Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TIE1
  • Mouse genes Tie1
  • Rat genes Tie1
  • Zfish genes tie1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tie1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	TIE1	IPI	UniProtKB:Q15238	Human	PMID:21982860
Molecular Function	GO:0005515	protein binding	TIE1	IPI	UniProtKB:Q6A162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TIE1	IPI	UniProtKB:Q93062	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TIE1	IPI	UniProtKB:P60410	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TIE1	IPI	UniProtKB:Q15654	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TIE1	IPI	UniProtKB:Q9UGI0	Human	PMID:32296183
Cellular Component	GO:0005886	plasma membrane	Tie1	IDA		Mouse	PMID:17717145
Biological Process	GO:0003180	aortic valve morphogenesis	Tie1	IMP		Mouse	MGI:MGI:6370101|PMID:31319059
Biological Process	GO:0001568	blood vessel development	Tie1	IMP	MGI:MGI:5544797	Mouse	PMID:23918385
Biological Process	GO:0001568	blood vessel development	tie1	IMP	ZFIN:ZDB-MRPHLNO-100823-14	Zfish	PMID:19880500
Biological Process	GO:0060854	branching involved in lymph vessel morphogenesis	Tie1	IMP		Mouse	MGI:MGI:4439415|PMID:20223757
Biological Process	GO:0071603	endothelial cell-cell adhesion	tie1	IMP	ZFIN:ZDB-MRPHLNO-100823-14	Zfish	PMID:19880500
Biological Process	GO:0007507	heart development	tie1	IGI	ZFIN:ZDB-GENO-110210-1,ZFIN:ZDB-MRPHLNO-110113-3	Zfish	PMID:21045210
Biological Process	GO:0001701	in utero embryonic development	Tie1	IGI	MGI:MGI:108448	Mouse	PMID:11172728
Biological Process	GO:0060836	lymphatic endothelial cell differentiation	Tie1	IMP		Mouse	MGI:MGI:4439415|PMID:20223757
Biological Process	GO:0016525	negative regulation of angiogenesis	Tie1	IMP	MGI:MGI:2159359	Mouse	PMID:9683559
Biological Process	GO:0030336	negative regulation of cell migration	Tie1	IMP	MGI:MGI:2159359	Mouse	PMID:9683559
Biological Process	GO:0045026	plasma membrane fusion	Tie1	IMP	MGI:MGI:2159359	Mouse	PMID:9683559
Biological Process	GO:0001936	regulation of endothelial cell proliferation	Tie1	IMP		Mouse	MGI:MGI:4439415|PMID:20223757
Biological Process	GO:1901201	regulation of extracellular matrix assembly	Tie1	IMP		Mouse	MGI:MGI:6370101|PMID:31319059
Biological Process	GO:0032526	response to retinoic acid	Tie1	IDA		Mouse	MGI:MGI:3799604|PMID:18439490
Biological Process	GO:0048771	tissue remodeling	Tie1	IMP		Mouse	MGI:MGI:4439415|PMID:20223757
Biological Process	GO:0001944	vasculature development	tie1	IMP	ZFIN:ZDB-MRPHLNO-100823-14	Zfish	PMID:26436659
Biological Process	GO:0001570	vasculogenesis	Tie1	IDA		Rat	PMID:10474040|RGD:724771

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern