Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Tjp1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes TJP1
- Mouse genes Tjp1
- Rat genes Tjp1
- Zfish genes tjp1a,tjp1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tjp1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	Tjp1	IPI	RGD:70487	Rat	PMID:12960056\|RGD:150530287
Molecular Function	GO:0045296	cadherin binding	TJP1	HDA		Human	PMID:25468996
Molecular Function	GO:0071253	connexin binding	Tjp1	IPI	UniProtKB:P08050\|UniProtKB:P23242	Mouse	MGI:MGI:5882903\|PMID:14699011
Molecular Function	GO:0071253	connexin binding	Tjp1	IPI	UniProtKB:P08050	Mouse	MGI:MGI:5882902\|PMID:15492000
Molecular Function	GO:0005515	protein binding	TJP1	IPI	UniProtKB:Q9P2M7	Human	PMID:11042084
Molecular Function	GO:0005515	protein binding	TJP1	IPI	UniProtKB:P78310	Human	PMID:11734628
Molecular Function	GO:0005515	protein binding	TJP1	IPI	UniProtKB:Q8N144	Human	PMID:12154091
Molecular Function	GO:0005515	protein binding	TJP1	IPI	UniProtKB:O43707	Human	PMID:16944923
Molecular Function	GO:0005515	protein binding	TJP1	IPI	UniProtKB:P17302	Human	PMID:16944923
Molecular Function	GO:0005515	protein binding	TJP1	IPI	UniProtKB:Q6XZF7	Human	PMID:17015620
Molecular Function	GO:0005515	protein binding	TJP1	IPI	UniProtKB:Q96GC9	Human	PMID:17724469
Molecular Function	GO:0005515	protein binding	TJP1	IPI	UniProtKB:Q9NPG3	Human	PMID:18823282
Molecular Function	GO:0005515	protein binding	TJP1	IPI	UniProtKB:Q16625	Human	PMID:19332538
Molecular Function	GO:0005515	protein binding	TJP1	IPI	UniProtKB:Q16625	Human	PMID:20164257
Molecular Function	GO:0005515	protein binding	TJP1	IPI	UniProtKB:Q9EPK5	Human	PMID:20850437
Molecular Function	GO:0005515	protein binding	TJP1	IPI	UniProtKB:Q96J84	Human	PMID:21402783
Molecular Function	GO:0005515	protein binding	TJP1	IPI	UniProtKB:Q96J84	Human	PMID:22262837
Molecular Function	GO:0005515	protein binding	TJP1	IPI	UniProtKB:P55196	Human	PMID:23885123
Molecular Function	GO:0005515	protein binding	TJP1	IPI	UniProtKB:Q9UDY2	Human	PMID:23885123
Molecular Function	GO:0005515	protein binding	TJP1	IPI	UniProtKB:Q0VF96	Human	PMID:25753039
Molecular Function	GO:0005515	protein binding	TJP1	IPI	UniProtKB:Q8N4S9	Human	PMID:28661558
Molecular Function	GO:0005515	protein binding	TJP1	IPI	UniProtKB:P17302	Human	PMID:29366904
Molecular Function	GO:0005515	protein binding	TJP1	IPI	UniProtKB:P17302	Human	PMID:30992345
Molecular Function	GO:0005515	protein binding	TJP1	IPI	UniProtKB:Q9Y4P9	Human	PMID:31473225
Molecular Function	GO:0005515	protein binding	TJP1	IPI	UniProtKB:P17302	Human	PMID:9707407
Molecular Function	GO:0005515	protein binding	Tjp1	IPI	UniProtKB:P57780	Mouse	MGI:MGI:3696587\|PMID:16944923
Molecular Function	GO:0005515	protein binding	Tjp1	IPI	UniProtKB:Q9ES83	Mouse	MGI:MGI:3607041\|PMID:16188940
Molecular Function	GO:0005515	protein binding	Tjp1	IPI	UniProtKB:O35054\|UniProtKB:O54942\|UniProtKB:O88551\|UniProtKB:O88552\|UniProtKB:Q9Z0G9\|UniProtKB:Q9Z260\|UniProtKB:Q9Z261\|UniProtKB:Q9Z262	Mouse	MGI:MGI:1350677\|PMID:10601346
Molecular Function	GO:0005515	protein binding	Tjp1	IPI	UniProtKB:Q01705\|UniProtKB:Q61483	Mouse	MGI:MGI:5565112\|PMID:24715457
Molecular Function	GO:0005515	protein binding	Tjp1	IPI	UniProtKB:P23242	Mouse	MGI:MGI:4939823\|PMID:21282606
Molecular Function	GO:0005515	protein binding	Tjp1	IPI	UniProtKB:P23242\|UniProtKB:P70689	Mouse	MGI:MGI:5508268\|PMID:16045494
Molecular Function	GO:0005515	protein binding	Tjp1	IPI	UniProtKB:Q64727	Mouse	MGI:MGI:5578691\|PMID:24413171
Molecular Function	GO:0005515	protein binding	Tjp1	IPI	UniProtKB:P23242	Mouse	MGI:MGI:5578691\|PMID:24413171
Molecular Function	GO:0005515	protein binding	Tjp1	IPI	PR:P15975	Mouse	PMID:26609154
Molecular Function	GO:0005515	protein binding	Tjp1	IPI	RGD:727803	Rat	PMID:16617054\|RGD:1582382
Molecular Function	GO:0005515	protein binding	Tjp1	IPI	UniProtKB:Q6P6T5	Rat	PMID:19470647\|RGD:13432232
