Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TH
  • Mouse genes Th
  • Rat genes Th
  • Zfish genes th
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Th

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016597	amino acid binding	Th	IPI	CHEBI:18186	Rat	PMID:15639226|RGD:1580027
Molecular Function	GO:0016597	amino acid binding	Th	IDA		Rat	PMID:19489646|RGD:4139886
Molecular Function	GO:0016597	amino acid binding	Th	IDA		Rat	PMID:20025246|RGD:4139888
Molecular Function	GO:0035240	dopamine binding	Th	IPI	CHEBI:18243	Rat	PMID:15639226|RGD:1580027
Molecular Function	GO:0019899	enzyme binding	TH	IPI	UniProtKB:P20711	Human	PMID:19703902
Molecular Function	GO:0008199	ferric iron binding	Th	IDA		Rat	PMID:16475826|RGD:1580023
Molecular Function	GO:0008199	ferric iron binding	Th	IDA		Rat	PMID:19489646|RGD:4139886
Molecular Function	GO:0008198	ferrous iron binding	Th	IDA		Rat	PMID:16475826|RGD:1580023
Molecular Function	GO:0008198	ferrous iron binding	Th	IDA		Rat	PMID:19489646|RGD:4139886
Molecular Function	GO:0004497	monooxygenase activity	Th	IDA		Rat	PMID:33381|RGD:8553784
Molecular Function	GO:0019825	oxygen binding	Th	IDA		Rat	PMID:19489646|RGD:4139886
Molecular Function	GO:0019825	oxygen binding	Th	IDA		Rat	PMID:20025246|RGD:4139888
Molecular Function	GO:0005515	protein binding	TH	IPI	UniProtKB:P37840	Human	PMID:11943812
Molecular Function	GO:0005515	protein binding	TH	IPI	UniProtKB:Q99497	Human	PMID:19703902
Molecular Function	GO:0005515	protein binding	Th	IPI	RGD:3729	Rat	PMID:11943812|RGD:5129111
Molecular Function	GO:0005515	protein binding	Th	IPI	RGD:67383	Rat	PMID:17507557|RGD:8694085
Molecular Function	GO:0005515	protein binding	Th	IPI	RGD:3693	Rat	PMID:19903816|RGD:5128868
Molecular Function	GO:0005515	protein binding	Th	IPI	RGD:3694	Rat	PMID:19903816|RGD:5128868
Molecular Function	GO:0019904	protein domain specific binding	Th	IPI	RGD:734009	Rat	PMID:19903816|RGD:5128868
Molecular Function	GO:0036094	small molecule binding	Th	IDA		Rat	PMID:10375411|RGD:152995565
Molecular Function	GO:0036094	small molecule binding	Th	EXP		Rat	PMID:19371093|RGD:152995543
Molecular Function	GO:0034617	tetrahydrobiopterin binding	Th	IDA		Rat	PMID:19489646|RGD:4139886
Molecular Function	GO:0034617	tetrahydrobiopterin binding	Th	IDA		Rat	PMID:20025246|RGD:4139888
Molecular Function	GO:0004511	tyrosine 3-monooxygenase activity	TH	IDA		Human	PMID:11943812
Molecular Function	GO:0004511	tyrosine 3-monooxygenase activity	TH	IDA		Human	PMID:12631248
Molecular Function	GO:0004511	tyrosine 3-monooxygenase activity	TH	IDA		Human	PMID:16338639
Molecular Function	GO:0004511	tyrosine 3-monooxygenase activity	TH	IDA		Human	PMID:1680128
Molecular Function	GO:0004511	tyrosine 3-monooxygenase activity	TH	IDA		Human	PMID:19703902
Molecular Function	GO:0004511	tyrosine 3-monooxygenase activity	TH	IDA		Human	PMID:2896667
Molecular Function	GO:0004511	tyrosine 3-monooxygenase activity	Th	IDA		Rat	PMID:19489646|RGD:4139886
Molecular Function	GO:0004511	tyrosine 3-monooxygenase activity	Th	IDA		Rat	PMID:20025246|RGD:4139888
Molecular Function	GO:0004511	tyrosine 3-monooxygenase activity	Th	IDA		Rat	PMID:20412389|RGD:4139887
Molecular Function	GO:0004511	tyrosine 3-monooxygenase activity	th	IMP		Zfish	PMID:23754283
Cellular Component	GO:0030424	axon	Th	IDA		Mouse	PMID:17761882
Cellular Component	GO:0030424	axon	Th	IDA		Mouse	PMID:15814794
Cellular Component	GO:0030424	axon	Th	IDA		Rat	PMID:14681933|RGD:1580024
Cellular Component	GO:0005737	cytoplasm	TH	IDA		Human	PMID:10907721
Cellular Component	GO:0005737	cytoplasm	TH	IDA		Human	PMID:21392500
Cellular Component	GO:0005737	cytoplasm	Th	IDA		Mouse	PMID:10707987
Cellular Component	GO:0005737	cytoplasm	Th	IDA		Rat	PMID:14681933|RGD:1580024
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	TH	IDA		Human	PMID:12457228
Cellular Component	GO:0031410	cytoplasmic vesicle	TH	IDA		Human	PMID:12457228
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	Th	IDA		Rat	PMID:11943812|RGD:5129111
Cellular Component	GO:0005829	cytosol	Th	IDA		Rat	PMID:15496595|RGD:1580025
Cellular Component	GO:0030425	dendrite	Th	IDA		Rat	PMID:21362438|RGD:5128613
Cellular Component	GO:0033162	melanosome membrane	TH	IDA		Human	PMID:12631248
Cellular Component	GO:0005739	mitochondrion	Th	IDA		Rat	PMID:11943812|RGD:5129111
Cellular Component	GO:0043005	neuron projection	TH	IDA		Human	PMID:17135716
Cellular Component	GO:0043005	neuron projection	Th	IDA		Mouse	PMID:12074840
Cellular Component	GO:0043005	neuron projection	Th	IDA		Mouse	PMID:23680462
Cellular Component	GO:0043005	neuron projection	Th	IDA		Rat	PMID:20412389|RGD:4139887
Cellular Component	GO:0043025	neuronal cell body	Th	IDA		Rat	PMID:21325515|RGD:5128615
Cellular Component	GO:0005634	nucleus	TH	IDA		Human	PMID:21392500
Cellular Component	GO:0005634	nucleus	Th	IDA		Mouse	PMID:15643613
Cellular Component	GO:0043204	perikaryon	Th	IDA		Mouse	PMID:10350535
Cellular Component	GO:0043204	perikaryon	Th	IDA		Rat	PMID:20434498|RGD:5129701
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Th	IDA		Mouse	MGI:MGI:6359287|PMID:30936473
Cellular Component	GO:0005790	smooth endoplasmic reticulum	TH	IDA		Human	PMID:12457228
Cellular Component	GO:0008021	synaptic vesicle	Th	IDA		Rat	PMID:15496595|RGD:1580025
Cellular Component	GO:0008021	synaptic vesicle	Th	IDA		Rat	PMID:19903816|RGD:5128868
Cellular Component	GO:0043195	terminal bouton	Th	IDA		Rat	PMID:14681933|RGD:1580024
Biological Process	GO:0015842	aminergic neurotransmitter loading into synaptic vesicle	Th	IDA		Rat	PMID:19903816|RGD:5128868
Biological Process	GO:0009887	animal organ morphogenesis	Th	IMP	MGI:MGI:1860450	Mouse	PMID:7715703
Biological Process	GO:0042423	catecholamine biosynthetic process	Th	IDA		Rat	PMID:20025246|RGD:4139888
Biological Process	GO:0042423	catecholamine biosynthetic process	th	IMP	ZFIN:ZDB-MRPHLNO-150831-3,ZFIN:ZDB-MRPHLNO-150831-4	Zfish	PMID:27539857
Biological Process	GO:0071312	cellular response to alkaloid	Th	IEP		Rat	PMID:18696327|RGD:5129084
Biological Process	GO:0071333	cellular response to glucose stimulus	Th	IEP		Rat	PMID:21217063|RGD:5128715
Biological Process	GO:0071363	cellular response to growth factor stimulus	Th	IEP		Rat	PMID:17306206|RGD:5129106
Biological Process	GO:0071287	cellular response to manganese ion	Th	IEP		Rat	PMID:19781568|RGD:5130971
Biological Process	GO:0071316	cellular response to nicotine	Th	IEP		Rat	PMID:20827341|RGD:5129209
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Th	IEP		Rat	PMID:18602388|RGD:5129085
Biological Process	GO:0021987	cerebral cortex development	Th	IEP		Rat	PMID:21295554|RGD:5128671
Biological Process	GO:0042745	circadian sleep/wake cycle	Th	IEP		Rat	PMID:20980612|RGD:5128829
Biological Process	GO:0050890	cognition	Th	IEP		Rat	PMID:20096955|RGD:5129469
Biological Process	GO:0042416	dopamine biosynthetic process	TH	IDA		Human	PMID:12457228
Biological Process	GO:0042416	dopamine biosynthetic process	th	IMP	ZFIN:ZDB-MRPHLNO-120827-3	Zfish	PMID:22879998
Biological Process	GO:0042416	dopamine biosynthetic process	th	IMP	ZFIN:ZDB-MRPHLNO-120827-4	Zfish	PMID:22879998
Biological Process	GO:0006585	dopamine biosynthetic process from tyrosine	Th	IMP	MGI:MGI:1860450	Mouse	PMID:7715703
Biological Process	GO:0006585	dopamine biosynthetic process from tyrosine	Th	IMP	MGI:MGI:1860450	Mouse	PMID:7592982
Biological Process	GO:0006585	dopamine biosynthetic process from tyrosine	Th	IDA		Mouse	PMID:9520487
Biological Process	GO:0006585	dopamine biosynthetic process from tyrosine	Th	IMP		Rat	PMID:11943812|RGD:5129111
Biological Process	GO:0006585	dopamine biosynthetic process from tyrosine	Th	IMP		Rat	PMID:19584816|RGD:5130972
Biological Process	GO:0006585	dopamine biosynthetic process from tyrosine	Th	IDA		Rat	PMID:2427363|RGD:1580046
Biological Process	GO:0042755	eating behavior	Th	IGI	MGI:MGI:104663	Mouse	PMID:10802666
Biological Process	GO:0042755	eating behavior	Th	IMP	MGI:MGI:1928960	Mouse	PMID:11430814
Biological Process	GO:0042755	eating behavior	Th	IGI	MGI:MGI:87934	Mouse	PMID:12538862
Biological Process	GO:0042755	eating behavior	Th	IMP	MGI:MGI:1928960	Mouse	PMID:15374756
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	Th	IMP		Mouse	MGI:MGI:3617102|PMID:16445854
Biological Process	GO:0042418	epinephrine biosynthetic process	TH	IDA		Human	PMID:12457228
Biological Process	GO:0042462	eye photoreceptor cell development	Th	IMP		Mouse	MGI:MGI:3617102|PMID:16445854
Biological Process	GO:0006631	fatty acid metabolic process	Th	IEP		Rat	PMID:21071351|RGD:5128814
Biological Process	GO:0016137	glycoside metabolic process	Th	IEP		Rat	PMID:20183248|RGD:5128866
Biological Process	GO:0007507	heart development	Th	IMP	MGI:MGI:1860480	Mouse	PMID:10212311
Biological Process	GO:0007507	heart development	Th	IMP	MGI:MGI:1860450	Mouse	PMID:7715703
Biological Process	GO:0007507	heart development	Th	IDA		Rat	PMID:21280046|RGD:5128679
Biological Process	GO:1990384	hyaloid vascular plexus regression	Th	IMP		Mouse	MGI:MGI:6359287|PMID:30936473
Biological Process	GO:0033076	isoquinoline alkaloid metabolic process	Th	IEP		Rat	PMID:18305432|RGD:5129087
Biological Process	GO:0007612	learning	Th	IMP	MGI:MGI:1928960	Mouse	PMID:14684249
Biological Process	GO:0007626	locomotory behavior	Th	IMP	MGI:MGI:1928960	Mouse	PMID:11430814
Biological Process	GO:0007626	locomotory behavior	Th	IMP	MGI:MGI:1928960	Mouse	PMID:14684249
Biological Process	GO:0007626	locomotory behavior	Th	IGI	MGI:MGI:87934	Mouse	PMID:12538862
Biological Process	GO:0007617	mating behavior	Th	IMP	MGI:MGI:1928960	Mouse	PMID:9829800
Biological Process	GO:0007613	memory	Th	IMP	MGI:MGI:1928960	Mouse	PMID:14684249
Biological Process	GO:0010259	multicellular organism aging	Th	IEP		Rat	PMID:17112516|RGD:5129108
Biological Process	GO:0042421	norepinephrine biosynthetic process	TH	IDA		Human	PMID:12457228
Biological Process	GO:0018963	phthalate metabolic process	Th	IEP		Rat	PMID:21145954|RGD:5128805
Biological Process	GO:0052314	phytoalexin metabolic process	Th	IEP		Rat	PMID:19185027|RGD:5128879
Biological Process	GO:0008016	regulation of heart contraction	Th	IMP	MGI:MGI:1860453	Mouse	PMID:7592982
Biological Process	GO:0008016	regulation of heart contraction	Th	IMP	MGI:MGI:1860450	Mouse	PMID:7715703
Biological Process	GO:0014823	response to activity	Th	IEP		Rat	PMID:21276429|RGD:5128681
Biological Process	GO:0001975	response to amphetamine	Th	IEP		Rat	PMID:21078367|RGD:5128808
Biological Process	GO:0051412	response to corticosterone	Th	IEP		Rat	PMID:19494803|RGD:5130973
Biological Process	GO:0051602	response to electrical stimulus	Th	IEP		Rat	PMID:21296669|RGD:5128670
Biological Process	GO:0032355	response to estradiol	Th	IEP		Rat	PMID:11914591|RGD:727567
Biological Process	GO:0045471	response to ethanol	TH	IDA		Human	PMID:18343820
Biological Process	GO:0045471	response to ethanol	Th	IEP		Rat	PMID:16713504|RGD:5130703
Biological Process	GO:0045472	response to ether	Th	IEP		Rat	PMID:15896472|RGD:5130730
Biological Process	GO:0070848	response to growth factor	Th	IEP		Rat	PMID:21236244|RGD:5128712
Biological Process	GO:0009635	response to herbicide	Th	IEP		Rat	PMID:20553223|RGD:5130934
Biological Process	GO:0001666	response to hypoxia	TH	IDA		Human	PMID:17520326
Biological Process	GO:0001666	response to hypoxia	Th	IDA		Rat	PMID:12692140|RGD:1580029
Biological Process	GO:0001666	response to hypoxia	Th	IEP		Rat	PMID:21075155|RGD:5128812
Biological Process	GO:0035902	response to immobilization stress	Th	IEP		Rat	PMID:11858766|RGD:727666
Biological Process	GO:0017085	response to insecticide	Th	IEP		Rat	PMID:21277943|RGD:5128680
Biological Process	GO:0035900	response to isolation stress	Th	IEP		Rat	PMID:19893991|RGD:9684986
Biological Process	GO:0009416	response to light stimulus	Th	IEP		Rat	PMID:21185915|RGD:5128767
Biological Process	GO:0032496	response to lipopolysaccharide	Th	IEP		Rat	PMID:21239462|RGD:5128710
Biological Process	GO:0010038	response to metal ion	Th	IEP		Rat	PMID:20224926|RGD:5130952
Biological Process	GO:0035094	response to nicotine	Th	IEP		Rat	PMID:17437548|RGD:5129090
Biological Process	GO:0031667	response to nutrient levels	Th	IEP		Rat	PMID:21364997|RGD:5128611
Biological Process	GO:0014070	response to organic cyclic compound	Th	IEP		Rat	PMID:20951685|RGD:5128840
Biological Process	GO:0043434	response to peptide hormone	Th	IEP		Rat	PMID:21129429|RGD:5128806
Biological Process	GO:0046684	response to pyrethroid	Th	IEP		Rat	PMID:16229977|RGD:5129144
Biological Process	GO:0009651	response to salt stress	Th	IEP		Rat	PMID:21113619|RGD:5128807
Biological Process	GO:0048545	response to steroid hormone	Th	IEP		Rat	PMID:11883789|RGD:1601633
Biological Process	GO:0009414	response to water deprivation	Th	IEP		Rat	PMID:15637337|RGD:5130758
Biological Process	GO:0009410	response to xenobiotic stimulus	Th	IEP		Rat	PMID:21396352|RGD:5128664
Biological Process	GO:0010043	response to zinc ion	Th	IEP		Rat	PMID:20553223|RGD:5130934
Biological Process	GO:0007605	sensory perception of sound	Th	IEP		Rat	PMID:16080996|RGD:5130729
Biological Process	GO:0035176	social behavior	Th	IEP		Rat	PMID:15345906|RGD:5130765
Biological Process	GO:0006665	sphingolipid metabolic process	Th	IEP		Rat	PMID:21076868|RGD:5128811
Biological Process	GO:0021522	spinal cord motor neuron differentiation	th	IMP	ZFIN:ZDB-MRPHLNO-130822-1	Zfish	PMID:23707737
Biological Process	GO:0001963	synaptic transmission, dopaminergic	Th	IMP	MGI:MGI:1928960	Mouse	PMID:12604788
Biological Process	GO:0001963	synaptic transmission, dopaminergic	Th	IMP	MGI:MGI:1928960	Mouse	PMID:15317940
Biological Process	GO:0042214	terpene metabolic process	Th	IEP		Rat	PMID:20934257|RGD:5128841
Biological Process	GO:0007601	visual perception	Th	IMP		Mouse	MGI:MGI:3617102|PMID:16445854

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern