:0005515protein bindingTGFBR3IPIUniProtKB:P05111HumanPMID:10746731
Molecular FunctionGO:0005515protein bindingTGFBR3IPIUniProtKB:P01137HumanPMID:10746731
Molecular FunctionGO:0005515protein bindingTGFBR3IPIUniProtKB:P61812HumanPMID:11157754
Molecular FunctionGO:0005515protein bindingTGFBR3IPIUniProtKB:O14908HumanPMID:11546783
Molecular FunctionGO:0005515protein bindingTGFBR3IPIUniProtKB:P32121HumanPMID:12958365
Molecular FunctionGO:0005515protein bindingTGFBR3IPIUniProtKB:P12643HumanPMID:18184661
Molecular FunctionGO:0005515protein bindingTGFBR3IPIUniProtKB:P18075HumanPMID:18184661
Molecular FunctionGO:0005515protein bindingTGFBR3IPIUniProtKB:P01137HumanPMID:20856203
Molecular FunctionGO:0005515protein bindingTgfbr3IPIUniProtKB:P04202MouseMGI:MGI:2663364|PMID:12773577
Molecular FunctionGO:0005515protein bindingTgfbr3IPIRGD:736727RatPMID:16522726|RGD:1579944
Molecular FunctionGO:0005515protein bindingTgfbr3IPIUniProtKB:P61812RatPMID:7852346|RGD:8553463
Molecular FunctionGO:0005515protein bindingTgfbr3IPIUniProtKB:P38438RatPMID:8106553|RGD:1579949
Molecular FunctionGO:0046332SMAD bindingTGFBR3IMPHumanPMID:11157754
Molecular FunctionGO:0046332SMAD bindingTgfbr3IMPMouseMGI:MGI:3699491|PMID:17295310
Molecular FunctionGO:0050431transforming growth factor beta bindingTGFBR3IPIUniProtKB:P61812HumanPMID:11157754
Molecular FunctionGO:0050431transforming growth factor beta bindingTGFBR3IDAHumanPMID:11157754
Molecular FunctionGO:0050431transforming growth factor beta bindingTGFBR3IDAHumanPMID:12958365
Molecular FunctionGO:0050431transforming growth factor beta bindingTgfbr3IDAMouseMGI:MGI:3699491|PMID:17295310
Molecular FunctionGO:0050431transforming growth factor beta bindingTgfbr3IPIUniProtKB:P61812RatPMID:7852346|RGD:8553463
Molecular FunctionGO:0050431transforming growth factor beta bindingTgfbr3IDARatPMID:1657407|RGD:729942
Molecular FunctionGO:0050431transforming growth factor beta bindingTgfbr3IDARatPMID:1744125|RGD:2302518
Molecular FunctionGO:0050431transforming growth factor beta bindingTgfbr3IDARatPMID:8106553|RGD:1579949
Molecular FunctionGO:0005024transforming growth factor beta receptor activityTGFBR3IDAHumanPMID:12958365
Molecular FunctionGO:0005024transforming growth factor beta receptor activityTgfbr3IDAMousePMID:9659379
Molecular FunctionGO:0005024transforming growth factor beta receptor activityTgfbr3IMPMousePMID:17823118
Molecular FunctionGO:0070123transforming growth factor beta receptor activity, type IIITGFBR3IDAHumanPMID:10746731
Molecular FunctionGO:0070123transforming growth factor beta receptor activity, type IIITGFBR3IDAHumanPMID:11157754
Molecular FunctionGO:0070123transforming growth factor beta receptor activity, type IIITgfbr3IDARatPMID:8106553|RGD:1579949
Molecular FunctionGO:0005160transforming growth factor beta receptor bindingTgfbr3IDARatPMID:8106553|RGD:1579949
Molecular FunctionGO:0005114type II transforming growth factor beta receptor bindingTGFBR3IDAHumanPMID:11157754
Cellular ComponentGO:0009986cell surfaceTgfbr3IDAMouseMGI:MGI:3807767|PMID:11546783
Cellular ComponentGO:0005737cytoplasmTgfbr3IDAMousePMID:18236212
Cellular ComponentGO:0005737cytoplasmTgfbr3IDAMousePMID:9921650
Cellular ComponentGO:0005737cytoplasmTgfbr3IDARatPMID:10207840|RGD:1579948
Cellular ComponentGO:0005783endoplasmic reticulumTgfbr3IDAMousePMID:9921650
Cellular ComponentGO:0009897external side of plasma membraneTGFBR3IDAHumanPMID:12958365
Cellular ComponentGO:0070062extracellular exosomeTGFBR3HDAHumanPMID:19056867
Cellular ComponentGO:0070062extracellular exosomeTGFBR3HDAHumanPMID:19199708
Cellular ComponentGO:0031012extracellular matrixTgfbr3IDARatPMID:10207840|RGD:1579948
Cellular ComponentGO:0005615extracellular spaceTGFBR3HDAHumanPMID:16502470
Cellular ComponentGO:0005615extracellular spaceTgfbr3IDARatPMID:2592419|RGD:1579952
Cellular ComponentGO:0034673inhibin-betaglycan-ActRII complexTGFBR3IDAHumanPMID:10746731
Cellular ComponentGO:0016020membraneTgfbr3IDARatPMID:8106553|RGD:1579949
Cellular ComponentGO:0005886plasma membraneTgfbr3IDARatPMID:10207840|RGD:1579948
Cellular ComponentGO:0043235receptor complexTGFBR3IDAHumanPMID:11157754
Cellular ComponentGO:0043235receptor complexTgfbr3IDARatPMID:7852346|RGD:8553463
Biological ProcessGO:0031100animal organ regenerationTgfbr3IEPRatPMID:9699514|RGD:2302035
Biological ProcessGO:0060561apoptotic process involved in morphogenesisTgfbr3IMPMousePMID:25382630
Biological ProcessGO:0001824blastocyst developmentTgfbr3IDAMousePMID:9921650
Biological ProcessGO:0001568blood vessel developmentTgfbr3IMPMGI:MGI:3818438MousePMID:17704211
Biological ProcessGO:0001974blood vessel remodelingTgfbr3IMPMousePMID:25382630
Biological ProcessGO:0030509BMP signaling pathwayTGFBR3IDAHumanPMID:18184661
Biological ProcessGO:0030509BMP signaling pathwayTgfbr3IMPMousePMID:25382630
Biological ProcessGO:0060317cardiac epithelial to mesenchymal transitionTGFBR3IDAHumanPMID:18184661
Biological ProcessGO:0060038cardiac muscle cell proliferationTgfbr3IMPMouseMGI:MGI:2663364|PMID:12773577
Biological ProcessGO:0008283cell population proliferationTgfbr3IMPMousePMID:25382630
Biological ProcessGO:0032963collagen metabolic processTgfbr3IGIRNAcentral:URS000039ED8D_10090MouseMGI:MGI:5688831|PMID:22960625
Biological ProcessGO:0060318definitive erythrocyte differentiationTgfbr3IMPMouseMGI:MGI:2663364|PMID:12773577
Biological ProcessGO:0060216definitive hemopoiesisTgfbr3IMPMouseMGI:MGI:2663364|PMID:12773577
Biological ProcessGO:0060939epicardium-derived cardiac fibroblast cell developmentTgfbr3IMPMouseMGI:MGI:3818140|PMID:17704211
Biological ProcessGO:0001837epithelial to mesenchymal transitionTGFBR3IDAHumanPMID:18184661
Biological ProcessGO:0060347heart trabecula formationTgfbr3IMPMouseMGI:MGI:2663364|PMID:12773577
Biological ProcessGO:0061384heart trabecula morphogenesisTgfbr3IMPMouseMGI:MGI:2663364|PMID:12773577
Biological ProcessGO:0006955immune responseTGFBR3IMPHumanPMID:16886151
Biological ProcessGO:0001701in utero embryonic developmentTgfbr3IMPMGI:MGI:3818438MousePMID:17704211
Biological ProcessGO:0035556intracellular signal transductionTGFBR3IMPHumanPMID:14557487
Biological ProcessGO:0001889liver developmentTgfbr3IMPMouseMGI:MGI:2663364|PMID:12773577
Biological ProcessGO:0003150muscular septum morphogenesisTgfbr3IMPMouseMGI:MGI:2663364|PMID:12773577
Biological ProcessGO:1902338negative regulation of apoptotic process involved in morphogenesisTgfbr3IMPMousePMID:25382630
Biological ProcessGO:0010633negative regulation of epithelial cell migrationTgfbr3IMPMousePMID:17823118
Biological ProcessGO:0050680negative regulation of epithelial cell proliferationTgfbr3IMPMouseMGI:MGI:3699491|PMID:17295310
Biological ProcessGO:0010719negative regulation of epithelial to mesenchymal transitionTgfbr3IMPMousePMID:17823118
Biological ProcessGO:0010629negative regulation of gene expressionTgfbr3IDAMouseMGI:MGI:5688831|PMID:22960625
Biological ProcessGO:0030512negative regulation of transforming growth factor beta receptor signaling pathwayTgfbr3IDARatPMID:10746731|RGD:1579946
Biological ProcessGO:0001649osteoblast differentiationTgfbr3IMPMousePMID:25382630