Molecular Function	GO:0005515	protein binding	Tjp1	IPI	RGD:2690	Rat	PMID:19825979\|RGD:2325130
Molecular Function	GO:0005515	protein binding	Tjp1	IPI	UniProtKB:Q6P6T5	Rat	PMID:22106313\|RGD:13432329
Molecular Function	GO:0005515	protein binding	Tjp1	IPI	UniProtKB:P08050	Rat	PMID:29021339\|RGD:13825187
Molecular Function	GO:0005515	protein binding	tjp1a	IPI	ZFIN:ZDB-GENE-050616-11	Zfish	PMID:25915619
Molecular Function	GO:0005515	protein binding	tjp1a	IPI	ZFIN:ZDB-GENE-991105-4	Zfish	PMID:25915619
Molecular Function	GO:0005515	protein binding	tjp1a	IPI	ZFIN:ZDB-GENE-050616-6	Zfish	PMID:25915619
Molecular Function	GO:0019904	protein domain specific binding	Tjp1	IPI	PR:A2ALU4	Mouse	PMID:17666436
Molecular Function	GO:0044325	transmembrane transporter binding	Tjp1	IPI	RGD:2690	Rat	PMID:15980428\|RGD:1582683
Cellular Component	GO:0005912	adherens junction	Tjp1	IDA		Mouse	PMID:11731229
Cellular Component	GO:0005912	adherens junction	Tjp1	IDA		Mouse	PMID:17666436
Cellular Component	GO:0005912	adherens junction	Tjp1	IDA		Mouse	PMID:12203721
Cellular Component	GO:0005912	adherens junction	Tjp1	IDA		Mouse	PMID:15728677
Cellular Component	GO:0043296	apical junction complex	TJP1	IDA		Human	PMID:16427635
Cellular Component	GO:0045177	apical part of cell	TJP1	IDA		Human	PMID:22006950
Cellular Component	GO:0045177	apical part of cell	Tjp1	IDA		Mouse	PMID:23863479
Cellular Component	GO:0045177	apical part of cell	Tjp1	IDA		Mouse	PMID:24191021
Cellular Component	GO:0045177	apical part of cell	Tjp1	IDA		Mouse	PMID:23610556
Cellular Component	GO:0045177	apical part of cell	Tjp1	IDA		Mouse	PMID:23434913
Cellular Component	GO:0016324	apical plasma membrane	Tjp1	IDA		Mouse	PMID:21947081
Cellular Component	GO:0016327	apicolateral plasma membrane	Tjp1	IDA		Mouse	PMID:16520537
Cellular Component	GO:0016323	basolateral plasma membrane	TJP1	IDA		Human	PMID:16427635
Cellular Component	GO:0005923	bicellular tight junction	TJP1	IDA		Human	PMID:11734628
Cellular Component	GO:0005923	bicellular tight junction	TJP1	IDA		Human	PMID:14757759
Cellular Component	GO:0005923	bicellular tight junction	TJP1	IDA		Human	PMID:18823282
Cellular Component	GO:0005923	bicellular tight junction	TJP1	IDA		Human	PMID:22006950
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	MGI:MGI:5009409\|PMID:16275913
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:12673830
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:17000770
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:25512490
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:18308723
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:14622136
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:15950600
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:10395790
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:19129494
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:17130295
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:23979167
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:17138661
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:21285373
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:22946046
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:20551175
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:19590046
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:17397395
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:11689568
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:16364283
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:16199027
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:15775979
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:12832289
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:16520537
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:14685273
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:20080746
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:11706048
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:11025210
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:17666436
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Mouse	PMID:16105026
Cellular Component	GO:0005923	bicellular tight junction	Tjp1	IDA		Rat	PMID:17899156\|RGD:2289800
Cellular Component	GO:0005923	bicellular tight junction	tjp1a	IDA		Zfish	PMID:18275946
Cellular Component	GO:0030054	cell junction	TJP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030054	cell junction	TJP1	IDA		Human	PMID:28169360
Cellular Component	GO:0030054	cell junction	Tjp1	IDA		Mouse	PMID:16427635
Cellular Component	GO:0030054	cell junction	Tjp1	IDA		Mouse	PMID:21884682
Cellular Component	GO:0030054	cell junction	Tjp1	IDA		Mouse	PMID:21411630
Cellular Component	GO:0005911	cell-cell junction	Tjp1	IDA		Mouse	MGI:MGI:6368095\|PMID:25486565
Cellular Component	GO:0005911	cell-cell junction	Tjp1	IDA		Mouse	PMID:24339795
Cellular Component	GO:0005911	cell-cell junction	Tjp1	IDA		Mouse	PMID:26609154
Cellular Component	GO:0005911	cell-cell junction	Tjp1	IDA		Mouse	PMID:23824537
Cellular Component	GO:0005911	cell-cell junction	Tjp1	IDA		Mouse	PMID:20473291
Cellular Component	GO:0005911	cell-cell junction	Tjp1	IDA		Mouse	PMID:18423437
Cellular Component	GO:0005911	cell-cell junction	Tjp1	IDA		Mouse	PMID:22512338
Cellular Component	GO:0005911	cell-cell junction	Tjp1	IDA		Mouse	PMID:20089884
Cellular Component	GO:0005911	cell-cell junction	Tjp1	IDA		Rat	PMID:25486565\|RGD:14995318
Cellular Component	GO:0005737	cytoplasm	TJP1	IDA		Human	PMID:11734628
Cellular Component	GO:0005737	cytoplasm	Tjp1	IDA		Mouse	PMID:16427635
Cellular Component	GO:0005737	cytoplasm	Tjp1	IDA		Rat	PMID:16567508\|RGD:2325150
Cellular Component	GO:0005829	cytosol	TJP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005921	gap junction	Tjp1	IDA		Rat	PMID:29021339\|RGD:13825187
Cellular Component	GO:0014704	intercalated disc	Tjp1	IDA		Mouse	PMID:18603586
Cellular Component	GO:0046581	intercellular canaliculus	Tjp1	IDA		Mouse	PMID:12068294
Cellular Component	GO:0016020	membrane	Tjp1	IDA		Mouse	PMID:15788452
Cellular Component	GO:0005634	nucleus	Tjp1	IDA		Mouse	MGI:MGI:6368095\|PMID:25486565
Cellular Component	GO:0005634	nucleus	Tjp1	IDA		Mouse	PMID:14685273
Cellular Component	GO:0005634	nucleus	Tjp1	IDA		Mouse	PMID:16427635
Cellular Component	GO:0005886	plasma membrane	TJP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	TJP1	IDA		Human	PMID:11090614
Cellular Component	GO:0005886	plasma membrane	Tjp1	IDA		Mouse	MGI:MGI:5882903\|PMID:14699011
Cellular Component	GO:0005886	plasma membrane	Tjp1	IDA		Mouse	PMID:12507281
Cellular Component	GO:0005886	plasma membrane	Tjp1	IDA		Mouse	PMID:15775979
Cellular Component	GO:0005886	plasma membrane	Tjp1	IDA		Mouse	PMID:15084279
Cellular Component	GO:0005886	plasma membrane	Tjp1	IDA		Mouse	PMID:12060405
Cellular Component	GO:0005886	plasma membrane	Tjp1	IDA		Mouse	PMID:17122142
Cellular Component	GO:0032991	protein-containing complex	TJP1	IDA		Human	PMID:25753039
Cellular Component	GO:0032991	protein-containing complex	Tjp1	IMP		Mouse	MGI:MGI:5882902\|PMID:15492000
Cellular Component	GO:0070160	tight junction	TJP1	IDA		Human	PMID:22855531
Cellular Component	GO:0070160	tight junction	TJP1	IMP		Human	PMID:24854121
Cellular Component	GO:0070160	tight junction	TJP1	IDA		Human	PMID:27037668
Cellular Component	GO:0070160	tight junction	TJP1	IDA		Human	PMID:30734065
Cellular Component	GO:0070160	tight junction	Tjp1	IDA		Mouse	MGI:MGI:6369916\|PMID:30734065
Cellular Component	GO:0070160	tight junction	Tjp1	IDA		Mouse	PMID:34166821
Cellular Component	GO:0070160	tight junction	Tjp1	IDA		Mouse	PMID:24889144
Biological Process	GO:0031032	actomyosin structure organization	TJP1	IMP		Human	PMID:25753039
Biological Process	GO:0034334	adherens junction maintenance	TJP1	IMP		Human	PMID:25753039
Biological Process	GO:0001825	blastocyst formation	Tjp1	IMP		Mouse	PMID:18423437
Biological Process	GO:0045216	cell-cell junction organization	TJP1	IMP		Human	PMID:25753039
Biological Process	GO:0071333	cellular response to glucose stimulus	Tjp1	IEP		Rat	PMID:16567508\|RGD:2325150
Biological Process	GO:0090557	establishment of endothelial intestinal barrier	TJP1	IMP		Human	PMID:23885123
Biological Process	GO:0016264	gap junction assembly	tjp1b	IMP	ZFIN:ZDB-GENO-220414-2	Zfish	PMID:29103941
Biological Process	GO:2000250	negative regulation of actin cytoskeleton reorganization	TJP1	IMP		Human	PMID:25753039
Biological Process	GO:0043066	negative regulation of apoptotic process	TJP1	IMP		Human	PMID:29771433
Biological Process	GO:0051497	negative regulation of stress fiber assembly	Tjp1	IMP		Mouse	MGI:MGI:6206452\|PMID:25753039
Biological Process	GO:0043116	negative regulation of vascular permeability	Tjp1	IEP		Rat	PMID:20137299\|RGD:2325126
Biological Process	GO:0043473	pigmentation	tjp1a	IMP	ZFIN:ZDB-GENO-151209-1	Zfish	PMID:25915619
Biological Process	GO:0043473	pigmentation	tjp1a	IGI	ZFIN:ZDB-GENO-151209-14	Zfish	PMID:25915619
Biological Process	GO:0043473	pigmentation	tjp1a	IGI	ZFIN:ZDB-GENO-151209-15	Zfish	PMID:25915619
Biological Process	GO:1905605	positive regulation of blood-brain barrier permeability	TJP1	IMP		Human	PMID:24854121
Biological Process	GO:0030335	positive regulation of cell migration	TJP1	IMP		Human	PMID:25753039
Biological Process	GO:0008284	positive regulation of cell population proliferation	TJP1	IMP		Human	PMID:29771433
Biological Process	GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	TJP1	IMP		Human	PMID:25753039
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	TJP1	IMP		Human	PMID:25753039
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	Tjp1	IMP		Mouse	MGI:MGI:6206452\|PMID:25753039
Biological Process	GO:0071896	protein localization to adherens junction	TJP1	IMP	UniProtKB:Q9NRY4	Human	PMID:25753039
Biological Process	GO:1902396	protein localization to bicellular tight junction	TJP1	IMP	UniProtKB:O00501,UniProtKB:Q9Y624	Human	PMID:25753039
Biological Process	GO:0150105	protein localization to cell-cell junction	TJP1	IMP	UniProtKB:O00501\|UniProtKB:P18206\|UniProtKB:P49023\|UniProtKB:P60709\|UniProtKB:Q0VF96\|UniProtKB:Q13177\|UniProtKB:Q6ZSZ5\|UniProtKB:Q9UKX2	Human	PMID:25753039
Biological Process	GO:0150105	protein localization to cell-cell junction	Tjp1	IMP	UniProtKB:P18206	Mouse	MGI:MGI:6206452\|PMID:25753039
Biological Process	GO:2000810	regulation of bicellular tight junction assembly	TJP1	IMP		Human	PMID:25753039
Biological Process	GO:1901888	regulation of cell junction assembly	TJP1	IMP		Human	PMID:25753039
Biological Process	GO:0051493	regulation of cytoskeleton organization	TJP1	IMP		Human	PMID:25753039
Biological Process	GO:0045471	response to ethanol	Tjp1	IEP		Rat	PMID:17515855\|RGD:2325148
Biological Process	GO:0032496	response to lipopolysaccharide	Tjp1	IEP		Rat	PMID:17515855\|RGD:2325148
Biological Process	GO:0071000	response to magnetism	Tjp1	IEP		Rat	PMID:20137299\|RGD:2325126
Biological Process	GO:0009410	response to xenobiotic stimulus	Tjp1	IEP		Rat	PMID:18360096\|RGD:2325140
Biological Process	GO:0007605	sensory perception of sound	Tjp1	IMP	MGI:MGI:5550095	Mouse	PMID:23979167
Biological Process	GO:0036060	slit diaphragm assembly	tjp1a	IMP	ZFIN:ZDB-MRPHLNO-200127-3,ZFIN:ZDB-MRPHLNO-200127-4	Zfish	PMID:31171632
Biological Process	GO:0007416	synapse assembly	tjp1b	IMP	ZFIN:ZDB-GENO-230130-1	Zfish	PMID:35855444
Biological Process	GO:0007416	synapse assembly	tjp1b	IMP	ZFIN:ZDB-GENO-230130-2	Zfish	PMID:35855444
Biological Process	GO:0007416	synapse assembly	tjp1b	IMP		Zfish	PMID:25867848

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/15/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.