Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Tiam1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes TIAM1
- Mouse genes Tiam1
- Rat genes Tiam1
- Zfish genes tiam1a,tiam1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tiam1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0046875	ephrin receptor binding	Tiam1	IPI	PR:P52795	Mouse	PMID:14988728
Molecular Function	GO:0046875	ephrin receptor binding	Tiam1	IPI	PR:Q03145	Mouse	PMID:14988728
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	TIAM1	EXP		Human	PMID:15721239
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	TIAM1	IMP		Human	PMID:20361982
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	TIAM1	IDA		Human	PMID:23109420
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	TIAM1	IMP		Human	PMID:25684205
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Tiam1	IMP		Mouse	MGI:MGI:5466648\|PMID:23109420
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Tiam1	IDA		Mouse	PMID:12525493
Molecular Function	GO:0019900	kinase binding	TIAM1	IPI	UniProtKB:P49674	Human	PMID:23109420
Molecular Function	GO:0019900	kinase binding	TIAM1	IPI	UniProtKB:Q9JMK2	Human	PMID:23109420
Molecular Function	GO:0008017	microtubule binding	Tiam1	IDA		Mouse	PMID:23533177
Molecular Function	GO:0008017	microtubule binding	Tiam1	IDA		Rat	PMID:11264310\|RGD:10043321
Molecular Function	GO:0005543	phospholipid binding	Tiam1	IDA		Mouse	PMID:12525493
Molecular Function	GO:0005515	protein binding	TIAM1	IPI	UniProtKB:P54763	Human	PMID:17440041
Molecular Function	GO:0005515	protein binding	TIAM1	IPI	UniProtKB:O14936	Human	PMID:21763699
Molecular Function	GO:0005515	protein binding	TIAM1	IPI	UniProtKB:Q60838	Human	PMID:23109420
Molecular Function	GO:0005515	protein binding	TIAM1	IPI	UniProtKB:Q92997	Human	PMID:23109420
Molecular Function	GO:0005515	protein binding	TIAM1	IPI	UniProtKB:P18827	Human	PMID:23395182
Molecular Function	GO:0005515	protein binding	TIAM1	IPI	UniProtKB:Q9C0A0-1	Human	PMID:23395182
Molecular Function	GO:0005515	protein binding	TIAM1	IPI	UniProtKB:O14936	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Tiam1	IPI	UniProtKB:Q61062	Mouse	MGI:MGI:5466648\|PMID:23109420
Molecular Function	GO:0005515	protein binding	Tiam1	IPI	UniProtKB:P15379	Mouse	MGI:MGI:4420511\|PMID:19893486
Molecular Function	GO:0005515	protein binding	Tiam1	IPI	UniProtKB:Q60838	Mouse	MGI:MGI:5466648\|PMID:23109420
Molecular Function	GO:0005515	protein binding	Tiam1	IPI	RGD:731438	Rat	PMID:12446731\|RGD:629540
Molecular Function	GO:0005515	protein binding	Tiam1	IPI	RGD:619814	Rat	PMID:15899863\|RGD:10043187
Molecular Function	GO:0005515	protein binding	Tiam1	IPI	RGD:620374	Rat	PMID:16474385\|RGD:10043325
Molecular Function	GO:0005515	protein binding	Tiam1	IPI	RGD:1305608	Rat	PMID:23595754\|RGD:13831359
Molecular Function	GO:0030971	receptor tyrosine kinase binding	Tiam1	IPI	UniProtKB:P15209	Mouse	MGI:MGI:5306304\|PMID:16801538
Molecular Function	GO:0030971	receptor tyrosine kinase binding	Tiam1	IPI	RGD:3213	Rat	PMID:16801538\|RGD:10043330
Cellular Component	GO:0044295	axonal growth cone	Tiam1	IDA		Rat	PMID:11264310\|RGD:10043321
Cellular Component	GO:0044291	cell-cell contact zone	TIAM1	IDA		Human	PMID:20361982
Cellular Component	GO:0005911	cell-cell junction	TIAM1	IDA		Human	PMID:20332120
Cellular Component	GO:0005737	cytoplasm	Tiam1	IDA		Rat	PMID:12446731\|RGD:629540
Cellular Component	GO:0005829	cytosol	TIAM1	IDA		Human	PMID:23109420
Cellular Component	GO:0005829	cytosol	Tiam1	IDA		Rat	PMID:18930714\|RGD:10043296
Cellular Component	GO:0043197	dendritic spine	Tiam1	IDA		Rat	PMID:16474385\|RGD:10043325
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	TIAM1	IDA		Human	PMID:20361982
Cellular Component	GO:0099147	extrinsic component of postsynaptic density membrane	Tiam1	IDA		Rat	PMID:15721239\|RGD:12050147
Cellular Component	GO:0098978	glutamatergic synapse	Tiam1	IDA		Rat	PMID:15721239\|RGD:12050147
Cellular Component	GO:0098978	glutamatergic synapse	Tiam1	IMP		Rat	PMID:15721239\|RGD:12050147
Cellular Component	GO:0060091	kinocilium	Tiam1	IDA		Mouse	PMID:23533177
Cellular Component	GO:0044304	main axon	Tiam1	IDA		Rat	PMID:11264310\|RGD:10043321
Cellular Component	GO:0005874	microtubule	Tiam1	IDA		Rat	PMID:11264310\|RGD:10043321
Cellular Component	GO:0043025	neuronal cell body	Tiam1	IDA		Rat	PMID:11264310\|RGD:10043321
Cellular Component	GO:0005634	nucleus	Tiam1	IDA		Rat	PMID:12446731\|RGD:629540
Cellular Component	GO:0000242	pericentriolar material	Tiam1	IDA		Mouse	PMID:23533177
Cellular Component	GO:0005886	plasma membrane	TIAM1	IDA		Human	PMID:23109420
Cellular Component	GO:0005886	plasma membrane	Tiam1	IDA		Mouse	PMID:12525493
Cellular Component	GO:0005886	plasma membrane	Tiam1	IDA		Mouse	PMID:22750946
Cellular Component	GO:0014069	postsynaptic density	Tiam1	IDA		Rat	PMID:15721239\|RGD:12050147
Cellular Component	GO:0014069	postsynaptic density	Tiam1	IDA		Rat	PMID:23595754\|RGD:13831359
Cellular Component	GO:0032587	ruffle membrane	Tiam1	IDA		Rat	PMID:12446731\|RGD:629540
Cellular Component	GO:0036477	somatodendritic compartment	Tiam1	IDA		Rat	PMID:23300879\|RGD:10043324
Cellular Component	GO:0045202	synapse	Tiam1	IDA		Rat	PMID:16474385\|RGD:10043325
Biological Process	GO:0090630	activation of GTPase activity	TIAM1	IDA		Human	PMID:23109420
Biological Process	GO:0090630	activation of GTPase activity	Tiam1	IMP		Mouse	MGI:MGI:5466648\|PMID:23109420
Biological Process	GO:0090630	activation of GTPase activity	Tiam1	IMP		Rat	PMID:18930714\|RGD:10043296
Biological Process	GO:0006915	apoptotic process	Tiam1	IDA		Rat	PMID:11751455\|RGD:10043305
Biological Process	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway	Tiam1	IDA		Mouse	MGI:MGI:5306304\|PMID:16801538
Biological Process	GO:0003300	cardiac muscle hypertrophy	Tiam1	IMP		Rat	PMID:22564263\|RGD:9835036
Biological Process	GO:0016477	cell migration	TIAM1	IMP		Human	PMID:20361982
Biological Process	GO:0007160	cell-matrix adhesion	TIAM1	IMP		Human	PMID:20361982
Biological Process	GO:0048013	ephrin receptor signaling pathway	Tiam1	IDA		Mouse	PMID:14988728
Biological Process	GO:1990138	neuron projection extension	Tiam1	IMP		Rat	PMID:20333299\|RGD:10043323
Biological Process	GO:0098989	NMDA selective glutamate receptor signaling pathway	Tiam1	IMP		Rat	PMID:15721239\|RGD:12050147
Biological Process	GO:0050772	positive regulation of axonogenesis	Tiam1	IMP		Mouse	PMID:14988728
Biological Process	GO:0050772	positive regulation of axonogenesis	Tiam1	IMP		Rat	PMID:11264310\|RGD:10043321
Biological Process	GO:0030335	positive regulation of cell migration	TIAM1	IDA		Human	PMID:25032858
Biological Process	GO:0030335	positive regulation of cell migration	Tiam1	IMP		Rat	PMID:24123220\|RGD:10043188
Biological Process	GO:0008284	positive regulation of cell population proliferation	TIAM1	IDA		Human	PMID:25032858
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	Tiam1	IMP		Rat	PMID:16474385\|RGD:10043325
Biological Process	GO:0043507	positive regulation of JUN kinase activity	Tiam1	IMP		Rat	PMID:16203995\|RGD:10043312
Biological Process	GO:0010976	positive regulation of neuron projection development	Tiam1	IDA		Mouse	MGI:MGI:5306304\|PMID:16801538
Biological Process	GO:0010976	positive regulation of neuron projection development	Tiam1	IMP		Rat	PMID:20333299\|RGD:10043323
Biological Process	GO:0032092	positive regulation of protein binding	TIAM1	IDA		Human	PMID:23109420
Biological Process	GO:1904268	positive regulation of Schwann cell chemotaxis	Tiam1	IMP		Rat	PMID:16203995\|RGD:10043312
Biological Process	GO:0072657	protein localization to membrane	Tiam1	IMP		Rat	PMID:18930714\|RGD:10043296
Biological Process	GO:0065003	protein-containing complex assembly	TIAM1	IDA		Human	PMID:23109420
Biological Process	GO:0016601	Rac protein signal transduction	TIAM1	IMP		Human	PMID:20361982
Biological Process	GO:1904338	regulation of dopaminergic neuron differentiation	Tiam1	IMP		Mouse	MGI:MGI:5466648\|PMID:23109420
Biological Process	GO:0010717	regulation of epithelial to mesenchymal transition	TIAM1	IDA		Human	PMID:20826792
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	Tiam1	IMP		Rat	PMID:22564263\|RGD:9835036
Biological Process	GO:0043087	regulation of GTPase activity	Tiam1	IDA		Mouse	MGI:MGI:5306304\|PMID:16801538
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	Tiam1	IMP		Rat	PMID:18930714\|RGD:10043296
Biological Process	GO:1905274	regulation of modification of postsynaptic actin cytoskeleton	Tiam1	IDA		Rat	PMID:15721239\|RGD:12050147
Biological Process	GO:1905274	regulation of modification of postsynaptic actin cytoskeleton	Tiam1	IMP		Rat	PMID:15721239\|RGD:12050147
Biological Process	GO:2000050	regulation of non-canonical Wnt signaling pathway	Tiam1	IGI	UniProtKB:P22725	Mouse	MGI:MGI:5466648\|PMID:23109420
Biological Process	GO:0099175	regulation of postsynapse organization	Tiam1	IDA		Rat	PMID:15721239\|RGD:12050147
Biological Process	GO:0099175	regulation of postsynapse organization	Tiam1	IMP		Rat	PMID:15721239\|RGD:12050147
Biological Process	GO:0042220	response to cocaine	Tiam1	IEP		Rat	PMID:23745104\|RGD:10043322
Biological Process	GO:0007264	small GTPase mediated signal transduction	Tiam1	IDA		Mouse	PMID:12525493

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/09/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.