Biological ProcessGO:0003151outflow tract morphogenesisTgfbr3IMPMouseMGI:MGI:3818140|PMID:17704211
Biological ProcessGO:0060389pathway-restricted SMAD protein phosphorylationTGFBR3IMPHumanPMID:11157754
Biological ProcessGO:0060389pathway-restricted SMAD protein phosphorylationTgfbr3IMPMouseMGI:MGI:3699491|PMID:17295310
Biological ProcessGO:0030513positive regulation of BMP signaling pathwayTgfbr3IMPMousePMID:25382630
Biological ProcessGO:0060045positive regulation of cardiac muscle cell proliferationTgfbr3IMPMouseMGI:MGI:2663364|PMID:12773577
Biological ProcessGO:0008284positive regulation of cell population proliferationTgfbr3IMPMousePMID:25382630
Biological ProcessGO:0051092positive regulation of NF-kappaB transcription factor activityTgfbr3IMPMousePMID:17823118
Biological ProcessGO:0030511positive regulation of transforming growth factor beta receptor signaling pathwayTgfbr3IMPMousePMID:25382630
Biological ProcessGO:0030511positive regulation of transforming growth factor beta receptor signaling pathwayTgfbr3IMPRatPMID:8106553|RGD:1579949
Biological ProcessGO:0065003protein-containing complex assemblyTgfbr3IDARatPMID:12385827|RGD:1579945
Biological ProcessGO:0043393regulation of protein bindingTgfbr3IDARatPMID:12385827|RGD:1579945
Biological ProcessGO:0032354response to follicle-stimulating hormoneTGFBR3IDAHumanPMID:14557487
Biological ProcessGO:0001666response to hypoxiaTgfbr3IEPRatPMID:12183510|RGD:727411
Biological ProcessGO:0034699response to luteinizing hormoneTGFBR3IDAHumanPMID:14557487
Biological ProcessGO:0034695response to prostaglandin ETGFBR3IDAHumanPMID:14557487
Biological ProcessGO:0060021roof of mouth developmentTgfbr3IMPMousePMID:25382630
Biological ProcessGO:0062009secondary palate developmentTgfbr3IMPMouseMGI:MGI:3699491|PMID:17295310
Biological ProcessGO:0061053somite developmenttgfbr3IMPZFIN:ZDB-MRPHLNO-160902-3ZfishPMID:26174808
Biological ProcessGO:0002040sprouting angiogenesistgfbr3IMPZFIN:ZDB-MRPHLNO-160902-3ZfishPMID:26174808
Biological ProcessGO:0007181transforming growth factor beta receptor complex assemblyTgfbr3IMPRatPMID:8106553|RGD:1579949
Biological ProcessGO:0007179transforming growth factor beta receptor signaling pathwayTGFBR3IMPHumanPMID:11157754
Biological ProcessGO:0007179transforming growth factor beta receptor signaling pathwayTGFBR3IDAHumanPMID:12958365
Biological ProcessGO:0007179transforming growth factor beta receptor signaling pathwayTgfbr3IGIUniProtKB:P27090MouseMGI:MGI:2663364|PMID:12773577
Biological ProcessGO:0007179transforming growth factor beta receptor signaling pathwayTgfbr3IDAMouseMGI:MGI:3699491|PMID:17295310
Biological ProcessGO:0007179transforming growth factor beta receptor signaling pathwayTgfbr3IDAMouseMGI:MGI:3807767|PMID:11546783
Biological ProcessGO:0007179transforming growth factor beta receptor signaling pathwayTgfbr3IMPMousePMID:25382630
Biological ProcessGO:0001570vasculogenesisTgfbr3IMPMousePMID:25382630
Biological ProcessGO:0060979vasculogenesis involved in coronary vascular morphogenesisTgfbr3IMPMouseMGI:MGI:3818140|PMID:17704211
Biological ProcessGO:0055010ventricular cardiac muscle tissue morphogenesisTgfbr3IMPMouseMGI:MGI:2663364|PMID:12773577
Biological ProcessGO:0003223ventricular compact myocardium morphogenesisTgfbr3IMPMouseMGI:MGI:3818140|PMID:17704211
Biological ProcessGO:0003223ventricular compact myocardium morphogenesisTgfbr3IMPMouseMGI:MGI:2663364|PMID:12773577
Biological ProcessGO:0060412ventricular septum morphogenesisTgfbr3IMPMouseMGI:MGI:3818140|PMID:17704211

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory