Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TIMP2
  • Mouse genes Timp2
  • Rat genes Timp2
  • Zfish genes timp2a,timp2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Timp2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008047	enzyme activator activity	Timp2	IMP	MGI:MGI:1888708	Mouse	PMID:10827175
Molecular Function	GO:0008047	enzyme activator activity	Timp2	IMP	MGI:MGI:1888709	Mouse	PMID:10827176
Molecular Function	GO:0005178	integrin binding	Timp2	IDA		Mouse	PMID:15901773
Molecular Function	GO:0005178	integrin binding	Timp2	IPI	RGD:1310333	Rat	PMID:15901773|RGD:1598578
Molecular Function	GO:0008191	metalloendopeptidase inhibitor activity	Timp2	IMP	MGI:MGI:1888709	Mouse	PMID:10827176
Molecular Function	GO:0008191	metalloendopeptidase inhibitor activity	Timp2	IMP		Rat	PMID:15901773|RGD:1598578
Molecular Function	GO:0140678	molecular function inhibitor activity	TIMP2	IMP		Human	PMID:8476862
Molecular Function	GO:0030414	peptidase inhibitor activity	TIMP2	IDA		Human	PMID:9573338
Molecular Function	GO:0002020	protease binding	TIMP2	IPI	UniProtKB:P08254	Human	PMID:9573338
Molecular Function	GO:0005515	protein binding	TIMP2	IPI	UniProtKB:P08253	Human	PMID:12032297
Molecular Function	GO:0005515	protein binding	TIMP2	IPI	UniProtKB:P50281	Human	PMID:24112707
Molecular Function	GO:0005515	protein binding	TIMP2	IPI	UniProtKB:P08253	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	TIMP2	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Molecular Function	GO:0008270	zinc ion binding	TIMP2	IDA		Human	PMID:24073280
Cellular Component	GO:0005604	basement membrane	Timp2	IDA		Mouse	PMID:12950084
Cellular Component	GO:0009986	cell surface	Timp2	IDA		Mouse	PMID:15901773
Cellular Component	GO:0009986	cell surface	Timp2	IDA		Rat	PMID:15901773|RGD:1598578
Cellular Component	GO:0062023	collagen-containing extracellular matrix	TIMP2	HDA		Human	PMID:23979707
Cellular Component	GO:0005615	extracellular space	Timp2	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Timp2	IDA		Rat	PMID:15901773|RGD:1598578
Cellular Component	GO:0005615	extracellular space	timp2a	IDA		Zfish	PMID:12736828
Cellular Component	GO:0030426	growth cone	Timp2	IDA		Rat	PMID:15901773|RGD:1598578
Cellular Component	GO:0043005	neuron projection	Timp2	IDA		Rat	PMID:15901773|RGD:1598578
Cellular Component	GO:0043025	neuronal cell body	Timp2	IDA		Rat	PMID:15901773|RGD:1598578
Biological Process	GO:0007568	aging	Timp2	IEP		Rat	PMID:16208432|RGD:8694091
Biological Process	GO:0007568	aging	Timp2	IEP		Rat	PMID:18278151|RGD:2290357
Biological Process	GO:0071310	cellular response to organic substance	Timp2	IDA		Mouse	PMID:11869290
Biological Process	GO:0007417	central nervous system development	Timp2	IEP		Rat	PMID:11044612|RGD:2290466
Biological Process	GO:0021782	glial cell development	timp2b	IMP	ZFIN:ZDB-CRISPR-191009-15,ZFIN:ZDB-CRISPR-191009-16	Zfish	PMID:30924555
Biological Process	GO:0008285	negative regulation of cell population proliferation	Timp2	IDA		Mouse	PMID:15901773
Biological Process	GO:0008285	negative regulation of cell population proliferation	Timp2	IDA		Rat	PMID:15901773|RGD:1598578
Biological Process	GO:1905049	negative regulation of metallopeptidase activity	TIMP2	IDA		Human	PMID:9573338
Biological Process	GO:0045930	negative regulation of mitotic cell cycle	Timp2	IDA		Rat	PMID:15901773|RGD:1598578
Biological Process	GO:0045861	negative regulation of proteolysis	Timp2	IMP		Rat	PMID:17532789|RGD:2290425
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction	Timp2	IDA		Rat	PMID:15901773|RGD:1598578
Biological Process	GO:0045762	positive regulation of adenylate cyclase activity	Timp2	IMP		Rat	PMID:15901773|RGD:1598578
Biological Process	GO:0043410	positive regulation of MAPK cascade	Timp2	IDA		Rat	PMID:15901773|RGD:1598578
Biological Process	GO:0045666	positive regulation of neuron differentiation	Timp2	IDA		Rat	PMID:15901773|RGD:1598578
Biological Process	GO:0043408	regulation of MAPK cascade	Timp2	IDA		Mouse	PMID:15901773
Biological Process	GO:0045664	regulation of neuron differentiation	Timp2	IMP		Mouse	PMID:15901773
Biological Process	GO:0045664	regulation of neuron differentiation	Timp2	IDA		Mouse	PMID:15901773
Biological Process	GO:0032487	regulation of Rap protein signal transduction	Timp2	IDA		Rat	PMID:15901773|RGD:1598578
Biological Process	GO:0034097	response to cytokine	Timp2	IEP		Rat	PMID:17822627|RGD:2290405
Biological Process	GO:0009410	response to xenobiotic stimulus	Timp2	IEP		Rat	PMID:17491697|RGD:2290407
Biological Process	GO:0060041	retina development in camera-type eye	timp2b	IMP	ZFIN:ZDB-CRISPR-191009-15,ZFIN:ZDB-CRISPR-191009-16	Zfish	PMID:30924555

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern