Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TKT
  • Mouse genes Tkt
  • Rat genes Tkt
  • Zfish genes tkta,tktb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tkt

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	TKT	IDA		Human	PMID:20667822
Molecular Function	GO:0030246	carbohydrate binding	Tkt	IDA		Rat	PMID:2843500|RGD:1599574
Molecular Function	GO:0000287	magnesium ion binding	TKT	IDA		Human	PMID:9611778
Molecular Function	GO:0000287	magnesium ion binding	Tkt	IDA		Rat	PMID:16116031|RGD:1580394
Molecular Function	GO:0048029	monosaccharide binding	Tkt	IDA		Rat	PMID:16116031|RGD:1580394
Molecular Function	GO:0005515	protein binding	TKT	IPI	UniProtKB:P54274	Human	PMID:21044950
Molecular Function	GO:0042803	protein homodimerization activity	TKT	IDA		Human	PMID:20667822
Molecular Function	GO:0042803	protein homodimerization activity	TKT	IDA		Human	PMID:9357955
Molecular Function	GO:0030976	thiamine pyrophosphate binding	Tkt	IDA		Rat	PMID:16116031|RGD:1580394
Molecular Function	GO:0004802	transketolase activity	TKT	IDA		Human	PMID:20667822
Molecular Function	GO:0004802	transketolase activity	TKT	IDA		Human	PMID:8419340
Molecular Function	GO:0004802	transketolase activity	TKT	IDA		Human	PMID:9357955
Molecular Function	GO:0004802	transketolase activity	TKT	IDA		Human	PMID:9611778
Molecular Function	GO:0004802	transketolase activity	Tkt	IDA		Mouse	PMID:5360673
Molecular Function	GO:0004802	transketolase activity	Tkt	IDA		Mouse	PMID:12167708
Molecular Function	GO:0004802	transketolase activity	Tkt	IDA		Rat	PMID:16116031|RGD:1580394
Molecular Function	GO:0004802	transketolase activity	Tkt	IDA		Rat	PMID:17447164|RGD:1624966
Molecular Function	GO:0004802	transketolase activity	Tkt	IDA		Rat	PMID:2843500|RGD:1599574
Cellular Component	GO:0005829	cytosol	Tkt	IDA		Mouse	PMID:5360673
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Tkt	IDA		Rat	PMID:16116031|RGD:1580394
Cellular Component	GO:0070062	extracellular exosome	TKT	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	TKT	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	TKT	HDA		Human	PMID:23533145
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Tkt	IDA		Rat	PMID:2843500|RGD:1599574
Cellular Component	GO:0043209	myelin sheath	Tkt	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0016604	nuclear body	TKT	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	TKT	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005777	peroxisome	Tkt	IDA		Rat	PMID:16116031|RGD:1580394
Cellular Component	GO:0031982	vesicle	TKT	HDA		Human	PMID:19190083
Biological Process	GO:0046166	glyceraldehyde-3-phosphate biosynthetic process	TKT	IDA		Human	PMID:9611778
Biological Process	GO:0006098	pentose-phosphate shunt	TKT	IDA		Human	PMID:20667822
Biological Process	GO:0006098	pentose-phosphate shunt	Tkt	IDA		Mouse	PMID:5360673
Biological Process	GO:0006098	pentose-phosphate shunt	Tkt	IDA		Mouse	PMID:13405914
Biological Process	GO:0006098	pentose-phosphate shunt	Tkt	IDA		Rat	PMID:2843500|RGD:1599574
Biological Process	GO:0009052	pentose-phosphate shunt, non-oxidative branch	Tkt	IDA		Rat	PMID:16116031|RGD:1580394
Biological Process	GO:0009052	pentose-phosphate shunt, non-oxidative branch	Tkt	IDA		Rat	PMID:3079759|RGD:1641816
Biological Process	GO:0040008	regulation of growth	Tkt	IMP	MGI:MGI:2671068	Mouse	PMID:12167708
Biological Process	GO:0046390	ribose phosphate biosynthetic process	Tkt	IDA		Rat	PMID:16116031|RGD:1580394
Biological Process	GO:1901159	xylulose 5-phosphate biosynthetic process	Tkt	IDA		Mouse	PMID:5360673

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern