Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes THRB
  • Mouse genes Thrb
  • Rat genes Thrb
  • Zfish genes thrb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Thrb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Thrb	IDA		Mouse	PMID:22079090
Molecular Function	GO:0031490	chromatin DNA binding	Thrb	IDA		Mouse	PMID:17952069
Molecular Function	GO:0003690	double-stranded DNA binding	Thrb	IDA		Rat	PMID:15766871|RGD:1601662
Molecular Function	GO:0019899	enzyme binding	THRB	IPI	UniProtKB:P55345	Human	PMID:12039952
Molecular Function	GO:0042802	identical protein binding	Thrb	IPI	RGD:3858	Rat	PMID:15766871|RGD:1601662
Molecular Function	GO:0004879	nuclear receptor activity	THRB	IDA		Human	PMID:15466465
Molecular Function	GO:0004879	nuclear receptor activity	Thrb	IMP	MGI:2657173	Mouse	PMID:20203194
Molecular Function	GO:0004879	nuclear receptor activity	Thrb	IMP	MGI:MGI:2657173	Mouse	PMID:20203194
Molecular Function	GO:0004879	nuclear receptor activity	Thrb	IDA		Rat	PMID:2457590|RGD:729962
Molecular Function	GO:0004879	nuclear receptor activity	thrb	IDA		Zfish	PMID:17583703
Molecular Function	GO:0005515	protein binding	THRB	IPI	UniProtKB:Q60974	Human	PMID:12904255
Molecular Function	GO:0005515	protein binding	THRB	IPI	UniProtKB:P51843	Human	PMID:15100213
Molecular Function	GO:0005515	protein binding	THRB	IPI	UniProtKB:P32780	Human	PMID:15625236
Molecular Function	GO:0005515	protein binding	THRB	IPI	UniProtKB:P62195	Human	PMID:7870181
Molecular Function	GO:0005515	protein binding	Thrb	IPI	UniProtKB:O08915	Mouse	MGI:MGI:3692520|PMID:16936638
Molecular Function	GO:0005515	protein binding	Thrb	IPI	PR:P23611	Mouse	PMID:25331958
Molecular Function	GO:0005515	protein binding	Thrb	IPI	PR:Q60974	Mouse	PMID:19052228
Molecular Function	GO:0005515	protein binding	Thrb	IPI	PR:O35473	Mouse	PMID:9405624
Molecular Function	GO:0005515	protein binding	Thrb	IPI	PR:P26450	Mouse	PMID:17606624
Molecular Function	GO:0005515	protein binding	thrb	IPI	UniProtKB:Q98TW1	Zfish	PMID:18248177|ZFIN:ZDB-PUB-050628-9
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	THRB	IDA		Human	PMID:28473536
Molecular Function	GO:0070324	thyroid hormone binding	THRB	IDA		Human	PMID:15466465
Molecular Function	GO:0001223	transcription coactivator binding	THRB	IPI	UniProtKB:Q9H0E9	Human	PMID:9368056
Cellular Component	GO:0016604	nuclear body	THRB	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Thrb	IDA		Mouse	PMID:17952069
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	THRB	IDA		Human	PMID:26289479
Biological Process	GO:0009887	animal organ morphogenesis	Thrb	IMP	MGI:MGI:1860407	Mouse	PMID:9927422
Biological Process	GO:0043010	camera-type eye development	thrb	IMP	ZFIN:ZDB-MRPHLNO-160429-6	Zfish	PMID:26802880
Biological Process	GO:0097067	cellular response to thyroid hormone stimulus	THRB	IDA		Human	PMID:9368056
Biological Process	GO:0048568	embryonic organ development	Thrb	IEP		Rat	PMID:17496154|RGD:2314319
Biological Process	GO:0008050	female courtship behavior	Thrb	IMP	MGI:MGI:1860441	Mouse	PMID:10769387
Biological Process	GO:0048839	inner ear development	thrb	IMP	ZFIN:ZDB-MRPHLNO-160429-6	Zfish	PMID:26802880
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	THRB	IDA		Human	PMID:26289479
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Thrb	IDA		Mouse	PMID:15062575
Biological Process	GO:0007621	negative regulation of female receptivity	Thrb	IMP	MGI:MGI:1860434	Mouse	PMID:10769387
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Thrb	IGI	MGI:MGI:1349717	Mouse	PMID:7566114
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Thrb	IGI	MGI:MGI:98214	Mouse	PMID:22001906
Biological Process	GO:0008284	positive regulation of cell population proliferation	Thrb	IMP		Rat	PMID:16574785|RGD:1601660
Biological Process	GO:0032332	positive regulation of chondrocyte differentiation	Thrb	IDA		Rat	PMID:15647824|RGD:1601663
Biological Process	GO:0045778	positive regulation of ossification	Thrb	IDA		Rat	PMID:15647824|RGD:1601663
Biological Process	GO:0002157	positive regulation of thyroid hormone mediated signaling pathway	THRB	IDA		Human	PMID:26289479
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	THRB	IDA		Human	PMID:26289479
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Thrb	IGI	MGI:MGI:1346317	Mouse	PMID:12407160
Biological Process	GO:0090181	regulation of cholesterol metabolic process	Thrb	IMP		Rat	PMID:17878314|RGD:2315101
Biological Process	GO:0006355	regulation of DNA-templated transcription	thrb	IDA		Zfish	PMID:17583703
Biological Process	GO:0008016	regulation of heart contraction	Thrb	IMP		Mouse	PMID:9832432
Biological Process	GO:0019216	regulation of lipid metabolic process	Thrb	IDA		Rat	PMID:15941710|RGD:1601661
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Thrb	IGI	MGI:MGI:1349717	Mouse	PMID:19052228
Biological Process	GO:0090207	regulation of triglyceride metabolic process	Thrb	IMP		Rat	PMID:17878314|RGD:2315101
Biological Process	GO:0097474	retinal cone cell apoptotic process	Thrb	IMP		Mouse	PMID:20203194
Biological Process	GO:0046549	retinal cone cell development	Thrb	IMP		Mouse	PMID:20203194
Biological Process	GO:0046549	retinal cone cell development	thrb	IMP	ZFIN:ZDB-GENO-230228-5	Zfish	PMID:32569302
Biological Process	GO:0046549	retinal cone cell development	thrb	IMP	ZFIN:ZDB-MRPHLNO-131114-1	Zfish	PMID:23980162
Biological Process	GO:0042670	retinal cone cell differentiation	thrb	IMP	ZFIN:ZDB-GENO-220131-4	Zfish	PMID:32541022
Biological Process	GO:0042671	retinal cone cell fate determination	thrb	IMP	ZFIN:ZDB-GENO-130130-6	Zfish	PMID:30592497
Biological Process	GO:0007605	sensory perception of sound	Thrb	IMP	MGI:MGI:1860434	Mouse	PMID:8673137
Biological Process	GO:0002154	thyroid hormone mediated signaling pathway	thrb	IMP	ZFIN:ZDB-MRPHLNO-160429-6	Zfish	PMID:26802880
Biological Process	GO:0060509	type I pneumocyte differentiation	Thrb	IGI	MGI:MGI:1337080	Mouse	PMID:22001906
Biological Process	GO:0060509	type I pneumocyte differentiation	Thrb	IGI	MGI:MGI:98742	Mouse	PMID:22001906

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern