Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Thra

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes THRA
- Mouse genes Thra
- Rat genes Thra
- Zfish genes thraa,thrab
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Thra

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031490	chromatin DNA binding	Thra	IDA		Mouse	PMID:17952069
Molecular Function	GO:0003700	DNA-binding transcription factor activity	THRA	IDA		Human	PMID:18052923
Molecular Function	GO:0003700	DNA-binding transcription factor activity	THRA	IDA		Human	PMID:8710870
Molecular Function	GO:0003700	DNA-binding transcription factor activity	THRA	IDA		Human	PMID:9653119
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Thra	IDA		Rat	PMID:12039959\|RGD:625494
Molecular Function	GO:0140296	general transcription initiation factor binding	THRA	IPI	UniProtKB:Q00403	Human	PMID:8524305
Molecular Function	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding	Thra	IDA		Rat	PMID:20368265\|RGD:2324624
Molecular Function	GO:0004879	nuclear receptor activity	THRA	IDA		Human	PMID:15466465
Molecular Function	GO:0004879	nuclear receptor activity	THRA	IDA		Human	PMID:18052923
Molecular Function	GO:0004879	nuclear receptor activity	THRA	IDA		Human	PMID:8710870
Molecular Function	GO:0004879	nuclear receptor activity	Thra	IDA		Mouse	PMID:15322135
Molecular Function	GO:0004879	nuclear receptor activity	thraa	IDA		Zfish	PMID:17583703
Molecular Function	GO:0005515	protein binding	THRA	IPI	UniProtKB:Q9JLI4	Human	PMID:10866662
Molecular Function	GO:0005515	protein binding	THRA	IPI	UniProtKB:Q8TAP6	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	THRA	IPI	UniProtKB:Q96JM7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	THRA	IPI	UniProtKB:Q9Y2J4-4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	THRA	IPI	UniProtKB:O75410-7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	THRA	IPI	UniProtKB:O95971	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	THRA	IPI	UniProtKB:P31321	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	THRA	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	THRA	IPI	UniProtKB:Q8TAP6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	THRA	IPI	UniProtKB:Q96A49	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	THRA	IPI	UniProtKB:Q9Y2J4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	THRA	IPI	UniProtKB:Q15648	Human	PMID:9653119
Molecular Function	GO:0005515	protein binding	Thra	IPI	UniProtKB:D4A055	Mouse	MGI:MGI:5441119\|PMID:22892567
Molecular Function	GO:0005515	protein binding	Thra	IPI	UniProtKB:O54943	Mouse	MGI:MGI:4429726\|PMID:20159955
Molecular Function	GO:0005515	protein binding	Thra	IPI	PR:Q61645	Mouse	PMID:11641275
Molecular Function	GO:0005515	protein binding	Thra	IPI	PR:Q5SEK5	Mouse	PMID:15322135
Molecular Function	GO:0005515	protein binding	Thra	IPI	UniProtKB:O75410-10	Rat	PMID:20078863\|RGD:14995312
Molecular Function	GO:0005515	protein binding	thraa	IPI	UniProtKB:Q98TW1	Zfish	PMID:17583703\|ZFIN:ZDB-PUB-070629-26
Molecular Function	GO:0019904	protein domain specific binding	THRA	IPI	UniProtKB:Q15648	Human	PMID:9653119
Molecular Function	GO:0042803	protein homodimerization activity	Thra	IDA		Rat	PMID:8407924\|RGD:1580108
Molecular Function	GO:0044877	protein-containing complex binding	Thra	IDA		Mouse	PMID:15340084
Molecular Function	GO:0044877	protein-containing complex binding	Thra	IDA		Rat	PMID:12039959\|RGD:625494
Molecular Function	GO:0044877	protein-containing complex binding	Thra	IDA		Rat	PMID:8407924\|RGD:1580108
Molecular Function	GO:0043565	sequence-specific DNA binding	Thra	IDA		Rat	PMID:8407924\|RGD:1580108
Molecular Function	GO:0003727	single-stranded RNA binding	Thra	IDA		Rat	PMID:16356627\|RGD:1580096
Molecular Function	GO:0017025	TBP-class protein binding	THRA	IDA		Human	PMID:8524305
Molecular Function	GO:0070324	thyroid hormone binding	THRA	IDA		Human	PMID:15466465
Molecular Function	GO:0070324	thyroid hormone binding	THRA	IPI	CHEBI:18258	Human	PMID:2879243
Molecular Function	GO:0070324	thyroid hormone binding	THRA	IDA		Human	PMID:8710870
Molecular Function	GO:0000976	transcription cis-regulatory region binding	THRA	IDA		Human	PMID:18052923
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Thra	IDA		Mouse	MGI:MGI:5700300\|PMID:19001373
Cellular Component	GO:0005737	cytoplasm	Thra	IDA		Rat	PMID:16356627\|RGD:1580096
Cellular Component	GO:0005829	cytosol	THRA	IDA		Human	PMID:19158403
Cellular Component	GO:0005829	cytosol	Thra	IDA		Rat	PMID:16155104\|RGD:1580094
Cellular Component	GO:0005739	mitochondrion	Thra	IDA		Rat	PMID:17159345\|RGD:2314322
Cellular Component	GO:0005634	nucleus	THRA	IDA		Human	PMID:19158403
Cellular Component	GO:0005634	nucleus	THRA	IDA		Human	PMID:8710870
Cellular Component	GO:0005634	nucleus	Thra	IDA		Mouse	PMID:17952069
Cellular Component	GO:0005634	nucleus	Thra	IDA		Rat	PMID:16155104\|RGD:1580094
Cellular Component	GO:0005634	nucleus	Thra	IDA		Rat	PMID:16356627\|RGD:1580096
Cellular Component	GO:0005634	nucleus	thraa	IDA		Zfish	PMID:9447705\|ZFIN:ZDB-PUB-980123-3
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	Thra	IDA		Mouse	MGI:MGI:6827315\|PMID:8910441
Biological Process	GO:0030325	adrenal gland development	Thra	IEP		Rat	PMID:17496154\|RGD:2314319
Biological Process	GO:0009887	animal organ morphogenesis	Thra	IMP	MGI:MGI:1860407	Mouse	PMID:9927422
Biological Process	GO:0007420	brain development	Thra	IEP		Rat	PMID:17496154\|RGD:2314319
Biological Process	GO:0001502	cartilage condensation	Thra	IMP	MGI:MGI:1860442	Mouse	PMID:9250685
Biological Process	GO:0048565	digestive tract development	Thra	IEP		Rat	PMID:17496154\|RGD:2314319
Biological Process	GO:0048568	embryonic organ development	Thra	IEP		Rat	PMID:17496154\|RGD:2314319
Biological Process	GO:0030218	erythrocyte differentiation	Thra	IMP	MGI:MGI:1860442	Mouse	PMID:18203951
Biological Process	GO:0008050	female courtship behavior	Thra	IMP	MGI:MGI:1860441	Mouse	PMID:10769387
Biological Process	GO:0007507	heart development	thraa	IMP	ZFIN:ZDB-GENO-220519-2	Zfish	PMID:32762296
Biological Process	GO:0007507	heart development	thrab	IMP	ZFIN:ZDB-GENO-220519-3	Zfish	PMID:32762296
Biological Process	GO:0009755	hormone-mediated signaling pathway	THRA	IDA		Human	PMID:18052923
Biological Process	GO:0001822	kidney development	Thra	IEP		Rat	PMID:17496154\|RGD:2314319
Biological Process	GO:0007611	learning or memory	Thra	IMP	MGI:MGI:1860442	Mouse	PMID:17129617
Biological Process	GO:0001889	liver development	Thra	IEP		Rat	PMID:17496154\|RGD:2314319
Biological Process	GO:0030324	lung development	Thra	IEP		Rat	PMID:17496154\|RGD:2314319
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	Thra	IDA		Mouse	MGI:MGI:6827315\|PMID:8910441
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	Thra	IDA		Rat	PMID:2537467\|RGD:1580107
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	THRA	IDA		Human	PMID:8710870
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Thra	IDA		Mouse	PMID:11641275
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Thra	IDA		Mouse	PMID:15062575
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Thra	IDA		Mouse	PMID:15322135
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	thraa	IDA		Zfish	PMID:9447705\|ZFIN:ZDB-PUB-980123-3
Biological Process	GO:2000143	negative regulation of DNA-templated transcription initiation	THRA	IDA		Human	PMID:8524305
Biological Process	GO:0017055	negative regulation of RNA polymerase II transcription preinitiation complex assembly	THRA	IDA		Human	PMID:8524305
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	thraa	IMP		Zfish	PMID:9447705\|ZFIN:ZDB-PUB-980123-3
Biological Process	GO:0014032	neural crest cell development	thraa	IMP	ZFIN:ZDB-MRPHLNO-130306-1	Zfish	PMID:23165295
Biological Process	GO:0001503	ossification	Thra	IMP	MGI:MGI:1860407	Mouse	PMID:9927422
Biological Process	GO:0001503	ossification	Thra	IMP	MGI:MGI:1860442	Mouse	PMID:9250685
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Thra	IMP		Mouse	MGI:MGI:5141341\|PMID:21652727
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	thraa	IDA		Zfish	PMID:9447705\|ZFIN:ZDB-PUB-980123-3
Biological Process	GO:0045925	positive regulation of female receptivity	Thra	IMP	MGI:MGI:1860441	Mouse	PMID:10769387
Biological Process	GO:0060298	positive regulation of sarcomere organization	thrab	IMP	ZFIN:ZDB-GENO-220519-3	Zfish	PMID:32762296
Biological Process	GO:0060298	positive regulation of sarcomere organization	thraa	IMP	ZFIN:ZDB-GENO-220519-2	Zfish	PMID:32762296
Biological Process	GO:0002157	positive regulation of thyroid hormone mediated signaling pathway	Thra	IDA		Mouse	MGI:MGI:6827315\|PMID:8910441
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Thra	IDA		Mouse	MGI:MGI:6827315\|PMID:8910441
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Thra	IMP		Mouse	MGI:MGI:5700300\|PMID:19001373
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Thra	IDA		Mouse	PMID:15340084
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Thra	IDA		Rat	PMID:12039959\|RGD:625494
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	thraa	IMP		Zfish	PMID:9447705\|ZFIN:ZDB-PUB-980123-3
Biological Process	GO:0006355	regulation of DNA-templated transcription	thraa	IDA		Zfish	PMID:17583703
Biological Process	GO:0008016	regulation of heart contraction	Thra	IMP	MGI:MGI:1860441	Mouse	PMID:9430637
Biological Process	GO:0008016	regulation of heart contraction	Thra	IMP	MGI:MGI:2183135	Mouse	PMID:15240882
Biological Process	GO:0050994	regulation of lipid catabolic process	Thra	IMP	MGI:MGI:2679056	Mouse	PMID:12869545
Biological Process	GO:0033032	regulation of myeloid cell apoptotic process	Thra	IMP	MGI:MGI:1860442	Mouse	PMID:18203951
Biological Process	GO:0002155	regulation of thyroid hormone mediated signaling pathway	Thra	IMP	MGI:MGI:2679056	Mouse	PMID:12869545
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	THRA	IDA		Human	PMID:18052923
Biological Process	GO:0009409	response to cold	Thra	IMP	MGI:MGI:2679056	Mouse	PMID:12869545
Biological Process	GO:0009725	response to hormone	thraa	IDA		Zfish	PMID:17418841
Biological Process	GO:0031667	response to nutrient levels	Thra	IEP		Rat	PMID:19794517\|RGD:2314312
Biological Process	GO:0009410	response to xenobiotic stimulus	Thra	IEP		Rat	PMID:18930353\|RGD:2314318
Biological Process	GO:0030878	thyroid gland development	Thra	IGI	MGI:MGI:97492	Mouse	PMID:11773436
Biological Process	GO:0002154	thyroid hormone mediated signaling pathway	thraa	IMP	ZFIN:ZDB-MRPHLNO-160429-5	Zfish	PMID:26802880
Biological Process	GO:0006366	transcription by RNA polymerase II	THRA	IDA		Human	PMID:8710870
Biological Process	GO:0006366	transcription by RNA polymerase II	THRA	IDA		Human	PMID:9653119
Biological Process	GO:0060509	type I pneumocyte differentiation	Thra	IGI	MGI:MGI:1337080	Mouse	PMID:22001906
Biological Process	GO:0060509	type I pneumocyte differentiation	Thra	IGI	MGI:MGI:98743	Mouse	PMID:22001906
Biological Process	GO:0021591	ventricular system development	thraa	IMP	ZFIN:ZDB-MRPHLNO-160429-5	Zfish	PMID:26802880

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/03/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.