Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TK1
  • Mouse genes Tk1
  • Rat genes Tk1
  • Zfish genes tk1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	TK1	IPI	UniProtKB:P04183	Human	PMID:21900206
Molecular Function	GO:0042802	identical protein binding	TK1	IPI	UniProtKB:P04183	Human	PMID:22385435
Molecular Function	GO:0042802	identical protein binding	Tk1	IPI	UniProtKB:P27158	Rat	PMID:23351158|RGD:8554244
Molecular Function	GO:0005515	protein binding	TK1	IPI	UniProtKB:Q1RN33	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TK1	IPI	UniProtKB:A0A087WZT3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TK1	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TK1	IPI	UniProtKB:Q92993	Human	PMID:32814053
Molecular Function	GO:0004797	thymidine kinase activity	TK1	IDA		Human	PMID:14697231
Molecular Function	GO:0004797	thymidine kinase activity	TK1	IDA		Human	PMID:22385435
Molecular Function	GO:0004797	thymidine kinase activity	Tk1	IDA		Mouse	PMID:204065
Molecular Function	GO:0008270	zinc ion binding	TK1	IDA		Human	PMID:17407781
Biological Process	GO:0009157	deoxyribonucleoside monophosphate biosynthetic process	Tk1	IDA		Mouse	MGI:MGI:54423|PMID:204065
Biological Process	GO:0048565	digestive tract development	Tk1	IEP		Rat	PMID:6701043|RGD:2317231
Biological Process	GO:1904860	DNA synthesis involved in mitotic DNA replication	TK1	IDA		Human	PMID:14697231
Biological Process	GO:0060138	fetal process involved in parturition	Tk1	IEP		Rat	PMID:7208144|RGD:2317233
Biological Process	GO:0001889	liver development	Tk1	IEP		Rat	PMID:995499|RGD:2317236
Biological Process	GO:0009165	nucleotide biosynthetic process	Tk1	IDA		Mouse	MGI:MGI:54423|PMID:204065
Biological Process	GO:0051289	protein homotetramerization	TK1	IDA		Human	PMID:14697231
Biological Process	GO:0051289	protein homotetramerization	TK1	IPI	UniProtKB:P04183	Human	PMID:17407781
Biological Process	GO:0046688	response to copper ion	Tk1	IEP		Rat	PMID:6642140|RGD:2317232
Biological Process	GO:0051414	response to cortisol	Tk1	IEP		Rat	PMID:7208144|RGD:2317233
Biological Process	GO:0031667	response to nutrient levels	Tk1	IEP		Rat	PMID:6701043|RGD:2317231
Biological Process	GO:0009636	response to toxic substance	Tk1	IEP		Rat	PMID:6642140|RGD:2317232
Biological Process	GO:0014856	skeletal muscle cell proliferation	Tk1	IEP		Rat	PMID:15748706|RGD:2317229
Biological Process	GO:0046105	thymidine biosynthetic process	TK1	IDA		Human	PMID:14697231
Biological Process	GO:0046104	thymidine metabolic process	TK1	IDA		Human	PMID:22385435
Biological Process	GO:0046104	thymidine metabolic process	Tk1	IDA		Rat	PMID:6642140|RGD:2317232

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern