Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TIA1
  • Mouse genes Tia1
  • Rat genes Tia1
  • Zfish genes tia1,tia1l
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tia1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0035925	mRNA 3'-UTR AU-rich region binding	Tia1	IDA		Mouse	PMID:10921895
Molecular Function	GO:0003730	mRNA 3'-UTR binding	Tia1	IDA		Mouse	MGI:MGI:6827200|PMID:16227602
Molecular Function	GO:0003730	mRNA 3'-UTR binding	tia1	IDA		Zfish	PMID:31227602
Molecular Function	GO:0005515	protein binding	TIA1	IPI	UniProtKB:P08621	Human	PMID:12486009
Molecular Function	GO:0005515	protein binding	TIA1	IPI	UniProtKB:P09012	Human	PMID:12486009
Molecular Function	GO:0005515	protein binding	TIA1	IPI	UniProtKB:P09234	Human	PMID:12486009
Molecular Function	GO:0005515	protein binding	TIA1	IPI	UniProtKB:Q14296	Human	PMID:17135269
Molecular Function	GO:0005515	protein binding	TIA1	IPI	UniProtKB:Q92879	Human	PMID:18164289
Molecular Function	GO:0005515	protein binding	TIA1	IPI	UniProtKB:Q14296	Human	PMID:7544399
Molecular Function	GO:0005515	protein binding	Tia1	IPI	UniProtKB:P70372|UniProtKB:Q03160	Mouse	MGI:MGI:5284766|PMID:18273060
Molecular Function	GO:0003723	RNA binding	TIA1	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	TIA1	HDA		Human	PMID:22681889
Molecular Function	GO:0003723	RNA binding	TIA1	IDA		Human	PMID:8576255
Cellular Component	GO:0005737	cytoplasm	TIA1	IDA		Human	PMID:24965446
Cellular Component	GO:0005737	cytoplasm	TIA1	IDA		Human	PMID:7488725
Cellular Component	GO:0005737	cytoplasm	Tia1	IDA		Mouse	MGI:MGI:6827199|PMID:11514562
Cellular Component	GO:0005737	cytoplasm	Tia1	IDA		Mouse	PMID:12388085
Cellular Component	GO:0010494	cytoplasmic stress granule	TIA1	IDA		Human	PMID:21984414
Cellular Component	GO:0010494	cytoplasmic stress granule	TIA1	IDA		Human	PMID:8576255
Cellular Component	GO:0010494	cytoplasmic stress granule	Tia1	IDA		Mouse	MGI:MGI:6827198|PMID:29298433
Cellular Component	GO:0010494	cytoplasmic stress granule	Tia1	IDA		Mouse	MGI:MGI:6148443|PMID:27430620
Cellular Component	GO:0010494	cytoplasmic stress granule	Tia1	IDA		Mouse	PMID:22022532
Cellular Component	GO:0010494	cytoplasmic stress granule	Tia1	IDA		Mouse	PMID:21933836
Cellular Component	GO:0010494	cytoplasmic stress granule	Tia1	IDA		Rat	PMID:16055272|RGD:10059581
Cellular Component	GO:0005829	cytosol	TIA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0097165	nuclear stress granule	TIA1	IDA		Human	PMID:21984414
Cellular Component	GO:0097165	nuclear stress granule	Tia1	IDA		Mouse	PMID:22022532
Cellular Component	GO:0005654	nucleoplasm	TIA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	TIA1	IDA		Human	PMID:8576255
Cellular Component	GO:0005634	nucleus	TIA1	IDA		Human	PMID:18164289
Cellular Component	GO:0005634	nucleus	Tia1	IDA		Mouse	PMID:12388085
Cellular Component	GO:0005634	nucleus	Tia1	IDA		Mouse	PMID:16278295
Cellular Component	GO:0005634	nucleus	Tia1	IDA		Rat	PMID:12855701|RGD:10059306
Cellular Component	GO:1990904	ribonucleoprotein complex	Tia1	IDA		Rat	PMID:12855701|RGD:10059306
Biological Process	GO:0001818	negative regulation of cytokine production	Tia1	IMP	MGI:MGI:3037091	Mouse	PMID:10921895
Biological Process	GO:0017148	negative regulation of translation	Tia1	IDA		Mouse	MGI:MGI:6827200|PMID:16227602
Biological Process	GO:0017148	negative regulation of translation	Tia1	IMP	MGI:MGI:3037091	Mouse	PMID:10921895
Biological Process	GO:1904037	positive regulation of epithelial cell apoptotic process	Tia1	IMP		Rat	PMID:22555848|RGD:10059425
Biological Process	GO:1903608	protein localization to cytoplasmic stress granule	TIA1	IMP		Human	PMID:24965446
Biological Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	TIA1	IDA		Human	PMID:14966131
Biological Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	TIA1	IDA		Human	PMID:17580305
Biological Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	Tia1	IDA		Mouse	MGI:MGI:6827311|PMID:10938105
Biological Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	Tia1	IDA		Mouse	MGI:MGI:6827199|PMID:11514562
Biological Process	GO:0048024	regulation of mRNA splicing, via spliceosome	TIA1	IDA		Human	PMID:11106748
Biological Process	GO:0048024	regulation of mRNA splicing, via spliceosome	TIA1	IDA		Human	PMID:7488725
Biological Process	GO:0034063	stress granule assembly	TIA1	IDA		Human	PMID:8576255

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern