Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TGIF1
  • Mouse genes Tgif1
  • Rat genes Tgif1
  • Zfish genes tgif1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tgif1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Tgif1	IDA		Mouse	PMID:16428452
Molecular Function	GO:0070410	co-SMAD binding	Tgif1	IPI	RGD:3033	Rat	PMID:15153551|RGD:1599409
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	TGIF1	IDA		Human	PMID:10764806
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	TGIF1	IMP		Human	PMID:10764806
Molecular Function	GO:0005515	protein binding	TGIF1	IPI	UniProtKB:P56545	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	TGIF1	IPI	UniProtKB:O00214	Human	PMID:18511908
Molecular Function	GO:0005515	protein binding	TGIF1	IPI	UniProtKB:P29590	Human	PMID:18511908
Molecular Function	GO:0005515	protein binding	TGIF1	IPI	UniProtKB:P56545	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	TGIF1	IPI	UniProtKB:Q99750	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	TGIF1	IPI	UniProtKB:P56545	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TGIF1	IPI	UniProtKB:Q13363-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TGIF1	IPI	UniProtKB:Q99750	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TGIF1	IPI	UniProtKB:O15169	Human	PMID:25873176
Molecular Function	GO:0005515	protein binding	TGIF1	IPI	UniProtKB:O35625	Human	PMID:25873176
Molecular Function	GO:0005515	protein binding	TGIF1	IPI	UniProtKB:O88566	Human	PMID:25873176
Molecular Function	GO:0005515	protein binding	TGIF1	IPI	UniProtKB:Q9Y2T1	Human	PMID:25873176
Molecular Function	GO:0005515	protein binding	TGIF1	IPI	UniProtKB:O14494	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TGIF1	IPI	UniProtKB:P00491	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TGIF1	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TGIF1	IPI	UniProtKB:P53350	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TGIF1	IPI	UniProtKB:P84022	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TGIF1	IPI	UniProtKB:Q06787-7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TGIF1	IPI	UniProtKB:Q9UBQ0-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Tgif1	IPI	PR:P28700	Mouse	PMID:16428452
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	TGIF1	IDA		Human	PMID:10764806
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	TGIF1	IDA		Human	PMID:28473536
Cellular Component	GO:0005654	nucleoplasm	TGIF1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Tgif1	IDA		Mouse	PMID:21503901
Cellular Component	GO:0005634	nucleus	Tgif1	IDA		Rat	PMID:15153551|RGD:1599409
Biological Process	GO:0035881	amacrine cell differentiation	Tgif1	IDA		Mouse	PMID:18973577
Biological Process	GO:0048854	brain morphogenesis	tgif1	IMP	ZFIN:ZDB-MRPHLNO-080501-1	Zfish	PMID:17998248
Biological Process	GO:0008283	cell population proliferation	Tgif1	IMP	MGI:MGI:3698004	Mouse	PMID:17082251
Biological Process	GO:0071363	cellular response to growth factor stimulus	Tgif1	IEP		Rat	PMID:15153551|RGD:1599409
Biological Process	GO:0071363	cellular response to growth factor stimulus	Tgif1	IEP		Rat	PMID:18441095|RGD:2317192
Biological Process	GO:0007368	determination of left/right symmetry	Tgif1	IMP	MGI:MGI:3652354	Mouse	PMID:16705179
Biological Process	GO:0009953	dorsal/ventral pattern formation	Tgif1	IMP	MGI:MGI:3698004	Mouse	PMID:17082251
Biological Process	GO:0048144	fibroblast proliferation	Tgif1	IMP	MGI:MGI:3652354	Mouse	PMID:16705179
Biological Process	GO:0021797	forebrain anterior/posterior pattern specification	tgif1	IGI	ZFIN:ZDB-GENE-990415-44,ZFIN:ZDB-MRPHLNO-080501-1	Zfish	PMID:17998248
Biological Process	GO:0008285	negative regulation of cell population proliferation	Tgif1	IMP	MGI:MGI:3698004	Mouse	PMID:17082251
Biological Process	GO:0010629	negative regulation of gene expression	Tgif1	IMP		Rat	PMID:18441095|RGD:2317192
Biological Process	GO:0048387	negative regulation of retinoic acid receptor signaling pathway	Tgif1	IMP	MGI:MGI:3617788	Mouse	PMID:16428452
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	TGIF1	IDA		Human	PMID:10764806
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	TGIF1	IMP		Human	PMID:10764806
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Tgif1	IGI	MGI:MGI:98214	Mouse	PMID:16428452
Biological Process	GO:0001843	neural tube closure	Tgif1	IMP	MGI:MGI:3698004	Mouse	PMID:17082251
Biological Process	GO:0030182	neuron differentiation	Tgif1	IDA		Mouse	PMID:18973577
Biological Process	GO:0038092	nodal signaling pathway	Tgif1	IGI	MGI:MGI:1915299	Mouse	PMID:20040491
Biological Process	GO:0046530	photoreceptor cell differentiation	tgif1	IGI	ZFIN:ZDB-GENO-200316-8,ZFIN:ZDB-MRPHLNO-090616-11	Zfish	PMID:30615274
Biological Process	GO:0046530	photoreceptor cell differentiation	tgif1	IMP	ZFIN:ZDB-GENO-200316-8	Zfish	PMID:30615274
Biological Process	GO:1902871	positive regulation of amacrine cell differentiation	Tgif1	IDA		Mouse	PMID:18973577
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Tgif1	IMP	MGI:MGI:3652354	Mouse	PMID:16705179
Biological Process	GO:0010470	regulation of gastrulation	Tgif1	IGI	MGI:MGI:97359	Mouse	PMID:20040491
Biological Process	GO:0010470	regulation of gastrulation	Tgif1	IGI	MGI:MGI:1915299	Mouse	PMID:20040491
Biological Process	GO:0048385	regulation of retinoic acid receptor signaling pathway	tgif1	IMP	ZFIN:ZDB-MRPHLNO-080501-1	Zfish	PMID:17998248
Biological Process	GO:0072091	regulation of stem cell proliferation	tgif1	IMP	ZFIN:ZDB-GENO-131016-13	Zfish	PMID:23918319
Biological Process	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	tgif1	IMP	ZFIN:ZDB-GENO-131016-13	Zfish	PMID:23918319
Biological Process	GO:0009410	response to xenobiotic stimulus	Tgif1	IEP		Rat	PMID:12169274|RGD:2317195
Biological Process	GO:0060041	retina development in camera-type eye	Tgif1	IDA		Mouse	PMID:18973577
Biological Process	GO:0070654	sensory epithelium regeneration	tgif1	IGI	ZFIN:ZDB-GENO-131030-2	Zfish	PMID:23918319
Biological Process	GO:0070654	sensory epithelium regeneration	tgif1	IMP	ZFIN:ZDB-GENO-131016-13	Zfish	PMID:23918319

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern