Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TIMELESS
  • Mouse genes Timeless
  • Rat genes Timeless
  • Zfish genes timeless
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Timeless

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	Timeless	IPI	PR:Q9R1X4	Mouse	PMID:12875843
Molecular Function	GO:0005515	protein binding	TIMELESS	IPI	UniProtKB:O14757	Human	PMID:15798197
Molecular Function	GO:0005515	protein binding	TIMELESS	IPI	UniProtKB:Q9BVW5	Human	PMID:17102137
Molecular Function	GO:0005515	protein binding	TIMELESS	IPI	UniProtKB:Q96FC9	Human	PMID:20124417
Molecular Function	GO:0005515	protein binding	TIMELESS	IPI	UniProtKB:P09874	Human	PMID:26344098
Molecular Function	GO:0005515	protein binding	TIMELESS	IPI	UniProtKB:P09874	Human	PMID:30356214
Molecular Function	GO:0005515	protein binding	Timeless	IPI	UniProtKB:P97784	Mouse	MGI:MGI:5567851|PMID:24489120
Molecular Function	GO:0005515	protein binding	Timeless	IPI	UniProtKB:O35973|UniProtKB:O54943	Mouse	MGI:MGI:1316573|PMID:9856465
Molecular Function	GO:0005515	protein binding	Timeless	IPI	UniProtKB:O35280|UniProtKB:P97784	Mouse	MGI:MGI:5578016|PMID:23418588
Molecular Function	GO:0005515	protein binding	Timeless	IPI	PR:Q91WA1	Mouse	PMID:12875843
Molecular Function	GO:0005515	protein binding	Timeless	IPI	PR:O35973	Mouse	PMID:10231394
Molecular Function	GO:0005515	protein binding	Timeless	IPI	UniProtKB:Q9Z301	Rat	PMID:11112428|RGD:2308863
Molecular Function	GO:0005515	protein binding	Timeless	IPI	RGD:61945	Rat	PMID:9765215|RGD:61691
Cellular Component	GO:0000785	chromatin	TIMELESS	IDA		Human	PMID:17102137
Cellular Component	GO:0005654	nucleoplasm	TIMELESS	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	TIMELESS	IDA		Human	PMID:17102137
Cellular Component	GO:0005634	nucleus	Timeless	IDA		Mouse	MGI:MGI:5567851|PMID:24489120
Cellular Component	GO:0005634	nucleus	Timeless	IDA		Mouse	MGI:MGI:5578016|PMID:23418588
Cellular Component	GO:0005634	nucleus	Timeless	IDA		Mouse	PMID:12950082
Cellular Component	GO:0005634	nucleus	Timeless	IDA		Mouse	PMID:12875843
Cellular Component	GO:0005634	nucleus	Timeless	IDA		Rat	PMID:11112428|RGD:2308863
Cellular Component	GO:0035861	site of double-strand break	TIMELESS	IDA		Human	PMID:26344098
Cellular Component	GO:0035861	site of double-strand break	TIMELESS	IDA		Human	PMID:30356214
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	Timeless	IMP		Rat	PMID:10963667|RGD:2308864
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	Timeless	IMP		Mouse	PMID:12950082
Biological Process	GO:0044770	cell cycle phase transition	TIMELESS	IMP		Human	PMID:17102137
Biological Process	GO:1904976	cellular response to bleomycin	TIMELESS	IMP		Human	PMID:23797032
Biological Process	GO:0072719	cellular response to cisplatin	TIMELESS	IMP		Human	PMID:23797032
Biological Process	GO:0072711	cellular response to hydroxyurea	TIMELESS	IMP		Human	PMID:23797032
Biological Process	GO:0007623	circadian rhythm	Timeless	IEP		Mouse	MGI:MGI:5578016|PMID:23418588
Biological Process	GO:0007623	circadian rhythm	Timeless	IEP		Mouse	MGI:MGI:1344065|PMID:10231394
Biological Process	GO:0006974	DNA damage response	TIMELESS	IMP		Human	PMID:23797032
Biological Process	GO:0006974	DNA damage response	Timeless	IMP		Mouse	MGI:MGI:5578016|PMID:23418588
Biological Process	GO:0009790	embryo development	Timeless	IMP	MGI:MGI:3051143	Mouse	PMID:10903565
Biological Process	GO:0001822	kidney development	Timeless	IMP		Rat	PMID:10963667|RGD:2308864
Biological Process	GO:0030324	lung development	Timeless	IMP		Mouse	PMID:12950082
Biological Process	GO:0002009	morphogenesis of an epithelium	Timeless	IEP		Mouse	MGI:MGI:1889156|PMID:10963667
Biological Process	GO:0002009	morphogenesis of an epithelium	Timeless	IEP		Rat	PMID:10963667|RGD:2308864
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	TIMELESS	IDA		Human	PMID:9856465
Biological Process	GO:0042753	positive regulation of circadian rhythm	Timeless	IMP		Rat	PMID:14564007|RGD:734503
Biological Process	GO:2000781	positive regulation of double-strand break repair	TIMELESS	IMP		Human	PMID:23797032
Biological Process	GO:1905168	positive regulation of double-strand break repair via homologous recombination	TIMELESS	IDA		Human	PMID:26344098
Biological Process	GO:1905168	positive regulation of double-strand break repair via homologous recombination	TIMELESS	IDA		Human	PMID:30356214
Biological Process	GO:0042752	regulation of circadian rhythm	TIMELESS	IMP		Human	PMID:23418588
Biological Process	GO:0042752	regulation of circadian rhythm	Timeless	IMP		Mouse	MGI:MGI:5578016|PMID:23418588

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern